Click here to switch to the map view.

The map label for this gene is gcvT [H]

Identifier: 154244873

GI number: 154244873

Start: 1041213

End: 1042352

Strand: Direct

Name: gcvT [H]

Synonym: Xaut_0923

Alternate gene names: 154244873

Gene position: 1041213-1042352 (Clockwise)

Preceding gene: 154244872

Following gene: 154244874

Centisome position: 19.61

GC content: 69.21

Gene sequence:

>1140_bases
ATGACCCAGGCTACTCCCGCCTATTCCCGCCTGTCGGTGCTGTCGGACCGGCATCGTGCGCTCGGCACCGGATTCGAGGC
GTCGTGGAACGACATGCCGGTGCCGCAGAACTACGCCACCGATCCCTATGACGAGGTGGTCGCGGTACGCACCGCCGCCG
GCCTGTTCGACGTGTCGGCGCTCAGGATGATCGACGTGTCGGGGCGCGAGGCGCTCGCCGTGCTCAACGAGATGTGCACC
TCGGACATTTCGAGGATCGCGCCCGGCGCCTCCTCCCTCACCAGCGTGGTGGACGAGGAGGGCGCGCTCATCGACGACGT
GCTCGTCTATTGCGACGGTCCGGACGCCTACCGCATCTCCCATGGCGGCGGGTCGCTGGAGGACATCCTGCCCGGCATTG
CCCAAGGGCGCGAGGTGACCTTCACCAAGGACAACGACGTTCACATCCTCTCCCTGCAGGGGCCGAAGGCGCTTGATATC
CTCAGCCCCCACACGCCGTTCGCGCTGGAGGGCCTGCCCTATTTCGGGCACCAGAAGACGACGCTGTTCGGCCGCCCGGT
CTCCATCGCCCGCGGCGGCTATTCCGGCGAGCGGGGCTACGAGGTGTTCTGCGCCTCGGCCGATGCGGTGTTCCTCTGGG
ACAGCATCCTCGCGGCCGGCAAGCCGCTGGGGGGCCTGCCTGCCTCCTGGTCGTGCCTCGACGTGGTGCGGGTGGAAGGC
GGCCTGCTGTTCTTCCCCTATGACATGCCCCAGGGCGATACCTCGCCGTGGGAAGTGGGCCTCGGCTGGACCGTCGACCT
GTCAAAGCCGGCCTTCCGCGGCCGGGACGCCCTGGTGCGCCGCAAGGGGCAGGAGCGGGTGGCGCAGGTGGGGGTGGAGA
TCGACCACCATGCCGCCGTCGAGCCGGGCGCCAGGCTGTTCAGGGACGGCAAGGAGGTGGGCCTTGTGAACTCCACCGCC
TACAGCCGCTACCTCATGCGCTCGCTGGCGCTCGCCCATGTGGCGCCGGAGCTGTCCGCCTGCGGCACGGAGCTGGAGCT
GCGGGGAGCCGACGGCACCTTCGCGGCGCGGGTGGTGAAGACGCCCTTCTACGATCCGCTGCGCCTGCGCACCCATCCGC
TTGAAGAACGCACGGCCTGA

Upstream 100 bases:

>100_bases
CGCCGGCATCCTGCCCTATCTCGCGCTCATCGCCGGCATCGTCGTGGTGCTCGTCTCCAACTGGCTGTTCCACCTCTGAT
CTGTTGAAGGATTTCCCAAG

Downstream 100 bases:

>100_bases
GCCCTCTCTTAGCCCCTCAGGCTGTTGCGGCCCCCAGGGCTTCCTCCTGGGTGCTGGCCGGAGAGCGCGATCGTCGCCGT
CGCGCTCTCCGGTCTTTTTC

Product: glycine cleavage T protein (aminomethyl transferase)

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 379; Mature: 378

Protein sequence:

>379_residues
MTQATPAYSRLSVLSDRHRALGTGFEASWNDMPVPQNYATDPYDEVVAVRTAAGLFDVSALRMIDVSGREALAVLNEMCT
SDISRIAPGASSLTSVVDEEGALIDDVLVYCDGPDAYRISHGGGSLEDILPGIAQGREVTFTKDNDVHILSLQGPKALDI
LSPHTPFALEGLPYFGHQKTTLFGRPVSIARGGYSGERGYEVFCASADAVFLWDSILAAGKPLGGLPASWSCLDVVRVEG
GLLFFPYDMPQGDTSPWEVGLGWTVDLSKPAFRGRDALVRRKGQERVAQVGVEIDHHAAVEPGARLFRDGKEVGLVNSTA
YSRYLMRSLALAHVAPELSACGTELELRGADGTFAARVVKTPFYDPLRLRTHPLEERTA

Sequences:

>Translated_379_residues
MTQATPAYSRLSVLSDRHRALGTGFEASWNDMPVPQNYATDPYDEVVAVRTAAGLFDVSALRMIDVSGREALAVLNEMCT
SDISRIAPGASSLTSVVDEEGALIDDVLVYCDGPDAYRISHGGGSLEDILPGIAQGREVTFTKDNDVHILSLQGPKALDI
LSPHTPFALEGLPYFGHQKTTLFGRPVSIARGGYSGERGYEVFCASADAVFLWDSILAAGKPLGGLPASWSCLDVVRVEG
GLLFFPYDMPQGDTSPWEVGLGWTVDLSKPAFRGRDALVRRKGQERVAQVGVEIDHHAAVEPGARLFRDGKEVGLVNSTA
YSRYLMRSLALAHVAPELSACGTELELRGADGTFAARVVKTPFYDPLRLRTHPLEERTA
>Mature_378_residues
TQATPAYSRLSVLSDRHRALGTGFEASWNDMPVPQNYATDPYDEVVAVRTAAGLFDVSALRMIDVSGREALAVLNEMCTS
DISRIAPGASSLTSVVDEEGALIDDVLVYCDGPDAYRISHGGGSLEDILPGIAQGREVTFTKDNDVHILSLQGPKALDIL
SPHTPFALEGLPYFGHQKTTLFGRPVSIARGGYSGERGYEVFCASADAVFLWDSILAAGKPLGGLPASWSCLDVVRVEGG
LLFFPYDMPQGDTSPWEVGLGWTVDLSKPAFRGRDALVRRKGQERVAQVGVEIDHHAAVEPGARLFRDGKEVGLVNSTAY
SRYLMRSLALAHVAPELSACGTELELRGADGTFAARVVKTPFYDPLRLRTHPLEERTA

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=368, Percent_Identity=27.445652173913, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI257796258, Length=350, Percent_Identity=27.4285714285714, Blast_Score=99, Evalue=9e-21,
Organism=Homo sapiens, GI24797151, Length=339, Percent_Identity=25.0737463126844, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI257796256, Length=313, Percent_Identity=27.4760383386581, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI197927446, Length=324, Percent_Identity=23.4567901234568, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI21361378, Length=324, Percent_Identity=23.4567901234568, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI257796254, Length=360, Percent_Identity=25.5555555555556, Blast_Score=79, Evalue=6e-15,
Organism=Escherichia coli, GI1789272, Length=355, Percent_Identity=29.8591549295775, Blast_Score=117, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17560118, Length=384, Percent_Identity=24.7395833333333, Blast_Score=95, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI71994045, Length=237, Percent_Identity=28.6919831223629, Blast_Score=71, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI71994052, Length=237, Percent_Identity=28.6919831223629, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6320222, Length=393, Percent_Identity=26.4631043256997, Blast_Score=98, Evalue=2e-21,
Organism=Drosophila melanogaster, GI20129441, Length=337, Percent_Identity=31.7507418397626, Blast_Score=121, Evalue=6e-28,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 40909; Mature: 40777

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQATPAYSRLSVLSDRHRALGTGFEASWNDMPVPQNYATDPYDEVVAVRTAAGLFDVSA
CCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCHHHHCE
LRMIDVSGREALAVLNEMCTSDISRIAPGASSLTSVVDEEGALIDDVLVYCDGPDAYRIS
EEEEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEEEEEECCCCCEEEE
HGGGSLEDILPGIAQGREVTFTKDNDVHILSLQGPKALDILSPHTPFALEGLPYFGHQKT
CCCCCHHHHHHHHHCCCEEEEECCCCEEEEEECCCCEEECCCCCCCEEECCCCCCCCCCE
TLFGRPVSIARGGYSGERGYEVFCASADAVFLWDSILAAGKPLGGLPASWSCLDVVRVEG
EEECCCHHEECCCCCCCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCEEEEEECC
GLLFFPYDMPQGDTSPWEVGLGWTVDLSKPAFRGRDALVRRKGQERVAQVGVEIDHHAAV
CEEEEECCCCCCCCCCEEECCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCEECCCCCC
EPGARLFRDGKEVGLVNSTAYSRYLMRSLALAHVAPELSACGTELELRGADGTFAARVVK
CCCHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHCCHHHHCCCEEEEECCCCCEEEEEEC
TPFYDPLRLRTHPLEERTA
CCCCCCHHCCCCCCHHCCC
>Mature Secondary Structure 
TQATPAYSRLSVLSDRHRALGTGFEASWNDMPVPQNYATDPYDEVVAVRTAAGLFDVSA
CCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCHHHHCE
LRMIDVSGREALAVLNEMCTSDISRIAPGASSLTSVVDEEGALIDDVLVYCDGPDAYRIS
EEEEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEEEEEECCCCCEEEE
HGGGSLEDILPGIAQGREVTFTKDNDVHILSLQGPKALDILSPHTPFALEGLPYFGHQKT
CCCCCHHHHHHHHHCCCEEEEECCCCEEEEEECCCCEEECCCCCCCEEECCCCCCCCCCE
TLFGRPVSIARGGYSGERGYEVFCASADAVFLWDSILAAGKPLGGLPASWSCLDVVRVEG
EEECCCHHEECCCCCCCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCEEEEEECC
GLLFFPYDMPQGDTSPWEVGLGWTVDLSKPAFRGRDALVRRKGQERVAQVGVEIDHHAAV
CEEEEECCCCCCCCCCEEECCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCEECCCCCC
EPGARLFRDGKEVGLVNSTAYSRYLMRSLALAHVAPELSACGTELELRGADGTFAARVVK
CCCHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHCCHHHHCCCEEEEECCCCCEEEEEEC
TPFYDPLRLRTHPLEERTA
CCCCCCHHCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14621292 [H]