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The map label for this gene is coaBC [H]

Identifier: 154244036

GI number: 154244036

Start: 82273

End: 83490

Strand: Reverse

Name: coaBC [H]

Synonym: Xaut_0078

Alternate gene names: 154244036

Gene position: 83490-82273 (Counterclockwise)

Preceding gene: 154244056

Following gene: 154244035

Centisome position: 1.57

GC content: 70.28

Gene sequence:

>1218_bases
ATGCTTAACGATAAACGCATCCTCCTCCTGATCGGTGGCGGAATCGCCGCCTACAAGTGCCTGGAGCTGGTCCGCCGCCT
GAAGGAACGCGGCGCGAAAGTGCGGGCGGTCATGACCCGGGCGGCCGGGCAGTTCGTCACCCCCCTGTCCGTGGGCGCGA
TCACCGGCGAGCGCGTCTTCACCGACCTGTTCGACCTCACCGCCGAACACGACATCGGACACATCCGCCTTTCGCGGGAG
GCGGATCTTGTCGTGGTCGCGCCCGCCACGGCGGACCTGCTGGCCAAGATGGCACACGGCATCGCCGACGATCTTGCCAC
CACCGCGCTGCTCGCCACCGACAAGCCGGTGCTGGTGGCCCCCGCCATGAACCCGCGCATGTGGGCGCACCCCGCCACGC
GGCGCAACGTGGCGCAGCTGCGTGCCGACGGCATCGCCATGGTGGGGCCCAACGCTGGCGCCATGGCAGAACGCGACGAG
TTCGGGGAAGGCCGCATGGCCGAGCCCATGGAGATCCTCGCCGCCATCGAGGCCCATTTCGGGATCGCCGAGGCCCCCCT
GCTCAAGGGGCGGCGCATCCTCGTGACCTCCGGTCCGACGCACGAGCCCATCGACCCGGTGCGCTACATCGCCAACCGTT
CCTCCGGCAAGCAGGGCCACGCCATCGCCGCGGCGGCCCGGGCGGCGGGGGCGGAGGTGATTCTGGTGTCCGGCCCCGCC
GAGGTCGCCGACCCCAAGGGGGTCAAGGTGATCCATGCTGAGACGGCGCAACAGATGCTGGCCGCCGTGGAGGAAAGCCT
GCCGGTGGATGCCGCCGTGTTCGCCGCAGCGGTGGCCGACTGGCGCGTGGCCGACGCGTCCGACCAGAAGATCAAGAAGA
CCGCCGGCGGCGCCCCGACCCTGACCCTGGTGGAGAATCCCGACATCCTCGCCACCATCGCCCGCCATGGCACCCTGCGG
CCGCGCCTCGTGGTGGGGTTCGCGGCCGAGACCCAGGAGGTGGTGGCCCATGCCCGCGACAAGCGCCTGCGCAAGGGCTG
CGACTGGATCGTCGCCAACGACGTGTCGCCGGAAACCGGCATCATGGGAGGCGATGTGAACACCGTGCATCTTGTGACCG
CTGCCGGGGTGGAGGACTGGCCCTCCGCCTCCAAGGCCGAAGTCGCCCGCCATCTGGTGGCGCGCATGGCCGCCGAACTT
GCGGGAGAAGCCCGATGA

Upstream 100 bases:

>100_bases
CCTCGCGCGGCGGCGCGGTCTATATGGCGTTCATGACGATCCAAGGTCGGCAGCGGCGCCCGGCGCCACCGCCGGACCGC
AGGCCGAGCGGGAGCCGCCG

Downstream 100 bases:

>100_bases
GCCGCCCTTCGGTCCGCATCCAGCGCCTGCCCCATGGCGAAGGCCTGCCCCTGCCCGCCTATGCCACCGAGGGCGCGGCC
GGCCTCGACCTCTCCAGCGC

Product: phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 405; Mature: 405

Protein sequence:

>405_residues
MLNDKRILLLIGGGIAAYKCLELVRRLKERGAKVRAVMTRAAGQFVTPLSVGAITGERVFTDLFDLTAEHDIGHIRLSRE
ADLVVVAPATADLLAKMAHGIADDLATTALLATDKPVLVAPAMNPRMWAHPATRRNVAQLRADGIAMVGPNAGAMAERDE
FGEGRMAEPMEILAAIEAHFGIAEAPLLKGRRILVTSGPTHEPIDPVRYIANRSSGKQGHAIAAAARAAGAEVILVSGPA
EVADPKGVKVIHAETAQQMLAAVEESLPVDAAVFAAAVADWRVADASDQKIKKTAGGAPTLTLVENPDILATIARHGTLR
PRLVVGFAAETQEVVAHARDKRLRKGCDWIVANDVSPETGIMGGDVNTVHLVTAAGVEDWPSASKAEVARHLVARMAAEL
AGEAR

Sequences:

>Translated_405_residues
MLNDKRILLLIGGGIAAYKCLELVRRLKERGAKVRAVMTRAAGQFVTPLSVGAITGERVFTDLFDLTAEHDIGHIRLSRE
ADLVVVAPATADLLAKMAHGIADDLATTALLATDKPVLVAPAMNPRMWAHPATRRNVAQLRADGIAMVGPNAGAMAERDE
FGEGRMAEPMEILAAIEAHFGIAEAPLLKGRRILVTSGPTHEPIDPVRYIANRSSGKQGHAIAAAARAAGAEVILVSGPA
EVADPKGVKVIHAETAQQMLAAVEESLPVDAAVFAAAVADWRVADASDQKIKKTAGGAPTLTLVENPDILATIARHGTLR
PRLVVGFAAETQEVVAHARDKRLRKGCDWIVANDVSPETGIMGGDVNTVHLVTAAGVEDWPSASKAEVARHLVARMAAEL
AGEAR
>Mature_405_residues
MLNDKRILLLIGGGIAAYKCLELVRRLKERGAKVRAVMTRAAGQFVTPLSVGAITGERVFTDLFDLTAEHDIGHIRLSRE
ADLVVVAPATADLLAKMAHGIADDLATTALLATDKPVLVAPAMNPRMWAHPATRRNVAQLRADGIAMVGPNAGAMAERDE
FGEGRMAEPMEILAAIEAHFGIAEAPLLKGRRILVTSGPTHEPIDPVRYIANRSSGKQGHAIAAAARAAGAEVILVSGPA
EVADPKGVKVIHAETAQQMLAAVEESLPVDAAVFAAAVADWRVADASDQKIKKTAGGAPTLTLVENPDILATIARHGTLR
PRLVVGFAAETQEVVAHARDKRLRKGCDWIVANDVSPETGIMGGDVNTVHLVTAAGVEDWPSASKAEVARHLVARMAAEL
AGEAR

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=180, Percent_Identity=36.6666666666667, Blast_Score=85, Evalue=1e-16,
Organism=Escherichia coli, GI87082301, Length=392, Percent_Identity=47.9591836734694, Blast_Score=295, Evalue=3e-81,
Organism=Drosophila melanogaster, GI24657262, Length=191, Percent_Identity=31.413612565445, Blast_Score=76, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 42666; Mature: 42666

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNDKRILLLIGGGIAAYKCLELVRRLKERGAKVRAVMTRAAGQFVTPLSVGAITGERVF
CCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEECCCEECCCCHHHHH
TDLFDLTAEHDIGHIRLSREADLVVVAPATADLLAKMAHGIADDLATTALLATDKPVLVA
HHHHHHHCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHEECCCCEEEE
PAMNPRMWAHPATRRNVAQLRADGIAMVGPNAGAMAERDEFGEGRMAEPMEILAAIEAHF
CCCCCCCCCCCCHHHHHHHHHHCCEEEECCCCCCCCCCHHCCCCCCCCHHHHHHHHHHHC
GIAEAPLLKGRRILVTSGPTHEPIDPVRYIANRSSGKQGHAIAAAARAAGAEVILVSGPA
CCCCCHHHCCCEEEEECCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHCCCEEEEEECCH
EVADPKGVKVIHAETAQQMLAAVEESLPVDAAVFAAAVADWRVADASDQKIKKTAGGAPT
HHCCCCCEEEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHCCEECCCCCHHHHHHCCCCCE
LTLVENPDILATIARHGTLRPRLVVGFAAETQEVVAHARDKRLRKGCDWIVANDVSPETG
EEEECCCCHHHHHHHCCCCCCEEEEEECHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCC
IMGGDVNTVHLVTAAGVEDWPSASKAEVARHLVARMAAELAGEAR
CCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLNDKRILLLIGGGIAAYKCLELVRRLKERGAKVRAVMTRAAGQFVTPLSVGAITGERVF
CCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEECCCEECCCCHHHHH
TDLFDLTAEHDIGHIRLSREADLVVVAPATADLLAKMAHGIADDLATTALLATDKPVLVA
HHHHHHHCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHEECCCCEEEE
PAMNPRMWAHPATRRNVAQLRADGIAMVGPNAGAMAERDEFGEGRMAEPMEILAAIEAHF
CCCCCCCCCCCCHHHHHHHHHHCCEEEECCCCCCCCCCHHCCCCCCCCHHHHHHHHHHHC
GIAEAPLLKGRRILVTSGPTHEPIDPVRYIANRSSGKQGHAIAAAARAAGAEVILVSGPA
CCCCCHHHCCCEEEEECCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHCCCEEEEEECCH
EVADPKGVKVIHAETAQQMLAAVEESLPVDAAVFAAAVADWRVADASDQKIKKTAGGAPT
HHCCCCCEEEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHCCEECCCCCHHHHHHCCCCCE
LTLVENPDILATIARHGTLRPRLVVGFAAETQEVVAHARDKRLRKGCDWIVANDVSPETG
EEEECCCCHHHHHHHCCCCCCEEEEEECHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCC
IMGGDVNTVHLVTAAGVEDWPSASKAEVARHLVARMAAELAGEAR
CCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA