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The map label for this gene is glmS [H]

Identifier: 153951976

GI number: 153951976

Start: 261951

End: 263747

Strand: Direct

Name: glmS [H]

Synonym: JJD26997_0284

Alternate gene names: 153951976

Gene position: 261951-263747 (Clockwise)

Preceding gene: 153951333

Following gene: 153952596

Centisome position: 14.2

GC content: 34.0

Gene sequence:

>1797_bases
ATGTGTGGAATTGTAGGCTATATAGGAAATAATGAAAAAAAACAAATTATACTAAATGGACTTAAAGAATTAGAATACCG
TGGCTATGATAGTGCGGGTATGGCAGTGATGCAAGAAGGCGAACTTAGTTTTTTTAAAGCTGTAGGCAAACTTGAAAATT
TAGCTAATAAGTGCTCAGATTTTGAAAGTCAAGGTTATGGTTTTGCTGTAGGTCATACAAGATGGGCAACCCATGGTAAA
CCTACTGAAATCAACGCACACCCTCATTTAGGACAGTATTCTTGCGTGATTCACAATGGTATTATAGAAAATTATAAAGA
AATCAAAGATAAACTCGAAAAAGAAGGCGTGAGTTTTTTAAGTCAAACAGATACAGAAGTGATTGTTCAGCTTTTTGAAT
TTTATGCAAGAAATTTGGGAGTTTTTGAAGCTTGGCAAAAAACCATCAAAGAACTTCGTGGTGCTTTTGCTACTTTGTTG
GTAACAAAAAAAGATCCCAATCATGTGTATTTTGCGAAAAATGCCGCTCCTTTGATTATCGGTAAAAATGCAAATAAAGA
ATGGTATTTTTCTTCAGGCGATGCTCCTTTGATAGGAAGTTGTGATGAGGTAATGTATCTTGAAGATTTAAGCTTGGGAT
ATGCGAGTAAAGATGAGCTTGTCATTTATGAAAATGATATTTTAAAATCACTTTGTTTTTTTAAGCTTTCAGGCGATAAG
GCTTATGCAAAAAAAGATGGCTTTCGCTTTTTTGTGGAAAAAGAAATTTATGAACAAAGCCGTGTGATGAGTGAAGTTTT
AATGGGGCGTATTCAAGGCGATGAAGTTGTTTTTGATGAGTTAAACAATGAAGATTTAAGTCAAGTGGATGAAATCACGC
TTTGTGCTTGTGGAACAAGCTATCATGCTGCAATGGCAAGCGCTTATTTGTTTGAAAGAATTGCTAAAGTTAAAGTTAAA
GTAGAAATTGCAAGTGAATTTCGCTACCGTGAAGCAATTATAAAAAAAGATTCTTTATTTATCGTTATTTCTCAAAGTGG
AGAAACAGCAGACACTTTAGAGGCTTTAAAGATTGCAAAAGAGCAGGGTGCTAAGACTTTTGCAATTTGTAATGTGGATA
ATTCTAATATAGTGCGTTTAGCACACCTAAGTCTTTTAACTCGTGCGGGTATAGAAAAAGGAGTTGCTTCAACTAAAGCT
TTTGCCACTCAGGTTTTAACACTTTGGATGCTTGCTATTTTTATGGCGCAAAAAAGAAATTTAAATGTTTCTGCTGAAAT
TAAAGCGCTTTTACATACTCCAAATTGTGTGAGTGTAAAACAGGCTTTACATGAAAAAATTCATCGTTTATCTAAGCGTT
ATTTAGATGGACATGGCTTTTTCTTTATAGGTAGAGATGTTTTTTATCCTTTGGCCTTAGAAGGAGCTTTGAAACTTAAA
GAATTATCTTATTTTCATGCTGAAGGTTATCCTGCAGGAGAGATGAAACATGGCCCTATTGCTTTGGCTGATTCTAAGCT
TTACACTATAGCTTTAATGCCAAAGCACATGCTTTATGAAAAAACAAAATCAAATGTTGAAGAGCTTATTGCTAGGGATT
CTACAGTGCTTAGCATTTCGCCTTTAGAATTTGATTTAAGTGATGATTTTATAAAAACCAATGAGCAAGATCATTATATG
TGTGAATTTTTTGAAATGATGGTAATTACTCAACTTTTAGCGATGGAAATTTCCATAAGACTTGGTAATGATGTGGATAT
GCCAAGAAATTTGGCTAAAAGCGTAACAGTGGAATAA

Upstream 100 bases:

>100_bases
CATAAGACAAAGGACGCGTAATATTTTTATTTTTCAAAAGAATGAAAAATTAGAACATAGCGAGCAAAAGTTAGTTAATT
TATTAATAAGTGAGTAAAAA

Downstream 100 bases:

>100_bases
TCCGTGCAGTTTAAATAAACTGCACATAACTTTCAAATACTTCAAAAAATATAAATAAATTTTAAATTATAAGCTAACTT
TATGCTTATTTTTGTTTAAA

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 598; Mature: 598

Protein sequence:

>598_residues
MCGIVGYIGNNEKKQIILNGLKELEYRGYDSAGMAVMQEGELSFFKAVGKLENLANKCSDFESQGYGFAVGHTRWATHGK
PTEINAHPHLGQYSCVIHNGIIENYKEIKDKLEKEGVSFLSQTDTEVIVQLFEFYARNLGVFEAWQKTIKELRGAFATLL
VTKKDPNHVYFAKNAAPLIIGKNANKEWYFSSGDAPLIGSCDEVMYLEDLSLGYASKDELVIYENDILKSLCFFKLSGDK
AYAKKDGFRFFVEKEIYEQSRVMSEVLMGRIQGDEVVFDELNNEDLSQVDEITLCACGTSYHAAMASAYLFERIAKVKVK
VEIASEFRYREAIIKKDSLFIVISQSGETADTLEALKIAKEQGAKTFAICNVDNSNIVRLAHLSLLTRAGIEKGVASTKA
FATQVLTLWMLAIFMAQKRNLNVSAEIKALLHTPNCVSVKQALHEKIHRLSKRYLDGHGFFFIGRDVFYPLALEGALKLK
ELSYFHAEGYPAGEMKHGPIALADSKLYTIALMPKHMLYEKTKSNVEELIARDSTVLSISPLEFDLSDDFIKTNEQDHYM
CEFFEMMVITQLLAMEISIRLGNDVDMPRNLAKSVTVE

Sequences:

>Translated_598_residues
MCGIVGYIGNNEKKQIILNGLKELEYRGYDSAGMAVMQEGELSFFKAVGKLENLANKCSDFESQGYGFAVGHTRWATHGK
PTEINAHPHLGQYSCVIHNGIIENYKEIKDKLEKEGVSFLSQTDTEVIVQLFEFYARNLGVFEAWQKTIKELRGAFATLL
VTKKDPNHVYFAKNAAPLIIGKNANKEWYFSSGDAPLIGSCDEVMYLEDLSLGYASKDELVIYENDILKSLCFFKLSGDK
AYAKKDGFRFFVEKEIYEQSRVMSEVLMGRIQGDEVVFDELNNEDLSQVDEITLCACGTSYHAAMASAYLFERIAKVKVK
VEIASEFRYREAIIKKDSLFIVISQSGETADTLEALKIAKEQGAKTFAICNVDNSNIVRLAHLSLLTRAGIEKGVASTKA
FATQVLTLWMLAIFMAQKRNLNVSAEIKALLHTPNCVSVKQALHEKIHRLSKRYLDGHGFFFIGRDVFYPLALEGALKLK
ELSYFHAEGYPAGEMKHGPIALADSKLYTIALMPKHMLYEKTKSNVEELIARDSTVLSISPLEFDLSDDFIKTNEQDHYM
CEFFEMMVITQLLAMEISIRLGNDVDMPRNLAKSVTVE
>Mature_598_residues
MCGIVGYIGNNEKKQIILNGLKELEYRGYDSAGMAVMQEGELSFFKAVGKLENLANKCSDFESQGYGFAVGHTRWATHGK
PTEINAHPHLGQYSCVIHNGIIENYKEIKDKLEKEGVSFLSQTDTEVIVQLFEFYARNLGVFEAWQKTIKELRGAFATLL
VTKKDPNHVYFAKNAAPLIIGKNANKEWYFSSGDAPLIGSCDEVMYLEDLSLGYASKDELVIYENDILKSLCFFKLSGDK
AYAKKDGFRFFVEKEIYEQSRVMSEVLMGRIQGDEVVFDELNNEDLSQVDEITLCACGTSYHAAMASAYLFERIAKVKVK
VEIASEFRYREAIIKKDSLFIVISQSGETADTLEALKIAKEQGAKTFAICNVDNSNIVRLAHLSLLTRAGIEKGVASTKA
FATQVLTLWMLAIFMAQKRNLNVSAEIKALLHTPNCVSVKQALHEKIHRLSKRYLDGHGFFFIGRDVFYPLALEGALKLK
ELSYFHAEGYPAGEMKHGPIALADSKLYTIALMPKHMLYEKTKSNVEELIARDSTVLSISPLEFDLSDDFIKTNEQDHYM
CEFFEMMVITQLLAMEISIRLGNDVDMPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI4826742, Length=687, Percent_Identity=32.1688500727802, Blast_Score=317, Evalue=3e-86,
Organism=Homo sapiens, GI205277386, Length=686, Percent_Identity=31.1953352769679, Blast_Score=301, Evalue=1e-81,
Organism=Escherichia coli, GI1790167, Length=619, Percent_Identity=41.1954765751212, Blast_Score=453, Evalue=1e-128,
Organism=Escherichia coli, GI1788651, Length=201, Percent_Identity=26.3681592039801, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17532899, Length=428, Percent_Identity=33.6448598130841, Blast_Score=210, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI17532897, Length=428, Percent_Identity=33.6448598130841, Blast_Score=210, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI17539970, Length=429, Percent_Identity=32.6340326340326, Blast_Score=204, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6322745, Length=444, Percent_Identity=32.4324324324324, Blast_Score=210, Evalue=6e-55,
Organism=Saccharomyces cerevisiae, GI6323731, Length=427, Percent_Identity=30.9133489461358, Blast_Score=166, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6323730, Length=207, Percent_Identity=32.8502415458937, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI21357745, Length=694, Percent_Identity=31.700288184438, Blast_Score=319, Evalue=3e-87,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 67265; Mature: 67265

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGYIGNNEKKQIILNGLKELEYRGYDSAGMAVMQEGELSFFKAVGKLENLANKCSD
CCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHC
FESQGYGFAVGHTRWATHGKPTEINAHPHLGQYSCVIHNGIIENYKEIKDKLEKEGVSFL
HHHCCCEEEECCCEECCCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHH
SQTDTEVIVQLFEFYARNLGVFEAWQKTIKELRGAFATLLVTKKDPNHVYFAKNAAPLII
HCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHEEEEEEECCCCEEEEECCCCEEEE
GKNANKEWYFSSGDAPLIGSCDEVMYLEDLSLGYASKDELVIYENDILKSLCFFKLSGDK
ECCCCCCEEEECCCCCCCCCCCCEEEEECCCCCCCCCCCEEEEEHHHHHHHHHEEECCCC
AYAKKDGFRFFVEKEIYEQSRVMSEVLMGRIQGDEVVFDELNNEDLSQVDEITLCACGTS
HHHCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHCEEEEECCCH
YHAAMASAYLFERIAKVKVKVEIASEFRYREAIIKKDSLFIVISQSGETADTLEALKIAK
HHHHHHHHHHHHHHHHHEEEEEEHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHH
EQGAKTFAICNVDNSNIVRLAHLSLLTRAGIEKGVASTKAFATQVLTLWMLAIFMAQKRN
HCCCCEEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
LNVSAEIKALLHTPNCVSVKQALHEKIHRLSKRYLDGHGFFFIGRDVFYPLALEGALKLK
CCCHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHCHHHHH
ELSYFHAEGYPAGEMKHGPIALADSKLYTIALMPKHMLYEKTKSNVEELIARDSTVLSIS
HHHHHHCCCCCCCCCCCCCEEEECCCEEEEEECCHHHHHHHHHHHHHHHHHCCCEEEEEE
PLEFDLSDDFIKTNEQDHYMCEFFEMMVITQLLAMEISIRLGNDVDMPRNLAKSVTVE
CCEECCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHCCCC
>Mature Secondary Structure
MCGIVGYIGNNEKKQIILNGLKELEYRGYDSAGMAVMQEGELSFFKAVGKLENLANKCSD
CCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHC
FESQGYGFAVGHTRWATHGKPTEINAHPHLGQYSCVIHNGIIENYKEIKDKLEKEGVSFL
HHHCCCEEEECCCEECCCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHH
SQTDTEVIVQLFEFYARNLGVFEAWQKTIKELRGAFATLLVTKKDPNHVYFAKNAAPLII
HCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHEEEEEEECCCCEEEEECCCCEEEE
GKNANKEWYFSSGDAPLIGSCDEVMYLEDLSLGYASKDELVIYENDILKSLCFFKLSGDK
ECCCCCCEEEECCCCCCCCCCCCEEEEECCCCCCCCCCCEEEEEHHHHHHHHHEEECCCC
AYAKKDGFRFFVEKEIYEQSRVMSEVLMGRIQGDEVVFDELNNEDLSQVDEITLCACGTS
HHHCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHCEEEEECCCH
YHAAMASAYLFERIAKVKVKVEIASEFRYREAIIKKDSLFIVISQSGETADTLEALKIAK
HHHHHHHHHHHHHHHHHEEEEEEHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHH
EQGAKTFAICNVDNSNIVRLAHLSLLTRAGIEKGVASTKAFATQVLTLWMLAIFMAQKRN
HCCCCEEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
LNVSAEIKALLHTPNCVSVKQALHEKIHRLSKRYLDGHGFFFIGRDVFYPLALEGALKLK
CCCHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHCHHHHH
ELSYFHAEGYPAGEMKHGPIALADSKLYTIALMPKHMLYEKTKSNVEELIARDSTVLSIS
HHHHHHCCCCCCCCCCCCCEEEECCCEEEEEECCHHHHHHHHHHHHHHHHHCCCEEEEEE
PLEFDLSDDFIKTNEQDHYMCEFFEMMVITQLLAMEISIRLGNDVDMPRNLAKSVTVE
CCEECCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10688204 [H]