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The map label for this gene is clcA

Identifier: 153948554

GI number: 153948554

Start: 3741089

End: 3742525

Strand: Reverse

Name: clcA

Synonym: YpsIP31758_3329

Alternate gene names: 153948554

Gene position: 3742525-3741089 (Counterclockwise)

Preceding gene: 153949423

Following gene: 153947889

Centisome position: 79.24

GC content: 50.45

Gene sequence:

>1437_bases
ATGACTCATTCAACGCAACAACTTTCTCCTGAAGGCGTCGCTGAAGGCAAGCGTGGCCGTTTGATCCGTGAACTGGTTAA
TCGTGATAAGACACCCTTAATTATTCTTATCATGGCCGCTGTTGTCGGTGTGGTAACGGGATTATTAGGCGTAGCATTTG
ATCGCGGTGTCGATTGGGTCCAGCAACAGCGGCTGCTAGCGCTGGCTAATGTCGCGGATTACGCACTCTTGGTGTGGCCT
CTGGCTTTTATCATGTCCGCACTGCTAGCGATGATGGGCTATTTTTTGGTTAGTCGCTTTGCTCCTGAGGCTGGGGGGTC
TGGGATCCCCGAAATCGAAGGGGCAATGGAGGAAATGCGGCCAGTGCGCTGGTGGCGCGTAATCCCCGTTAAATTTATTG
GCGGCCTTGGGACATTGGGCGCAGGAATGGTTTTAGGCCGTGAAGGACCCATGGTCCAAATGGGGGGCAACAGTGGGCGA
ATGATCGTGGATATTTTTCGTTTGCGTAGCCCGGAAGCCCGTCATTCACTATTAGCAACCGGTGCAGCCGCAGGGCTGTC
TGCGGCATTTAATGCCCCGCTGGCAGGGATTCTGTTTGTTATCGAAGAGATGCGCTCGCAGTTTCGCTACAGCCTAGTCT
CTATTAAAGCCGTATTTATCGGGGTGATTACCTCAACGATTGTTTACCGCTATTTTAATGGTGAACGTGCAATTATTGAG
GTCGGTAAACTCAGTGATGCTCCACTAAACACCCTTTGGCTTTATTTATTATTAGGCATTATTTTCGGTGCTGTGGGCGT
CATATTCAATGCTCTTATCTTTCGAACACAAGATATGTTTGTGCGCTTTCATGGTGGTGATTGGCGTAAATTAGTTCTGA
TCGGTGGCTTGCTTGGCGGAATGTGCGGTTTATTAGCACTGCTTCATGGCAATGCGGTGGGAGGGGGGTTTGCATTGATC
CCTATCGCGGCAGCCGGTAATTTCAGCATCGGCATGCTGTTGTTTATTTTTATCGCTCGGGTCATCACGACCTTGCTGTG
TTTTGGATCGGGCGCTCCAGGGGGAATATTTGCCCCAATGTTGGCATTAGGGACCATTTTGGGGACCGCATTTGGTCTGT
CTTGCGCGCACTTTTTCCCACAATATGGCATCGAAGCCGGTACTTTCGCCATTGCGGGTATGGGCGCACTGTTTGCTGCC
TCAGTACGTGCACCGTTGACTGGGATCGTATTGGTACTGGAAATGACCGATAATTATCAGCTTATTTTACCGATGATTGT
TACCTGCCTGGGAGCGACGTTGATCGCTCAATTTATGGGGGGGAAACCGTTGTATTCGGCCATCCTAGCTCGCACATTAG
CCAAGCAAGAGCAAGCGCGTGCCACGGTAATAGCACAAGAACCGGCGGTTGAAAATACCCCACAAACAGGCAGATAA

Upstream 100 bases:

>100_bases
CATTTCATGGCTATATGGCGGCGCACCATGAGTTCATAGACTAGACTCTGGTTACATCAAATTTGTATTATGTATTGCTC
AACTGATAAACAAATTAACT

Downstream 100 bases:

>100_bases
TATAACATTAGCCCTGAGTACTTGAATGAAATACTCAGGTATTAGATAATCGAGCCATAGATCAGGCTGCCAGTGTAGTA
ACCTGCAACGCGAAGTAGTA

Product: chloride channel protein

Products: Cl Ion [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 478; Mature: 477

Protein sequence:

>478_residues
MTHSTQQLSPEGVAEGKRGRLIRELVNRDKTPLIILIMAAVVGVVTGLLGVAFDRGVDWVQQQRLLALANVADYALLVWP
LAFIMSALLAMMGYFLVSRFAPEAGGSGIPEIEGAMEEMRPVRWWRVIPVKFIGGLGTLGAGMVLGREGPMVQMGGNSGR
MIVDIFRLRSPEARHSLLATGAAAGLSAAFNAPLAGILFVIEEMRSQFRYSLVSIKAVFIGVITSTIVYRYFNGERAIIE
VGKLSDAPLNTLWLYLLLGIIFGAVGVIFNALIFRTQDMFVRFHGGDWRKLVLIGGLLGGMCGLLALLHGNAVGGGFALI
PIAAAGNFSIGMLLFIFIARVITTLLCFGSGAPGGIFAPMLALGTILGTAFGLSCAHFFPQYGIEAGTFAIAGMGALFAA
SVRAPLTGIVLVLEMTDNYQLILPMIVTCLGATLIAQFMGGKPLYSAILARTLAKQEQARATVIAQEPAVENTPQTGR

Sequences:

>Translated_478_residues
MTHSTQQLSPEGVAEGKRGRLIRELVNRDKTPLIILIMAAVVGVVTGLLGVAFDRGVDWVQQQRLLALANVADYALLVWP
LAFIMSALLAMMGYFLVSRFAPEAGGSGIPEIEGAMEEMRPVRWWRVIPVKFIGGLGTLGAGMVLGREGPMVQMGGNSGR
MIVDIFRLRSPEARHSLLATGAAAGLSAAFNAPLAGILFVIEEMRSQFRYSLVSIKAVFIGVITSTIVYRYFNGERAIIE
VGKLSDAPLNTLWLYLLLGIIFGAVGVIFNALIFRTQDMFVRFHGGDWRKLVLIGGLLGGMCGLLALLHGNAVGGGFALI
PIAAAGNFSIGMLLFIFIARVITTLLCFGSGAPGGIFAPMLALGTILGTAFGLSCAHFFPQYGIEAGTFAIAGMGALFAA
SVRAPLTGIVLVLEMTDNYQLILPMIVTCLGATLIAQFMGGKPLYSAILARTLAKQEQARATVIAQEPAVENTPQTGR
>Mature_477_residues
THSTQQLSPEGVAEGKRGRLIRELVNRDKTPLIILIMAAVVGVVTGLLGVAFDRGVDWVQQQRLLALANVADYALLVWPL
AFIMSALLAMMGYFLVSRFAPEAGGSGIPEIEGAMEEMRPVRWWRVIPVKFIGGLGTLGAGMVLGREGPMVQMGGNSGRM
IVDIFRLRSPEARHSLLATGAAAGLSAAFNAPLAGILFVIEEMRSQFRYSLVSIKAVFIGVITSTIVYRYFNGERAIIEV
GKLSDAPLNTLWLYLLLGIIFGAVGVIFNALIFRTQDMFVRFHGGDWRKLVLIGGLLGGMCGLLALLHGNAVGGGFALIP
IAAAGNFSIGMLLFIFIARVITTLLCFGSGAPGGIFAPMLALGTILGTAFGLSCAHFFPQYGIEAGTFAIAGMGALFAAS
VRAPLTGIVLVLEMTDNYQLILPMIVTCLGATLIAQFMGGKPLYSAILARTLAKQEQARATVIAQEPAVENTPQTGR

Specific function: Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcA subfamily

Homologues:

Organism=Homo sapiens, GI4557473, Length=477, Percent_Identity=24.3186582809224, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI189217923, Length=481, Percent_Identity=24.3243243243243, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI189217921, Length=481, Percent_Identity=24.3243243243243, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI55770838, Length=462, Percent_Identity=23.1601731601732, Blast_Score=76, Evalue=8e-14,
Organism=Homo sapiens, GI55770840, Length=452, Percent_Identity=23.2300884955752, Blast_Score=76, Evalue=9e-14,
Organism=Homo sapiens, GI153252026, Length=451, Percent_Identity=23.2815964523282, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1786350, Length=447, Percent_Identity=72.7069351230425, Blast_Score=590, Evalue=1e-170,
Organism=Escherichia coli, GI87081943, Length=318, Percent_Identity=28.6163522012579, Blast_Score=82, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17532615, Length=431, Percent_Identity=23.4338747099768, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71980828, Length=484, Percent_Identity=23.5537190082645, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71980824, Length=484, Percent_Identity=23.5537190082645, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17559050, Length=427, Percent_Identity=25.9953161592506, Blast_Score=75, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI71980820, Length=489, Percent_Identity=23.721881390593, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71985148, Length=505, Percent_Identity=23.3663366336634, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71985141, Length=502, Percent_Identity=23.5059760956175, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322500, Length=487, Percent_Identity=22.3819301848049, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24665008, Length=451, Percent_Identity=25.0554323725055, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI45551566, Length=437, Percent_Identity=25.1716247139588, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI281361606, Length=452, Percent_Identity=23.6725663716814, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI161078208, Length=452, Percent_Identity=23.6725663716814, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI28573073, Length=452, Percent_Identity=23.6725663716814, Blast_Score=66, Evalue=6e-11,
Organism=Drosophila melanogaster, GI281361608, Length=452, Percent_Identity=23.6725663716814, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI28573075, Length=452, Percent_Identity=23.6725663716814, Blast_Score=65, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLCA_YERP3 (A7FM08)

Other databases:

- EMBL:   CP000720
- RefSeq:   YP_001402286.1
- ProteinModelPortal:   A7FM08
- SMR:   A7FM08
- STRING:   A7FM08
- GeneID:   5385921
- GenomeReviews:   CP000720_GR
- KEGG:   ypi:YpsIP31758_3329
- NMPDR:   fig|349747.3.peg.3383
- eggNOG:   COG0038
- HOGENOM:   HBG493510
- OMA:   MAGYFGA
- ProtClustDB:   PRK05277
- BioCyc:   YPSE349747:YPSIP31758_3329-MONOMER
- HAMAP:   MF_01128
- InterPro:   IPR014743
- InterPro:   IPR001807
- Gene3D:   G3DSA:1.10.3080.10
- PANTHER:   PTHR11689
- PRINTS:   PR00762

Pfam domain/function: PF00654 Voltage_CLC; SSF81340 Cl-channel_core

EC number: NA

Molecular weight: Translated: 50864; Mature: 50733

Theoretical pI: Translated: 9.55; Mature: 9.55

Prosite motif: NA

Important sites: BINDING 107-107 BINDING 356-356 BINDING 357-357 BINDING 445-445

Signals:

None

Transmembrane regions:

HASH(0x21e0d214)-; HASH(0x21fcaa04)-; HASH(0x22d9691c)-; HASH(0x22d80dbc)-; HASH(0x226abc24)-; HASH(0x1fd24a88)-; HASH(0x21f35c10)-; HASH(0x22545570)-; HASH(0x22832bd8)-; HASH(0x222269c8)-;

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHSTQQLSPEGVAEGKRGRLIRELVNRDKTPLIILIMAAVVGVVTGLLGVAFDRGVDWV
CCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHH
QQQRLLALANVADYALLVWPLAFIMSALLAMMGYFLVSRFAPEAGGSGIPEIEGAMEEMR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCC
PVRWWRVIPVKFIGGLGTLGAGMVLGREGPMVQMGGNSGRMIVDIFRLRSPEARHSLLAT
HHHHHEEEHHHHHCCHHHHCCCEEECCCCCEEEECCCCCCEEEEHHHHCCCHHHHHHHHH
GAAAGLSAAFNAPLAGILFVIEEMRSQFRYSLVSIKAVFIGVITSTIVYRYFNGERAIIE
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
VGKLSDAPLNTLWLYLLLGIIFGAVGVIFNALIFRTQDMFVRFHGGDWRKLVLIGGLLGG
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHH
MCGLLALLHGNAVGGGFALIPIAAAGNFSIGMLLFIFIARVITTLLCFGSGAPGGIFAPM
HHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
LALGTILGTAFGLSCAHFFPQYGIEAGTFAIAGMGALFAASVRAPLTGIVLVLEMTDNYQ
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCE
LILPMIVTCLGATLIAQFMGGKPLYSAILARTLAKQEQARATVIAQEPAVENTPQTGR
EHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCH
>Mature Secondary Structure 
THSTQQLSPEGVAEGKRGRLIRELVNRDKTPLIILIMAAVVGVVTGLLGVAFDRGVDWV
CCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHH
QQQRLLALANVADYALLVWPLAFIMSALLAMMGYFLVSRFAPEAGGSGIPEIEGAMEEMR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCC
PVRWWRVIPVKFIGGLGTLGAGMVLGREGPMVQMGGNSGRMIVDIFRLRSPEARHSLLAT
HHHHHEEEHHHHHCCHHHHCCCEEECCCCCEEEECCCCCCEEEEHHHHCCCHHHHHHHHH
GAAAGLSAAFNAPLAGILFVIEEMRSQFRYSLVSIKAVFIGVITSTIVYRYFNGERAIIE
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
VGKLSDAPLNTLWLYLLLGIIFGAVGVIFNALIFRTQDMFVRFHGGDWRKLVLIGGLLGG
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHH
MCGLLALLHGNAVGGGFALIPIAAAGNFSIGMLLFIFIARVITTLLCFGSGAPGGIFAPM
HHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
LALGTILGTAFGLSCAHFFPQYGIEAGTFAIAGMGALFAASVRAPLTGIVLVLEMTDNYQ
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCE
LILPMIVTCLGATLIAQFMGGKPLYSAILARTLAKQEQARATVIAQEPAVENTPQTGR
EHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Cl Ion [Periplasm] [C]

Specific reaction: Cl Ion [Periplasm] = Cl Ion [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA