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The map label for this gene is groL1 [H]

Identifier: 154245114

GI number: 154245114

Start: 1341309

End: 1342955

Strand: Direct

Name: groL1 [H]

Synonym: Xaut_1166

Alternate gene names: 154245114

Gene position: 1341309-1342955 (Clockwise)

Preceding gene: 154245113

Following gene: 154245117

Centisome position: 25.27

GC content: 66.06

Gene sequence:

>1647_bases
ATGGCTGCCAAAGACGTAAAGTTCTCCGGCGACGCTCGTGAAAAGCTGCTGCGCGGCGTCGACATTCTCGCCAACGCGGT
GAAGGTCACCCTCGGCCCCAAGGGCCGCAACGTGGTGATCGAGAAGTCGTTCGGCGCCCCGCGCATCACCAAGGACGGCG
TCACCGTCGCCAAGGAGATCGAGCTGGAAGACCGGTTCGAGAACCTCGGCGCCCAGCTGGTGCGTGAGGTCGCCTCCAAG
ACCAACGACCTCGCCGGCGACGGCACCACCACCGCCACCGTGCTGGCCCAGGCCATCGTGAAGGAAGGCGCCAAGTCGGT
CGCCGCCGGCATGAACCCCATGGACCTGAAGCGCGGCATCGACCTCGCCGTGGCCGCCGCCATCGCCGACATCCGCGCCC
GCGCCAAGAAGGTCTCCTCCTCCGCCGAAGTCGCGCAGGTCGGCACCATCTCCGCCAACGGCGATGCCTCCATCGGCGAG
ATGATCGCCGGCGCCATGCAGCGCGTGGGCAATGAAGGCGTCATCACCGTCGAGGAAGCCAAGACCGCCGAGACCGAGCT
CGAAGTGGTCGAAGGCATGCAGTTCGACCGCGGCTATCTCTCTCCCTATTTCATCACCAATGCGGAGAAGATGATCGCCG
ATCTGGAAGAGCCATATCTCCTCATCTTCGAGAAGAAGCTCTCCGGCCTGCAGCCGATCCTGCCCGTGCTCGAAGCCGTG
GTGCAGACCGGCCGTCCGCTGGTCATCGTGGCCGAGGACGTGGAAGGCGAGGCGCTGGCCACCCTGGTGGTCAACAAGCT
GCGTGGCGGCCTGAAGGTCGCGGCGGTGAAGGCTCCCGGCTTCGGTGATCGCCGCAAGGCCATGCTGGAGGATATCGCCA
TCCTCACCGGCGGCACGGTGATCTCGGAAGATCTCGGCATCAAGCTCGAGAACGTGACCATCGCCCAGCTCGGCCGCGCC
AAGAAGGTGATTCTCGAGAAGGAGAAGACCACCATCGTGGACGGCGTCGGCGAGAAGGCCGACATCGAGGCCCGCGTGAA
CCAGATCAAGGCGCAGATCGAGGAGACCTCCTCGGACTACGACCGCGAGAAGCTCCAGGAGCGTCTGGCCAAGCTTGCGG
GCGGCGTCGCCGTGATCCGCGTCGGCGGCTCCACGGAAGTGGAAGTCAAGGAGAAGAAGGACCGCGTTGACGACGCGCTG
AACGCCACCCGCGCTGCGGTGGAAGAAGGCATCGTCCCCGGCGGCGGCGTGGCCCTGCTGCGCGCCAAGAAGGCGGTCGA
GCTGGTGACTTCGGAGAACCCCGACATCACCGCCGGCATCAAGATCGTCCTGCGCGCCCTTGAGGCCCCCATCCGCCAGA
TCGCCGAGAATTCCGGCGTGGAAGGCTCCATCGTGGTGGGCAAGGTGCAGGAGTCCAACGATCCGAACTTTGGCTTCAAT
GCCCAGAGCGAGGAATATGTGGACATGATCGGCGCCGGCATCGTCGACCCGGCAAAGGTGGTGCGCACCGCCCTGCAGGA
CGCGGCCTCCATCGCCGCCCTGATCGTCACCACCGAAGCCCTCGTGGCCGAGCTGCCCAAGCGCGACAGCGGCATGCCCG
CCATGCCCGGCGGCGGCATGGGTGGCATGGGCGGCATGGACTTCTGA

Upstream 100 bases:

>100_bases
TTGCCGGTTGAGTGTCGCTGCCGCGTGCGGGTTTCGCCAAGTGATGCCAGGTGATGGCGGCCTGAACGCACCCCATAATC
CCAGAATTTAGGAGGCCGTA

Downstream 100 bases:

>100_bases
GGAAGTCTGTTCGTCTCTAAGTTTGCGAGAGGGCGCGGCTTCGGCCGCGCCCTTTTCGTTTGGCTGGTCGGCTCGATCAG
CTCGCTCTCGTGCCCCGGCC

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 1; Protein Cpn60 1 [H]

Number of amino acids: Translated: 548; Mature: 547

Protein sequence:

>548_residues
MAAKDVKFSGDAREKLLRGVDILANAVKVTLGPKGRNVVIEKSFGAPRITKDGVTVAKEIELEDRFENLGAQLVREVASK
TNDLAGDGTTTATVLAQAIVKEGAKSVAAGMNPMDLKRGIDLAVAAAIADIRARAKKVSSSAEVAQVGTISANGDASIGE
MIAGAMQRVGNEGVITVEEAKTAETELEVVEGMQFDRGYLSPYFITNAEKMIADLEEPYLLIFEKKLSGLQPILPVLEAV
VQTGRPLVIVAEDVEGEALATLVVNKLRGGLKVAAVKAPGFGDRRKAMLEDIAILTGGTVISEDLGIKLENVTIAQLGRA
KKVILEKEKTTIVDGVGEKADIEARVNQIKAQIEETSSDYDREKLQERLAKLAGGVAVIRVGGSTEVEVKEKKDRVDDAL
NATRAAVEEGIVPGGGVALLRAKKAVELVTSENPDITAGIKIVLRALEAPIRQIAENSGVEGSIVVGKVQESNDPNFGFN
AQSEEYVDMIGAGIVDPAKVVRTALQDAASIAALIVTTEALVAELPKRDSGMPAMPGGGMGGMGGMDF

Sequences:

>Translated_548_residues
MAAKDVKFSGDAREKLLRGVDILANAVKVTLGPKGRNVVIEKSFGAPRITKDGVTVAKEIELEDRFENLGAQLVREVASK
TNDLAGDGTTTATVLAQAIVKEGAKSVAAGMNPMDLKRGIDLAVAAAIADIRARAKKVSSSAEVAQVGTISANGDASIGE
MIAGAMQRVGNEGVITVEEAKTAETELEVVEGMQFDRGYLSPYFITNAEKMIADLEEPYLLIFEKKLSGLQPILPVLEAV
VQTGRPLVIVAEDVEGEALATLVVNKLRGGLKVAAVKAPGFGDRRKAMLEDIAILTGGTVISEDLGIKLENVTIAQLGRA
KKVILEKEKTTIVDGVGEKADIEARVNQIKAQIEETSSDYDREKLQERLAKLAGGVAVIRVGGSTEVEVKEKKDRVDDAL
NATRAAVEEGIVPGGGVALLRAKKAVELVTSENPDITAGIKIVLRALEAPIRQIAENSGVEGSIVVGKVQESNDPNFGFN
AQSEEYVDMIGAGIVDPAKVVRTALQDAASIAALIVTTEALVAELPKRDSGMPAMPGGGMGGMGGMDF
>Mature_547_residues
AAKDVKFSGDAREKLLRGVDILANAVKVTLGPKGRNVVIEKSFGAPRITKDGVTVAKEIELEDRFENLGAQLVREVASKT
NDLAGDGTTTATVLAQAIVKEGAKSVAAGMNPMDLKRGIDLAVAAAIADIRARAKKVSSSAEVAQVGTISANGDASIGEM
IAGAMQRVGNEGVITVEEAKTAETELEVVEGMQFDRGYLSPYFITNAEKMIADLEEPYLLIFEKKLSGLQPILPVLEAVV
QTGRPLVIVAEDVEGEALATLVVNKLRGGLKVAAVKAPGFGDRRKAMLEDIAILTGGTVISEDLGIKLENVTIAQLGRAK
KVILEKEKTTIVDGVGEKADIEARVNQIKAQIEETSSDYDREKLQERLAKLAGGVAVIRVGGSTEVEVKEKKDRVDDALN
ATRAAVEEGIVPGGGVALLRAKKAVELVTSENPDITAGIKIVLRALEAPIRQIAENSGVEGSIVVGKVQESNDPNFGFNA
QSEEYVDMIGAGIVDPAKVVRTALQDAASIAALIVTTEALVAELPKRDSGMPAMPGGGMGGMGGMDF

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=528, Percent_Identity=54.3560606060606, Blast_Score=568, Evalue=1e-162,
Organism=Homo sapiens, GI31542947, Length=528, Percent_Identity=54.3560606060606, Blast_Score=568, Evalue=1e-162,
Organism=Homo sapiens, GI5453607, Length=543, Percent_Identity=22.0994475138122, Blast_Score=69, Evalue=8e-12,
Organism=Escherichia coli, GI1790586, Length=530, Percent_Identity=65.8490566037736, Blast_Score=692, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=529, Percent_Identity=53.1190926275992, Blast_Score=560, Evalue=1e-160,
Organism=Caenorhabditis elegans, GI193210679, Length=220, Percent_Identity=50.9090909090909, Blast_Score=219, Evalue=4e-57,
Organism=Saccharomyces cerevisiae, GI6323288, Length=526, Percent_Identity=55.893536121673, Blast_Score=583, Evalue=1e-167,
Organism=Saccharomyces cerevisiae, GI6322524, Length=511, Percent_Identity=22.8962818003914, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24641193, Length=528, Percent_Identity=56.0606060606061, Blast_Score=584, Evalue=1e-167,
Organism=Drosophila melanogaster, GI24641191, Length=528, Percent_Identity=56.0606060606061, Blast_Score=584, Evalue=1e-167,
Organism=Drosophila melanogaster, GI45550936, Length=525, Percent_Identity=52.9523809523809, Blast_Score=550, Evalue=1e-156,
Organism=Drosophila melanogaster, GI45550132, Length=525, Percent_Identity=52.9523809523809, Blast_Score=550, Evalue=1e-156,
Organism=Drosophila melanogaster, GI45550935, Length=525, Percent_Identity=52.9523809523809, Blast_Score=550, Evalue=1e-156,
Organism=Drosophila melanogaster, GI17864606, Length=549, Percent_Identity=44.4444444444444, Blast_Score=473, Evalue=1e-133,
Organism=Drosophila melanogaster, GI24584129, Length=538, Percent_Identity=36.9888475836431, Blast_Score=336, Evalue=3e-92,
Organism=Drosophila melanogaster, GI19921262, Length=538, Percent_Identity=36.9888475836431, Blast_Score=336, Evalue=3e-92,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 57552; Mature: 57421

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAKDVKFSGDAREKLLRGVDILANAVKVTLGPKGRNVVIEKSFGAPRITKDGVTVAKEI
CCCCCCCCCCHHHHHHHHHHHHHHHHEEEEECCCCCEEEEEECCCCCCCCCCCCCCHHHC
ELEDRFENLGAQLVREVASKTNDLAGDGTTTATVLAQAIVKEGAKSVAAGMNPMDLKRGI
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCC
DLAVAAAIADIRARAKKVSSSAEVAQVGTISANGDASIGEMIAGAMQRVGNEGVITVEEA
HHHHHHHHHHHHHHHHHHCCCCCHHHEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEECC
KTAETELEVVEGMQFDRGYLSPYFITNAEKMIADLEEPYLLIFEKKLSGLQPILPVLEAV
CCHHHHHHHHHCCCCCCCCCCCEEECCHHHHHHHCCCCEEEEEEHHHCCCCHHHHHHHHH
VQTGRPLVIVAEDVEGEALATLVVNKLRGGLKVAAVKAPGFGDRRKAMLEDIAILTGGTV
HHCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCEE
ISEDLGIKLENVTIAQLGRAKKVILEKEKTTIVDGVGEKADIEARVNQIKAQIEETSSDY
EECCCCEEEECEEHHHHCCHHHHHHCCCCHHEECCCCCCCHHHHHHHHHHHHHHHCCCCC
DREKLQERLAKLAGGVAVIRVGGSTEVEVKEKKDRVDDALNATRAAVEEGIVPGGGVALL
CHHHHHHHHHHHHCCEEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RAKKAVELVTSENPDITAGIKIVLRALEAPIRQIAENSGVEGSIVVGKVQESNDPNFGFN
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCC
AQSEEYVDMIGAGIVDPAKVVRTALQDAASIAALIVTTEALVAELPKRDSGMPAMPGGGM
CCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
GGMGGMDF
CCCCCCCC
>Mature Secondary Structure 
AAKDVKFSGDAREKLLRGVDILANAVKVTLGPKGRNVVIEKSFGAPRITKDGVTVAKEI
CCCCCCCCCHHHHHHHHHHHHHHHHEEEEECCCCCEEEEEECCCCCCCCCCCCCCHHHC
ELEDRFENLGAQLVREVASKTNDLAGDGTTTATVLAQAIVKEGAKSVAAGMNPMDLKRGI
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCC
DLAVAAAIADIRARAKKVSSSAEVAQVGTISANGDASIGEMIAGAMQRVGNEGVITVEEA
HHHHHHHHHHHHHHHHHHCCCCCHHHEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEECC
KTAETELEVVEGMQFDRGYLSPYFITNAEKMIADLEEPYLLIFEKKLSGLQPILPVLEAV
CCHHHHHHHHHCCCCCCCCCCCEEECCHHHHHHHCCCCEEEEEEHHHCCCCHHHHHHHHH
VQTGRPLVIVAEDVEGEALATLVVNKLRGGLKVAAVKAPGFGDRRKAMLEDIAILTGGTV
HHCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCEE
ISEDLGIKLENVTIAQLGRAKKVILEKEKTTIVDGVGEKADIEARVNQIKAQIEETSSDY
EECCCCEEEECEEHHHHCCHHHHHHCCCCHHEECCCCCCCHHHHHHHHHHHHHHHCCCCC
DREKLQERLAKLAGGVAVIRVGGSTEVEVKEKKDRVDDALNATRAAVEEGIVPGGGVALL
CHHHHHHHHHHHHCCEEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RAKKAVELVTSENPDITAGIKIVLRALEAPIRQIAENSGVEGSIVVGKVQESNDPNFGFN
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCC
AQSEEYVDMIGAGIVDPAKVVRTALQDAASIAALIVTTEALVAELPKRDSGMPAMPGGGM
CCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
GGMGGMDF
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA