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The map label for this gene is ltaE [H]

Identifier: 153947812

GI number: 153947812

Start: 2976923

End: 2977942

Strand: Direct

Name: ltaE [H]

Synonym: YpsIP31758_2620

Alternate gene names: 153947812

Gene position: 2976923-2977942 (Clockwise)

Preceding gene: 153948591

Following gene: 153948112

Centisome position: 63.03

GC content: 52.75

Gene sequence:

>1020_bases
ATGCTGATCGATTTACGCAGTGACACAGTAACGCAACCCTGTGCCGCCATGCGCGCCGCGATGGCGAATGCCGAGGTCGG
CGATGATGTGTATGGCGATGACCCAACCGTCAATGCGCTTGAAGCCAAAGCCGCCAGTTTATCCGGTAAAGAAGCCGCGC
TGTTTCTGCCAACAGGCACTCAGGCAAATTTGGTGGCGCTATTGACCCATTGTCAGCGTGGTGAAGAGTATATTGTCGGC
CAAAAAGCCCATAACTATTTGTATGAAGCCGGGGGTGCCGCCGTTTTGGGCAGTATCCAACCACAACCTATTGATGCCAA
CGATGACGGCACCTTATCACTGGATAACGTTCTGGCCGCCATCAAACCCGATGACATTCACTTTGCCCCCACCCGGCTGT
TAAGTTTGGAAAATACTCACAATGGCAAAGTCTTGCCTTTGCGTTATTTACAGCAAGCCTGGGCGTTGACCCGCGAGAAA
AAACTGGCGTTACATATTGATGGTGCACGTGTTTTTAATGCTGCGGTGGCGCTGAATGTGCCACTGAACGATATTAGCCA
GTATTGCGATACCCTGACAATTTGTCTGTCAAAAGGGTTAGGGACGCCTGTTGGTTCCCTGCTCTGTGGCAGCGCAGAAT
TCATTCATCGCGCCCGGCGCTGGCGAAAAATGACCGGTGGTGGTATGCGTCAGGCCGGTATTTTAGCGGCAGCCGGGTTG
TATGCGCTGCAACATAATGTGGCGAGACTCAAAGATGATCACGATAACGCCCAGTGGTTGGAGCAGCAATTACGTGACTT
AGGCATTGAGATAGCCGCCCCCGGCGCGCAAACAAACGTGCTGTACATTACGCAATCTGCCGAATCAGCGTTGAAACTTG
GCCCCTGGATGCGTGAACGTGGTGTGCTGATCAGTGCCGGGCCGCTCACCCGCCTGATTACTCACCTTAACGTGAGCCGA
AAAGATCTGGAAAAAGTCGTCGCGCTGTGGCGTGAATTTATTGCCGAGCAACATTCATGA

Upstream 100 bases:

>100_bases
TCCGTCGCGGGCACTTTGTCAATAACCTCGAGCCAGTAGGCTTTTTTGTTTCGATATTCTCGCTATGATGAAATCTATTT
TTCTAGCCAATGAGAAAACG

Downstream 100 bases:

>100_bases
CACCACAACGGATATTAGTATTAGGTGCCAGTGGCTATATTGGCCAACATTTGGTCCCCTTGCTAAGCCAGCAAGGCCAT
CAAGTCACGGCTGCTGGCCG

Product: L-threonine aldolase

Products: NA

Alternate protein names: Low-specificity L-TA [H]

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MLIDLRSDTVTQPCAAMRAAMANAEVGDDVYGDDPTVNALEAKAASLSGKEAALFLPTGTQANLVALLTHCQRGEEYIVG
QKAHNYLYEAGGAAVLGSIQPQPIDANDDGTLSLDNVLAAIKPDDIHFAPTRLLSLENTHNGKVLPLRYLQQAWALTREK
KLALHIDGARVFNAAVALNVPLNDISQYCDTLTICLSKGLGTPVGSLLCGSAEFIHRARRWRKMTGGGMRQAGILAAAGL
YALQHNVARLKDDHDNAQWLEQQLRDLGIEIAAPGAQTNVLYITQSAESALKLGPWMRERGVLISAGPLTRLITHLNVSR
KDLEKVVALWREFIAEQHS

Sequences:

>Translated_339_residues
MLIDLRSDTVTQPCAAMRAAMANAEVGDDVYGDDPTVNALEAKAASLSGKEAALFLPTGTQANLVALLTHCQRGEEYIVG
QKAHNYLYEAGGAAVLGSIQPQPIDANDDGTLSLDNVLAAIKPDDIHFAPTRLLSLENTHNGKVLPLRYLQQAWALTREK
KLALHIDGARVFNAAVALNVPLNDISQYCDTLTICLSKGLGTPVGSLLCGSAEFIHRARRWRKMTGGGMRQAGILAAAGL
YALQHNVARLKDDHDNAQWLEQQLRDLGIEIAAPGAQTNVLYITQSAESALKLGPWMRERGVLISAGPLTRLITHLNVSR
KDLEKVVALWREFIAEQHS
>Mature_339_residues
MLIDLRSDTVTQPCAAMRAAMANAEVGDDVYGDDPTVNALEAKAASLSGKEAALFLPTGTQANLVALLTHCQRGEEYIVG
QKAHNYLYEAGGAAVLGSIQPQPIDANDDGTLSLDNVLAAIKPDDIHFAPTRLLSLENTHNGKVLPLRYLQQAWALTREK
KLALHIDGARVFNAAVALNVPLNDISQYCDTLTICLSKGLGTPVGSLLCGSAEFIHRARRWRKMTGGGMRQAGILAAAGL
YALQHNVARLKDDHDNAQWLEQQLRDLGIEIAAPGAQTNVLYITQSAESALKLGPWMRERGVLISAGPLTRLITHLNVSR
KDLEKVVALWREFIAEQHS

Specific function: Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde. L-threo-phenylserine and L- erythro-phenylserine are also good substrates [H]

COG id: COG2008

COG function: function code E; Threonine aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1787095, Length=334, Percent_Identity=68.8622754491018, Blast_Score=479, Evalue=1e-136,
Organism=Caenorhabditis elegans, GI193206522, Length=346, Percent_Identity=42.1965317919075, Blast_Score=257, Evalue=7e-69,
Organism=Caenorhabditis elegans, GI193206520, Length=346, Percent_Identity=42.1965317919075, Blast_Score=256, Evalue=1e-68,
Organism=Caenorhabditis elegans, GI193206524, Length=346, Percent_Identity=42.1965317919075, Blast_Score=256, Evalue=1e-68,
Organism=Saccharomyces cerevisiae, GI6320789, Length=329, Percent_Identity=38.2978723404255, Blast_Score=202, Evalue=5e-53,
Organism=Drosophila melanogaster, GI21355439, Length=296, Percent_Identity=48.3108108108108, Blast_Score=268, Evalue=4e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001597
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01212 Beta_elim_lyase [H]

EC number: =4.1.2.5 [H]

Molecular weight: Translated: 36710; Mature: 36710

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIDLRSDTVTQPCAAMRAAMANAEVGDDVYGDDPTVNALEAKAASLSGKEAALFLPTGT
CEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCC
QANLVALLTHCQRGEEYIVGQKAHNYLYEAGGAAVLGSIQPQPIDANDDGTLSLDNVLAA
CHHHHHHHHHHHCCCCEEECHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCEEHHHHHHH
IKPDDIHFAPTRLLSLENTHNGKVLPLRYLQQAWALTREKKLALHIDGARVFNAAVALNV
CCCCCCEECCHHEEEECCCCCCCEEHHHHHHHHHHHHHCCEEEEEECCHHEEEEEEEEEC
PLNDISQYCDTLTICLSKGLGTPVGSLLCGSAEFIHRARRWRKMTGGGMRQAGILAAAGL
CHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
YALQHNVARLKDDHDNAQWLEQQLRDLGIEIAAPGAQTNVLYITQSAESALKLGPWMRER
HHHHHHHHHHCCCCCCHHHHHHHHHHCCEEEECCCCCCEEEEEECCCHHHHHHCCCHHHC
GVLISAGPLTRLITHLNVSRKDLEKVVALWREFIAEQHS
CEEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLIDLRSDTVTQPCAAMRAAMANAEVGDDVYGDDPTVNALEAKAASLSGKEAALFLPTGT
CEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCC
QANLVALLTHCQRGEEYIVGQKAHNYLYEAGGAAVLGSIQPQPIDANDDGTLSLDNVLAA
CHHHHHHHHHHHCCCCEEECHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCEEHHHHHHH
IKPDDIHFAPTRLLSLENTHNGKVLPLRYLQQAWALTREKKLALHIDGARVFNAAVALNV
CCCCCCEECCHHEEEECCCCCCCEEHHHHHHHHHHHHHCCEEEEEECCHHEEEEEEEEEC
PLNDISQYCDTLTICLSKGLGTPVGSLLCGSAEFIHRARRWRKMTGGGMRQAGILAAAGL
CHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
YALQHNVARLKDDHDNAQWLEQQLRDLGIEIAAPGAQTNVLYITQSAESALKLGPWMRER
HHHHHHHHHHCCCCCCHHHHHHHHHHCCEEEECCCCCCEEEEEECCCHHHHHHCCCHHHC
GVLISAGPLTRLITHLNVSRKDLEKVVALWREFIAEQHS
CEEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]