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The map label for this gene is mmlH [H]

Identifier: 153950382

GI number: 153950382

Start: 2475785

End: 2477014

Strand: Direct

Name: mmlH [H]

Synonym: YpsIP31758_2152

Alternate gene names: 153950382

Gene position: 2475785-2477014 (Clockwise)

Preceding gene: 153950367

Following gene: 153947417

Centisome position: 52.42

GC content: 50.89

Gene sequence:

>1230_bases
ATGCGTTGGTTTAGCGATCTCAACCAGACAGAAAGAAAAACTTTCATTGCTGCTTTTGGCGGTTGGGCATTGGATGCGCT
AGATTTCATGGTTTTTACATTCGTGATTGCTACGCTGATGGCTCTCTGGCAAATCGACGCAGGCCAGGCCGGAATGCTGA
GCACCGTCACCCTGCTTTTCTCCGCTATTGGTGGCTGGGGTGCAGGTATCCTTGCTGATCGTTATGGCAGGGTGCGTATC
CTGCAAATAACTATTTTATGGTTCTCCTTATGTACGGTACTCATCGGATTTGCTCAGAACTTCGAACACGTTTTCATCCT
ACGCGCGCTACAAGGTTTAGGTTTTGGTGGTGAATGGGCCGTAGGTTCTGTATTGATGGGGGAAATCGTCCGCGCCGAAC
ATCGCGGGAAAGCCGTAGGCACCGTGCAAAGTGGATGGGCGATTGGTTGGGGTGCAGCAGCCTTGCTTTACACGCTAATG
TTCTCGGTACTATCAGAGGAGTGGGCGTGGCGCGCATTATTCTGGATTGGTGTGCTTCCCGCCCTTTTAGTACTCTACAT
ACGTAAAAACGTCCCAGAACCCGCGTTATTCCTGAAATCCCGCCACGAGCAGCAAGCCAAGGATCGACGCGTTTCTTCCT
TCGCCATTTTCTCCCCCGCGCTACTCAAGACCACCGTTCTGGCTTCTTTACTCTGTACCGGAGTGCAAGGCGGCTACTAC
GCCATCACAACTTGGCTGCCCACTTTTCTCAAACTCGAACGCAATCTCTCGGTGATCGGTACTGGTGGGTATCTCATGGT
GATTATATTTGGCTCTTTCGTCGGCTATATTTGTGGCGCTTATCTCACCGACAAACTTGGGCGACGGGCAAATCTGATTA
TCTTCTCACTGCTGTCGTGTATAACAATTTTTGCTTATACCCAACTTACGCTGACCAACACGCAGATGCTCGTTCTGGGA
TTCCCACTCGGCTTTTCGGCATCCGGGATCTTCAGCGGCATGGGTGCCTTTCTCACTGAGCTTTTTCCTTCGGCGGTACG
TGCTACAGGACAAGGTTTTACCTATAGTTTTGGTCGTGCCGCCGGTGCACTCTTTCCGGGGCTGGTCGGCTATCTGAGTC
AGTCAAGCAGTCTGGCATTTGCCATTGGAGTCTTCGCTGGCAGTGCCTATTGCATCGTATTGGTAATGAGCCTATTGCTG
CCCGAGACCAAAAATAAACAGCTAGAATAA

Upstream 100 bases:

>100_bases
TGGTCGATAACCCTGCTCGTCTATATGATTTTTAAAAATAACAAAATAACTTGTGAGGTGCTCACAAGAGTTAAAAAGCC
AGTCTGTAAAGGAGATATTT

Downstream 100 bases:

>100_bases
GTGACGATTTATGGCCATGAGCATCAGACTGTTTCTCTGATATTTATGCTTCTAAGCTGCCTGTACAACAGTGAACAGAA
AGCAACGCATCCGTTTGGAT

Product: major facilitator transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 409; Mature: 409

Protein sequence:

>409_residues
MRWFSDLNQTERKTFIAAFGGWALDALDFMVFTFVIATLMALWQIDAGQAGMLSTVTLLFSAIGGWGAGILADRYGRVRI
LQITILWFSLCTVLIGFAQNFEHVFILRALQGLGFGGEWAVGSVLMGEIVRAEHRGKAVGTVQSGWAIGWGAAALLYTLM
FSVLSEEWAWRALFWIGVLPALLVLYIRKNVPEPALFLKSRHEQQAKDRRVSSFAIFSPALLKTTVLASLLCTGVQGGYY
AITTWLPTFLKLERNLSVIGTGGYLMVIIFGSFVGYICGAYLTDKLGRRANLIIFSLLSCITIFAYTQLTLTNTQMLVLG
FPLGFSASGIFSGMGAFLTELFPSAVRATGQGFTYSFGRAAGALFPGLVGYLSQSSSLAFAIGVFAGSAYCIVLVMSLLL
PETKNKQLE

Sequences:

>Translated_409_residues
MRWFSDLNQTERKTFIAAFGGWALDALDFMVFTFVIATLMALWQIDAGQAGMLSTVTLLFSAIGGWGAGILADRYGRVRI
LQITILWFSLCTVLIGFAQNFEHVFILRALQGLGFGGEWAVGSVLMGEIVRAEHRGKAVGTVQSGWAIGWGAAALLYTLM
FSVLSEEWAWRALFWIGVLPALLVLYIRKNVPEPALFLKSRHEQQAKDRRVSSFAIFSPALLKTTVLASLLCTGVQGGYY
AITTWLPTFLKLERNLSVIGTGGYLMVIIFGSFVGYICGAYLTDKLGRRANLIIFSLLSCITIFAYTQLTLTNTQMLVLG
FPLGFSASGIFSGMGAFLTELFPSAVRATGQGFTYSFGRAAGALFPGLVGYLSQSSSLAFAIGVFAGSAYCIVLVMSLLL
PETKNKQLE
>Mature_409_residues
MRWFSDLNQTERKTFIAAFGGWALDALDFMVFTFVIATLMALWQIDAGQAGMLSTVTLLFSAIGGWGAGILADRYGRVRI
LQITILWFSLCTVLIGFAQNFEHVFILRALQGLGFGGEWAVGSVLMGEIVRAEHRGKAVGTVQSGWAIGWGAAALLYTLM
FSVLSEEWAWRALFWIGVLPALLVLYIRKNVPEPALFLKSRHEQQAKDRRVSSFAIFSPALLKTTVLASLLCTGVQGGYY
AITTWLPTFLKLERNLSVIGTGGYLMVIIFGSFVGYICGAYLTDKLGRRANLIIFSLLSCITIFAYTQLTLTNTQMLVLG
FPLGFSASGIFSGMGAFLTELFPSAVRATGQGFTYSFGRAAGALFPGLVGYLSQSSSLAFAIGVFAGSAYCIVLVMSLLL
PETKNKQLE

Specific function: Probable uptake of 4-methylmuconolactone [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Homo sapiens, GI24308167, Length=446, Percent_Identity=22.6457399103139, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI213021148, Length=445, Percent_Identity=25.8426966292135, Blast_Score=82, Evalue=7e-16,
Organism=Escherichia coli, GI87082404, Length=374, Percent_Identity=29.144385026738, Blast_Score=144, Evalue=9e-36,
Organism=Escherichia coli, GI87082231, Length=464, Percent_Identity=27.5862068965517, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1790550, Length=432, Percent_Identity=26.1574074074074, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI87081723, Length=378, Percent_Identity=28.5714285714286, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788292, Length=433, Percent_Identity=23.7875288683603, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI87082159, Length=390, Percent_Identity=25.3846153846154, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1789941, Length=443, Percent_Identity=26.6365688487585, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1788942, Length=345, Percent_Identity=24.6376811594203, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI32564663, Length=444, Percent_Identity=25, Blast_Score=89, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 44532; Mature: 44532

Theoretical pI: Translated: 9.45; Mature: 9.45

Prosite motif: PS50850 MFS ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRWFSDLNQTERKTFIAAFGGWALDALDFMVFTFVIATLMALWQIDAGQAGMLSTVTLLF
CCCHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
SAIGGWGAGILADRYGRVRILQITILWFSLCTVLIGFAQNFEHVFILRALQGLGFGGEWA
HHHCCCCHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHH
VGSVLMGEIVRAEHRGKAVGTVQSGWAIGWGAAALLYTLMFSVLSEEWAWRALFWIGVLP
HHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALLVLYIRKNVPEPALFLKSRHEQQAKDRRVSSFAIFSPALLKTTVLASLLCTGVQGGYY
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
AITTWLPTFLKLERNLSVIGTGGYLMVIIFGSFVGYICGAYLTDKLGRRANLIIFSLLSC
EHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
ITIFAYTQLTLTNTQMLVLGFPLGFSASGIFSGMGAFLTELFPSAVRATGQGFTYSFGRA
HHHHHHHHHEECCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHH
AGALFPGLVGYLSQSSSLAFAIGVFAGSAYCIVLVMSLLLPETKNKQLE
HHHHHHHHHHHHCCCCCHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MRWFSDLNQTERKTFIAAFGGWALDALDFMVFTFVIATLMALWQIDAGQAGMLSTVTLLF
CCCHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
SAIGGWGAGILADRYGRVRILQITILWFSLCTVLIGFAQNFEHVFILRALQGLGFGGEWA
HHHCCCCHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHH
VGSVLMGEIVRAEHRGKAVGTVQSGWAIGWGAAALLYTLMFSVLSEEWAWRALFWIGVLP
HHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALLVLYIRKNVPEPALFLKSRHEQQAKDRRVSSFAIFSPALLKTTVLASLLCTGVQGGYY
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
AITTWLPTFLKLERNLSVIGTGGYLMVIIFGSFVGYICGAYLTDKLGRRANLIIFSLLSC
EHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
ITIFAYTQLTLTNTQMLVLGFPLGFSASGIFSGMGAFLTELFPSAVRATGQGFTYSFGRA
HHHHHHHHHEECCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHH
AGALFPGLVGYLSQSSSLAFAIGVFAGSAYCIVLVMSLLLPETKNKQLE
HHHHHHHHHHHHCCCCCHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9461415 [H]