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The map label for this gene is zwf [H]

Identifier: 154245200

GI number: 154245200

Start: 1442057

End: 1443532

Strand: Reverse

Name: zwf [H]

Synonym: Xaut_1252

Alternate gene names: 154245200

Gene position: 1443532-1442057 (Counterclockwise)

Preceding gene: 154245201

Following gene: 154245199

Centisome position: 27.19

GC content: 67.95

Gene sequence:

>1476_bases
ATGGTTGCGCGTGTGGTCGCGGTCGAACCCTTCGACATCATCGTGTTCGGCGCCACCGGCGATCTCGCGCGGCGCAAGCT
GCTGCCGGCCCTGTTCGAGCGTGATCTCGCCGGCCAGATGCCCGACGAGGCCCGCATCATCGGCGTCTCCCGGCGCCCCA
TGGAGCGGGCGGCATTCCAGGATTTCGCCCGGGACGCGGTGGAGATGTCCGACGGCATCGAGGATGCCCGCCCCGCCCGC
CTCGCCCATTTCCTCGACCGGCTCGACTATGTGGCGGTTGACGCCCAGTCCGACGCCGGCTGGGCTGACCTTGCCCGCCT
GCTGGACGAGGGACGCGACCATGTCCGGGTGCTCTATCTCGCCGTGGGGCCGGACCTGTTCGATCCCATCTGCGCCCGCA
TCGGGGAACACGGCATCGTCACCGACAAGACCCGCGTGGTGGTGGAAAAGCCGGTGGGTAAGGACCTCGCCTCGGCGCTG
AAGGTCAATGCCGCCGTCGGCAAGGTCTTCCGCGAGGAAGCGGTGTTCCGCATCGATCATTATCTCGGCAAGGAAACAGT
GCAGAACCTGATGGCGCTCAGGTTCGCCAACGCCCTGTTCGAGCCGGTGTGGAACAACGCCCACATCGACCATGTGCAGA
TCACGGTGGCCGAGAGCATCGGCACCGCGGGCCGCGCCGGTTACTACGACACCGCCGGCGCCCTGCGCGACATGGTGCAG
AACCATATTCTCCAGCTGCTCTGCCTGGTGGCCATGGAGCCGCCCGTATCGCTGGACGCGGATGCGGTGCGCGACGAGAA
GCTGAAGGTTCTCAAAGCCCTCACCCCCATCACCGAGGCCAATGCCGCCCAGCTCACCGTGCGCGGCCAGTATCGCGCCG
GCGCTTCATCGGGCGGGGCCGTGCCGGGCTATCTGGAGGAGCTGGGCTCCTCCACCTCGGAGACCGAGACCTTCGTGGCC
CTGAAGGCGGAAATCGGCAACTGGCGCTGGTCCGGCGTGCCTTTCTACCTGCGCACCGGCAAGAGGCTGGCATCGCGGGT
GTCGGAGATCGTGGTCGCGTTCCGGCCCATTCCCCATTCGGTGTTCGACGCGCAGGCGGGTCCCATCGTGGCCAACCGCC
TCGTCATGCGGCTCCAGCCCGACGAGGGCGTGAAGCTCTGGCTCATGATCAAGGACCCCGGCCCCGGCGGCATGCGGCTC
CAGCACGTGCCCCTCGACATGAGCTTCGCCAGCGTGTTCGGCGTGCGCAACGCCGACGCCTACGAGCGCCTCATCATGGA
TGTGGTGCGCGGCAACCAGACCCTGTTCATGCGCCGCGACGAGGTGGAGGCGGCCTGGAACTGGATCGATCCCATCCTCG
ACGCCTGGCGAACCTCCCGCGAGCTGCCCAAGCCCTACACCGCCGGCACCTGGGGGCCCTCCGCCGCCATCGCCCTCATC
GAGCGGGACGGACGGACCTGGACCGACGATGCCTGA

Upstream 100 bases:

>100_bases
TCAGATCGGAACGTGATCTAGAGTGCCAGCGGCGGACGCGGATGCGGCGGCCCCGGGCGCGCTCCGGGTGCGGCAGGCGC
CGCGGTCAGGGGAGAGGCTC

Downstream 100 bases:

>100_bases
GGCCGCCTTTTCCGAGAAACCCATGACGACATCCTCCCACCCGACACCCGCCCTCCCCTTCGCCCTTGCCGCCTATGACG
ACCCCGCTGCCCTTGCCCGC

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 491; Mature: 491

Protein sequence:

>491_residues
MVARVVAVEPFDIIVFGATGDLARRKLLPALFERDLAGQMPDEARIIGVSRRPMERAAFQDFARDAVEMSDGIEDARPAR
LAHFLDRLDYVAVDAQSDAGWADLARLLDEGRDHVRVLYLAVGPDLFDPICARIGEHGIVTDKTRVVVEKPVGKDLASAL
KVNAAVGKVFREEAVFRIDHYLGKETVQNLMALRFANALFEPVWNNAHIDHVQITVAESIGTAGRAGYYDTAGALRDMVQ
NHILQLLCLVAMEPPVSLDADAVRDEKLKVLKALTPITEANAAQLTVRGQYRAGASSGGAVPGYLEELGSSTSETETFVA
LKAEIGNWRWSGVPFYLRTGKRLASRVSEIVVAFRPIPHSVFDAQAGPIVANRLVMRLQPDEGVKLWLMIKDPGPGGMRL
QHVPLDMSFASVFGVRNADAYERLIMDVVRGNQTLFMRRDEVEAAWNWIDPILDAWRTSRELPKPYTAGTWGPSAAIALI
ERDGRTWTDDA

Sequences:

>Translated_491_residues
MVARVVAVEPFDIIVFGATGDLARRKLLPALFERDLAGQMPDEARIIGVSRRPMERAAFQDFARDAVEMSDGIEDARPAR
LAHFLDRLDYVAVDAQSDAGWADLARLLDEGRDHVRVLYLAVGPDLFDPICARIGEHGIVTDKTRVVVEKPVGKDLASAL
KVNAAVGKVFREEAVFRIDHYLGKETVQNLMALRFANALFEPVWNNAHIDHVQITVAESIGTAGRAGYYDTAGALRDMVQ
NHILQLLCLVAMEPPVSLDADAVRDEKLKVLKALTPITEANAAQLTVRGQYRAGASSGGAVPGYLEELGSSTSETETFVA
LKAEIGNWRWSGVPFYLRTGKRLASRVSEIVVAFRPIPHSVFDAQAGPIVANRLVMRLQPDEGVKLWLMIKDPGPGGMRL
QHVPLDMSFASVFGVRNADAYERLIMDVVRGNQTLFMRRDEVEAAWNWIDPILDAWRTSRELPKPYTAGTWGPSAAIALI
ERDGRTWTDDA
>Mature_491_residues
MVARVVAVEPFDIIVFGATGDLARRKLLPALFERDLAGQMPDEARIIGVSRRPMERAAFQDFARDAVEMSDGIEDARPAR
LAHFLDRLDYVAVDAQSDAGWADLARLLDEGRDHVRVLYLAVGPDLFDPICARIGEHGIVTDKTRVVVEKPVGKDLASAL
KVNAAVGKVFREEAVFRIDHYLGKETVQNLMALRFANALFEPVWNNAHIDHVQITVAESIGTAGRAGYYDTAGALRDMVQ
NHILQLLCLVAMEPPVSLDADAVRDEKLKVLKALTPITEANAAQLTVRGQYRAGASSGGAVPGYLEELGSSTSETETFVA
LKAEIGNWRWSGVPFYLRTGKRLASRVSEIVVAFRPIPHSVFDAQAGPIVANRLVMRLQPDEGVKLWLMIKDPGPGGMRL
QHVPLDMSFASVFGVRNADAYERLIMDVVRGNQTLFMRRDEVEAAWNWIDPILDAWRTSRELPKPYTAGTWGPSAAIALI
ERDGRTWTDDA

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI108773793, Length=485, Percent_Identity=38.1443298969072, Blast_Score=312, Evalue=5e-85,
Organism=Homo sapiens, GI109389365, Length=482, Percent_Identity=38.1742738589212, Blast_Score=311, Evalue=7e-85,
Organism=Homo sapiens, GI52145310, Length=497, Percent_Identity=29.9798792756539, Blast_Score=179, Evalue=5e-45,
Organism=Escherichia coli, GI1788158, Length=483, Percent_Identity=49.6894409937888, Blast_Score=486, Evalue=1e-138,
Organism=Caenorhabditis elegans, GI17538218, Length=495, Percent_Identity=36.3636363636364, Blast_Score=317, Evalue=8e-87,
Organism=Saccharomyces cerevisiae, GI6324088, Length=485, Percent_Identity=35.6701030927835, Blast_Score=281, Evalue=2e-76,
Organism=Drosophila melanogaster, GI24643350, Length=487, Percent_Identity=34.4969199178645, Blast_Score=281, Evalue=1e-75,
Organism=Drosophila melanogaster, GI24643352, Length=487, Percent_Identity=34.4969199178645, Blast_Score=280, Evalue=2e-75,
Organism=Drosophila melanogaster, GI221513548, Length=488, Percent_Identity=30.5327868852459, Blast_Score=212, Evalue=5e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 54160; Mature: 54160

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVARVVAVEPFDIIVFGATGDLARRKLLPALFERDLAGQMPDEARIIGVSRRPMERAAFQ
CCEEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHH
DFARDAVEMSDGIEDARPARLAHFLDRLDYVAVDAQSDAGWADLARLLDEGRDHVRVLYL
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHCCCCEEEEEEE
AVGPDLFDPICARIGEHGIVTDKTRVVVEKPVGKDLASALKVNAAVGKVFREEAVFRIDH
EECCCHHHHHHHHHCCCCCEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
YLGKETVQNLMALRFANALFEPVWNNAHIDHVQITVAESIGTAGRAGYYDTAGALRDMVQ
HHCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEHHCCCCCCCCCCCHHHHHHHHHH
NHILQLLCLVAMEPPVSLDADAVRDEKLKVLKALTPITEANAAQLTVRGQYRAGASSGGA
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCC
VPGYLEELGSSTSETETFVALKAEIGNWRWSGVPFYLRTGKRLASRVSEIVVAFRPIPHS
CCHHHHHHCCCCCCCCEEEEEEEECCCEEECCCCEEECCCHHHHHHHHHHHHHHCCCCCH
VFDAQAGPIVANRLVMRLQPDEGVKLWLMIKDPGPGGMRLQHVPLDMSFASVFGVRNADA
HHCCCCCCHHHHEEEEEECCCCCCEEEEEEECCCCCCCEEEECCCCCHHHHHHCCCCCHH
YERLIMDVVRGNQTLFMRRDEVEAAWNWIDPILDAWRTSRELPKPYTAGTWGPSAAIALI
HHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEE
ERDGRTWTDDA
ECCCCCCCCCC
>Mature Secondary Structure
MVARVVAVEPFDIIVFGATGDLARRKLLPALFERDLAGQMPDEARIIGVSRRPMERAAFQ
CCEEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHH
DFARDAVEMSDGIEDARPARLAHFLDRLDYVAVDAQSDAGWADLARLLDEGRDHVRVLYL
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHCCCCEEEEEEE
AVGPDLFDPICARIGEHGIVTDKTRVVVEKPVGKDLASALKVNAAVGKVFREEAVFRIDH
EECCCHHHHHHHHHCCCCCEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
YLGKETVQNLMALRFANALFEPVWNNAHIDHVQITVAESIGTAGRAGYYDTAGALRDMVQ
HHCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEHHCCCCCCCCCCCHHHHHHHHHH
NHILQLLCLVAMEPPVSLDADAVRDEKLKVLKALTPITEANAAQLTVRGQYRAGASSGGA
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCC
VPGYLEELGSSTSETETFVALKAEIGNWRWSGVPFYLRTGKRLASRVSEIVVAFRPIPHS
CCHHHHHHCCCCCCCCEEEEEEEECCCEEECCCCEEECCCHHHHHHHHHHHHHHCCCCCH
VFDAQAGPIVANRLVMRLQPDEGVKLWLMIKDPGPGGMRLQHVPLDMSFASVFGVRNADA
HHCCCCCCHHHHEEEEEECCCCCCEEEEEEECCCCCCCEEEECCCCCHHHHHHCCCCCHH
YERLIMDVVRGNQTLFMRRDEVEAAWNWIDPILDAWRTSRELPKPYTAGTWGPSAAIALI
HHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEE
ERDGRTWTDDA
ECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10400573; 11481430 [H]