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The map label for this gene is oxc [H]

Identifier: 154244443

GI number: 154244443

Start: 538432

End: 540186

Strand: Direct

Name: oxc [H]

Synonym: Xaut_0486

Alternate gene names: 154244443

Gene position: 538432-540186 (Clockwise)

Preceding gene: 154244442

Following gene: 154244444

Centisome position: 10.14

GC content: 66.78

Gene sequence:

>1755_bases
ATGGCAACGGCGGAAAAGACCAAGATCGAAGACAACGTGGTGCATCTCGACCCCGCGGCCGAGCAGGAGCTTACCGACGG
CTTCCACCTCGTCATTGATGCCCTGAAGCTGAACGGCATCGAGACCATCTACGGCGTCCCCGGCATCCCGATCACCGACC
TCGGCCGCATGGCCCAGGAGGAGGGGATCCGCGTCATCTCTTTCCGTCATGAGCAGAATGCCGGCAACGCGGCGGCCATC
GCCGGCTTCCTCACCAAGAAGCCGGGCGTGTGCCTCACCGTCTCCGCGCCGGGCTTCCTCAACGGCCTGACCGCGCTGGC
GAACGCCACCACCAACTGCTTCCCGATGATCCTCATCTCCGGCTCGTCCGAGCGCGAGATCGTCGACCTGCAGCAGGGCG
ACTACGAGGAGATGGACCAGCTCGCCATCGCCAAGCCCCTGTGCAAGGCGGCCTTCCGCGTGCTGCACGCGGCGGATATC
GGCATCGGCGTGGCGCGGGCCATCCGCGCGGCGGTGTCGGGCCGTCCCGGCGGCGTCTATCTCGACCTGCCGGCGAAGCT
CTTCTCCCAGGCGATGGATGCCGAAGCCGGCGCGAAATCGCTGGTGAAGGTGATCGATGCCGCTCCCGCGCAGATCCCCT
CGCCCGCCGCCGTGGACCGCGCCATCGACCTGCTGAAGGGCGCCAAGAAGCCCCTCATCATCCTCGGCAAGGGCGCGGCC
TATGCCCAGGCCGATGAAGAGATCCGCGCGTTCGTCGAGAACAGCGGCATTCCCTTCCTGCCCATGAGCATGGCCAAGGG
CCTTTTGCCCGACACCCATCCCCAGTCCGCCGGTGCCGCGCGCTCCACCGCGCTGAAGGATGCCGACGTGGTGCTCCTCG
TCGGCGCCCGCCTCAACTGGCTGCTGTCGCACGGCAAGGGCAAGACCTGGGGCGACAAGCCCAAGCAGTTCATCCAGGTG
GACATCGAGCCCCGCGAGATGGACTCCAACGTGGAGATCAAGGCGCCGCTGGTGGGTGACATCGGCTCTGTCATCGCGGC
GCTGAACGCCCGCATCGACGGCAGCTGGCAGGCTCCGCCCGCCGAGTGGGTGGAGACCATCCGCTCCAAGAAGGAAGCCA
ACATCGCCAAGATGGCGCCGAAGCTGCTCAAGAATTCGGTACCCATGGACTTCCACTCGGCGCTCGGCGCGCTGAAGAAT
GTGATCAAGGAGCGGCCCGACGCCATCCTCGTCAATGAGGGCGCCAACACGCTCGATCTCGCCCGCGGCATCATCGACAT
GCACCAGCCGCGCAAGCGCCTGGACGTGGGCACCTGGGGCGTGATGGGCATCGGCATGGGCTTCGCGGTGGGCGCGGCCG
TGGAGACCGGCAAGCCGGTGCTCGCGGTGGAAGGCGACAGCGCCTTCGGCTTCTCCGGCATGGAGGTGGAGACCATCTGC
CGCTACGACCTGCCGGTCACCATCGTGATCTTCAACAACAACGGCATCTATCGCGGCACCGACACCGACCCCACCGGGCG
TGATCCCGGCACCACGGTGTTCGTGCCCGGCGCCCGCTACGACAAGATGATGGAAGCCTTCGGCGGCGTGGGCGTGCATG
TCACCTCCCCCGACGAGCTCTATCGCGCCGTGAGCGCCGCCATGGACAGCGGCAAGCCCACCCTGATCAACGCGGTGATC
GACCCGGCGGCCGGCTCCGAGAGCGGCAACATCGGTTCGCTCAACCCGCAGAGCGTGGTCAAAAAGAAGAAGTGA

Upstream 100 bases:

>100_bases
CACACCATGGGTCTTGCGGCCCATGTGGAGCGGCACGGTGTCTTTCCCGAATAGGCCGAGAACAAGCCAAACCGGGACGA
CGCGCTGAAGGAGACGCCTC

Downstream 100 bases:

>100_bases
GCTTTTCGATCCCATGAGACTGACAGGCGGGACAAGTCCCGCCTGTCAAACCCGAAGACCAAATAACAAAAACAGTAAAC
CGGGAACGAGACACTAGAAG

Product: putative oxalyl-CoA decarboxylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 584; Mature: 583

Protein sequence:

>584_residues
MATAEKTKIEDNVVHLDPAAEQELTDGFHLVIDALKLNGIETIYGVPGIPITDLGRMAQEEGIRVISFRHEQNAGNAAAI
AGFLTKKPGVCLTVSAPGFLNGLTALANATTNCFPMILISGSSEREIVDLQQGDYEEMDQLAIAKPLCKAAFRVLHAADI
GIGVARAIRAAVSGRPGGVYLDLPAKLFSQAMDAEAGAKSLVKVIDAAPAQIPSPAAVDRAIDLLKGAKKPLIILGKGAA
YAQADEEIRAFVENSGIPFLPMSMAKGLLPDTHPQSAGAARSTALKDADVVLLVGARLNWLLSHGKGKTWGDKPKQFIQV
DIEPREMDSNVEIKAPLVGDIGSVIAALNARIDGSWQAPPAEWVETIRSKKEANIAKMAPKLLKNSVPMDFHSALGALKN
VIKERPDAILVNEGANTLDLARGIIDMHQPRKRLDVGTWGVMGIGMGFAVGAAVETGKPVLAVEGDSAFGFSGMEVETIC
RYDLPVTIVIFNNNGIYRGTDTDPTGRDPGTTVFVPGARYDKMMEAFGGVGVHVTSPDELYRAVSAAMDSGKPTLINAVI
DPAAGSESGNIGSLNPQSVVKKKK

Sequences:

>Translated_584_residues
MATAEKTKIEDNVVHLDPAAEQELTDGFHLVIDALKLNGIETIYGVPGIPITDLGRMAQEEGIRVISFRHEQNAGNAAAI
AGFLTKKPGVCLTVSAPGFLNGLTALANATTNCFPMILISGSSEREIVDLQQGDYEEMDQLAIAKPLCKAAFRVLHAADI
GIGVARAIRAAVSGRPGGVYLDLPAKLFSQAMDAEAGAKSLVKVIDAAPAQIPSPAAVDRAIDLLKGAKKPLIILGKGAA
YAQADEEIRAFVENSGIPFLPMSMAKGLLPDTHPQSAGAARSTALKDADVVLLVGARLNWLLSHGKGKTWGDKPKQFIQV
DIEPREMDSNVEIKAPLVGDIGSVIAALNARIDGSWQAPPAEWVETIRSKKEANIAKMAPKLLKNSVPMDFHSALGALKN
VIKERPDAILVNEGANTLDLARGIIDMHQPRKRLDVGTWGVMGIGMGFAVGAAVETGKPVLAVEGDSAFGFSGMEVETIC
RYDLPVTIVIFNNNGIYRGTDTDPTGRDPGTTVFVPGARYDKMMEAFGGVGVHVTSPDELYRAVSAAMDSGKPTLINAVI
DPAAGSESGNIGSLNPQSVVKKKK
>Mature_583_residues
ATAEKTKIEDNVVHLDPAAEQELTDGFHLVIDALKLNGIETIYGVPGIPITDLGRMAQEEGIRVISFRHEQNAGNAAAIA
GFLTKKPGVCLTVSAPGFLNGLTALANATTNCFPMILISGSSEREIVDLQQGDYEEMDQLAIAKPLCKAAFRVLHAADIG
IGVARAIRAAVSGRPGGVYLDLPAKLFSQAMDAEAGAKSLVKVIDAAPAQIPSPAAVDRAIDLLKGAKKPLIILGKGAAY
AQADEEIRAFVENSGIPFLPMSMAKGLLPDTHPQSAGAARSTALKDADVVLLVGARLNWLLSHGKGKTWGDKPKQFIQVD
IEPREMDSNVEIKAPLVGDIGSVIAALNARIDGSWQAPPAEWVETIRSKKEANIAKMAPKLLKNSVPMDFHSALGALKNV
IKERPDAILVNEGANTLDLARGIIDMHQPRKRLDVGTWGVMGIGMGFAVGAAVETGKPVLAVEGDSAFGFSGMEVETICR
YDLPVTIVIFNNNGIYRGTDTDPTGRDPGTTVFVPGARYDKMMEAFGGVGVHVTSPDELYRAVSAAMDSGKPTLINAVID
PAAGSESGNIGSLNPQSVVKKKK

Specific function: Oxalic acid catabolism; second step. [C]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI93004078, Length=571, Percent_Identity=39.9299474605954, Blast_Score=431, Evalue=1e-121,
Organism=Homo sapiens, GI21361361, Length=570, Percent_Identity=29.4736842105263, Blast_Score=190, Evalue=4e-48,
Organism=Escherichia coli, GI1788716, Length=558, Percent_Identity=61.6487455197133, Blast_Score=675, Evalue=0.0,
Organism=Escherichia coli, GI87081685, Length=557, Percent_Identity=25.1346499102334, Blast_Score=169, Evalue=4e-43,
Organism=Escherichia coli, GI1790104, Length=484, Percent_Identity=28.099173553719, Blast_Score=159, Evalue=7e-40,
Organism=Escherichia coli, GI1786717, Length=482, Percent_Identity=26.1410788381743, Blast_Score=128, Evalue=9e-31,
Organism=Caenorhabditis elegans, GI17531301, Length=551, Percent_Identity=39.7459165154265, Blast_Score=372, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI17531299, Length=551, Percent_Identity=39.7459165154265, Blast_Score=372, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI17542570, Length=557, Percent_Identity=28.5457809694794, Blast_Score=188, Evalue=7e-48,
Organism=Saccharomyces cerevisiae, GI6320816, Length=545, Percent_Identity=34.8623853211009, Blast_Score=293, Evalue=6e-80,
Organism=Saccharomyces cerevisiae, GI6323755, Length=568, Percent_Identity=22.887323943662, Blast_Score=115, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6323073, Length=507, Percent_Identity=23.8658777120316, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI19922626, Length=561, Percent_Identity=41.7112299465241, Blast_Score=405, Evalue=1e-113,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017660
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =4.1.1.8 [H]

Molecular weight: Translated: 61656; Mature: 61524

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATAEKTKIEDNVVHLDPAAEQELTDGFHLVIDALKLNGIETIYGVPGIPITDLGRMAQE
CCCCCCCCCCCCEEEECCCHHHHHCCCHHHHHHHHHCCCCCEECCCCCCCHHHHHHHHHH
EGIRVISFRHEQNAGNAAAIAGFLTKKPGVCLTVSAPGFLNGLTALANATTNCFPMILIS
CCCEEEEEEECCCCCCHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHCCCCCCEEEEEEC
GSSEREIVDLQQGDYEEMDQLAIAKPLCKAAFRVLHAADIGIGVARAIRAAVSGRPGGVY
CCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
LDLPAKLFSQAMDAEAGAKSLVKVIDAAPAQIPSPAAVDRAIDLLKGAKKPLIILGKGAA
EECCHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCC
YAQADEEIRAFVENSGIPFLPMSMAKGLLPDTHPQSAGAARSTALKDADVVLLVGARLNW
HHHHHHHHHHHHHCCCCCEECHHHHCCCCCCCCCCCCCCHHHHHCCCCCEEEEECCHHHH
LLSHGKGKTWGDKPKQFIQVDIEPREMDSNVEIKAPLVGDIGSVIAALNARIDGSWQAPP
HHCCCCCCCCCCCCCEEEEEECCHHHCCCCCEEECCCHHHHHHHHHHHHCCCCCCCCCCH
AEWVETIRSKKEANIAKMAPKLLKNSVPMDFHSALGALKNVIKERPDAILVNEGANTLDL
HHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCHHHH
ARGIIDMHQPRKRLDVGTWGVMGIGMGFAVGAAVETGKPVLAVEGDSAFGFSGMEVETIC
HHHHHHHCCCHHHCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEEHHEE
RYDLPVTIVIFNNNGIYRGTDTDPTGRDPGTTVFVPGARYDKMMEAFGGVGVHVTSPDEL
ECCCCEEEEEECCCCEEECCCCCCCCCCCCCEEEECCCHHHHHHHHHCCCEEEECCHHHH
YRAVSAAMDSGKPTLINAVIDPAAGSESGNIGSLNPQSVVKKKK
HHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHCCCC
>Mature Secondary Structure 
ATAEKTKIEDNVVHLDPAAEQELTDGFHLVIDALKLNGIETIYGVPGIPITDLGRMAQE
CCCCCCCCCCCEEEECCCHHHHHCCCHHHHHHHHHCCCCCEECCCCCCCHHHHHHHHHH
EGIRVISFRHEQNAGNAAAIAGFLTKKPGVCLTVSAPGFLNGLTALANATTNCFPMILIS
CCCEEEEEEECCCCCCHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHCCCCCCEEEEEEC
GSSEREIVDLQQGDYEEMDQLAIAKPLCKAAFRVLHAADIGIGVARAIRAAVSGRPGGVY
CCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
LDLPAKLFSQAMDAEAGAKSLVKVIDAAPAQIPSPAAVDRAIDLLKGAKKPLIILGKGAA
EECCHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCC
YAQADEEIRAFVENSGIPFLPMSMAKGLLPDTHPQSAGAARSTALKDADVVLLVGARLNW
HHHHHHHHHHHHHCCCCCEECHHHHCCCCCCCCCCCCCCHHHHHCCCCCEEEEECCHHHH
LLSHGKGKTWGDKPKQFIQVDIEPREMDSNVEIKAPLVGDIGSVIAALNARIDGSWQAPP
HHCCCCCCCCCCCCCEEEEEECCHHHCCCCCEEECCCHHHHHHHHHHHHCCCCCCCCCCH
AEWVETIRSKKEANIAKMAPKLLKNSVPMDFHSALGALKNVIKERPDAILVNEGANTLDL
HHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCHHHH
ARGIIDMHQPRKRLDVGTWGVMGIGMGFAVGAAVETGKPVLAVEGDSAFGFSGMEVETIC
HHHHHHHCCCHHHCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEEHHEE
RYDLPVTIVIFNNNGIYRGTDTDPTGRDPGTTVFVPGARYDKMMEAFGGVGVHVTSPDEL
ECCCCEEEEEECCCCEEECCCCCCCCCCCCCEEEECCCHHHHHHHHHCCCEEEECCHHHH
YRAVSAAMDSGKPTLINAVIDPAAGSESGNIGSLNPQSVVKKKK
HHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8157618 [H]