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The map label for this gene is argF [H]

Identifier: 154245167

GI number: 154245167

Start: 1402347

End: 1403276

Strand: Direct

Name: argF [H]

Synonym: Xaut_1219

Alternate gene names: 154245167

Gene position: 1402347-1403276 (Clockwise)

Preceding gene: 154245166

Following gene: 154245168

Centisome position: 26.41

GC content: 65.7

Gene sequence:

>930_bases
ATGAAGGGGAACGGCGTGCGCCATTTTCTAGACCTGTCCGAGATCCCGGCCGAGGAGTTGCGCCGGGTTCTCGATTTTTC
CAAGGACCTCAAGGCCCGGCGCAAGGCCGGCGAGGTGGACCGGCCGCTCGCGGGCAAGACACTCGCCATGGTGTTCGACA
AGCCGTCGACCCGCACCCGCGTGTCGTTCGACCTCGCCATGCGCCAGCTCGGTGGCGAGACCATCATGCTCACCGGCCAG
GAGATGCAGCTCGGGCGCGGCGAGACCATCGCCGACACCGCCCGGGTGCTGTCGCGCTTCGTGGATGCCATCATGATCCG
CATCCTGGACCATGACGACCTCACCGAGCTGGCGAAGCACGCCACGGTGCCGGTGATCAACGGGCTCACCCGCATCTCCC
ATCCCTGCCAGGTGATGGCGGATGTGCTGACCTTCGAGGAGCACAGGGGCAACATCACGGGCCGCTCCGTGGCCTGGACC
GGCGACGCCAACAATGTGCTGGCGTCCTGGGTACATGCCGCCCAGCGCTTCGATTTCTCGCTCAAGGTCGCCACCCCGAA
GGAGCTTTCGCCGCGCCAGGCGCTGAAGGACTTCGTCAAGCGCACCAAGGCGAAGGTGAAGTTCATGCGCGATCCTGAGG
AAGCGGTGGAGGGCGTGGACTGCGTCGTCACCGACACCTGGGTCTCCATGGGCGACAAGGAGGCGGAGCGCCGCCACAAC
CTTTTGAAGCCCTACCAGGTGAACCGTTCGCTCATGGCGCGGGCCGACAAGGAAGCCATCTTCATGCATTGCCTGCCCGC
CCATCGCGGCGAGGAGGTGAGCGACGAGGTGATGGACGGCCCGCAGTCGGTGGTGTTCGACGAGGCGGAGAACCGGCTGC
ATGCCCAGAAGGGCATTCTGGCCTGGTGCTTTAACGCGGCGGGCGACTGA

Upstream 100 bases:

>100_bases
TGAGCGAGGAGGAGGTGGGCATCGCCGTGGAGAAGATCGAAGCTGCCTGCCGGCGTATCGAGGACCGCCTCGTCGCCGCT
CCGGTGCAGGGAGCGGCGGA

Downstream 100 bases:

>100_bases
ACGCGGGACGCCGACGCGGGATAGCTCCGGGGCCGGTGCGGTTAGAGTTGTTCAGGCCCGGTGATCCGGCGGCATCTTCC
GCCGGCGGGGTCGGGTGACT

Product: ornithine carbamoyltransferase

Products: NA

Alternate protein names: OTCase [H]

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MKGNGVRHFLDLSEIPAEELRRVLDFSKDLKARRKAGEVDRPLAGKTLAMVFDKPSTRTRVSFDLAMRQLGGETIMLTGQ
EMQLGRGETIADTARVLSRFVDAIMIRILDHDDLTELAKHATVPVINGLTRISHPCQVMADVLTFEEHRGNITGRSVAWT
GDANNVLASWVHAAQRFDFSLKVATPKELSPRQALKDFVKRTKAKVKFMRDPEEAVEGVDCVVTDTWVSMGDKEAERRHN
LLKPYQVNRSLMARADKEAIFMHCLPAHRGEEVSDEVMDGPQSVVFDEAENRLHAQKGILAWCFNAAGD

Sequences:

>Translated_309_residues
MKGNGVRHFLDLSEIPAEELRRVLDFSKDLKARRKAGEVDRPLAGKTLAMVFDKPSTRTRVSFDLAMRQLGGETIMLTGQ
EMQLGRGETIADTARVLSRFVDAIMIRILDHDDLTELAKHATVPVINGLTRISHPCQVMADVLTFEEHRGNITGRSVAWT
GDANNVLASWVHAAQRFDFSLKVATPKELSPRQALKDFVKRTKAKVKFMRDPEEAVEGVDCVVTDTWVSMGDKEAERRHN
LLKPYQVNRSLMARADKEAIFMHCLPAHRGEEVSDEVMDGPQSVVFDEAENRLHAQKGILAWCFNAAGD
>Mature_309_residues
MKGNGVRHFLDLSEIPAEELRRVLDFSKDLKARRKAGEVDRPLAGKTLAMVFDKPSTRTRVSFDLAMRQLGGETIMLTGQ
EMQLGRGETIADTARVLSRFVDAIMIRILDHDDLTELAKHATVPVINGLTRISHPCQVMADVLTFEEHRGNITGRSVAWT
GDANNVLASWVHAAQRFDFSLKVATPKELSPRQALKDFVKRTKAKVKFMRDPEEAVEGVDCVVTDTWVSMGDKEAERRHN
LLKPYQVNRSLMARADKEAIFMHCLPAHRGEEVSDEVMDGPQSVVFDEAENRLHAQKGILAWCFNAAGD

Specific function: Arginine biosynthesis; sixth step. [C]

COG id: COG0078

COG function: function code E; Ornithine carbamoyltransferase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATCase/OTCase family [H]

Homologues:

Organism=Homo sapiens, GI38788445, Length=292, Percent_Identity=41.4383561643836, Blast_Score=233, Evalue=1e-61,
Organism=Homo sapiens, GI18105007, Length=303, Percent_Identity=26.0726072607261, Blast_Score=108, Evalue=4e-24,
Organism=Escherichia coli, GI1790703, Length=331, Percent_Identity=36.5558912386707, Blast_Score=202, Evalue=2e-53,
Organism=Escherichia coli, GI1786469, Length=325, Percent_Identity=36, Blast_Score=193, Evalue=9e-51,
Organism=Escherichia coli, GI2367364, Length=307, Percent_Identity=27.6872964169381, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI48994908, Length=318, Percent_Identity=27.6729559748428, Blast_Score=78, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI193204318, Length=310, Percent_Identity=27.741935483871, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6322373, Length=326, Percent_Identity=33.7423312883436, Blast_Score=187, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6322331, Length=305, Percent_Identity=26.2295081967213, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24642586, Length=312, Percent_Identity=28.525641025641, Blast_Score=113, Evalue=2e-25,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2066 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006132
- InterPro:   IPR006130
- InterPro:   IPR006131
- InterPro:   IPR002292 [H]

Pfam domain/function: PF00185 OTCace; PF02729 OTCace_N [H]

EC number: =2.1.3.3 [H]

Molecular weight: Translated: 34619; Mature: 34619

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: PS00097 CARBAMOYLTRANSFERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGNGVRHFLDLSEIPAEELRRVLDFSKDLKARRKAGEVDRPLAGKTLAMVFDKPSTRTR
CCCCCCHHHHCHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCHH
VSFDLAMRQLGGETIMLTGQEMQLGRGETIADTARVLSRFVDAIMIRILDHDDLTELAKH
HHHHHHHHHHCCCEEEEECCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
ATVPVINGLTRISHPCQVMADVLTFEEHRGNITGRSVAWTGDANNVLASWVHAAQRFDFS
CCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCE
LKVATPKELSPRQALKDFVKRTKAKVKFMRDPEEAVEGVDCVVTDTWVSMGDKEAERRHN
EEECCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHCCCEEEEEHHHHHCCCHHHHHHHC
LLKPYQVNRSLMARADKEAIFMHCLPAHRGEEVSDEVMDGPQSVVFDEAENRLHAQKGIL
CCCCHHHCHHHHHHCCHHHHEEEECCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHH
AWCFNAAGD
HHHHCCCCC
>Mature Secondary Structure
MKGNGVRHFLDLSEIPAEELRRVLDFSKDLKARRKAGEVDRPLAGKTLAMVFDKPSTRTR
CCCCCCHHHHCHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCHH
VSFDLAMRQLGGETIMLTGQEMQLGRGETIADTARVLSRFVDAIMIRILDHDDLTELAKH
HHHHHHHHHHCCCEEEEECCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
ATVPVINGLTRISHPCQVMADVLTFEEHRGNITGRSVAWTGDANNVLASWVHAAQRFDFS
CCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCE
LKVATPKELSPRQALKDFVKRTKAKVKFMRDPEEAVEGVDCVVTDTWVSMGDKEAERRHN
EEECCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHCCCEEEEEHHHHHCCCHHHHHHHC
LLKPYQVNRSLMARADKEAIFMHCLPAHRGEEVSDEVMDGPQSVVFDEAENRLHAQKGIL
CCCCHHHCHHHHHHCCHHHHEEEECCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHH
AWCFNAAGD
HHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA