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The map label for this gene is qacF [H]

Identifier: 153948379

GI number: 153948379

Start: 2085939

End: 2086271

Strand: Direct

Name: qacF [H]

Synonym: YpsIP31758_1804

Alternate gene names: 153948379

Gene position: 2085939-2086271 (Clockwise)

Preceding gene: 153949126

Following gene: 153950043

Centisome position: 44.16

GC content: 45.95

Gene sequence:

>333_bases
ATGAGCAGTTTTGTCTATTTATTTATGGCGATTATTGCCGAAGTAGTTGCAACGACGATGCTAAAAGCATCCGATGGTTT
TTCTCGATTAGTCCCTTCAGTGGTGGTCGTGATTGGTTATGGTATTGCTTTTTGGGGGCTTTCGCAGGTAGTCAAAACCA
TGCCGCTGGGTATTGCTTATGCGATTTGGTCCGGTTTGGGGATTGTACTGGTCTCAATCGCTGCCACCTTTATGTATCAA
CAAAAGCTGGATTGGGCGGCGGTTGTCGGTATGGCGCTGATTATTTCGGGTGTTATGGTGATTAACCTCCTGTCCAAGAC
ACCGATGCATTAA

Upstream 100 bases:

>100_bases
CACTGACTTGTAAAGCCGCTGTGAAGCCGGTGTCAATTTAATGAAGATTTAACTTTGTACGGGCATAATGTCGCCCTTAT
GTTGAAATGAGAGAATGATA

Downstream 100 bases:

>100_bases
TCTGACATCCTTATTTTCCGCGTTACCGTTGATTGGACGATAACGCGGAGCCAAACGTGCTACTTAATATCTAACTGATG
TATTCCCTCAATAGCTAATA

Product: multidrug resistance protein, SMR family protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Quaternary ammonium determinant F [H]

Number of amino acids: Translated: 110; Mature: 109

Protein sequence:

>110_residues
MSSFVYLFMAIIAEVVATTMLKASDGFSRLVPSVVVVIGYGIAFWGLSQVVKTMPLGIAYAIWSGLGIVLVSIAATFMYQ
QKLDWAAVVGMALIISGVMVINLLSKTPMH

Sequences:

>Translated_110_residues
MSSFVYLFMAIIAEVVATTMLKASDGFSRLVPSVVVVIGYGIAFWGLSQVVKTMPLGIAYAIWSGLGIVLVSIAATFMYQ
QKLDWAAVVGMALIISGVMVINLLSKTPMH
>Mature_109_residues
SSFVYLFMAIIAEVVATTMLKASDGFSRLVPSVVVVIGYGIAFWGLSQVVKTMPLGIAYAIWSGLGIVLVSIAATFMYQQ
KLDWAAVVGMALIISGVMVINLLSKTPMH

Specific function: Multidrug exporter. Is implicated for the resistance to bacteriocidal quaternary ammonium compounds [H]

COG id: COG2076

COG function: function code P; Membrane transporters of cations and cationic drugs

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the small multidrug resistance (SMR) protein family [H]

Homologues:

Organism=Escherichia coli, GI1786755, Length=110, Percent_Identity=50.9090909090909, Blast_Score=115, Evalue=9e-28,
Organism=Escherichia coli, GI1787883, Length=98, Percent_Identity=35.7142857142857, Blast_Score=63, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000390 [H]

Pfam domain/function: PF00893 Multi_Drug_Res [H]

EC number: NA

Molecular weight: Translated: 11788; Mature: 11657

Theoretical pI: Translated: 9.55; Mature: 9.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
7.3 %Met     (Translated Protein)
7.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
6.4 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSFVYLFMAIIAEVVATTMLKASDGFSRLVPSVVVVIGYGIAFWGLSQVVKTMPLGIAY
CCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIWSGLGIVLVSIAATFMYQQKLDWAAVVGMALIISGVMVINLLSKTPMH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SSFVYLFMAIIAEVVATTMLKASDGFSRLVPSVVVVIGYGIAFWGLSQVVKTMPLGIAY
CHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIWSGLGIVLVSIAATFMYQQKLDWAAVVGMALIISGVMVINLLSKTPMH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9756755 [H]