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The map label for this gene is dut

Identifier: 154244035

GI number: 154244035

Start: 81800

End: 82276

Strand: Reverse

Name: dut

Synonym: Xaut_0077

Alternate gene names: 154244035

Gene position: 82276-81800 (Counterclockwise)

Preceding gene: 154244036

Following gene: 154244034

Centisome position: 1.55

GC content: 66.88

Gene sequence:

>477_bases
ATGAGCCGCCCTTCGGTCCGCATCCAGCGCCTGCCCCATGGCGAAGGCCTGCCCCTGCCCGCCTATGCCACCGAGGGCGC
GGCCGGCCTCGACCTCTCCAGCGCCCTGCCGGAGGAGACCCCCCTCATCCTCCTGCCCGGGGCGTTCGCCGCCGTTCCCA
CCGGCTTCGCCATCGCCTTGCCGGAGGGCTTCGAGGCCCAGGTGCGTCCCCGCTCGGGCCTTGCCCGCAAGCACGGGGTG
AGCGTGCTCAATACGCCCGGCACCATCGACTGGGATTATCGCGGCGAGCTGATGGTCCTGCTCATCAATCACGGGCCCGA
GCCGTTCACCGTGACGCGGGGCATGCGCATCGCCCAGATGGTGGTTGCCCCGGTCACCCAAATAATGCTGGAAGAATCCG
GAGATCTGAGTGAAACTGCACGCGGCTCCGGTGGTTTTGGTTCAACCGGCTTCGGAGCTACGTTTTTGAAGAAGTAG

Upstream 100 bases:

>100_bases
TGACCGCTGCCGGGGTGGAGGACTGGCCCTCCGCCTCCAAGGCCGAAGTCGCCCGCCATCTGGTGGCGCGCATGGCCGCC
GAACTTGCGGGAGAAGCCCG

Downstream 100 bases:

>100_bases
CTACAGCCTGATGCCGCGTTTATCCGACAAAAGCCTCCTCGCCATTGCAGCCGTCGTGGATGTGGCCGTGCACGCGCGCG
GCGCTCCGGTGGCTGCCAAG

Product: deoxyuridine 5'-triphosphate nucleotidohydrolase

Products: NA

Alternate protein names: dUTPase; dUTP pyrophosphatase [H]

Number of amino acids: Translated: 158; Mature: 157

Protein sequence:

>158_residues
MSRPSVRIQRLPHGEGLPLPAYATEGAAGLDLSSALPEETPLILLPGAFAAVPTGFAIALPEGFEAQVRPRSGLARKHGV
SVLNTPGTIDWDYRGELMVLLINHGPEPFTVTRGMRIAQMVVAPVTQIMLEESGDLSETARGSGGFGSTGFGATFLKK

Sequences:

>Translated_158_residues
MSRPSVRIQRLPHGEGLPLPAYATEGAAGLDLSSALPEETPLILLPGAFAAVPTGFAIALPEGFEAQVRPRSGLARKHGV
SVLNTPGTIDWDYRGELMVLLINHGPEPFTVTRGMRIAQMVVAPVTQIMLEESGDLSETARGSGGFGSTGFGATFLKK
>Mature_157_residues
SRPSVRIQRLPHGEGLPLPAYATEGAAGLDLSSALPEETPLILLPGAFAAVPTGFAIALPEGFEAQVRPRSGLARKHGVS
VLNTPGTIDWDYRGELMVLLINHGPEPFTVTRGMRIAQMVVAPVTQIMLEESGDLSETARGSGGFGSTGFGATFLKK

Specific function: This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA [H]

COG id: COG0756

COG function: function code F; dUTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dUTPase family [H]

Homologues:

Organism=Homo sapiens, GI70906444, Length=146, Percent_Identity=44.5205479452055, Blast_Score=100, Evalue=8e-22,
Organism=Homo sapiens, GI4503423, Length=146, Percent_Identity=44.5205479452055, Blast_Score=99, Evalue=2e-21,
Organism=Homo sapiens, GI70906441, Length=145, Percent_Identity=44.8275862068966, Blast_Score=96, Evalue=1e-20,
Organism=Escherichia coli, GI1790071, Length=151, Percent_Identity=43.7086092715232, Blast_Score=116, Evalue=8e-28,
Organism=Caenorhabditis elegans, GI71988561, Length=151, Percent_Identity=42.3841059602649, Blast_Score=105, Evalue=8e-24,
Organism=Saccharomyces cerevisiae, GI6319729, Length=152, Percent_Identity=34.8684210526316, Blast_Score=82, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24583610, Length=132, Percent_Identity=40.1515151515151, Blast_Score=83, Evalue=9e-17,
Organism=Drosophila melanogaster, GI19921126, Length=132, Percent_Identity=40.1515151515151, Blast_Score=82, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008180
- InterPro:   IPR008181 [H]

Pfam domain/function: PF00692 dUTPase [H]

EC number: =3.6.1.23 [H]

Molecular weight: Translated: 16637; Mature: 16506

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRPSVRIQRLPHGEGLPLPAYATEGAAGLDLSSALPEETPLILLPGAFAAVPTGFAIAL
CCCCCCEEEECCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCEEEECCCHHHCCCCEEEEC
PEGFEAQVRPRSGLARKHGVSVLNTPGTIDWDYRGELMVLLINHGPEPFTVTRGMRIAQM
CCCCCEEECCCCCCHHHHCCEEECCCCEEEECCCCCEEEEEECCCCCCEEEECCCHHHHH
VVAPVTQIMLEESGDLSETARGSGGFGSTGFGATFLKK
HHHHHHHHHHHCCCCCCHHCCCCCCCCCCCCCCHHHCC
>Mature Secondary Structure 
SRPSVRIQRLPHGEGLPLPAYATEGAAGLDLSSALPEETPLILLPGAFAAVPTGFAIAL
CCCCCEEEECCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCEEEECCCHHHCCCCEEEEC
PEGFEAQVRPRSGLARKHGVSVLNTPGTIDWDYRGELMVLLINHGPEPFTVTRGMRIAQM
CCCCCEEECCCCCCHHHHCCEEECCCCEEEECCCCCEEEEEECCCCCCEEEECCCHHHHH
VVAPVTQIMLEESGDLSETARGSGGFGSTGFGATFLKK
HHHHHHHHHHHCCCCCCHHCCCCCCCCCCCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA