Click here to switch to the map view.

The map label for this gene is csdA [H]

Identifier: 153950116

GI number: 153950116

Start: 1199043

End: 1200248

Strand: Reverse

Name: csdA [H]

Synonym: YpsIP31758_0998

Alternate gene names: 153950116

Gene position: 1200248-1199043 (Counterclockwise)

Preceding gene: 153948056

Following gene: 153948590

Centisome position: 25.41

GC content: 47.01

Gene sequence:

>1206_bases
ATGAAAGTTTTTAATCCAATGGATTTTCGTCGGGAATTCCCTGCGCTCAGTGATAAATTAACCTATCTGGACAGTGCGGC
GACCGCCTTGAAACCACGTGCAATGATTGACGCGACACAGCAATTTTATCAGCAGGATTCAGCAACGGTACACCGCAGCC
AACATCAATCGGCGCTGTCATTAACGGTTCGCTTTGAAAACACCCGCCAACAAGTGGCTGATTTTATTAACTCATCTACA
GCAGAAAATATTATCTGGACGCGAGGAACAACTGAAGCCATCAATCTGATCGCGCAAAGTTATGCCCGCCCCCGTTTACA
ACCTGAAGATGAAATTATTGTCAGCGAAGCTGAACATCATGCGAATTTAATTCCCTGGTTGATGGTAGCGGAGCAGACCG
GTGCAAAAATAGTCAAATTACCTCTTGGCCTTGATCATCTGCCAGATTTACAGCAACTCCCTCAACTACTTAATGAAAAA
ACACGCATATTAGCGCTGGGGCAGATGTCTAACGTAACAGGCGGTAGCCCTGATCTGGCTCAGGCTATTAGGCTGGCTCA
CCAATATGACTGTGTTGTCGTGGTTGACGGTGCTCAGGGGATTGTTCATTGCCCAGCCGATGTTCAGGCATTGGATATTG
ATTTTTATGCATTCTCTTCCCATAAATTGTATGGCCCAACCGGCATTGGCGTGCTGTATGGGAAGACTGAATTATTAGAA
GAGATGCCCGCCTGGCAAGGCGGCGGTAAAATGCTTACCCATGTATCATTCGGGGGCTTTACACCTCATGAAGTGCCTTA
TCGCTTTGAAGCGGGTACACCCAATATTGCTGGCGTTATTGGTTTATCAGCGGTACTCAAATGGCTGGAACATATTGATC
TGGAAGAGGCCGAAGTTTATAGCCAAGGTTTAGCTACAATGGCAGAAAATAAGCTCGCACAATTACCGGGTTTTCACAGT
TACCGTTGCCAGCAATCCAGTTTATTAGCATTTACTTTCGATGGTGTTCATCACAGTGATTTAGTGGCGTTATTGGCCGA
GCAAGGTATCGCACTACGTGCTGGGCAACACTGCGCACAGCCACTGATGGCCGCTCTGGGAGTCAATGGCAGTCTACGGG
CTTCTTTTGCGCCTTATAATACCCCCCAAGATGTTGAAATGCTTTGCTCGGCGCTTGGTAAGGCATTGGAACTGCTTCAA
GACTAA

Upstream 100 bases:

>100_bases
AATGTGTATAACGTCAATATGCATAACATCATTGCTCAAACACGCGACCATGATAAAAGCAAAAAAATTTCGGGGTCACT
CACAGGATGCCAACAACAGT

Downstream 100 bases:

>100_bases
TTACTGCTAATGATGATTTCGATATATCCTAAATAATTCCAGTTGCAGGACAGCGTCAATAAAGTACACGAAGGCAGTCA
ACACAAGCAGCTTGAAGAAT

Product: cysteine sulfinate desulfinase

Products: @ALAN01txt*L-Alanine! [C]

Alternate protein names: CSD [H]

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MKVFNPMDFRREFPALSDKLTYLDSAATALKPRAMIDATQQFYQQDSATVHRSQHQSALSLTVRFENTRQQVADFINSST
AENIIWTRGTTEAINLIAQSYARPRLQPEDEIIVSEAEHHANLIPWLMVAEQTGAKIVKLPLGLDHLPDLQQLPQLLNEK
TRILALGQMSNVTGGSPDLAQAIRLAHQYDCVVVVDGAQGIVHCPADVQALDIDFYAFSSHKLYGPTGIGVLYGKTELLE
EMPAWQGGGKMLTHVSFGGFTPHEVPYRFEAGTPNIAGVIGLSAVLKWLEHIDLEEAEVYSQGLATMAENKLAQLPGFHS
YRCQQSSLLAFTFDGVHHSDLVALLAEQGIALRAGQHCAQPLMAALGVNGSLRASFAPYNTPQDVEMLCSALGKALELLQ
D

Sequences:

>Translated_401_residues
MKVFNPMDFRREFPALSDKLTYLDSAATALKPRAMIDATQQFYQQDSATVHRSQHQSALSLTVRFENTRQQVADFINSST
AENIIWTRGTTEAINLIAQSYARPRLQPEDEIIVSEAEHHANLIPWLMVAEQTGAKIVKLPLGLDHLPDLQQLPQLLNEK
TRILALGQMSNVTGGSPDLAQAIRLAHQYDCVVVVDGAQGIVHCPADVQALDIDFYAFSSHKLYGPTGIGVLYGKTELLE
EMPAWQGGGKMLTHVSFGGFTPHEVPYRFEAGTPNIAGVIGLSAVLKWLEHIDLEEAEVYSQGLATMAENKLAQLPGFHS
YRCQQSSLLAFTFDGVHHSDLVALLAEQGIALRAGQHCAQPLMAALGVNGSLRASFAPYNTPQDVEMLCSALGKALELLQ
D
>Mature_401_residues
MKVFNPMDFRREFPALSDKLTYLDSAATALKPRAMIDATQQFYQQDSATVHRSQHQSALSLTVRFENTRQQVADFINSST
AENIIWTRGTTEAINLIAQSYARPRLQPEDEIIVSEAEHHANLIPWLMVAEQTGAKIVKLPLGLDHLPDLQQLPQLLNEK
TRILALGQMSNVTGGSPDLAQAIRLAHQYDCVVVVDGAQGIVHCPADVQALDIDFYAFSSHKLYGPTGIGVLYGKTELLE
EMPAWQGGGKMLTHVSFGGFTPHEVPYRFEAGTPNIAGVIGLSAVLKWLEHIDLEEAEVYSQGLATMAENKLAQLPGFHS
YRCQQSSLLAFTFDGVHHSDLVALLAEQGIALRAGQHCAQPLMAALGVNGSLRASFAPYNTPQDVEMLCSALGKALELLQ
D

Specific function: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine. L-cysteine sulfinic acid is the best substrate. Functions as a selenium delivery protein in the pathway f

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=229, Percent_Identity=27.9475982532751, Blast_Score=91, Evalue=2e-18,
Organism=Escherichia coli, GI1789175, Length=401, Percent_Identity=67.3316708229426, Blast_Score=564, Evalue=1e-162,
Organism=Escherichia coli, GI1787970, Length=404, Percent_Identity=45.2970297029703, Blast_Score=349, Evalue=2e-97,
Organism=Escherichia coli, GI48994898, Length=406, Percent_Identity=25.615763546798, Blast_Score=95, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI25143064, Length=380, Percent_Identity=25.2631578947368, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI193211090, Length=390, Percent_Identity=25.3846153846154, Blast_Score=82, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6319831, Length=397, Percent_Identity=23.1738035264484, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI20129463, Length=394, Percent_Identity=25.1269035532995, Blast_Score=102, Evalue=5e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR022471
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: 4.4.1.- [C]

Molecular weight: Translated: 43914; Mature: 43914

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVFNPMDFRREFPALSDKLTYLDSAATALKPRAMIDATQQFYQQDSATVHRSQHQSALS
CCCCCCHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHCCCEEE
LTVRFENTRQQVADFINSSTAENIIWTRGTTEAINLIAQSYARPRLQPEDEIIVSEAEHH
EEEEECHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHCCCCCCCCCCEEEECCHHH
ANLIPWLMVAEQTGAKIVKLPLGLDHLPDLQQLPQLLNEKTRILALGQMSNVTGGSPDLA
CCCCHHHEEECCCCCEEEEECCCCCCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCHHHH
QAIRLAHQYDCVVVVDGAQGIVHCPADVQALDIDFYAFSSHKLYGPTGIGVLYGKTELLE
HHHHHHHHCCEEEEEECCCCEEECCCCCEEEEEEEEEECCCEEECCCCCEEEECCHHHHH
EMPAWQGGGKMLTHVSFGGFTPHEVPYRFEAGTPNIAGVIGLSAVLKWLEHIDLEEAEVY
HCCCCCCCCCEEEEEECCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHHH
SQGLATMAENKLAQLPGFHSYRCQQSSLLAFTFDGVHHSDLVALLAEQGIALRAGQHCAQ
HHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCEECCCHHHHH
PLMAALGVNGSLRASFAPYNTPQDVEMLCSALGKALELLQD
HHHHHHCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKVFNPMDFRREFPALSDKLTYLDSAATALKPRAMIDATQQFYQQDSATVHRSQHQSALS
CCCCCCHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHCCCEEE
LTVRFENTRQQVADFINSSTAENIIWTRGTTEAINLIAQSYARPRLQPEDEIIVSEAEHH
EEEEECHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHCCCCCCCCCCEEEECCHHH
ANLIPWLMVAEQTGAKIVKLPLGLDHLPDLQQLPQLLNEKTRILALGQMSNVTGGSPDLA
CCCCHHHEEECCCCCEEEEECCCCCCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCHHHH
QAIRLAHQYDCVVVVDGAQGIVHCPADVQALDIDFYAFSSHKLYGPTGIGVLYGKTELLE
HHHHHHHHCCEEEEEECCCCEEECCCCCEEEEEEEEEECCCEEECCCCCEEEECCHHHHH
EMPAWQGGGKMLTHVSFGGFTPHEVPYRFEAGTPNIAGVIGLSAVLKWLEHIDLEEAEVY
HCCCCCCCCCEEEEEECCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHHH
SQGLATMAENKLAQLPGFHSYRCQQSSLLAFTFDGVHHSDLVALLAEQGIALRAGQHCAQ
HHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCEECCCHHHHH
PLMAALGVNGSLRASFAPYNTPQDVEMLCSALGKALELLQD
HHHHHHCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Pyridoxal phosphate [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-cystine; L-selenocystine [C]

Specific reaction: Catalyzes the removal of elemental sulfur and selenium atoms from l-cysteine, l-cystine, l-selenocysteine, and l- selenocystine to produce @ALAN01.txt*l-Alanine! [C]

General reaction: Remove sulfur and selenium atoms [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278392; 9278503; 10829016; 10739946 [H]