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The map label for this gene is yfhQ [H]

Identifier: 154245120

GI number: 154245120

Start: 1347976

End: 1349043

Strand: Direct

Name: yfhQ [H]

Synonym: Xaut_1172

Alternate gene names: 154245120

Gene position: 1347976-1349043 (Clockwise)

Preceding gene: 154245117

Following gene: 154245122

Centisome position: 25.39

GC content: 73.69

Gene sequence:

>1068_bases
GTGCCATCGGCCCCCGGCGGACCCGATCCTGCCGCGCTGCTCGCCTGGTACGACCGTCACCGCCGCCGCCTGCCCTGGCG
GGCCGAGCCGGGGCGGCGGGCCGATCCCTACCATGTGTTCCTCTCCGAGATCATGTTGCAGCAGACCACGGTGAAGGCGG
TGGGGCCGTATTTCGGGGCCTTCCTGGCCCGCTGGCCCAGCGTGTCGCATCTCGCCGACGCGCCGCTGGAGGAGGTGCTC
TCCGCCTGGGCGGGGCTCGGCTATTACGCCCGCGCCCGCAATCTGCACGCCTGCGCCAGGGCGGTGGTGGACCGCCACGG
CGGAGCGTTTCCGGATGCCGAGGCGGCGCTGCTGGATCTTCCCGGCATTGGCCCCTACACGGCCGCCGCCATCGCCGCCA
TCGCCTTCGACCGGCCGGCAAGCCCGGTGGACGGCAATATCGAGCGCGTCATCTCCCGCCTCTATGCCATCGGCGAGCCG
TTGCCGGGGGCGAAACCCGCCATCAAGGCCCGAGCCGCCGCGCTGACGCCGCCGGATCGGCCAGGGGATTTCGCCCAGGC
CATGATGGATCTCGGCGCCACCATCTGCACGCCGAAATCCCCCGCCTGCTCGCTCTGCCCCTGGATGGAGCCGTGCGCGG
CGCGGGCCGAGGGCGATGCCGCCCGCTATCCGGTGAAGGCGCCCAAGGGCGACAAGCCCCGGCGCGAGGGCACCGCCTTC
CTCGCCGTGCGGGCGGATGGCGCGGTGCTGCTGCGCACCCGGCCGGACAAGGGCCTTCTGGCGAAGATGACGGAAGTGCC
CTCCACCCCCTGGGACAGCCGGGCGGGGGCGAAGGCGCCGGCGCGCGCCGAGGATCACGCCCCCTTCCCGACCCGCTGGC
GCGCTGTGCCGGGGGTGGTGGAGCACGTCTTCACCCATTTTGCGCTGACGCTGAAGGTGCTCCGCGCCGACCTGCCCGCT
GCCACGCCGGCCCCGGAGGGCCATCGCTGGGTGCGGCCGGAGGGCTTCGGGCGGGAGGCGCTGCCCTCGCTCATGCGCAA
GGTGCTGGCCCACGGGGGGATCGAGTAG

Upstream 100 bases:

>100_bases
AGCCGCAGCGCGCGCCGCTGCGAGAGCGACTGCGCGGGCCTCGGCCCATGCCGCAGCCAGTCCGGACGCAACAAGCTCCA
GCGCTCCTGTCGCCGCGCCC

Downstream 100 bases:

>100_bases
AGGACGGCCGCTGTCATCCCCCGAACCACCGTCATCCCCGGCTTGACCGGGGAGGTCCATCAGGCATCCGTGGCCGGGCT
TTGAAGAGGGGATGCTGCGG

Product: A/G-specific adenine glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 355; Mature: 354

Protein sequence:

>355_residues
MPSAPGGPDPAALLAWYDRHRRRLPWRAEPGRRADPYHVFLSEIMLQQTTVKAVGPYFGAFLARWPSVSHLADAPLEEVL
SAWAGLGYYARARNLHACARAVVDRHGGAFPDAEAALLDLPGIGPYTAAAIAAIAFDRPASPVDGNIERVISRLYAIGEP
LPGAKPAIKARAAALTPPDRPGDFAQAMMDLGATICTPKSPACSLCPWMEPCAARAEGDAARYPVKAPKGDKPRREGTAF
LAVRADGAVLLRTRPDKGLLAKMTEVPSTPWDSRAGAKAPARAEDHAPFPTRWRAVPGVVEHVFTHFALTLKVLRADLPA
ATPAPEGHRWVRPEGFGREALPSLMRKVLAHGGIE

Sequences:

>Translated_355_residues
MPSAPGGPDPAALLAWYDRHRRRLPWRAEPGRRADPYHVFLSEIMLQQTTVKAVGPYFGAFLARWPSVSHLADAPLEEVL
SAWAGLGYYARARNLHACARAVVDRHGGAFPDAEAALLDLPGIGPYTAAAIAAIAFDRPASPVDGNIERVISRLYAIGEP
LPGAKPAIKARAAALTPPDRPGDFAQAMMDLGATICTPKSPACSLCPWMEPCAARAEGDAARYPVKAPKGDKPRREGTAF
LAVRADGAVLLRTRPDKGLLAKMTEVPSTPWDSRAGAKAPARAEDHAPFPTRWRAVPGVVEHVFTHFALTLKVLRADLPA
ATPAPEGHRWVRPEGFGREALPSLMRKVLAHGGIE
>Mature_354_residues
PSAPGGPDPAALLAWYDRHRRRLPWRAEPGRRADPYHVFLSEIMLQQTTVKAVGPYFGAFLARWPSVSHLADAPLEEVLS
AWAGLGYYARARNLHACARAVVDRHGGAFPDAEAALLDLPGIGPYTAAAIAAIAFDRPASPVDGNIERVISRLYAIGEPL
PGAKPAIKARAAALTPPDRPGDFAQAMMDLGATICTPKSPACSLCPWMEPCAARAEGDAARYPVKAPKGDKPRREGTAFL
AVRADGAVLLRTRPDKGLLAKMTEVPSTPWDSRAGAKAPARAEDHAPFPTRWRAVPGVVEHVFTHFALTLKVLRADLPAA
TPAPEGHRWVRPEGFGREALPSLMRKVLAHGGIE

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine, 8- oxo-dGTP) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal effici

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HhH domain [H]

Homologues:

Organism=Homo sapiens, GI115298650, Length=397, Percent_Identity=36.7758186397985, Blast_Score=219, Evalue=2e-57,
Organism=Homo sapiens, GI115298654, Length=397, Percent_Identity=36.7758186397985, Blast_Score=219, Evalue=2e-57,
Organism=Homo sapiens, GI115298652, Length=397, Percent_Identity=36.7758186397985, Blast_Score=219, Evalue=2e-57,
Organism=Homo sapiens, GI115298648, Length=397, Percent_Identity=36.7758186397985, Blast_Score=219, Evalue=2e-57,
Organism=Homo sapiens, GI190358497, Length=397, Percent_Identity=36.7758186397985, Blast_Score=219, Evalue=3e-57,
Organism=Homo sapiens, GI6912520, Length=397, Percent_Identity=36.7758186397985, Blast_Score=219, Evalue=3e-57,
Organism=Escherichia coli, GI1789331, Length=305, Percent_Identity=42.2950819672131, Blast_Score=216, Evalue=2e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 38109; Mature: 37978

Theoretical pI: Translated: 9.72; Mature: 9.72

Prosite motif: PS00764 ENDONUCLEASE_III_1 ; PS01155 ENDONUCLEASE_III_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSAPGGPDPAALLAWYDRHRRRLPWRAEPGRRADPYHVFLSEIMLQQTTVKAVGPYFGA
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
FLARWPSVSHLADAPLEEVLSAWAGLGYYARARNLHACARAVVDRHGGAFPDAEAALLDL
HHHHCCCHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHEEEC
PGIGPYTAAAIAAIAFDRPASPVDGNIERVISRLYAIGEPLPGAKPAIKARAAALTPPDR
CCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCC
PGDFAQAMMDLGATICTPKSPACSLCPWMEPCAARAEGDAARYPVKAPKGDKPRREGTAF
CCHHHHHHHHCCCEECCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEE
LAVRADGAVLLRTRPDKGLLAKMTEVPSTPWDSRAGAKAPARAEDHAPFPTRWRAVPGVV
EEEECCCEEEEEECCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
EHVFTHFALTLKVLRADLPAATPAPEGHRWVRPEGFGREALPSLMRKVLAHGGIE
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PSAPGGPDPAALLAWYDRHRRRLPWRAEPGRRADPYHVFLSEIMLQQTTVKAVGPYFGA
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
FLARWPSVSHLADAPLEEVLSAWAGLGYYARARNLHACARAVVDRHGGAFPDAEAALLDL
HHHHCCCHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHEEEC
PGIGPYTAAAIAAIAFDRPASPVDGNIERVISRLYAIGEPLPGAKPAIKARAAALTPPDR
CCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCC
PGDFAQAMMDLGATICTPKSPACSLCPWMEPCAARAEGDAARYPVKAPKGDKPRREGTAF
CCHHHHHHHHCCCEECCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEE
LAVRADGAVLLRTRPDKGLLAKMTEVPSTPWDSRAGAKAPARAEDHAPFPTRWRAVPGVV
EEEECCCEEEEEECCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
EHVFTHFALTLKVLRADLPAATPAPEGHRWVRPEGFGREALPSLMRKVLAHGGIE
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8946165; 9384377 [H]