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The map label for this gene is garR [H]

Identifier: 154245124

GI number: 154245124

Start: 1351951

End: 1352859

Strand: Reverse

Name: garR [H]

Synonym: Xaut_1176

Alternate gene names: 154245124

Gene position: 1352859-1351951 (Counterclockwise)

Preceding gene: 154245127

Following gene: 154245121

Centisome position: 25.48

GC content: 67.88

Gene sequence:

>909_bases
ATGACCGAGGATACGACCAAGGCGCGGGTGGGCTTCATCGGCGTGGGCCTGATGGGGCACGGGATGGCGAAGAACATCCT
CGCCAGGGGTTTTCCGCTTGCAGTGCTGGGCCATCGCAACCGGGCGCCGGTGGAAGACCTCGTCGGGCGCGGCGCCACCG
AGGTGAAGTCCGCCGCCGAGCTGGCGCAGGTGAGCGACATCATCGTCCTGTGCGTCACCGGCGCGCCGCAGGTGGAAGCG
GTGCTGCGCGGGGAAAACGGCATCCTCTCCACCGCGAGGTCCGGCCTCCATATCATCGATACCTCCACCTCCGAGCCCAC
CCTCACCATGGCGCTGGCGGCGGAGCTGGAGGCGCGCGGCATCTTCTTCTGCGATTCGCCCCTCGGCGGCACGCCGGTGC
AGGCGGACGAAGGCACGCTCTCGGCCATGGTGGGTGCCCACGACGCCGCCTTCGCGGTGATCGAGCCGGTGGTGGCGGCC
TATGCAAACCGCATCGTGCGGGTGGGCGCGCCGGGGGCGGGGCACACCATGAAGCTGCTCAACAACTTCCTGTCGCTGGG
CTATGGCGCCATCTATGCGGAAGCGCTGGCGCTGGCCGCCAAGGCGGGGGTGACGCCGCAGGTGTTCGACGCGGTGATCC
GCGGCGGGCGCATGGATTGCGGCTTCTACCGCACCTTCATGGGCTATGCGCTGGACGGCGACGTGAACGCCCACCGCTTC
ACCATCACCAACGCGCACAAAGACATGCGCTATGTGACCAACCTCGCCACCAACACCGGCGCGGCGGCCTTCATCAGCGC
CACGGTGAAAAACCTCTACGCCACCGCCGAGGGGCTGGGGAACGGCGAGAAGAACGTGCCGCTGCTGGTGGACGTGGTGG
CGCAGATGAACGGGGTCAAGAAAAGCTGA

Upstream 100 bases:

>100_bases
TTCCCTATAACCGGATCTGTCGCGTCTCGCGCCGTCCTTTCGTTCATGTTAAACGATTTAACGGCAACGACCAATGGTAA
TTGGCACGGGGACGACCGAC

Downstream 100 bases:

>100_bases
ACCCGCCCCGGAGCACGTGACGATCCGCCATGACGCGGTCGGTACGTGCTCCGGCGGGCTGTGTGGGCAGTGTTCCGGCT
CGGGGCTCAGGCCGCGTTCT

Product: NAD-binding 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 302; Mature: 301

Protein sequence:

>302_residues
MTEDTTKARVGFIGVGLMGHGMAKNILARGFPLAVLGHRNRAPVEDLVGRGATEVKSAAELAQVSDIIVLCVTGAPQVEA
VLRGENGILSTARSGLHIIDTSTSEPTLTMALAAELEARGIFFCDSPLGGTPVQADEGTLSAMVGAHDAAFAVIEPVVAA
YANRIVRVGAPGAGHTMKLLNNFLSLGYGAIYAEALALAAKAGVTPQVFDAVIRGGRMDCGFYRTFMGYALDGDVNAHRF
TITNAHKDMRYVTNLATNTGAAAFISATVKNLYATAEGLGNGEKNVPLLVDVVAQMNGVKKS

Sequences:

>Translated_302_residues
MTEDTTKARVGFIGVGLMGHGMAKNILARGFPLAVLGHRNRAPVEDLVGRGATEVKSAAELAQVSDIIVLCVTGAPQVEA
VLRGENGILSTARSGLHIIDTSTSEPTLTMALAAELEARGIFFCDSPLGGTPVQADEGTLSAMVGAHDAAFAVIEPVVAA
YANRIVRVGAPGAGHTMKLLNNFLSLGYGAIYAEALALAAKAGVTPQVFDAVIRGGRMDCGFYRTFMGYALDGDVNAHRF
TITNAHKDMRYVTNLATNTGAAAFISATVKNLYATAEGLGNGEKNVPLLVDVVAQMNGVKKS
>Mature_301_residues
TEDTTKARVGFIGVGLMGHGMAKNILARGFPLAVLGHRNRAPVEDLVGRGATEVKSAAELAQVSDIIVLCVTGAPQVEAV
LRGENGILSTARSGLHIIDTSTSEPTLTMALAAELEARGIFFCDSPLGGTPVQADEGTLSAMVGAHDAAFAVIEPVVAAY
ANRIVRVGAPGAGHTMKLLNNFLSLGYGAIYAEALALAAKAGVTPQVFDAVIRGGRMDCGFYRTFMGYALDGDVNAHRFT
ITNAHKDMRYVTNLATNTGAAAFISATVKNLYATAEGLGNGEKNVPLLVDVVAQMNGVKKS

Specific function: D-galactarate metabolism; third step. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=288, Percent_Identity=30.5555555555556, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI40556376, Length=281, Percent_Identity=23.4875444839858, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI145693186, Length=277, Percent_Identity=33.5740072202166, Blast_Score=135, Evalue=4e-33,
Organism=Escherichia coli, GI1790315, Length=287, Percent_Identity=30.3135888501742, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1786719, Length=294, Percent_Identity=32.6530612244898, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1789092, Length=280, Percent_Identity=29.6428571428571, Blast_Score=82, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17557316, Length=278, Percent_Identity=29.136690647482, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24655230, Length=294, Percent_Identity=25.8503401360544, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI19922568, Length=294, Percent_Identity=25.8503401360544, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 31404; Mature: 31273

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEDTTKARVGFIGVGLMGHGMAKNILARGFPLAVLGHRNRAPVEDLVGRGATEVKSAAE
CCCCCCHHEEEEEEECHHCCCHHHHHHHCCCCEEEECCCCCCCHHHHHCCCHHHHHHHHH
LAQVSDIIVLCVTGAPQVEAVLRGENGILSTARSGLHIIDTSTSEPTLTMALAAELEARG
HHHHCCEEEEEECCCCCEEHEEECCCCCHHHHCCCEEEEECCCCCCEEEEEEEHHHHHCE
IFFCDSPLGGTPVQADEGTLSAMVGAHDAAFAVIEPVVAAYANRIVRVGAPGAGHTMKLL
EEEECCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHCEEEECCCCCCHHHHHH
NNFLSLGYGAIYAEALALAAKAGVTPQVFDAVIRGGRMDCGFYRTFMGYALDGDVNAHRF
HHHHHHCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHCEEECCCCCCEEE
TITNAHKDMRYVTNLATNTGAAAFISATVKNLYATAEGLGNGEKNVPLLVDVVAQMNGVK
EEECCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCC
KS
CC
>Mature Secondary Structure 
TEDTTKARVGFIGVGLMGHGMAKNILARGFPLAVLGHRNRAPVEDLVGRGATEVKSAAE
CCCCCHHEEEEEEECHHCCCHHHHHHHCCCCEEEECCCCCCCHHHHHCCCHHHHHHHHH
LAQVSDIIVLCVTGAPQVEAVLRGENGILSTARSGLHIIDTSTSEPTLTMALAAELEARG
HHHHCCEEEEEECCCCCEEHEEECCCCCHHHHCCCEEEEECCCCCCEEEEEEEHHHHHCE
IFFCDSPLGGTPVQADEGTLSAMVGAHDAAFAVIEPVVAAYANRIVRVGAPGAGHTMKLL
EEEECCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHCEEEECCCCCCHHHHHH
NNFLSLGYGAIYAEALALAAKAGVTPQVFDAVIRGGRMDCGFYRTFMGYALDGDVNAHRF
HHHHHHCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHCEEECCCCCCEEE
TITNAHKDMRYVTNLATNTGAAAFISATVKNLYATAEGLGNGEKNVPLLVDVVAQMNGVK
EEECCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCC
KS
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]