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The map label for this gene is fhuB [H]

Identifier: 153949423

GI number: 153949423

Start: 3744520

End: 3746532

Strand: Reverse

Name: fhuB [H]

Synonym: YpsIP31758_3331

Alternate gene names: 153949423

Gene position: 3746532-3744520 (Counterclockwise)

Preceding gene: 153949125

Following gene: 153948554

Centisome position: 79.32

GC content: 54.69

Gene sequence:

>2013_bases
GTGGGGGAAAGCACCATGAGCGCCATAAGTTTACGCCAGGGTTGGCGGCTCCCTGCGGGTCTACTTGGCCTACTGGTGGT
TATTGCCGTTTCCCTGACATTTTATAACCTCAGTCAATTACTGCCTTCCTCTCTCTGGTCTGAAGCCCTATGGCGACCTG
ATCGAGACGATGTACGCCAGATGCTATTTCATTACAGCCAATTACCTCGCCTAGCGGTGGCATTACTCACCGGAGCGGGG
CTGGGGCTGGTAGGGGTTTTATTTCAACAAGTTCTGCGTAATCCCCTGGCTGAACCGGCCACTCTGGGGGTTGCCGCGGG
AGCCCAGTTAGGGCTAACGATAGCCACACTGTGGATGTTACCCGGTGGTGAGTTAACCCGGCAACTGGCGGCAATGGCCG
GTGGTATGACGGTTGGGGCACTGGTCTTTGGCGTAGCTTGGGGGAAGCGCCTGTCACCGGTGACATTGATTTTGGCCGGT
CTGGTGTTGGGGCTTTACTGTAGCGCGGTGAGTAACCTACTGGCACTGTTCAATTATGACCAGTTACAGGGGCTATTTTT
GTGGAGCAGTGGCGCACTGAATCAGCAGGATTGGAGTACGGTACAGTTTCTGTTACCGCGCTTACTGATTAGCGGCATAT
TGGCGGCCTTCTTGATTCGTCCGTTGACCCTCTTGGGGTTAGATGATGGTGTCGCTCGCAATCTGGGGTTAGGGCTGTCA
CTGGCCCGCCTGAGTGCGCTGGGATTAGCCATTATATTCAGCGCCATGTTGGTTAATGCGGTGGGTGTGATTGGTTTTAT
CGGGCTGTTTGCACCATTGTTGGCGAAAATTTTGGGGGCACGGCGCTTATCACAACGTCTGATACTGGCCCCTATTGTCG
GGGCATTGCTGCTCTGGGTGACGGACCAGGGCATCATCTGGCTGACACAAGTCTGGCGAGAGATCCCAACCGGTGCCGCT
ACGGCGCTGATTGGTGCGCCATTGTTATTGTGGTTGTTGCCTCGCTTACACAGTACGACTGCGCCAAACATGGATTTGGG
TGACTCGGTTCCGGTAGAGCGGCAGCGTTTAGGATTATGGATCAGCGCGGGTTTGCTGCTGCTGTTGGGGGGATTGATCG
TGGCGCTGATGTTTGGCCGTGATAGCCAAGGTTGGCGCTGGATCGTCGGTGATGAATTACAGGCGCTGTTACATTGGCGC
TGGCCACGGGTATTGGCGGCACTGGCTGCCGGTATGATGCTGGCGGTTGCAGGAACATTAATTCAAAAGTTGACTGGTAA
TCCGATGGCCAGCCCGGAAGTGTTGGGTATCAGCTCTGGTGCAGCTTTCGGCGTGGTCATTATGTTGTTTATCGTCCCTG
GTAATGCACTGGAATGGTTGTTGCCTGCGGGGAGCCTAGGGGCTGCCATCACGCTATTGCTGATCATGGTTGTCGCTGGG
CGAGGCGGGTTTTCTCCGGGCAGGATGCTATTGGCAGGGATTGCATTGAGTACCGCTTTTACCACGGTGATCACCATGTT
GCTGGCCAGTGGCGACCCACGGATGCGCGGGTTACTGGCATGGATTTCTGGCTCAACTTATTCTGTTGAGGGCTCACAAG
CGTTGACGACAGGCTTAATTGCCGTGGTGTTGATAGCACTAGCCCCTTTGTGCCGCCGTTGGTTAATGATTTTGCCATTA
GGCAGTGTAACCGCCAGAGCATTAGGGATGGCTCTGGCCCCCAGCCGGTTAGCGATTTTATTATTGGCAGCCACATTGAC
GGCTGCGGCGACCCTGACCGTCGGGCCGTTGAGTTTTGTGGGATTGATGGCTCCGCATATGGCCCGGATGCTGGGTTTCC
GTCGTGCTATTCCGCAACTGATTATTGCGGCTATTTTGGGCGGATTATTGATGATATTAGCTGATTGGTGTGGGCGGATG
CTGTTGTTCCCAAATCAGATCCCCGCAGGTCTATTAGCGACATTTATCGGGGCGCCCTATTTTGTTTATTTGCTGCGCAA
ACAGGGGCGGTAA

Upstream 100 bases:

>100_bases
TGTCTTTTGTACGAGAAAACCAATTACGTCTCTTGCCACCGGTTTGGTTCTACGGCGCGACACTGTCAGCTATGCGTTTC
GTTCGTTTACTGGAACAGGC

Downstream 100 bases:

>100_bases
TTTTATCAGGCGAATGCCCTGCTAATTTGACGCCGCCGCGTGACTATTCTGCCTATCCTCACCGTTTCAGATCGCGTCAT
TGAGGGTTGTCAGCAGTCTG

Product: iron-hydroxamate transporter permease subunit

Products: ADP; phosphate; iron (III) hydroxamate [Cytoplasm] [C]

Alternate protein names: Ferric hydroxamate uptake protein B; Ferrichrome transport system permease protein fhuB; Ferrichrome uptake protein fhuB; Iron(III)-hydroxamate import system permease protein fhuB [H]

Number of amino acids: Translated: 670; Mature: 669

Protein sequence:

>670_residues
MGESTMSAISLRQGWRLPAGLLGLLVVIAVSLTFYNLSQLLPSSLWSEALWRPDRDDVRQMLFHYSQLPRLAVALLTGAG
LGLVGVLFQQVLRNPLAEPATLGVAAGAQLGLTIATLWMLPGGELTRQLAAMAGGMTVGALVFGVAWGKRLSPVTLILAG
LVLGLYCSAVSNLLALFNYDQLQGLFLWSSGALNQQDWSTVQFLLPRLLISGILAAFLIRPLTLLGLDDGVARNLGLGLS
LARLSALGLAIIFSAMLVNAVGVIGFIGLFAPLLAKILGARRLSQRLILAPIVGALLLWVTDQGIIWLTQVWREIPTGAA
TALIGAPLLLWLLPRLHSTTAPNMDLGDSVPVERQRLGLWISAGLLLLLGGLIVALMFGRDSQGWRWIVGDELQALLHWR
WPRVLAALAAGMMLAVAGTLIQKLTGNPMASPEVLGISSGAAFGVVIMLFIVPGNALEWLLPAGSLGAAITLLLIMVVAG
RGGFSPGRMLLAGIALSTAFTTVITMLLASGDPRMRGLLAWISGSTYSVEGSQALTTGLIAVVLIALAPLCRRWLMILPL
GSVTARALGMALAPSRLAILLLAATLTAAATLTVGPLSFVGLMAPHMARMLGFRRAIPQLIIAAILGGLLMILADWCGRM
LLFPNQIPAGLLATFIGAPYFVYLLRKQGR

Sequences:

>Translated_670_residues
MGESTMSAISLRQGWRLPAGLLGLLVVIAVSLTFYNLSQLLPSSLWSEALWRPDRDDVRQMLFHYSQLPRLAVALLTGAG
LGLVGVLFQQVLRNPLAEPATLGVAAGAQLGLTIATLWMLPGGELTRQLAAMAGGMTVGALVFGVAWGKRLSPVTLILAG
LVLGLYCSAVSNLLALFNYDQLQGLFLWSSGALNQQDWSTVQFLLPRLLISGILAAFLIRPLTLLGLDDGVARNLGLGLS
LARLSALGLAIIFSAMLVNAVGVIGFIGLFAPLLAKILGARRLSQRLILAPIVGALLLWVTDQGIIWLTQVWREIPTGAA
TALIGAPLLLWLLPRLHSTTAPNMDLGDSVPVERQRLGLWISAGLLLLLGGLIVALMFGRDSQGWRWIVGDELQALLHWR
WPRVLAALAAGMMLAVAGTLIQKLTGNPMASPEVLGISSGAAFGVVIMLFIVPGNALEWLLPAGSLGAAITLLLIMVVAG
RGGFSPGRMLLAGIALSTAFTTVITMLLASGDPRMRGLLAWISGSTYSVEGSQALTTGLIAVVLIALAPLCRRWLMILPL
GSVTARALGMALAPSRLAILLLAATLTAAATLTVGPLSFVGLMAPHMARMLGFRRAIPQLIIAAILGGLLMILADWCGRM
LLFPNQIPAGLLATFIGAPYFVYLLRKQGR
>Mature_669_residues
GESTMSAISLRQGWRLPAGLLGLLVVIAVSLTFYNLSQLLPSSLWSEALWRPDRDDVRQMLFHYSQLPRLAVALLTGAGL
GLVGVLFQQVLRNPLAEPATLGVAAGAQLGLTIATLWMLPGGELTRQLAAMAGGMTVGALVFGVAWGKRLSPVTLILAGL
VLGLYCSAVSNLLALFNYDQLQGLFLWSSGALNQQDWSTVQFLLPRLLISGILAAFLIRPLTLLGLDDGVARNLGLGLSL
ARLSALGLAIIFSAMLVNAVGVIGFIGLFAPLLAKILGARRLSQRLILAPIVGALLLWVTDQGIIWLTQVWREIPTGAAT
ALIGAPLLLWLLPRLHSTTAPNMDLGDSVPVERQRLGLWISAGLLLLLGGLIVALMFGRDSQGWRWIVGDELQALLHWRW
PRVLAALAAGMMLAVAGTLIQKLTGNPMASPEVLGISSGAAFGVVIMLFIVPGNALEWLLPAGSLGAAITLLLIMVVAGR
GGFSPGRMLLAGIALSTAFTTVITMLLASGDPRMRGLLAWISGSTYSVEGSQALTTGLIAVVLIALAPLCRRWLMILPLG
SVTARALGMALAPSRLAILLLAATLTAAATLTVGPLSFVGLMAPHMARMLGFRRAIPQLIIAAILGGLLMILADWCGRML
LFPNQIPAGLLATFIGAPYFVYLLRKQGR

Specific function: Part of the ABC transporter complex fhuCDB involved in iron(3+)-hydroxamate import. Responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786347, Length=645, Percent_Identity=68.3720930232558, Blast_Score=779, Evalue=0.0,
Organism=Escherichia coli, GI1790741, Length=282, Percent_Identity=37.5886524822695, Blast_Score=125, Evalue=1e-29,
Organism=Escherichia coli, GI1790740, Length=309, Percent_Identity=33.0097087378641, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1786805, Length=288, Percent_Identity=34.375, Blast_Score=102, Evalue=6e-23,
Organism=Escherichia coli, GI1786804, Length=322, Percent_Identity=32.2981366459627, Blast_Score=100, Evalue=5e-22,
Organism=Escherichia coli, GI1788004, Length=273, Percent_Identity=31.1355311355311, Blast_Score=97, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522
- InterPro:   IPR006311 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 70861; Mature: 70730

Theoretical pI: Translated: 11.55; Mature: 11.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGESTMSAISLRQGWRLPAGLLGLLVVIAVSLTFYNLSQLLPSSLWSEALWRPDRDDVRQ
CCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
MLFHYSQLPRLAVALLTGAGLGLVGVLFQQVLRNPLAEPATLGVAAGAQLGLTIATLWML
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHCCCHHHHHHHHHHHC
PGGELTRQLAAMAGGMTVGALVFGVAWGKRLSPVTLILAGLVLGLYCSAVSNLLALFNYD
CCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHH
QLQGLFLWSSGALNQQDWSTVQFLLPRLLISGILAAFLIRPLTLLGLDDGVARNLGLGLS
HHCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCHH
LARLSALGLAIIFSAMLVNAVGVIGFIGLFAPLLAKILGARRLSQRLILAPIVGALLLWV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TDQGIIWLTQVWREIPTGAATALIGAPLLLWLLPRLHSTTAPNMDLGDSVPVERQRLGLW
CCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHH
ISAGLLLLLGGLIVALMFGRDSQGWRWIVGDELQALLHWRWPRVLAALAAGMMLAVAGTL
HHHHHHHHHHHHHHHHHHCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IQKLTGNPMASPEVLGISSGAAFGVVIMLFIVPGNALEWLLPAGSLGAAITLLLIMVVAG
HHHHCCCCCCCCCEEECCCCHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHHHHHC
RGGFSPGRMLLAGIALSTAFTTVITMLLASGDPRMRGLLAWISGSTYSVEGSQALTTGLI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEECCHHHHHHHHH
AVVLIALAPLCRRWLMILPLGSVTARALGMALAPSRLAILLLAATLTAAATLTVGPLSFV
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLMAPHMARMLGFRRAIPQLIIAAILGGLLMILADWCGRMLLFPNQIPAGLLATFIGAPY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCHHHHHHHHHHHH
FVYLLRKQGR
HHHHHHHCCC
>Mature Secondary Structure 
GESTMSAISLRQGWRLPAGLLGLLVVIAVSLTFYNLSQLLPSSLWSEALWRPDRDDVRQ
CCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
MLFHYSQLPRLAVALLTGAGLGLVGVLFQQVLRNPLAEPATLGVAAGAQLGLTIATLWML
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHCCCHHHHHHHHHHHC
PGGELTRQLAAMAGGMTVGALVFGVAWGKRLSPVTLILAGLVLGLYCSAVSNLLALFNYD
CCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHH
QLQGLFLWSSGALNQQDWSTVQFLLPRLLISGILAAFLIRPLTLLGLDDGVARNLGLGLS
HHCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCHH
LARLSALGLAIIFSAMLVNAVGVIGFIGLFAPLLAKILGARRLSQRLILAPIVGALLLWV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TDQGIIWLTQVWREIPTGAATALIGAPLLLWLLPRLHSTTAPNMDLGDSVPVERQRLGLW
CCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHH
ISAGLLLLLGGLIVALMFGRDSQGWRWIVGDELQALLHWRWPRVLAALAAGMMLAVAGTL
HHHHHHHHHHHHHHHHHHCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IQKLTGNPMASPEVLGISSGAAFGVVIMLFIVPGNALEWLLPAGSLGAAITLLLIMVVAG
HHHHCCCCCCCCCEEECCCCHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHHHHHC
RGGFSPGRMLLAGIALSTAFTTVITMLLASGDPRMRGLLAWISGSTYSVEGSQALTTGLI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEECCHHHHHHHHH
AVVLIALAPLCRRWLMILPLGSVTARALGMALAPSRLAILLLAATLTAAATLTVGPLSFV
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLMAPHMARMLGFRRAIPQLIIAAILGGLLMILADWCGRMLLFPNQIPAGLLATFIGAPY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCHHHHHHHHHHHH
FVYLLRKQGR
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron (III) hydroxamate [Periplasm]; H2O [C]

Specific reaction: ATP + iron (III) hydroxamate [Periplasm] + H2O = ADP + phosphate + iron (III) hydroxamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11677609; 10103258 [H]