Click here to switch to the map view.

The map label for this gene is hutH [H]

Identifier: 154244954

GI number: 154244954

Start: 1124682

End: 1126217

Strand: Reverse

Name: hutH [H]

Synonym: Xaut_1004

Alternate gene names: 154244954

Gene position: 1126217-1124682 (Counterclockwise)

Preceding gene: 154244965

Following gene: 154244953

Centisome position: 21.21

GC content: 68.88

Gene sequence:

>1536_bases
ATGAACGTTCATCGGACCCCTGTGATCCTCGTCGGTGCGCAGCGCCTTTCGCCGGCTGATGTCTGGGCGGTGGCCCAGGG
CACGAGCCGCGTCGCGCTGGATGGCTCTGCTGCATTTCGCCAGCGCATCGAGGCCGGCTCCGGCCTGCTGGGTCAGCGCA
TCGCCGCGGGCGAGCGGATCTACGGCGTCACCACCGGATTTGGCGAATCGGTGGTCACCGAGGTGCCGGTGCACCTGACC
GACGAGCTGTCTGCCAATCTCGTGCGCTTCCACGGCTGCGGCACCGGTGCGCTGTTCTCGCAAACCGAGGCGGCGGCGGT
ATTGCTGGCGCGCATCGCCTCCCTGTCCGCCGGCTGGTCCGGCGTGCGGTTCGAGGTGATCGAACGCCTCGCGGCGCTGC
TGGACCTCCGCATCCTCCCGGCCATCCCGAGCGAAGGCTCGGTGGGGGCGAGCGGCGACCTGACCCCCCTGTCCTATGTG
GCGGCCGTGGTCATGGGCGAGCGCGAGGTCTACAGCGGCGGCGAGGTTCTTCCGGCGGCCGAGGCCATGCGGGGGGCGGG
CATCACCCCCATCGCTCTGGCGCCCAAGGAAAGCCTCGCCATCATGAACGGCACCAGCGTCTCGGTGGCGCTGACGGCCC
TTGCCTTCGAGCGCGCCCGCTGGCTGGCGCGGCTGGCGGCGGCGCTCACCGCGCTCGCCAGCGACGTGACGCGCGGCAAC
CCCGCCCATTTCGATCCGCGCATCTTCGCAGCCAAGCCCCATCCCGGCCAGATGCTGTGCGCCTCCTGGATCGCGCAGGA
TATCGAGTACCAGCAAGGCACCGTGCACCAGGGCCGGCTGCAGGATCGCTATTCCATCCGCTGCGCCCCCCATGTGGTAG
GGGTGCTGATCGATGCGCTGGACTGGATGAAGCCCTGGATCGAGACCGAGCTGAACGGCGCCTCCGACAACCCGCTGATC
GACCCGGAGACCGGCGACCCGCTGTTCGGCGGCAATTTCTATGGCGGCCACGCCTGCTTCGTCGCCGATGGCCTGAAGAA
CGCCACCGCCAACGTCGCCGATCTGCTGGACCGCCAGCTCGCGCTCATCTGTTCCGCCGTCACCAGCAACGGGCTGCCGG
AAAACCTGGTGGGTGCGGACGGCGACGGATGCCGGGCGCACCACGGCTTCAAGGCCATGCAGATCGCGGCGTCCGCATTG
ACCGCGGAAGCGTTGAAGGCAACCATGCCGGCCAGCGTCTTCAGCCGCAGCACCGAGAACCACAACCAGGACAAGGTCAG
CATGAGCACGATCGCTGCCCGTGACAGCCTGCGCGTGCTGGAGCTGACCGAGACGGTGGCGGCCATCTGCCTGTTGGCGC
TGGTGCAGGCAGTGGACCTGCGCCGGGGGGAGGGCTGCCATGTGCGCAGCCGGCTGCTGCGCGATGCGGTGCGAGCCAAG
GTGCCGTTCAATGATCGCGACCGGCGCCAGGACGGCGACATCGCCATGGTCAAGGAAATGATCCAGCGGCGCACCCTGCC
CCTGGACTTCAACTGA

Upstream 100 bases:

>100_bases
CTGATTTTGAGCGCGATTCGCCGACCAAACTGGTTCAATTTGCCCGGATCGCGCTCTAGTCTCGCGCCCGAGGCCGTGCC
GCATCGAGTGATTCAAGCGC

Downstream 100 bases:

>100_bases
TGCCCGAGGCGACGCAGTCCCCGGCAGCGCCCGCCCTGACCAACCAGCAGCGAGCCCGCGCGGTCCGGCGGCTGTTCCTG
CGCATCGCGCTCCACATCTT

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 511; Mature: 511

Protein sequence:

>511_residues
MNVHRTPVILVGAQRLSPADVWAVAQGTSRVALDGSAAFRQRIEAGSGLLGQRIAAGERIYGVTTGFGESVVTEVPVHLT
DELSANLVRFHGCGTGALFSQTEAAAVLLARIASLSAGWSGVRFEVIERLAALLDLRILPAIPSEGSVGASGDLTPLSYV
AAVVMGEREVYSGGEVLPAAEAMRGAGITPIALAPKESLAIMNGTSVSVALTALAFERARWLARLAAALTALASDVTRGN
PAHFDPRIFAAKPHPGQMLCASWIAQDIEYQQGTVHQGRLQDRYSIRCAPHVVGVLIDALDWMKPWIETELNGASDNPLI
DPETGDPLFGGNFYGGHACFVADGLKNATANVADLLDRQLALICSAVTSNGLPENLVGADGDGCRAHHGFKAMQIAASAL
TAEALKATMPASVFSRSTENHNQDKVSMSTIAARDSLRVLELTETVAAICLLALVQAVDLRRGEGCHVRSRLLRDAVRAK
VPFNDRDRRQDGDIAMVKEMIQRRTLPLDFN

Sequences:

>Translated_511_residues
MNVHRTPVILVGAQRLSPADVWAVAQGTSRVALDGSAAFRQRIEAGSGLLGQRIAAGERIYGVTTGFGESVVTEVPVHLT
DELSANLVRFHGCGTGALFSQTEAAAVLLARIASLSAGWSGVRFEVIERLAALLDLRILPAIPSEGSVGASGDLTPLSYV
AAVVMGEREVYSGGEVLPAAEAMRGAGITPIALAPKESLAIMNGTSVSVALTALAFERARWLARLAAALTALASDVTRGN
PAHFDPRIFAAKPHPGQMLCASWIAQDIEYQQGTVHQGRLQDRYSIRCAPHVVGVLIDALDWMKPWIETELNGASDNPLI
DPETGDPLFGGNFYGGHACFVADGLKNATANVADLLDRQLALICSAVTSNGLPENLVGADGDGCRAHHGFKAMQIAASAL
TAEALKATMPASVFSRSTENHNQDKVSMSTIAARDSLRVLELTETVAAICLLALVQAVDLRRGEGCHVRSRLLRDAVRAK
VPFNDRDRRQDGDIAMVKEMIQRRTLPLDFN
>Mature_511_residues
MNVHRTPVILVGAQRLSPADVWAVAQGTSRVALDGSAAFRQRIEAGSGLLGQRIAAGERIYGVTTGFGESVVTEVPVHLT
DELSANLVRFHGCGTGALFSQTEAAAVLLARIASLSAGWSGVRFEVIERLAALLDLRILPAIPSEGSVGASGDLTPLSYV
AAVVMGEREVYSGGEVLPAAEAMRGAGITPIALAPKESLAIMNGTSVSVALTALAFERARWLARLAAALTALASDVTRGN
PAHFDPRIFAAKPHPGQMLCASWIAQDIEYQQGTVHQGRLQDRYSIRCAPHVVGVLIDALDWMKPWIETELNGASDNPLI
DPETGDPLFGGNFYGGHACFVADGLKNATANVADLLDRQLALICSAVTSNGLPENLVGADGDGCRAHHGFKAMQIAASAL
TAEALKATMPASVFSRSTENHNQDKVSMSTIAARDSLRVLELTETVAAICLLALVQAVDLRRGEGCHVRSRLLRDAVRAK
VPFNDRDRRQDGDIAMVKEMIQRRTLPLDFN

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=501, Percent_Identity=33.5329341317365, Blast_Score=249, Evalue=6e-66,
Organism=Caenorhabditis elegans, GI17567831, Length=508, Percent_Identity=32.6771653543307, Blast_Score=225, Evalue=4e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 54291; Mature: 54291

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: PS00488 PAL_HISTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVHRTPVILVGAQRLSPADVWAVAQGTSRVALDGSAAFRQRIEAGSGLLGQRIAAGERI
CCCCCCCEEEEECCCCCCHHHEEEECCCCEEEECCHHHHHHHHHHCCCHHHHHHHCCCEE
YGVTTGFGESVVTEVPVHLTDELSANLVRFHGCGTGALFSQTEAAAVLLARIASLSAGWS
EEEECCCCCHHHHHCCCEECCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCC
GVRFEVIERLAALLDLRILPAIPSEGSVGASGDLTPLSYVAAVVMGEREVYSGGEVLPAA
CHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHCCCCCCCCHH
EAMRGAGITPIALAPKESLAIMNGTSVSVALTALAFERARWLARLAAALTALASDVTRGN
HHHHCCCCCCEEECCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PAHFDPRIFAAKPHPGQMLCASWIAQDIEYQQGTVHQGRLQDRYSIRCAPHVVGVLIDAL
CCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEHHHHHHHHHHHH
DWMKPWIETELNGASDNPLIDPETGDPLFGGNFYGGHACFVADGLKNATANVADLLDRQL
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHH
ALICSAVTSNGLPENLVGADGDGCRAHHGFKAMQIAASALTAEALKATMPASVFSRSTEN
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCC
HNQDKVSMSTIAARDSLRVLELTETVAAICLLALVQAVDLRRGEGCHVRSRLLRDAVRAK
CCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHC
VPFNDRDRRQDGDIAMVKEMIQRRTLPLDFN
CCCCCCCCCCCCCHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MNVHRTPVILVGAQRLSPADVWAVAQGTSRVALDGSAAFRQRIEAGSGLLGQRIAAGERI
CCCCCCCEEEEECCCCCCHHHEEEECCCCEEEECCHHHHHHHHHHCCCHHHHHHHCCCEE
YGVTTGFGESVVTEVPVHLTDELSANLVRFHGCGTGALFSQTEAAAVLLARIASLSAGWS
EEEECCCCCHHHHHCCCEECCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCC
GVRFEVIERLAALLDLRILPAIPSEGSVGASGDLTPLSYVAAVVMGEREVYSGGEVLPAA
CHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHCCCCCCCCHH
EAMRGAGITPIALAPKESLAIMNGTSVSVALTALAFERARWLARLAAALTALASDVTRGN
HHHHCCCCCCEEECCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PAHFDPRIFAAKPHPGQMLCASWIAQDIEYQQGTVHQGRLQDRYSIRCAPHVVGVLIDAL
CCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEHHHHHHHHHHHH
DWMKPWIETELNGASDNPLIDPETGDPLFGGNFYGGHACFVADGLKNATANVADLLDRQL
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHH
ALICSAVTSNGLPENLVGADGDGCRAHHGFKAMQIAASALTAEALKATMPASVFSRSTEN
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCC
HNQDKVSMSTIAARDSLRVLELTETVAAICLLALVQAVDLRRGEGCHVRSRLLRDAVRAK
CCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHC
VPFNDRDRRQDGDIAMVKEMIQRRTLPLDFN
CCCCCCCCCCCCCHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA