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The map label for this gene is pcaR [H]

Identifier: 154245071

GI number: 154245071

Start: 1292868

End: 1293644

Strand: Direct

Name: pcaR [H]

Synonym: Xaut_1123

Alternate gene names: 154245071

Gene position: 1292868-1293644 (Clockwise)

Preceding gene: 154245064

Following gene: 154245072

Centisome position: 24.35

GC content: 66.92

Gene sequence:

>777_bases
ATGACCAAGGTGCAGGCGAGCGAGGACAAGGACTATGTGCAGTCCCTGGTGCGCGGGCTGGAGGTGATCCGCACCTTCAG
CCGCTACAAGCCGCGCATGACCCTGACCGAGGTGGCCGAGCAGACCGGAATGACCCGTGCCACCGCGCGCCGTTTCCTGC
TCACCCTGGTGCGGGAGGAATATGCCGAGACCGACGGCAAGTATTTCGCCCTGCGTCCCAAAGTATTGGACCTCGGCTTC
GCCTATCTCTCCTCGCTGCCGATCTGGGAGGTGGCCCAACCCATCATGCGCGACGTGGTGAATGCGCTGCACGAATCCTG
CTCGCTGGCGGTGCTGGACGGCCTCGACATCGTCTATGTGGCGCGGGTGCCCACCGAGCGGGTGATGACCATCGGCCTGT
CCATCGGCTCGCGCCTGCCGGCCTATTGCAGTTCCATGGGCCGCACCCTGCTGGCCGGCCTGCCACCGGCGGAGCTGGCG
GCCTATTACGACCGGGTGAAGATCGAGCGGCGCACCGAGCGCACGGTGGCCAACATGGTGGCCCTGAAGGACGCCATCGA
GACCTCCCGCCGGCAGGGCTGGACCCTGGTGGACCAGGAGCTGGAAATGGGCCTGCGCTCCATCGCGGCGCCGGTGAAGA
ACCGCCGCTCGGAGGTGCTGGCCGCGCTCAATGTCAGCACCCACGAGGGGCGCACCTCCATCGAGACCATCAAGACGCGC
TTTCTGCCGGTGCTGCTGGATGCCGCCCAGCGCATCTCGGCCGCGCTACCGCAATAG

Upstream 100 bases:

>100_bases
CGACAGCATCCGACGGCCTCAATCTTGTGCGCAATACGAACAAATGCTACATCCGGTCCGGCGACGCATTGCGCAACGCG
CGTCGCATCGGGGAGGGCGG

Downstream 100 bases:

>100_bases
AGGTAATATCGTCTGTATAGTCCGGGACTGGCGGAAATATTCCGGCGATCGGCGCCAGATTACGCAGCGTAATATATGTC
GGGCACGCCAGATTATCCCG

Product: beta-ketoadipate pathway transcription regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 258; Mature: 257

Protein sequence:

>258_residues
MTKVQASEDKDYVQSLVRGLEVIRTFSRYKPRMTLTEVAEQTGMTRATARRFLLTLVREEYAETDGKYFALRPKVLDLGF
AYLSSLPIWEVAQPIMRDVVNALHESCSLAVLDGLDIVYVARVPTERVMTIGLSIGSRLPAYCSSMGRTLLAGLPPAELA
AYYDRVKIERRTERTVANMVALKDAIETSRRQGWTLVDQELEMGLRSIAAPVKNRRSEVLAALNVSTHEGRTSIETIKTR
FLPVLLDAAQRISAALPQ

Sequences:

>Translated_258_residues
MTKVQASEDKDYVQSLVRGLEVIRTFSRYKPRMTLTEVAEQTGMTRATARRFLLTLVREEYAETDGKYFALRPKVLDLGF
AYLSSLPIWEVAQPIMRDVVNALHESCSLAVLDGLDIVYVARVPTERVMTIGLSIGSRLPAYCSSMGRTLLAGLPPAELA
AYYDRVKIERRTERTVANMVALKDAIETSRRQGWTLVDQELEMGLRSIAAPVKNRRSEVLAALNVSTHEGRTSIETIKTR
FLPVLLDAAQRISAALPQ
>Mature_257_residues
TKVQASEDKDYVQSLVRGLEVIRTFSRYKPRMTLTEVAEQTGMTRATARRFLLTLVREEYAETDGKYFALRPKVLDLGFA
YLSSLPIWEVAQPIMRDVVNALHESCSLAVLDGLDIVYVARVPTERVMTIGLSIGSRLPAYCSSMGRTLLAGLPPAELAA
YYDRVKIERRTERTVANMVALKDAIETSRRQGWTLVDQELEMGLRSIAAPVKNRRSEVLAALNVSTHEGRTSIETIKTRF
LPVLLDAAQRISAALPQ

Specific function: Positive regulator of all genes within the pca regulon, pcaBDC, pcaIJ and pcaF. Also required for the chemotactic response to aromatic compounds [H]

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI87082359, Length=247, Percent_Identity=27.1255060728745, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1786468, Length=218, Percent_Identity=29.8165137614679, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1788131, Length=258, Percent_Identity=28.2945736434109, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1789999, Length=249, Percent_Identity=28.1124497991968, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1786715, Length=248, Percent_Identity=24.1935483870968, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1788581, Length=214, Percent_Identity=26.1682242990654, Blast_Score=80, Evalue=9e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012794
- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 28861; Mature: 28730

Theoretical pI: Translated: 9.51; Mature: 9.51

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKVQASEDKDYVQSLVRGLEVIRTFSRYKPRMTLTEVAEQTGMTRATARRFLLTLVREE
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHH
YAETDGKYFALRPKVLDLGFAYLSSLPIWEVAQPIMRDVVNALHESCSLAVLDGLDIVYV
HHHCCCCEEEECCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCEECCCCEEEE
ARVPTERVMTIGLSIGSRLPAYCSSMGRTLLAGLPPAELAAYYDRVKIERRTERTVANMV
ECCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
ALKDAIETSRRQGWTLVDQELEMGLRSIAAPVKNRRSEVLAALNVSTHEGRTSIETIKTR
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
FLPVLLDAAQRISAALPQ
HHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TKVQASEDKDYVQSLVRGLEVIRTFSRYKPRMTLTEVAEQTGMTRATARRFLLTLVREE
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHH
YAETDGKYFALRPKVLDLGFAYLSSLPIWEVAQPIMRDVVNALHESCSLAVLDGLDIVYV
HHHCCCCEEEECCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCEECCCCEEEE
ARVPTERVMTIGLSIGSRLPAYCSSMGRTLLAGLPPAELAAYYDRVKIERRTERTVANMV
ECCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
ALKDAIETSRRQGWTLVDQELEMGLRSIAAPVKNRRSEVLAALNVSTHEGRTSIETIKTR
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
FLPVLLDAAQRISAALPQ
HHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8083169 [H]