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The map label for this gene is acoR [H]

Identifier: 154244324

GI number: 154244324

Start: 381444

End: 383534

Strand: Direct

Name: acoR [H]

Synonym: Xaut_0367

Alternate gene names: 154244324

Gene position: 381444-383534 (Clockwise)

Preceding gene: 154244321

Following gene: 154244330

Centisome position: 7.18

GC content: 73.08

Gene sequence:

>2091_bases
ATGCCTGCTGTGCCGACGCCCGCCGTGTCGACCTCTGCACTGTCGTCCTGCGCCGCGACCGATGCCGTCCTCGCCGCCCG
TCGCCGCTTCTTCTCCGGCGCGCCGGTGCCCGAGGACGCGCTGGCGCAGCCCATCCTGCGTTCCTGGACCCGCTGCGCCG
CGCGCGGACTGGGGCCGCAGTCCCGTTCGCGGATGGAGCCGCTGACCGACGGCGAGTTCACCGCCCGGCGCGAGCGCCAC
GAGACCCTGCGCCGCCGCTGCCGCCCGGAGCTGGAGGCGCTGCATGCCGCCGCCCGTGCGGCGGACAGCATCGTCATCCT
CACCGACCCGTCTGGGCTGGTGCTCGACACCGTGGGCAGCGCCGATTTCGCCGATCGCGCCGCCAAGGTGGCGCTGCGCC
CCGGCGTGAGCTGGAGCGAGGCCGAGACCGGTACCAACGCCATCGGCACCGCCCTGGTGGAGCGCCGCCCGGTGGAGGTG
CGCGGGGCCGAGCATTATGCCGAGGCCAACGGCATCCTCAGCTGTGCCGCCGCCCCCATCCACGACCCGTTCGGGGAACT
GGTGGGCCTGCTCGACCTGTCGGGGCCGGCCTCGGTGCCGCACCTGCATGCGCTGGCTCTGGTGGAGCTGGCCGCCGGCC
AGGTGGAGCACCGCATGTTCGAGGGCGCCTTCCCCGACCACAGCCTCGTGCGCTTCCACGCCGACCCGAGCTTTCTCGGC
ACGGCGCGGGAGGGCATCCTTGTCTTCGAGGATTATCGCCTCATCGCCGCCAACCGGCCGGGCCTCGCCCTGCTTGGCCT
TGGCTGGGATGCGCTGGGCGCCAAGCGTTTCGGCGACCTGTTCGAGGGCAGCCTCGGCAAGGCGGGGGAGGAGCGGCGGG
TCCGCACCCGTCGCGGCGACGTGGCCATGCGCCTCGAACGGCAGGGCATGCCGGTGCGGACCGTTGCGCCGCGCGCCACC
CCGTCAGCGGAGCGCCAGTCCGCGCCCGTGCCTGCCCAGGCTCCCGCCCAGACGGGCCCGCGCTTCGATGCCGCTACGGA
GCGTGACCTCGGCCGCGCCGTGCGCCTCATGGAGGCCGGCGTGCCGGTGCTGATCCAGGGCGAGACCGGCGTCGGCAAGG
AAGTGTTCGCCCGCCAGATCCACCGGCGCGGCAACCGGGGCGCTAGGGCGTTCGCGGCGGTCAATTGCGCGGCCTTGCCC
GAGGGCCTCATCGAATCCGAGCTGTTCGGCTATGAGGAAGGCGCCTTCACCGGCGCCCGCCGCGCCGGCTTCAAGGGCCT
GTTCCGCGAGGCGGACGGCGGGGTGCTGTTCCTTGACGAGATCGGCGACATGCCGCTTTCGCTCCAGAGCCGGCTCTTGC
GCGTGCTGCAGGAGCGGGAGGTGACGCCGCTCGGTGGCGGGCGGCCGGTGGCGGTGGATTTCGCCCTGGTCTGCGCCTCC
CACCGCGACCTCAAGCAGCGGGTGGAGGAGGGCAGCTTCCGCGCCGATCTTTATTTCCGCATCGCCCAATATACGGTGAC
GCTTCCGGCGCTGCGCACCCTCGCCGATCGCGAGGCGCTGGTGGATCGCCTGTGGGCGGAGATGGCCGGTGCCAGCCCCG
GCGCGCCGACCCTTTCGGTCGAATGCCGGGCCGCCCTCGCGGGTTATGGCTGGCCGGGCAATTTCCGCCAGCTGGTGGGC
GTCCTGCGGGTGCTCCAGGCCCTGGCGGAGCCGGGCGAGAGCGTGGGGGTCGAGGCCCTGCCGGCGGACGTGCGCAGCGC
GCCGCTGGAATGGCGCGGCGCAGGCCGGCCCGCGGAGATCATGCCCCCCGGTGCGCAGGCGGACACTGCCCCGTCGCAGG
AGTTCGGAGCCCGCGATTTTGGTGCTCGCGATCTTGGAACTCGCGATCTTGGAACACGTGATTTTGGAGCCGGTGATGTT
GGGGCCCGCGATCTTGGCGCCTGTGATCTTGGGGCGGTAACGCGCGCGGCCATGGATGCGGCGCTGGCCGCCAGCGGCGG
GAATGTCTCGCAGGCGGCGCGCCGGCTCGGCATCCACCGCAGCACCCTGCATCGCCATCTCGCCAGCCGCGGCTCCCGCG
GCGGGCATTGA

Upstream 100 bases:

>100_bases
AATAGTCGTGCCAGACTGGCGCACATAAGAACAAGAGCTGCGACACCTGTCGCGATTTGCGACAGGTGTTTCAGGGAGAG
ATGCCAAGCGAGGGACCAAG

Downstream 100 bases:

>100_bases
GACCTCAGCCCGTCAGGCCGCGGGCCGGACGGCACTCTCGGCGGCCTGCATCACCTCAGCGAGGGCGGGCAGCACCGTTT
CGCGCATGCGGCGGCCGTAG

Product: Fis family GAF modulated sigma54 specific transcriptional regulator

Products: NADP; 2 glutathione [C]

Alternate protein names: NA

Number of amino acids: Translated: 696; Mature: 695

Protein sequence:

>696_residues
MPAVPTPAVSTSALSSCAATDAVLAARRRFFSGAPVPEDALAQPILRSWTRCAARGLGPQSRSRMEPLTDGEFTARRERH
ETLRRRCRPELEALHAAARAADSIVILTDPSGLVLDTVGSADFADRAAKVALRPGVSWSEAETGTNAIGTALVERRPVEV
RGAEHYAEANGILSCAAAPIHDPFGELVGLLDLSGPASVPHLHALALVELAAGQVEHRMFEGAFPDHSLVRFHADPSFLG
TAREGILVFEDYRLIAANRPGLALLGLGWDALGAKRFGDLFEGSLGKAGEERRVRTRRGDVAMRLERQGMPVRTVAPRAT
PSAERQSAPVPAQAPAQTGPRFDAATERDLGRAVRLMEAGVPVLIQGETGVGKEVFARQIHRRGNRGARAFAAVNCAALP
EGLIESELFGYEEGAFTGARRAGFKGLFREADGGVLFLDEIGDMPLSLQSRLLRVLQEREVTPLGGGRPVAVDFALVCAS
HRDLKQRVEEGSFRADLYFRIAQYTVTLPALRTLADREALVDRLWAEMAGASPGAPTLSVECRAALAGYGWPGNFRQLVG
VLRVLQALAEPGESVGVEALPADVRSAPLEWRGAGRPAEIMPPGAQADTAPSQEFGARDFGARDLGTRDLGTRDFGAGDV
GARDLGACDLGAVTRAAMDAALAASGGNVSQAARRLGIHRSTLHRHLASRGSRGGH

Sequences:

>Translated_696_residues
MPAVPTPAVSTSALSSCAATDAVLAARRRFFSGAPVPEDALAQPILRSWTRCAARGLGPQSRSRMEPLTDGEFTARRERH
ETLRRRCRPELEALHAAARAADSIVILTDPSGLVLDTVGSADFADRAAKVALRPGVSWSEAETGTNAIGTALVERRPVEV
RGAEHYAEANGILSCAAAPIHDPFGELVGLLDLSGPASVPHLHALALVELAAGQVEHRMFEGAFPDHSLVRFHADPSFLG
TAREGILVFEDYRLIAANRPGLALLGLGWDALGAKRFGDLFEGSLGKAGEERRVRTRRGDVAMRLERQGMPVRTVAPRAT
PSAERQSAPVPAQAPAQTGPRFDAATERDLGRAVRLMEAGVPVLIQGETGVGKEVFARQIHRRGNRGARAFAAVNCAALP
EGLIESELFGYEEGAFTGARRAGFKGLFREADGGVLFLDEIGDMPLSLQSRLLRVLQEREVTPLGGGRPVAVDFALVCAS
HRDLKQRVEEGSFRADLYFRIAQYTVTLPALRTLADREALVDRLWAEMAGASPGAPTLSVECRAALAGYGWPGNFRQLVG
VLRVLQALAEPGESVGVEALPADVRSAPLEWRGAGRPAEIMPPGAQADTAPSQEFGARDFGARDLGTRDLGTRDFGAGDV
GARDLGACDLGAVTRAAMDAALAASGGNVSQAARRLGIHRSTLHRHLASRGSRGGH
>Mature_695_residues
PAVPTPAVSTSALSSCAATDAVLAARRRFFSGAPVPEDALAQPILRSWTRCAARGLGPQSRSRMEPLTDGEFTARRERHE
TLRRRCRPELEALHAAARAADSIVILTDPSGLVLDTVGSADFADRAAKVALRPGVSWSEAETGTNAIGTALVERRPVEVR
GAEHYAEANGILSCAAAPIHDPFGELVGLLDLSGPASVPHLHALALVELAAGQVEHRMFEGAFPDHSLVRFHADPSFLGT
AREGILVFEDYRLIAANRPGLALLGLGWDALGAKRFGDLFEGSLGKAGEERRVRTRRGDVAMRLERQGMPVRTVAPRATP
SAERQSAPVPAQAPAQTGPRFDAATERDLGRAVRLMEAGVPVLIQGETGVGKEVFARQIHRRGNRGARAFAAVNCAALPE
GLIESELFGYEEGAFTGARRAGFKGLFREADGGVLFLDEIGDMPLSLQSRLLRVLQEREVTPLGGGRPVAVDFALVCASH
RDLKQRVEEGSFRADLYFRIAQYTVTLPALRTLADREALVDRLWAEMAGASPGAPTLSVECRAALAGYGWPGNFRQLVGV
LRVLQALAEPGESVGVEALPADVRSAPLEWRGAGRPAEIMPPGAQADTAPSQEFGARDFGARDLGTRDLGTRDFGAGDVG
ARDLGACDLGAVTRAAMDAALAASGGNVSQAARRLGIHRSTLHRHLASRGSRGGH

Specific function: Required for sigma-54-dependent transcription of acoXABC [H]

COG id: COG3284

COG function: function code QK; Transcriptional activator of acetoin/glycerol metabolism

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1790299, Length=384, Percent_Identity=36.1979166666667, Blast_Score=195, Evalue=8e-51,
Organism=Escherichia coli, GI1788905, Length=224, Percent_Identity=46.4285714285714, Blast_Score=188, Evalue=8e-49,
Organism=Escherichia coli, GI1789233, Length=240, Percent_Identity=40.4166666666667, Blast_Score=188, Evalue=1e-48,
Organism=Escherichia coli, GI1786524, Length=219, Percent_Identity=47.0319634703196, Blast_Score=182, Evalue=9e-47,
Organism=Escherichia coli, GI1788550, Length=226, Percent_Identity=42.4778761061947, Blast_Score=180, Evalue=3e-46,
Organism=Escherichia coli, GI1790437, Length=373, Percent_Identity=34.5844504021448, Blast_Score=180, Evalue=3e-46,
Organism=Escherichia coli, GI87082117, Length=227, Percent_Identity=43.6123348017621, Blast_Score=178, Evalue=9e-46,
Organism=Escherichia coli, GI1789087, Length=202, Percent_Identity=45.5445544554455, Blast_Score=167, Evalue=2e-42,
Organism=Escherichia coli, GI87081872, Length=208, Percent_Identity=44.7115384615385, Blast_Score=159, Evalue=8e-40,
Organism=Escherichia coli, GI87082152, Length=202, Percent_Identity=43.0693069306931, Blast_Score=154, Evalue=2e-38,
Organism=Escherichia coli, GI1787583, Length=280, Percent_Identity=34.2857142857143, Blast_Score=145, Evalue=1e-35,
Organism=Escherichia coli, GI1789828, Length=284, Percent_Identity=34.1549295774648, Blast_Score=141, Evalue=1e-34,
Organism=Escherichia coli, GI87081858, Length=358, Percent_Identity=24.5810055865922, Blast_Score=95, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078 [H]

Pfam domain/function: PF02954 HTH_8; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 73926; Mature: 73794

Theoretical pI: Translated: 7.63; Mature: 7.63

Prosite motif: PS00675 SIGMA54_INTERACT_1 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAVPTPAVSTSALSSCAATDAVLAARRRFFSGAPVPEDALAQPILRSWTRCAARGLGPQ
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
SRSRMEPLTDGEFTARRERHETLRRRCRPELEALHAAARAADSIVILTDPSGLVLDTVGS
HHHHCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEECCCCEEEECCCC
ADFADRAAKVALRPGVSWSEAETGTNAIGTALVERRPVEVRGAEHYAEANGILSCAAAPI
CHHHHHHHHHHCCCCCCCHHCCCCCHHHHHHHHHCCCCEECCHHHHHHHCCCEEECCCCC
HDPFGELVGLLDLSGPASVPHLHALALVELAAGQVEHRMFEGAFPDHSLVRFHADPSFLG
CCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHC
TAREGILVFEDYRLIAANRPGLALLGLGWDALGAKRFGDLFEGSLGKAGEERRVRTRRGD
CCCCCEEEEECCEEEEECCCCEEEEECCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCC
VAMRLERQGMPVRTVAPRATPSAERQSAPVPAQAPAQTGPRFDAATERDLGRAVRLMEAG
EEEEEHHCCCCEEEECCCCCCCCHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
VPVLIQGETGVGKEVFARQIHRRGNRGARAFAAVNCAALPEGLIESELFGYEEGAFTGAR
CCEEEECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCHH
RAGFKGLFREADGGVLFLDEIGDMPLSLQSRLLRVLQEREVTPLGGGRPVAVDFALVCAS
HHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
HRDLKQRVEEGSFRADLYFRIAQYTVTLPALRTLADREALVDRLWAEMAGASPGAPTLSV
HHHHHHHHHCCCCCHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
ECRAALAGYGWPGNFRQLVGVLRVLQALAEPGESVGVEALPADVRSAPLEWRGAGRPAEI
EHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCC
MPPGAQADTAPSQEFGARDFGARDLGTRDLGTRDFGAGDVGARDLGACDLGAVTRAAMDA
CCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
ALAASGGNVSQAARRLGIHRSTLHRHLASRGSRGGH
HHHCCCCCHHHHHHHHCCHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
PAVPTPAVSTSALSSCAATDAVLAARRRFFSGAPVPEDALAQPILRSWTRCAARGLGPQ
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
SRSRMEPLTDGEFTARRERHETLRRRCRPELEALHAAARAADSIVILTDPSGLVLDTVGS
HHHHCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEECCCCEEEECCCC
ADFADRAAKVALRPGVSWSEAETGTNAIGTALVERRPVEVRGAEHYAEANGILSCAAAPI
CHHHHHHHHHHCCCCCCCHHCCCCCHHHHHHHHHCCCCEECCHHHHHHHCCCEEECCCCC
HDPFGELVGLLDLSGPASVPHLHALALVELAAGQVEHRMFEGAFPDHSLVRFHADPSFLG
CCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHC
TAREGILVFEDYRLIAANRPGLALLGLGWDALGAKRFGDLFEGSLGKAGEERRVRTRRGD
CCCCCEEEEECCEEEEECCCCEEEEECCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCC
VAMRLERQGMPVRTVAPRATPSAERQSAPVPAQAPAQTGPRFDAATERDLGRAVRLMEAG
EEEEEHHCCCCEEEECCCCCCCCHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
VPVLIQGETGVGKEVFARQIHRRGNRGARAFAAVNCAALPEGLIESELFGYEEGAFTGAR
CCEEEECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCHH
RAGFKGLFREADGGVLFLDEIGDMPLSLQSRLLRVLQEREVTPLGGGRPVAVDFALVCAS
HHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
HRDLKQRVEEGSFRADLYFRIAQYTVTLPALRTLADREALVDRLWAEMAGASPGAPTLSV
HHHHHHHHHCCCCCHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
ECRAALAGYGWPGNFRQLVGVLRVLQALAEPGESVGVEALPADVRSAPLEWRGAGRPAEI
EHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCC
MPPGAQADTAPSQEFGARDFGARDLGTRDLGTRDFGAGDVGARDLGACDLGAVTRAAMDA
CCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
ALAASGGNVSQAARRLGIHRSTLHRHLASRGSRGGH
HHHCCCCCHHHHHHHHCCHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADPH2; oxidized glutathione [C]

Specific reaction: NADPH2 + oxidized glutathione = NADP + 2 glutathione [C]

General reaction: Oxidoreductases; Acting on NADH or NADPH; With a disulfide as acceptor [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1378052 [H]