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The map label for this gene is serA [H]

Identifier: 154245150

GI number: 154245150

Start: 1381725

End: 1383311

Strand: Reverse

Name: serA [H]

Synonym: Xaut_1202

Alternate gene names: 154245150

Gene position: 1383311-1381725 (Counterclockwise)

Preceding gene: 154245151

Following gene: 154245143

Centisome position: 26.06

GC content: 66.16

Gene sequence:

>1587_bases
ATGGCACCCCGTGTTCTCATTTCCGACAAGCTCTCCCCCGCCGCCGTGCAGATCTTCAAGGATCGCGGCATCGAGGTGGA
TTTCCAGCCCGACCTCGGCAAGGACAAGGACAAGCTGGCCGAGATCATCGGCAATTATGACGGCCTCGCCATCCGCTCGG
CCACCAAGGTCACCCCGAAGATCCTTCAGAAGGCCGGCCGCCTGAAGGTCATCGGCCGCGCCGGCATCGGCGTTGACAAT
GTCGACCTGCCGGCGGCGACCGCCAAGGGCGTGATCGTGATGAACACGCCGTTCGGCAATTCCATCACCACCGCCGAGCA
TGCCATCGCCATGATGTTCGCGCTGGCCCGCGAGATCCCGGCGGCGGATGCCTCCACCCAGGCCGGCAAGTGGGAGAAGA
ACCGCTTCATGGGCGTCGAGGTCACCGCCAAGACGCTGGGCATCATCGGCTGCGGCAACATCGGCTCCATCGTGGCCGAG
CGCGGCGTGGGCCTGAAGATGAAGGTGATCGCCTTCGATCCCTTCCTCTCGGTGGAGCGGGCGCTGGATCTCGGCGTGGA
GAAGGTGGAGCTGGACGACCTGCTCGCCCGCGCCGACTTCATCACCCTGCACACGCCCTTGACCGAGAAGACCAAGAACA
TCCTCTCGGCCGAGAATATCGCCAGGACGAAGAAGGGCGTGCGCATCATCAACTGCGCCCGCGGCGGCCTGGTGGACGAA
GCCGCCCTGCGCGCCGCCCTCGACAGCAAGCATGTGGCGGGCGCCGCCTTCGACGTGTTCGCGGTGGAGCCGGCGGAGCA
GAACCCGCTGTTCGGTCATCCCAACGTGGTGTGCACGCCGCACCTCGGCGCCGCCACCAACGAGGCGCAGGAGAATGTCG
CCCTCCAGGTCGCCGAGCAGATGAGCGACTATCTCCTCACCGGCGCCATCACCAACGCGGTGAACTTCACCTCCATCACC
GCCGAGGAAGCGCCGAAGCTGAAGCCTTTCATCGCGCTCGCTGAGAAGCTCGGCTCGTTCGCCGGCCAGCTCACCGACAC
CGACATCAAGACTGTGCACATCGTCTACGAAGGCGCGGTGGCGGACCAGAAGGTGAAGGCGCTGACCTCGGCCGCGGTGG
CAGGGCTGCTGCGCCCGATGCTCTCAGAGGTCAATGTCGTGTCCGCCCCCACCGTCGCCAAGGAACGCGGCATCGTCATC
GAGGAGACCACCCGCGCCGCCACCGGCGACTATGACAGCCTCATCAGCATCACGGTGGTGACCGACACGTATGAGCGCGC
GATATCCGGCACCGTGTTCGCGGATGGCCGCCCGCGCATCGTGAACATCAAGGGCATCAATGTGGACGCCGAGTTCGCGC
CCTCCATGATCTATGTCACCAACGAGGACAAGCCCGGCTTCATCGGCCGCTTCGCCGGCCTGCTGGGTGATGCGGGCCTG
AACATCGCAACCTTCGCCCTCGGCCGCGACCATCTGGGCGGCGACGCCATCGCGCTGGTGGCGGTGGATGGCACCGTGCC
GGCCGACGTGCTCGGCAAGGTGCAGGCGCTGCCGCAGGTGAAGGCGGCCAAGGCGCTGGCGTTCTGA

Upstream 100 bases:

>100_bases
AAAGCTACTCCCGGCCTCCACGCGTGGATGGCCGGGTCAAGCCCGGCCATGACGGCAGCCAGAGCGGCACGGCTTATCCG
CGCAATTTCCGGAGCCCACC

Downstream 100 bases:

>100_bases
GGCGTTGGTGCTCTGACGATCTGCAACGGTCGCCCCTCGGGCGGCCGTCTGCTTTTCTGCGTTATGCGTTCAGCGCCGGT
CGAAAGCCGGGTCCGCCCGC

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 528; Mature: 527

Protein sequence:

>528_residues
MAPRVLISDKLSPAAVQIFKDRGIEVDFQPDLGKDKDKLAEIIGNYDGLAIRSATKVTPKILQKAGRLKVIGRAGIGVDN
VDLPAATAKGVIVMNTPFGNSITTAEHAIAMMFALAREIPAADASTQAGKWEKNRFMGVEVTAKTLGIIGCGNIGSIVAE
RGVGLKMKVIAFDPFLSVERALDLGVEKVELDDLLARADFITLHTPLTEKTKNILSAENIARTKKGVRIINCARGGLVDE
AALRAALDSKHVAGAAFDVFAVEPAEQNPLFGHPNVVCTPHLGAATNEAQENVALQVAEQMSDYLLTGAITNAVNFTSIT
AEEAPKLKPFIALAEKLGSFAGQLTDTDIKTVHIVYEGAVADQKVKALTSAAVAGLLRPMLSEVNVVSAPTVAKERGIVI
EETTRAATGDYDSLISITVVTDTYERAISGTVFADGRPRIVNIKGINVDAEFAPSMIYVTNEDKPGFIGRFAGLLGDAGL
NIATFALGRDHLGGDAIALVAVDGTVPADVLGKVQALPQVKAAKALAF

Sequences:

>Translated_528_residues
MAPRVLISDKLSPAAVQIFKDRGIEVDFQPDLGKDKDKLAEIIGNYDGLAIRSATKVTPKILQKAGRLKVIGRAGIGVDN
VDLPAATAKGVIVMNTPFGNSITTAEHAIAMMFALAREIPAADASTQAGKWEKNRFMGVEVTAKTLGIIGCGNIGSIVAE
RGVGLKMKVIAFDPFLSVERALDLGVEKVELDDLLARADFITLHTPLTEKTKNILSAENIARTKKGVRIINCARGGLVDE
AALRAALDSKHVAGAAFDVFAVEPAEQNPLFGHPNVVCTPHLGAATNEAQENVALQVAEQMSDYLLTGAITNAVNFTSIT
AEEAPKLKPFIALAEKLGSFAGQLTDTDIKTVHIVYEGAVADQKVKALTSAAVAGLLRPMLSEVNVVSAPTVAKERGIVI
EETTRAATGDYDSLISITVVTDTYERAISGTVFADGRPRIVNIKGINVDAEFAPSMIYVTNEDKPGFIGRFAGLLGDAGL
NIATFALGRDHLGGDAIALVAVDGTVPADVLGKVQALPQVKAAKALAF
>Mature_527_residues
APRVLISDKLSPAAVQIFKDRGIEVDFQPDLGKDKDKLAEIIGNYDGLAIRSATKVTPKILQKAGRLKVIGRAGIGVDNV
DLPAATAKGVIVMNTPFGNSITTAEHAIAMMFALAREIPAADASTQAGKWEKNRFMGVEVTAKTLGIIGCGNIGSIVAER
GVGLKMKVIAFDPFLSVERALDLGVEKVELDDLLARADFITLHTPLTEKTKNILSAENIARTKKGVRIINCARGGLVDEA
ALRAALDSKHVAGAAFDVFAVEPAEQNPLFGHPNVVCTPHLGAATNEAQENVALQVAEQMSDYLLTGAITNAVNFTSITA
EEAPKLKPFIALAEKLGSFAGQLTDTDIKTVHIVYEGAVADQKVKALTSAAVAGLLRPMLSEVNVVSAPTVAKERGIVIE
ETTRAATGDYDSLISITVVTDTYERAISGTVFADGRPRIVNIKGINVDAEFAPSMIYVTNEDKPGFIGRFAGLLGDAGLN
IATFALGRDHLGGDAIALVAVDGTVPADVLGKVQALPQVKAAKALAF

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=500, Percent_Identity=38.4, Blast_Score=336, Evalue=3e-92,
Organism=Homo sapiens, GI61743967, Length=284, Percent_Identity=34.1549295774648, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI4557497, Length=284, Percent_Identity=34.1549295774648, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI145580578, Length=254, Percent_Identity=35.8267716535433, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI4557499, Length=254, Percent_Identity=35.8267716535433, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI145580575, Length=244, Percent_Identity=36.4754098360656, Blast_Score=131, Evalue=2e-30,
Organism=Homo sapiens, GI6912396, Length=265, Percent_Identity=31.3207547169811, Blast_Score=112, Evalue=1e-24,
Organism=Escherichia coli, GI1789279, Length=293, Percent_Identity=39.2491467576792, Blast_Score=186, Evalue=4e-48,
Organism=Escherichia coli, GI87082289, Length=281, Percent_Identity=33.0960854092527, Blast_Score=142, Evalue=4e-35,
Organism=Escherichia coli, GI1787645, Length=202, Percent_Identity=37.1287128712871, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI87081824, Length=272, Percent_Identity=26.8382352941176, Blast_Score=76, Evalue=6e-15,
Organism=Escherichia coli, GI1788660, Length=270, Percent_Identity=30, Blast_Score=69, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17532191, Length=302, Percent_Identity=45.6953642384106, Blast_Score=270, Evalue=1e-72,
Organism=Caenorhabditis elegans, GI25147481, Length=259, Percent_Identity=31.6602316602317, Blast_Score=137, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6322116, Length=329, Percent_Identity=36.4741641337386, Blast_Score=206, Evalue=7e-54,
Organism=Saccharomyces cerevisiae, GI6320925, Length=329, Percent_Identity=35.258358662614, Blast_Score=200, Evalue=4e-52,
Organism=Saccharomyces cerevisiae, GI6324055, Length=272, Percent_Identity=27.9411764705882, Blast_Score=115, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6324964, Length=268, Percent_Identity=26.1194029850746, Blast_Score=91, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6325144, Length=122, Percent_Identity=34.4262295081967, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI19921140, Length=325, Percent_Identity=41.8461538461538, Blast_Score=260, Evalue=2e-69,
Organism=Drosophila melanogaster, GI24585516, Length=289, Percent_Identity=28.3737024221453, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24646446, Length=239, Percent_Identity=33.4728033472803, Blast_Score=119, Evalue=7e-27,
Organism=Drosophila melanogaster, GI24646448, Length=239, Percent_Identity=33.4728033472803, Blast_Score=119, Evalue=7e-27,
Organism=Drosophila melanogaster, GI24646452, Length=239, Percent_Identity=33.4728033472803, Blast_Score=119, Evalue=7e-27,
Organism=Drosophila melanogaster, GI24646450, Length=239, Percent_Identity=33.4728033472803, Blast_Score=119, Evalue=7e-27,
Organism=Drosophila melanogaster, GI62472511, Length=259, Percent_Identity=32.4324324324324, Blast_Score=118, Evalue=1e-26,
Organism=Drosophila melanogaster, GI28574286, Length=301, Percent_Identity=27.906976744186, Blast_Score=116, Evalue=4e-26,
Organism=Drosophila melanogaster, GI28574284, Length=267, Percent_Identity=27.3408239700375, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24585514, Length=267, Percent_Identity=27.3408239700375, Blast_Score=112, Evalue=6e-25,
Organism=Drosophila melanogaster, GI28574282, Length=267, Percent_Identity=27.3408239700375, Blast_Score=112, Evalue=6e-25,
Organism=Drosophila melanogaster, GI45551003, Length=267, Percent_Identity=27.3408239700375, Blast_Score=112, Evalue=7e-25,
Organism=Drosophila melanogaster, GI45552429, Length=267, Percent_Identity=27.3408239700375, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI28571528, Length=265, Percent_Identity=30.188679245283, Blast_Score=100, Evalue=4e-21,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 55565; Mature: 55433

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPRVLISDKLSPAAVQIFKDRGIEVDFQPDLGKDKDKLAEIIGNYDGLAIRSATKVTPK
CCCCEEEECCCCHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHCCCCCEEEECCCCCCHH
ILQKAGRLKVIGRAGIGVDNVDLPAATAKGVIVMNTPFGNSITTAEHAIAMMFALAREIP
HHHCCCCEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCC
AADASTQAGKWEKNRFMGVEVTAKTLGIIGCGNIGSIVAERGVGLKMKVIAFDPFLSVER
CCCCCCCCCCCCCCCEEEEEEEEEEEEEEECCCHHHHHHHCCCCEEEEEEEECCHHHHHH
ALDLGVEKVELDDLLARADFITLHTPLTEKTKNILSAENIARTKKGVRIINCARGGLVDE
HHHCCCCEECHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHH
AALRAALDSKHVAGAAFDVFAVEPAEQNPLFGHPNVVCTPHLGAATNEAQENVALQVAEQ
HHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHH
MSDYLLTGAITNAVNFTSITAEEAPKLKPFIALAEKLGSFAGQLTDTDIKTVHIVYEGAV
HHHHHHHHHHHCCEEEEEEEHHCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCC
ADQKVKALTSAAVAGLLRPMLSEVNVVSAPTVAKERGIVIEETTRAATGDYDSLISITVV
CHHHHHHHHHHHHHHHHHHHHHHCCEECCCCHHHHCCEEEEECCCCCCCCCCCEEEEEEE
TDTYERAISGTVFADGRPRIVNIKGINVDAEFAPSMIYVTNEDKPGFIGRFAGLLGDAGL
ECCHHHHHCCEEEECCCCEEEEEEEECCCHHHCCEEEEEECCCCCCHHHHHHHHHCCCCC
NIATFALGRDHLGGDAIALVAVDGTVPADVLGKVQALPQVKAAKALAF
CEEEEEECCCCCCCCEEEEEEECCCCCHHHHHHHHHCCCHHHHHHHCC
>Mature Secondary Structure 
APRVLISDKLSPAAVQIFKDRGIEVDFQPDLGKDKDKLAEIIGNYDGLAIRSATKVTPK
CCCEEEECCCCHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHCCCCCEEEECCCCCCHH
ILQKAGRLKVIGRAGIGVDNVDLPAATAKGVIVMNTPFGNSITTAEHAIAMMFALAREIP
HHHCCCCEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCC
AADASTQAGKWEKNRFMGVEVTAKTLGIIGCGNIGSIVAERGVGLKMKVIAFDPFLSVER
CCCCCCCCCCCCCCCEEEEEEEEEEEEEEECCCHHHHHHHCCCCEEEEEEEECCHHHHHH
ALDLGVEKVELDDLLARADFITLHTPLTEKTKNILSAENIARTKKGVRIINCARGGLVDE
HHHCCCCEECHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHH
AALRAALDSKHVAGAAFDVFAVEPAEQNPLFGHPNVVCTPHLGAATNEAQENVALQVAEQ
HHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHH
MSDYLLTGAITNAVNFTSITAEEAPKLKPFIALAEKLGSFAGQLTDTDIKTVHIVYEGAV
HHHHHHHHHHHCCEEEEEEEHHCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCC
ADQKVKALTSAAVAGLLRPMLSEVNVVSAPTVAKERGIVIEETTRAATGDYDSLISITVV
CHHHHHHHHHHHHHHHHHHHHHHCCEECCCCHHHHCCEEEEECCCCCCCCCCCEEEEEEE
TDTYERAISGTVFADGRPRIVNIKGINVDAEFAPSMIYVTNEDKPGFIGRFAGLLGDAGL
ECCHHHHHCCEEEECCCCEEEEEEEECCCHHHCCEEEEEECCCCCCHHHHHHHHHCCCCC
NIATFALGRDHLGGDAIALVAVDGTVPADVLGKVQALPQVKAAKALAF
CEEEEEECCCCCCCCEEEEEEECCCCCHHHHHHHHHCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8760912; 9384377; 7934829 [H]