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The map label for this gene is pepQ [H]

Identifier: 153952590

GI number: 153952590

Start: 1188800

End: 1190590

Strand: Direct

Name: pepQ [H]

Synonym: JJD26997_1346

Alternate gene names: 153952590

Gene position: 1188800-1190590 (Clockwise)

Preceding gene: 153951626

Following gene: 153951485

Centisome position: 64.43

GC content: 31.66

Gene sequence:

>1791_bases
ATGAGTATTTACAAACAAAGAGTATTAGAACTTAGAAGATTAATGAAAGAAAATAATATTGACGCCTATCTCATCTTAAG
CGCGGATCCGCATTTGAGCGAATATTTACCAGAATATTACAAAAACAGAGTCTTTATCAGTGGCTTTAAGGGTTCTGTTG
GAACAGTTCTTATCACACAAGAAGAAGGCTTTTTGTGGGTAGATGGAAGATATTGGCTTCAAGCACAAAAGGAATTAGAA
GGTAGTGGCATACTTTTACAAAAGCAAGATGCTAAAAATACTTTTACCAAATGGTTGGAAAAAAATTTAAGCGAAGATCA
AATTTTAGGCATCGATTTTACACTTTTACCTTTATCTTTGCAAAAAGATTTACAGATTAATTGCAAGGCAAATTTAAAAC
ATATAGATTTGATAAGTCCACTTTGGAAAGATCGTCCCACTTTACCACAAGAAAAAATTTATGAACACGAACTAGAATAC
TGCTCTTACTCAAGAAAAGAAAAATTAGCATTAGTGCGTCAAAAAATGAAAAATTTAAATGCTACCTCTCATTTAATCTC
CAGCCTTGATGATATAGCTTGGCTTACAAATTTAAGAGGGAATGATGTAAATTATAATCCTGTATTTTTAAGTCATTTGT
TAATCTTGGAAGACAAAGCTTTGCTTTTTGTTGATCAGAAAAAAGTAAATTTAGAACTTGAAAAAAAATTAAATTTAGAT
GGGTTTTGGCTTAAAAATTATGATGAAATCATCATAGAGCTTGAAAAACTTGCAAATACAAATTTGCTTATTGAACCTTC
AAAAATGACCGCTTTACTCGTAAATTCTTTAGATAAAAGCATAAAAATCATTCAAGAAATTAATCCAAGCACTCACTTAA
AAGCAGCTAAAAATACAAAAGAAATAGCGCATATAGAAGATGCTATGATAGAAGATGGAGTGGCTTTATGTAAATTTTTT
GCTTGGCTTGAAGAAGCGATAGAAAATAAAGAATTAATTAGCGAATTGGATATAGATACTAAAGCAAGCGAATTTAGAGC
ACAAAGCAAGTATTACATAAGTGATAGTTTTGCCACTATAGCAGGCTTTAATGAAAACGCAGCATATCCACATTATAAAG
CCACAAAAGAGAGTTTTGCTTATCTTAAAAAAGATGGACTTTTGCTTATTGATTCTGGTGGACAATATAAAAATGGCACA
ACAGATATTACACGCGTTGTACCTATAGGAAAGGCTAATGCAGAACAAATTCATGACTATACCTTGGTTTTAAAAGCACA
TATTGCCATTTCTAGTGCAATTTTTCCAAAAGATATAGCTATGCCACTACTTGATGCAATCACACGCGTACCTTTATGGA
AAGAACAAATTGACTATATACACGGCACAGGACATGGCGTGGGATATTTTTTAAATGTCCATGAAGGTCCACAAGTTTTA
TCTTATCTGTCCCCTGTGCTTGAAAAAACAAAAGCCAAAGAAGGTATGCTAACTTCCATAGAGCCAGGTATTTACAAAGT
AGGCAAATGGGGTATAAGACTTGAAAATTTAGCTATTCATACCAAAGTAGAAAATCCTAAAAATAAAGATTTTGGAGAGT
TTTTATACTTTAAACCTGTTACTCTTTGTCCTTTTGAAATATCTTGTATTGATACAAAAATGTTAGATGAAAAAGAAAAA
GAATGGTTAAACAATTACCACAAAGAAGTATTTGAAAAACTTTCTCCTAAACTAGGCGATTATCCAAAAGCTCTAGTTTG
GCTTGAAAAAAGAACAAAAGCCATCTTTTAA

Upstream 100 bases:

>100_bases
TTACCAATGTATGTGGATATTACTTGGTGCTGTTATAATTTTACTTATACTCAAAAAACCTATCAATAAAATACTAAAAA
ATTAATATTAAGGAAAAAAT

Downstream 100 bases:

>100_bases
GATACTTTGTTAATATAGATAAAATTTTCCTTGTATTAAACTTATAAAAAGTTTTTTTGAAAAACTCAATTCATAACTAA
AGATTATTTAAAATATCCAA

Product: M24 family peptidase

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 596; Mature: 595

Protein sequence:

>596_residues
MSIYKQRVLELRRLMKENNIDAYLILSADPHLSEYLPEYYKNRVFISGFKGSVGTVLITQEEGFLWVDGRYWLQAQKELE
GSGILLQKQDAKNTFTKWLEKNLSEDQILGIDFTLLPLSLQKDLQINCKANLKHIDLISPLWKDRPTLPQEKIYEHELEY
CSYSRKEKLALVRQKMKNLNATSHLISSLDDIAWLTNLRGNDVNYNPVFLSHLLILEDKALLFVDQKKVNLELEKKLNLD
GFWLKNYDEIIIELEKLANTNLLIEPSKMTALLVNSLDKSIKIIQEINPSTHLKAAKNTKEIAHIEDAMIEDGVALCKFF
AWLEEAIENKELISELDIDTKASEFRAQSKYYISDSFATIAGFNENAAYPHYKATKESFAYLKKDGLLLIDSGGQYKNGT
TDITRVVPIGKANAEQIHDYTLVLKAHIAISSAIFPKDIAMPLLDAITRVPLWKEQIDYIHGTGHGVGYFLNVHEGPQVL
SYLSPVLEKTKAKEGMLTSIEPGIYKVGKWGIRLENLAIHTKVENPKNKDFGEFLYFKPVTLCPFEISCIDTKMLDEKEK
EWLNNYHKEVFEKLSPKLGDYPKALVWLEKRTKAIF

Sequences:

>Translated_596_residues
MSIYKQRVLELRRLMKENNIDAYLILSADPHLSEYLPEYYKNRVFISGFKGSVGTVLITQEEGFLWVDGRYWLQAQKELE
GSGILLQKQDAKNTFTKWLEKNLSEDQILGIDFTLLPLSLQKDLQINCKANLKHIDLISPLWKDRPTLPQEKIYEHELEY
CSYSRKEKLALVRQKMKNLNATSHLISSLDDIAWLTNLRGNDVNYNPVFLSHLLILEDKALLFVDQKKVNLELEKKLNLD
GFWLKNYDEIIIELEKLANTNLLIEPSKMTALLVNSLDKSIKIIQEINPSTHLKAAKNTKEIAHIEDAMIEDGVALCKFF
AWLEEAIENKELISELDIDTKASEFRAQSKYYISDSFATIAGFNENAAYPHYKATKESFAYLKKDGLLLIDSGGQYKNGT
TDITRVVPIGKANAEQIHDYTLVLKAHIAISSAIFPKDIAMPLLDAITRVPLWKEQIDYIHGTGHGVGYFLNVHEGPQVL
SYLSPVLEKTKAKEGMLTSIEPGIYKVGKWGIRLENLAIHTKVENPKNKDFGEFLYFKPVTLCPFEISCIDTKMLDEKEK
EWLNNYHKEVFEKLSPKLGDYPKALVWLEKRTKAIF
>Mature_595_residues
SIYKQRVLELRRLMKENNIDAYLILSADPHLSEYLPEYYKNRVFISGFKGSVGTVLITQEEGFLWVDGRYWLQAQKELEG
SGILLQKQDAKNTFTKWLEKNLSEDQILGIDFTLLPLSLQKDLQINCKANLKHIDLISPLWKDRPTLPQEKIYEHELEYC
SYSRKEKLALVRQKMKNLNATSHLISSLDDIAWLTNLRGNDVNYNPVFLSHLLILEDKALLFVDQKKVNLELEKKLNLDG
FWLKNYDEIIIELEKLANTNLLIEPSKMTALLVNSLDKSIKIIQEINPSTHLKAAKNTKEIAHIEDAMIEDGVALCKFFA
WLEEAIENKELISELDIDTKASEFRAQSKYYISDSFATIAGFNENAAYPHYKATKESFAYLKKDGLLLIDSGGQYKNGTT
DITRVVPIGKANAEQIHDYTLVLKAHIAISSAIFPKDIAMPLLDAITRVPLWKEQIDYIHGTGHGVGYFLNVHEGPQVLS
YLSPVLEKTKAKEGMLTSIEPGIYKVGKWGIRLENLAIHTKVENPKNKDFGEFLYFKPVTLCPFEISCIDTKMLDEKEKE
WLNNYHKEVFEKLSPKLGDYPKALVWLEKRTKAIF

Specific function: Splits dipeptides with a prolyl in the C-terminal position and a nonpolar amino acid at the N-terminal position [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family. Archaeal-type prolidase subfamily [H]

Homologues:

Organism=Homo sapiens, GI264681563, Length=613, Percent_Identity=37.3572593800979, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI264681565, Length=613, Percent_Identity=35.5628058727569, Blast_Score=341, Evalue=1e-93,
Organism=Homo sapiens, GI93141226, Length=583, Percent_Identity=32.4185248713551, Blast_Score=318, Evalue=1e-86,
Organism=Escherichia coli, GI1788728, Length=193, Percent_Identity=33.160621761658, Blast_Score=78, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17509539, Length=609, Percent_Identity=33.1691297208539, Blast_Score=305, Evalue=5e-83,
Organism=Caenorhabditis elegans, GI25149105, Length=576, Percent_Identity=28.125, Blast_Score=234, Evalue=1e-61,
Organism=Saccharomyces cerevisiae, GI6322999, Length=649, Percent_Identity=32.6656394453005, Blast_Score=305, Evalue=2e-83,
Organism=Drosophila melanogaster, GI17137632, Length=609, Percent_Identity=36.7816091954023, Blast_Score=346, Evalue=2e-95,
Organism=Drosophila melanogaster, GI161078230, Length=626, Percent_Identity=28.4345047923323, Blast_Score=254, Evalue=2e-67,
Organism=Drosophila melanogaster, GI21357287, Length=626, Percent_Identity=28.4345047923323, Blast_Score=254, Evalue=2e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 68395; Mature: 68264

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIYKQRVLELRRLMKENNIDAYLILSADPHLSEYLPEYYKNRVFISGFKGSVGTVLITQ
CCHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHCCEEEEECCCCCEEEEEEE
EEGFLWVDGRYWLQAQKELEGSGILLQKQDAKNTFTKWLEKNLSEDQILGIDFTLLPLSL
CCCEEEECCCEEEEEHHCCCCCCEEEEECCCHHHHHHHHHCCCCCCEEEEEEEEEEEEEC
QKDLQINCKANLKHIDLISPLWKDRPTLPQEKIYEHELEYCSYSRKEKLALVRQKMKNLN
CCCCEEEEECCCEEEEHHCHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCC
ATSHLISSLDDIAWLTNLRGNDVNYNPVFLSHLLILEDKALLFVDQKKVNLELEKKLNLD
HHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCC
GFWLKNYDEIIIELEKLANTNLLIEPSKMTALLVNSLDKSIKIIQEINPSTHLKAAKNTK
EEEECCHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCH
EIAHIEDAMIEDGVALCKFFAWLEEAIENKELISELDIDTKASEFRAQSKYYISDSFATI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCEEEECCCEEE
AGFNENAAYPHYKATKESFAYLKKDGLLLIDSGGQYKNGTTDITRVVPIGKANAEQIHDY
ECCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCEEEEEECCCCCHHHHHHE
TLVLKAHIAISSAIFPKDIAMPLLDAITRVPLWKEQIDYIHGTGHGVGYFLNVHEGPQVL
EEEEEEHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHEEECCCCCEEEEEEECCCHHHH
SYLSPVLEKTKAKEGMLTSIEPGIYKVGKWGIRLENLAIHTKVENPKNKDFGEFLYFKPV
HHHHHHHHHHHHCCCCEECCCCCCEEECCCCEEEEEEEEEEECCCCCCCCCCCEEEECCC
TLCPFEISCIDTKMLDEKEKEWLNNYHKEVFEKLSPKLGDYPKALVWLEKRTKAIF
EECCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
SIYKQRVLELRRLMKENNIDAYLILSADPHLSEYLPEYYKNRVFISGFKGSVGTVLITQ
CHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHCCEEEEECCCCCEEEEEEE
EEGFLWVDGRYWLQAQKELEGSGILLQKQDAKNTFTKWLEKNLSEDQILGIDFTLLPLSL
CCCEEEECCCEEEEEHHCCCCCCEEEEECCCHHHHHHHHHCCCCCCEEEEEEEEEEEEEC
QKDLQINCKANLKHIDLISPLWKDRPTLPQEKIYEHELEYCSYSRKEKLALVRQKMKNLN
CCCCEEEEECCCEEEEHHCHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCC
ATSHLISSLDDIAWLTNLRGNDVNYNPVFLSHLLILEDKALLFVDQKKVNLELEKKLNLD
HHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCC
GFWLKNYDEIIIELEKLANTNLLIEPSKMTALLVNSLDKSIKIIQEINPSTHLKAAKNTK
EEEECCHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCH
EIAHIEDAMIEDGVALCKFFAWLEEAIENKELISELDIDTKASEFRAQSKYYISDSFATI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCEEEECCCEEE
AGFNENAAYPHYKATKESFAYLKKDGLLLIDSGGQYKNGTTDITRVVPIGKANAEQIHDY
ECCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCEEEEEECCCCCHHHHHHE
TLVLKAHIAISSAIFPKDIAMPLLDAITRVPLWKEQIDYIHGTGHGVGYFLNVHEGPQVL
EEEEEEHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHEEECCCCCEEEEEEECCCHHHH
SYLSPVLEKTKAKEGMLTSIEPGIYKVGKWGIRLENLAIHTKVENPKNKDFGEFLYFKPV
HHHHHHHHHHHHCCCCEECCCCCCEEECCCCEEEEEEEEEEECCCCCCCCCCCEEEECCC
TLCPFEISCIDTKMLDEKEKEWLNNYHKEVFEKLSPKLGDYPKALVWLEKRTKAIF
EECCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9733678; 11223522; 11210522 [H]