Click here to switch to the map view.

The map label for this gene is hutU [H]

Identifier: 153947989

GI number: 153947989

Start: 4608883

End: 4610574

Strand: Reverse

Name: hutU [H]

Synonym: YpsIP31758_4086

Alternate gene names: 153947989

Gene position: 4610574-4608883 (Counterclockwise)

Preceding gene: 153947158

Following gene: 153946871

Centisome position: 97.61

GC content: 51.18

Gene sequence:

>1692_bases
GTGACGACTCAAAACAGATTCCGAGATAATGAGATTCGAGCCCCGCAGGGTACGCAACTGACAGCGAAAAGCTGGCTGAC
TGAAGCCGCGCTACGCATGCTGATGAATAACCTCGATCCTGATGTGGCTGAGAATCCAAAAGAATTAGTGGTCTACGGCG
GTATTGGTCGCGCAGCCCGTAACTGGGAATGCTATGACAAGATTGTTGAAAGCCTGATCAATTTAAACGATGACGAAACT
TTGTTAATTCAATCGGGTAAGCCTGTCGGGATATTCAAAACCCACAGTAATGCGCCCAGGGTATTGATTGCCAACTCGAA
TTTGGTACCTCATTGGGCTAATTGGGAACATTTTAATGAATTGGACGCCAAAGGGCTGGCTATGTATGGCCAGATGACGG
CGGGCAGTTGGATCTATATTGGTAGCCAAGGCATTGTACAGGGTACTTATGAAACCTTTGTTGAAGCGGGTCGCCAGCAT
TTTGGCGGTAGCCTGAAAGGGCGTTGGGTCTTGACTGCTGGGCTAGGAGGAATGGGCGGCGCGCAACCTTTGGCCGCAAC
GTTAGCTGGTGCATGTTCTCTGAACATCGAATGCCAACAAAGCCGCATCGATTTTCGTCTCAAAACCCGTTATGTGGATG
AGCAAGCAACCGATCTGGATGATGCTTTAGCGCGCATCGAGAAATATACCGCTACAGGTGTCGCGGTTTCTATTGCACTG
TGCGGCAATGCGGCTGAAATCTTACCTGAGCTGGTGCGCCGTGGTGTTCGGCCTGATATGGTCACCGACCAAACCAGTGC
TCATGATCCATTGAACGGTTATCTGCCGAAGGGTTGGAATTGGGAAGAGTACCGCCAACGCGCTCAACATGAGCCAGCGC
TGGTGATCAATGCCGCGAAAATCTCCATGGCAGAGCATGTTGAAGCGATGTTAGCCTTCCACAACATGGGTATCCCAACC
TTTGATTACGGCAATAATATCCGTCAAATGGCCCACGATATGGGGGTTATTCGTGCCTTTGATTTCCCCGGTTTTGTTCC
GGCGTATATTCGTCCTCTTTTTTGTCGTGGTATTGGCCCATTCCGTTGGGTCGCGTTGTCGGGTAACCCAGACGATATTT
ATAAAACCGATGCTAAGGTCAAAGCACTGATCCCTGATGATGCACATTTGCATCATTGGCTAGATATGGCGCGTGAGCGT
ATTCGTTTTCAGGGGCTGCCAGCACGTATTTGCTGGGTTGGTCTAGGCCAGCGTGCCAAATTAGGTTTGGCATTTAACGA
AATGGTGCGCAGCGGCGAGCTCTCTGCGCCCGTTGTGATTGGCCGCGATCATCTGGATTCTGGATCGGTTGCCAGCCCTA
ATCGTGAAACGGAAGCGATGCAGGATGGCTCCGATGCGGTGTCTGACTGGCCGCTGCTCAATGCATTACTGAATACGGCT
AGCGGTGCGACGTGGGTATCTCTGCATCATGGTGGTGGCGTAGGGATGGGCTTCTCGCAACATTCAGGCATGGTGGTGGT
TTGTGATGGCAGTGATGAAGCCGCTGAACGTATTGCCAGAGTACTACATAACGATCCGGCTACGGGTGTGATGCGCCATG
CAGATGCGGGTTATGACATTGCGGTTAACTGCGCGCAAGAGCAAGGACTTAACCTACCAATGGTTGCCGCAACTCAGGGG
AAAAAATCATGA

Upstream 100 bases:

>100_bases
TCTGATCTTGATTGTACTTGTCTATACGAGTATATGTTAATAAGCACTCAAGGTGAGTAATGTCGTTTGACACCTGAAAA
ACTGGTTGAAGGAAATTGCC

Downstream 100 bases:

>100_bases
AGACAATAACACTACGTCCTGGTCAGATGACGCTGGCTGACTTACGGCATATTTATCAACATCCCGTACATATCACATTG
GATGAAAGTGCCTATGTACC

Product: urocanate hydratase

Products: NA

Alternate protein names: Urocanase; Imidazolonepropionate hydrolase [H]

Number of amino acids: Translated: 563; Mature: 562

Protein sequence:

>563_residues
MTTQNRFRDNEIRAPQGTQLTAKSWLTEAALRMLMNNLDPDVAENPKELVVYGGIGRAARNWECYDKIVESLINLNDDET
LLIQSGKPVGIFKTHSNAPRVLIANSNLVPHWANWEHFNELDAKGLAMYGQMTAGSWIYIGSQGIVQGTYETFVEAGRQH
FGGSLKGRWVLTAGLGGMGGAQPLAATLAGACSLNIECQQSRIDFRLKTRYVDEQATDLDDALARIEKYTATGVAVSIAL
CGNAAEILPELVRRGVRPDMVTDQTSAHDPLNGYLPKGWNWEEYRQRAQHEPALVINAAKISMAEHVEAMLAFHNMGIPT
FDYGNNIRQMAHDMGVIRAFDFPGFVPAYIRPLFCRGIGPFRWVALSGNPDDIYKTDAKVKALIPDDAHLHHWLDMARER
IRFQGLPARICWVGLGQRAKLGLAFNEMVRSGELSAPVVIGRDHLDSGSVASPNRETEAMQDGSDAVSDWPLLNALLNTA
SGATWVSLHHGGGVGMGFSQHSGMVVVCDGSDEAAERIARVLHNDPATGVMRHADAGYDIAVNCAQEQGLNLPMVAATQG
KKS

Sequences:

>Translated_563_residues
MTTQNRFRDNEIRAPQGTQLTAKSWLTEAALRMLMNNLDPDVAENPKELVVYGGIGRAARNWECYDKIVESLINLNDDET
LLIQSGKPVGIFKTHSNAPRVLIANSNLVPHWANWEHFNELDAKGLAMYGQMTAGSWIYIGSQGIVQGTYETFVEAGRQH
FGGSLKGRWVLTAGLGGMGGAQPLAATLAGACSLNIECQQSRIDFRLKTRYVDEQATDLDDALARIEKYTATGVAVSIAL
CGNAAEILPELVRRGVRPDMVTDQTSAHDPLNGYLPKGWNWEEYRQRAQHEPALVINAAKISMAEHVEAMLAFHNMGIPT
FDYGNNIRQMAHDMGVIRAFDFPGFVPAYIRPLFCRGIGPFRWVALSGNPDDIYKTDAKVKALIPDDAHLHHWLDMARER
IRFQGLPARICWVGLGQRAKLGLAFNEMVRSGELSAPVVIGRDHLDSGSVASPNRETEAMQDGSDAVSDWPLLNALLNTA
SGATWVSLHHGGGVGMGFSQHSGMVVVCDGSDEAAERIARVLHNDPATGVMRHADAGYDIAVNCAQEQGLNLPMVAATQG
KKS
>Mature_562_residues
TTQNRFRDNEIRAPQGTQLTAKSWLTEAALRMLMNNLDPDVAENPKELVVYGGIGRAARNWECYDKIVESLINLNDDETL
LIQSGKPVGIFKTHSNAPRVLIANSNLVPHWANWEHFNELDAKGLAMYGQMTAGSWIYIGSQGIVQGTYETFVEAGRQHF
GGSLKGRWVLTAGLGGMGGAQPLAATLAGACSLNIECQQSRIDFRLKTRYVDEQATDLDDALARIEKYTATGVAVSIALC
GNAAEILPELVRRGVRPDMVTDQTSAHDPLNGYLPKGWNWEEYRQRAQHEPALVINAAKISMAEHVEAMLAFHNMGIPTF
DYGNNIRQMAHDMGVIRAFDFPGFVPAYIRPLFCRGIGPFRWVALSGNPDDIYKTDAKVKALIPDDAHLHHWLDMARERI
RFQGLPARICWVGLGQRAKLGLAFNEMVRSGELSAPVVIGRDHLDSGSVASPNRETEAMQDGSDAVSDWPLLNALLNTAS
GATWVSLHHGGGVGMGFSQHSGMVVVCDGSDEAAERIARVLHNDPATGVMRHADAGYDIAVNCAQEQGLNLPMVAATQGK
KS

Specific function: Unknown

COG id: COG2987

COG function: function code E; Urocanate hydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the urocanase family [H]

Homologues:

Organism=Homo sapiens, GI21389467, Length=572, Percent_Identity=33.041958041958, Blast_Score=294, Evalue=2e-79,
Organism=Homo sapiens, GI260306182, Length=219, Percent_Identity=38.3561643835616, Blast_Score=161, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI71997891, Length=560, Percent_Identity=34.4642857142857, Blast_Score=317, Evalue=1e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000193 [H]

Pfam domain/function: PF01175 Urocanase [H]

EC number: =4.2.1.49 [H]

Molecular weight: Translated: 61535; Mature: 61404

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: PS01233 UROCANASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTQNRFRDNEIRAPQGTQLTAKSWLTEAALRMLMNNLDPDVAENPKELVVYGGIGRAAR
CCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCC
NWECYDKIVESLINLNDDETLLIQSGKPVGIFKTHSNAPRVLIANSNLVPHWANWEHFNE
CCHHHHHHHHHHHCCCCCCEEEEECCCCEEEEEECCCCCEEEEECCCCCCCCCCCHHHHH
LDAKGLAMYGQMTAGSWIYIGSQGIVQGTYETFVEAGRQHFGGSLKGRWVLTAGLGGMGG
CCCCCEEEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCC
AQPLAATLAGACSLNIECQQSRIDFRLKTRYVDEQATDLDDALARIEKYTATGVAVSIAL
CHHHHHHHHHHEEEEEEEECCCCCEEEEEEECCCHHCCHHHHHHHHHHHHHCCEEEEEEE
CGNAAEILPELVRRGVRPDMVTDQTSAHDPLNGYLPKGWNWEEYRQRAQHEPALVINAAK
CCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEEHHH
ISMAEHVEAMLAFHNMGIPTFDYGNNIRQMAHDMGVIRAFDFPGFVPAYIRPLFCRGIGP
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCEEEEECCCCCCHHHHHHHHHCCCCC
FRWVALSGNPDDIYKTDAKVKALIPDDAHLHHWLDMARERIRFQGLPARICWVGLGQRAK
EEEEEECCCCCHHEECCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCE
LGLAFNEMVRSGELSAPVVIGRDHLDSGSVASPNRETEAMQDGSDAVSDWPLLNALLNTA
ECHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHCC
SGATWVSLHHGGGVGMGFSQHSGMVVVCDGSDEAAERIARVLHNDPATGVMRHADAGYDI
CCCEEEEEECCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCHHHHHHCCCCCEE
AVNCAQEQGLNLPMVAATQGKKS
EEEEHHHCCCCCCEEECCCCCCC
>Mature Secondary Structure 
TTQNRFRDNEIRAPQGTQLTAKSWLTEAALRMLMNNLDPDVAENPKELVVYGGIGRAAR
CCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCC
NWECYDKIVESLINLNDDETLLIQSGKPVGIFKTHSNAPRVLIANSNLVPHWANWEHFNE
CCHHHHHHHHHHHCCCCCCEEEEECCCCEEEEEECCCCCEEEEECCCCCCCCCCCHHHHH
LDAKGLAMYGQMTAGSWIYIGSQGIVQGTYETFVEAGRQHFGGSLKGRWVLTAGLGGMGG
CCCCCEEEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCC
AQPLAATLAGACSLNIECQQSRIDFRLKTRYVDEQATDLDDALARIEKYTATGVAVSIAL
CHHHHHHHHHHEEEEEEEECCCCCEEEEEEECCCHHCCHHHHHHHHHHHHHCCEEEEEEE
CGNAAEILPELVRRGVRPDMVTDQTSAHDPLNGYLPKGWNWEEYRQRAQHEPALVINAAK
CCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEEHHH
ISMAEHVEAMLAFHNMGIPTFDYGNNIRQMAHDMGVIRAFDFPGFVPAYIRPLFCRGIGP
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCEEEEECCCCCCHHHHHHHHHCCCCC
FRWVALSGNPDDIYKTDAKVKALIPDDAHLHHWLDMARERIRFQGLPARICWVGLGQRAK
EEEEEECCCCCHHEECCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCE
LGLAFNEMVRSGELSAPVVIGRDHLDSGSVASPNRETEAMQDGSDAVSDWPLLNALLNTA
ECHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHCC
SGATWVSLHHGGGVGMGFSQHSGMVVVCDGSDEAAERIARVLHNDPATGVMRHADAGYDI
CCCEEEEEECCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCHHHHHHCCCCCEE
AVNCAQEQGLNLPMVAATQGKKS
EEEEHHHCCCCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA