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The map label for this gene is cdr [H]

Identifier: 153947324

GI number: 153947324

Start: 1533506

End: 1535152

Strand: Direct

Name: cdr [H]

Synonym: YpsIP31758_1310

Alternate gene names: 153947324

Gene position: 1533506-1535152 (Clockwise)

Preceding gene: 153946944

Following gene: 153947537

Centisome position: 32.47

GC content: 42.14

Gene sequence:

>1647_bases
ATGGGAAAAACAATTGTTATCGTCGGTGGTGTTGCCGGTGGTGCCAGTGCTGCTGCTCGCCTGCGCCGTTTAAATGAATA
TGACAATATTATTATTCTAGAAAGAGGCGAGTATATCTCTTTTGCCAACTGTGGCTTGCCTTATTATATCGGTGGTGTTA
TTACCGAAAGAGATAAACTTTTAATCCAAACGCCAGAGAAAATGAAGGATAGATTTAATATTGATGTCAGAACTGAAAAT
GAAGTCGTTGATATAGACAGTGCGAGTAAAACCATTACTGTGATTAATCATAAAGTGGGTAAGGAAGAGTTTATACAATA
TGACACATTAATTCTATCGCCGGGTGCCCGTCCTTTTATTCCAGACATTGCCGGTCTGTCAGTAAATAGCTCTGTATTTA
CCCTGCGTAATATGTTAGATACAGACAATATTAAAGCGTATCTAATTTCCGCTACACCTGAAGCTGTCACCATTATTGGT
GGTGGTTTTATCGGATTGGAAATGGCGGAGAATCTGGTGAGTAGTGGGTTGAAAGTCACTATTATTGAATTATCAAATCA
AATTCTTTCGCCACTTGATTATGAAATGGCAGCGATTGTCGAAAAGCATTTAAAAGACAACGGCATTGATGTGATAAAAA
ATGACGCAGTGGTACAGTTCGATGAATCTGCACATCAAATACATTTGAAATCAGGGAAAATTATTACCACCGACATGGTC
ATTCTGGCGATAGGTGTCGAACCTGAAAATGACTTGGCAAAGAAAGCTCATCTGGATTTGGGGATCAGAGGGAGCATCTT
GGTTAATGAGAAATTACAGACGAGTGTAGCGGATATTTATGCTATCGGTGATGCTATCCAGGTTGTCGATTATATCAATG
GTCAGGCAACGTATATTCCACTGGCCTGGCCGGCTAACCGGCAAGGCAGATTATTGGCTGATATTATTAATGGCCGTGAT
GTGCGCTATCACGGAACATTAGGCACTGCGATTGCCAAAGTACTTGATCTTAGCGCCGCCTGTACGGGTAACAACGAACG
TCTGTTAAAGCGTTTGGCGATCCCTTATCAAGTTGTTCATATTCATGGGATGTCACATGCGAGTTATTATCCTGGCGCTC
ATCAGATTTCATTGAAATTATTATTCTCGCCAGAGAACGGGCGTATTCTTGGTGCACAGGCTGTTGGTCAGGGGGGGACA
GATAAACGCATTGATGTGTTGGCGACCGCGATCAAAGGCAGGCTGACTATCTATGATCTTCCCGACTTAGAATTGGCTTA
TGCCCCACCTTATTCGTCAGCAAAAGATCCGGTCAATATGTTGGGTTATGTTGCAGAAAATATCTCGAATGGCGATGTGA
TGACGAAGCAATGGCATGAAGTGGATGCCTTTATGGCTGATGGGGGGATTATTATTGATGTACGAGATGAGGCGGAGTTT
ATCTCCGGCAGTATAAAAACTGCGGTGAATATCCCTCTGTCTGAATTGCGTCAAAAATTGGCATTAATACCCCAAGATAA
AAAGATACTGGTGACTTGCCAGGTTGGGCTAAGAGGGTACATTGCTGCAAGAATTCTGTCTCAATATGGCTATACCGTGG
CTAATTTAGATGGGGGATATTTGACCTTTAATTATGCTAATGCTTGA

Upstream 100 bases:

>100_bases
CATATTTAACAAGAAGCTATTATAAAGAAGTCACTGTTTAATAACCAATAGGCCATTTTCAAACTGGAAGTGGCCGTCCT
AATCTGAGTGATAAAGAGTT

Downstream 100 bases:

>100_bases
TGTTTATTTTGTATAAAAAGGGCATCTATACCCAAAATAATTCGCGTTGCAGTAAGGCAGTCAGGGCAGCTAACTCCCCT
GCAGCGTGAAGGACGATGGG

Product: pyridine nucleotide-disulphide oxidoreductase family protein

Products: NA

Alternate protein names: CoA-disulfide reductase; CoADR [H]

Number of amino acids: Translated: 548; Mature: 547

Protein sequence:

>548_residues
MGKTIVIVGGVAGGASAAARLRRLNEYDNIIILERGEYISFANCGLPYYIGGVITERDKLLIQTPEKMKDRFNIDVRTEN
EVVDIDSASKTITVINHKVGKEEFIQYDTLILSPGARPFIPDIAGLSVNSSVFTLRNMLDTDNIKAYLISATPEAVTIIG
GGFIGLEMAENLVSSGLKVTIIELSNQILSPLDYEMAAIVEKHLKDNGIDVIKNDAVVQFDESAHQIHLKSGKIITTDMV
ILAIGVEPENDLAKKAHLDLGIRGSILVNEKLQTSVADIYAIGDAIQVVDYINGQATYIPLAWPANRQGRLLADIINGRD
VRYHGTLGTAIAKVLDLSAACTGNNERLLKRLAIPYQVVHIHGMSHASYYPGAHQISLKLLFSPENGRILGAQAVGQGGT
DKRIDVLATAIKGRLTIYDLPDLELAYAPPYSSAKDPVNMLGYVAENISNGDVMTKQWHEVDAFMADGGIIIDVRDEAEF
ISGSIKTAVNIPLSELRQKLALIPQDKKILVTCQVGLRGYIAARILSQYGYTVANLDGGYLTFNYANA

Sequences:

>Translated_548_residues
MGKTIVIVGGVAGGASAAARLRRLNEYDNIIILERGEYISFANCGLPYYIGGVITERDKLLIQTPEKMKDRFNIDVRTEN
EVVDIDSASKTITVINHKVGKEEFIQYDTLILSPGARPFIPDIAGLSVNSSVFTLRNMLDTDNIKAYLISATPEAVTIIG
GGFIGLEMAENLVSSGLKVTIIELSNQILSPLDYEMAAIVEKHLKDNGIDVIKNDAVVQFDESAHQIHLKSGKIITTDMV
ILAIGVEPENDLAKKAHLDLGIRGSILVNEKLQTSVADIYAIGDAIQVVDYINGQATYIPLAWPANRQGRLLADIINGRD
VRYHGTLGTAIAKVLDLSAACTGNNERLLKRLAIPYQVVHIHGMSHASYYPGAHQISLKLLFSPENGRILGAQAVGQGGT
DKRIDVLATAIKGRLTIYDLPDLELAYAPPYSSAKDPVNMLGYVAENISNGDVMTKQWHEVDAFMADGGIIIDVRDEAEF
ISGSIKTAVNIPLSELRQKLALIPQDKKILVTCQVGLRGYIAARILSQYGYTVANLDGGYLTFNYANA
>Mature_547_residues
GKTIVIVGGVAGGASAAARLRRLNEYDNIIILERGEYISFANCGLPYYIGGVITERDKLLIQTPEKMKDRFNIDVRTENE
VVDIDSASKTITVINHKVGKEEFIQYDTLILSPGARPFIPDIAGLSVNSSVFTLRNMLDTDNIKAYLISATPEAVTIIGG
GFIGLEMAENLVSSGLKVTIIELSNQILSPLDYEMAAIVEKHLKDNGIDVIKNDAVVQFDESAHQIHLKSGKIITTDMVI
LAIGVEPENDLAKKAHLDLGIRGSILVNEKLQTSVADIYAIGDAIQVVDYINGQATYIPLAWPANRQGRLLADIINGRDV
RYHGTLGTAIAKVLDLSAACTGNNERLLKRLAIPYQVVHIHGMSHASYYPGAHQISLKLLFSPENGRILGAQAVGQGGTD
KRIDVLATAIKGRLTIYDLPDLELAYAPPYSSAKDPVNMLGYVAENISNGDVMTKQWHEVDAFMADGGIIIDVRDEAEFI
SGSIKTAVNIPLSELRQKLALIPQDKKILVTCQVGLRGYIAARILSQYGYTVANLDGGYLTFNYANA

Specific function: Catalyzes specifically the NADPH-dependent reduction of coenzyme A disulfide [H]

COG id: COG0446

COG function: function code R; Uncharacterized NAD(FAD)-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI65787454, Length=316, Percent_Identity=26.2658227848101, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI226437568, Length=316, Percent_Identity=26.2658227848101, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI21389617, Length=316, Percent_Identity=26.2658227848101, Blast_Score=104, Evalue=3e-22,
Organism=Escherichia coli, GI1789065, Length=259, Percent_Identity=30.8880308880309, Blast_Score=100, Evalue=4e-22,
Organism=Escherichia coli, GI87082354, Length=309, Percent_Identity=27.1844660194175, Blast_Score=89, Evalue=8e-19,
Organism=Escherichia coli, GI1788892, Length=290, Percent_Identity=27.2413793103448, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1789765, Length=341, Percent_Identity=24.633431085044, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1786307, Length=309, Percent_Identity=25.5663430420712, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1789915, Length=222, Percent_Identity=27.027027027027, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24639257, Length=288, Percent_Identity=25.6944444444444, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI281359715, Length=288, Percent_Identity=25.6944444444444, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI281359713, Length=288, Percent_Identity=25.6944444444444, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24639250, Length=288, Percent_Identity=25.6944444444444, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI18543267, Length=288, Percent_Identity=25.6944444444444, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24639252, Length=288, Percent_Identity=25.6944444444444, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24585130, Length=290, Percent_Identity=23.7931034482759, Blast_Score=69, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24581020, Length=254, Percent_Identity=28.740157480315, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI28573993, Length=254, Percent_Identity=28.740157480315, Blast_Score=66, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017758
- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.14 [H]

Molecular weight: Translated: 59562; Mature: 59431

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: PS50206 RHODANESE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKTIVIVGGVAGGASAAARLRRLNEYDNIIILERGEYISFANCGLPYYIGGVITERDKL
CCCEEEEEECCCCCHHHHHHHHHHCCCCCEEEEECCCEEEEECCCCCEEECCEEECCCEE
LIQTPEKMKDRFNIDVRTENEVVDIDSASKTITVINHKVGKEEFIQYDTLILSPGARPFI
EEECCHHHHHHEEEEEECCCCEEEECCCCCEEEEEECCCCHHHHHEEEEEEECCCCCCCC
PDIAGLSVNSSVFTLRNMLDTDNIKAYLISATPEAVTIIGGGFIGLEMAENLVSSGLKVT
CCCCCCCCCCHHHHHHHHCCCCCCEEEEEECCCCEEEEEECCEEHHHHHHHHHHCCCEEE
IIELSNQILSPLDYEMAAIVEKHLKDNGIDVIKNDAVVQFDESAHQIHLKSGKIITTDMV
EEEECHHHCCCCCHHHHHHHHHHHCCCCCEEEECCEEEEECCCCEEEEECCCCEEEEEEE
ILAIGVEPENDLAKKAHLDLGIRGSILVNEKLQTSVADIYAIGDAIQVVDYINGQATYIP
EEEEECCCCHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHCCHHEEHHHCCCCEEEEE
LAWPANRQGRLLADIINGRDVRYHGTLGTAIAKVLDLSAACTGNNERLLKRLAIPYQVVH
EECCCCCCCCEEEEECCCCEEEEECCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCEEEEE
IHGMSHASYYPGAHQISLKLLFSPENGRILGAQAVGQGGTDKRIDVLATAIKGRLTIYDL
EECCCCCCCCCCCEEEEEEEEEECCCCEEEEEHCCCCCCCCCHHHHHHHHHCCEEEEEEC
PDLELAYAPPYSSAKDPVNMLGYVAENISNGDVMTKQWHEVDAFMADGGIIIDVRDEAEF
CCCEEEECCCCCCCCCHHHHHHHHHHCCCCCCEEEHHHHHHHHEEECCCEEEEECCCHHH
ISGSIKTAVNIPLSELRQKLALIPQDKKILVTCQVGLRGYIAARILSQYGYTVANLDGGY
HCCCCEEEEECCHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHCCCEEEECCCCE
LTFNYANA
EEEEECCC
>Mature Secondary Structure 
GKTIVIVGGVAGGASAAARLRRLNEYDNIIILERGEYISFANCGLPYYIGGVITERDKL
CCEEEEEECCCCCHHHHHHHHHHCCCCCEEEEECCCEEEEECCCCCEEECCEEECCCEE
LIQTPEKMKDRFNIDVRTENEVVDIDSASKTITVINHKVGKEEFIQYDTLILSPGARPFI
EEECCHHHHHHEEEEEECCCCEEEECCCCCEEEEEECCCCHHHHHEEEEEEECCCCCCCC
PDIAGLSVNSSVFTLRNMLDTDNIKAYLISATPEAVTIIGGGFIGLEMAENLVSSGLKVT
CCCCCCCCCCHHHHHHHHCCCCCCEEEEEECCCCEEEEEECCEEHHHHHHHHHHCCCEEE
IIELSNQILSPLDYEMAAIVEKHLKDNGIDVIKNDAVVQFDESAHQIHLKSGKIITTDMV
EEEECHHHCCCCCHHHHHHHHHHHCCCCCEEEECCEEEEECCCCEEEEECCCCEEEEEEE
ILAIGVEPENDLAKKAHLDLGIRGSILVNEKLQTSVADIYAIGDAIQVVDYINGQATYIP
EEEEECCCCHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHCCHHEEHHHCCCCEEEEE
LAWPANRQGRLLADIINGRDVRYHGTLGTAIAKVLDLSAACTGNNERLLKRLAIPYQVVH
EECCCCCCCCEEEEECCCCEEEEECCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCEEEEE
IHGMSHASYYPGAHQISLKLLFSPENGRILGAQAVGQGGTDKRIDVLATAIKGRLTIYDL
EECCCCCCCCCCCEEEEEEEEEECCCCEEEEEHCCCCCCCCCHHHHHHHHHCCEEEEEEC
PDLELAYAPPYSSAKDPVNMLGYVAENISNGDVMTKQWHEVDAFMADGGIIIDVRDEAEF
CCCEEEECCCCCCCCCHHHHHHHHHHCCCCCCEEEHHHHHHHHEEECCCEEEEECCCHHH
ISGSIKTAVNIPLSELRQKLALIPQDKKILVTCQVGLRGYIAARILSQYGYTVANLDGGY
HCCCCEEEEECCHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHCCCEEEECCCCE
LTFNYANA
EEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA