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The map label for this gene is dnaA

Identifier: 154243959

GI number: 154243959

Start: 330

End: 1850

Strand: Direct

Name: dnaA

Synonym: Xaut_0001

Alternate gene names: 154243959

Gene position: 330-1850 (Clockwise)

Preceding gene: NA

Following gene: 154243960

Centisome position: 0.01

GC content: 68.9

Gene sequence:

>1521_bases
ATGGAATGCGCGACGACCGCGACCACCCCTTGGGAGCGCGTCCGTCAGCGCCTGCGTGAAGAGATCGGCGAGGAGAAGTT
CACCAGCTGGTTCGCCCGTATGGACCTCGACAAGCTGACCGCCGACGCGGTCCAGCTCTCCGTCCCCACGCGCTTCCTCA
AGTCGTGGATCCAGGAGAATTATCTGCCCCGCATCGCCGACATCTGGGCCGAGGAGAGCGGCGCCAAGCGGCGCGTGGAC
CTTGCCGTGCGCAATGCGTTCGCCCGTCCCGTGGCGCTGAAGGCGAACACGGTGCGCGAGGTGGTGACCGAGCGCACCGA
CATGCATTCCGGCGATACCCGCCAGCAGTCGGCCCGGATCTCCGACGGGCGCTCCACCGATGCCCGCGGTGCCGATGGAC
GCGGCTCTGATGCGCGGGCTGTCGAGCCCCGTGCCGCGGCGGCCGCCCTGTCCGACGCGGTGGCAGGGGACGTAGCGTCC
GGTTCCCCCCTCGACGCGCGCCTGACCTTCGAGACCTTCGTGGTGGGCAAGTCCAATTCGCTGGCTTTCGCCGCCGCCAA
GCAGGTGGCCGAGAGCGCCCCCGGCTCGGCGCCGGTGTTCAACCCGCTCTATCTCCATGCGGCCGTGGGCCTCGGCAAGA
CGCACCTGTTGCAGGCCATCGCCCGCGCCGGCGCGGTGGGCGGCCGGCGCACCACTTACCTGACCGCCGAGCGCTTCATG
TATGGCTTCGTGGCCGCCCTGAAGACCCATTCGGCCATTGCCTTCAAGGATGCCCTGCGCACCATCGACACGCTGGTGAT
CGACGACCTGCAGTTCCTGAAGGGCAACAATCTCCAGCAGGAATTCTGCCATACCCTCAACGCCCTGCTGGACGGCGGGC
GGCAGGTGGTGGTGGCGGCGGACTGTCTGCCCGGCGAGCTGGAGCATCTCGACGAGCGGGTCCGCTCGCGCCTCGCCGGC
GGCCTGGTGGTGGAACTGGCCGCGCTGGAGGAGGACCTGCGCCTCGAGATCCTCAAGGCCCGCTACCAGACCCTGACCGA
GCAGCATCCGGGCTTCGCGGTGCCGGCGCCGGTGCTGGAGTTCCTGGCGCGCAGCGTCGGCCAGAGTGGGCGCGACCTCG
ATGGCGCGCTGAACAAGCTGCTGGCCTTCAACCAGCTCACCGGCGAGCCGGTGACGCTGGAGATGGCGGAAAACGCGGTC
AAGGACCTCATCCGCCCCACCGATCCCAAGCGGGTGCGGGTGGACGACATCCTGCGCGTGGTGGCCAAGCATTATAATGT
GTCGCGCGCGGACCTGCTGTCCCAGCGCCGCACCGCCACCGTGGTGAAGCCGCGCCAGATCGCCATGTATCTGGCCAAGA
CCCTCACGCTGCGCTCGCTGCCGGAAATCGGCCGCCGCTTTGGCGGTCGTGACCACACCACCGTGCTGCACGCGGTGCGT
AAGATCGACGGCCTCGTCAACGCCGACCGGGCACTGGCCGAGGAAATCGAGGTGCTGAAGCGCCTCGCGCTGGAGGCCTG
A

Upstream 100 bases:

>100_bases
CGTCGAACGCGGTCGGGGCTCGATGCTCAAACCTCATGCGCCGGCCGCGCGTCGTGCCGGATCGAACACGTTTCAGCCTG
CCCTTGCGGAGACCGCCGGA

Downstream 100 bases:

>100_bases
GCGGGTCGTCATCGACGCTTCGGGCCCATGGTCCGCGAATCCGGCGCCTGACGGCGCCGTTTTCGTTTGTGCCGGCCGAG
TGGAGCGGGGCGTTCCAGCG

Product: chromosomal replication initiation protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 506; Mature: 506

Protein sequence:

>506_residues
MECATTATTPWERVRQRLREEIGEEKFTSWFARMDLDKLTADAVQLSVPTRFLKSWIQENYLPRIADIWAEESGAKRRVD
LAVRNAFARPVALKANTVREVVTERTDMHSGDTRQQSARISDGRSTDARGADGRGSDARAVEPRAAAAALSDAVAGDVAS
GSPLDARLTFETFVVGKSNSLAFAAAKQVAESAPGSAPVFNPLYLHAAVGLGKTHLLQAIARAGAVGGRRTTYLTAERFM
YGFVAALKTHSAIAFKDALRTIDTLVIDDLQFLKGNNLQQEFCHTLNALLDGGRQVVVAADCLPGELEHLDERVRSRLAG
GLVVELAALEEDLRLEILKARYQTLTEQHPGFAVPAPVLEFLARSVGQSGRDLDGALNKLLAFNQLTGEPVTLEMAENAV
KDLIRPTDPKRVRVDDILRVVAKHYNVSRADLLSQRRTATVVKPRQIAMYLAKTLTLRSLPEIGRRFGGRDHTTVLHAVR
KIDGLVNADRALAEEIEVLKRLALEA

Sequences:

>Translated_506_residues
MECATTATTPWERVRQRLREEIGEEKFTSWFARMDLDKLTADAVQLSVPTRFLKSWIQENYLPRIADIWAEESGAKRRVD
LAVRNAFARPVALKANTVREVVTERTDMHSGDTRQQSARISDGRSTDARGADGRGSDARAVEPRAAAAALSDAVAGDVAS
GSPLDARLTFETFVVGKSNSLAFAAAKQVAESAPGSAPVFNPLYLHAAVGLGKTHLLQAIARAGAVGGRRTTYLTAERFM
YGFVAALKTHSAIAFKDALRTIDTLVIDDLQFLKGNNLQQEFCHTLNALLDGGRQVVVAADCLPGELEHLDERVRSRLAG
GLVVELAALEEDLRLEILKARYQTLTEQHPGFAVPAPVLEFLARSVGQSGRDLDGALNKLLAFNQLTGEPVTLEMAENAV
KDLIRPTDPKRVRVDDILRVVAKHYNVSRADLLSQRRTATVVKPRQIAMYLAKTLTLRSLPEIGRRFGGRDHTTVLHAVR
KIDGLVNADRALAEEIEVLKRLALEA
>Mature_506_residues
MECATTATTPWERVRQRLREEIGEEKFTSWFARMDLDKLTADAVQLSVPTRFLKSWIQENYLPRIADIWAEESGAKRRVD
LAVRNAFARPVALKANTVREVVTERTDMHSGDTRQQSARISDGRSTDARGADGRGSDARAVEPRAAAAALSDAVAGDVAS
GSPLDARLTFETFVVGKSNSLAFAAAKQVAESAPGSAPVFNPLYLHAAVGLGKTHLLQAIARAGAVGGRRTTYLTAERFM
YGFVAALKTHSAIAFKDALRTIDTLVIDDLQFLKGNNLQQEFCHTLNALLDGGRQVVVAADCLPGELEHLDERVRSRLAG
GLVVELAALEEDLRLEILKARYQTLTEQHPGFAVPAPVLEFLARSVGQSGRDLDGALNKLLAFNQLTGEPVTLEMAENAV
KDLIRPTDPKRVRVDDILRVVAKHYNVSRADLLSQRRTATVVKPRQIAMYLAKTLTLRSLPEIGRRFGGRDHTTVLHAVR
KIDGLVNADRALAEEIEVLKRLALEA

Specific function: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box):5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phosph

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family

Homologues:

Organism=Escherichia coli, GI2367267, Length=503, Percent_Identity=33.7972166998012, Blast_Score=265, Evalue=7e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DNAA_XANP2 (A7IB67)

Other databases:

- EMBL:   CP000781
- RefSeq:   YP_001414917.1
- ProteinModelPortal:   A7IB67
- STRING:   A7IB67
- GeneID:   5421260
- GenomeReviews:   CP000781_GR
- KEGG:   xau:Xaut_0001
- eggNOG:   COG0593
- HOGENOM:   HBG695666
- OMA:   CHTLNAL
- ProtClustDB:   PRK00149
- BioCyc:   XAUT78245:XAUT_0001-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00377
- InterPro:   IPR001957
- InterPro:   IPR020591
- InterPro:   IPR018312
- InterPro:   IPR013159
- InterPro:   IPR013317
- InterPro:   IPR010921
- Gene3D:   G3DSA:1.10.1750.10
- PRINTS:   PR00051
- SMART:   SM00760
- TIGRFAMs:   TIGR00362

Pfam domain/function: PF00308 Bac_DnaA; PF08299 Bac_DnaA_C; SSF48295 Trp_repress_rep

EC number: NA

Molecular weight: Translated: 55421; Mature: 55421

Theoretical pI: Translated: 9.05; Mature: 9.05

Prosite motif: PS01008 DNAA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MECATTATTPWERVRQRLREEIGEEKFTSWFARMDLDKLTADAVQLSVPTRFLKSWIQEN
CCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
YLPRIADIWAEESGAKRRVDLAVRNAFARPVALKANTVREVVTERTDMHSGDTRQQSARI
CCCHHHHHHHCCCCCHHHHHHHHHHHHCCCEEECHHHHHHHHHHHHCCCCCCCHHHHHHC
SDGRSTDARGADGRGSDARAVEPRAAAAALSDAVAGDVASGSPLDARLTFETFVVGKSNS
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEEECCCC
LAFAAAKQVAESAPGSAPVFNPLYLHAAVGLGKTHLLQAIARAGAVGGRRTTYLTAERFM
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHCCCCCCCEEEHHHHHHH
YGFVAALKTHSAIAFKDALRTIDTLVIDDLQFLKGNNLQQEFCHTLNALLDGGRQVVVAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEEE
DCLPGELEHLDERVRSRLAGGLVVELAALEEDLRLEILKARYQTLTEQHPGFAVPAPVLE
CCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
FLARSVGQSGRDLDGALNKLLAFNQLTGEPVTLEMAENAVKDLIRPTDPKRVRVDDILRV
HHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHCCCCCCEECHHHHHHH
VAKHYNVSRADLLSQRRTATVVKPRQIAMYLAKTLTLRSLPEIGRRFGGRDHTTVLHAVR
HHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
KIDGLVNADRALAEEIEVLKRLALEA
HHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MECATTATTPWERVRQRLREEIGEEKFTSWFARMDLDKLTADAVQLSVPTRFLKSWIQEN
CCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
YLPRIADIWAEESGAKRRVDLAVRNAFARPVALKANTVREVVTERTDMHSGDTRQQSARI
CCCHHHHHHHCCCCCHHHHHHHHHHHHCCCEEECHHHHHHHHHHHHCCCCCCCHHHHHHC
SDGRSTDARGADGRGSDARAVEPRAAAAALSDAVAGDVASGSPLDARLTFETFVVGKSNS
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEEECCCC
LAFAAAKQVAESAPGSAPVFNPLYLHAAVGLGKTHLLQAIARAGAVGGRRTTYLTAERFM
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHCCCCCCCEEEHHHHHHH
YGFVAALKTHSAIAFKDALRTIDTLVIDDLQFLKGNNLQQEFCHTLNALLDGGRQVVVAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEEE
DCLPGELEHLDERVRSRLAGGLVVELAALEEDLRLEILKARYQTLTEQHPGFAVPAPVLE
CCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
FLARSVGQSGRDLDGALNKLLAFNQLTGEPVTLEMAENAVKDLIRPTDPKRVRVDDILRV
HHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHCCCCCCEECHHHHHHH
VAKHYNVSRADLLSQRRTATVVKPRQIAMYLAKTLTLRSLPEIGRRFGGRDHTTVLHAVR
HHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
KIDGLVNADRALAEEIEVLKRLALEA
HHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA