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The map label for this gene is copA [H]

Identifier: 153951967

GI number: 153951967

Start: 515916

End: 518267

Strand: Direct

Name: copA [H]

Synonym: JJD26997_0573

Alternate gene names: 153951967

Gene position: 515916-518267 (Clockwise)

Preceding gene: 153951001

Following gene: 153951059

Centisome position: 27.96

GC content: 31.29

Gene sequence:

>2352_bases
ATGAAATGTGAACATTGCAGACTTGATTATAAACAAGTCCAAATGATAGAGTATAAGGGTAAATTTTTTTGCTGTAAGGG
TTGTGAAAGCGTTTGGGAAATTTTGCATGAAAGCGGATTGGATGAGTTTTATGAAAAACTTGGAAATCAAACTTTAAGCC
CTGTAAATTTTCAAAATGAAATGAAAAATTATGATGAGTTTATCACTAAAACCAAAGAAGGATTTAGTGAAATTTATCTC
ATGATACACGGTATAGAATGTGCAGCTTGCGTATGGCTTAATGAGAAAATTTTAACCAAACAAGAAGGAATTTTAGAACT
TGATATCAATCATTTAAACCATAAAGCACGCATTGTTTTTGATGAGCAAAGCATTTCTTTGGTGCAAATTTTAAGACTTA
TTGAAAGTATAGGCTATAAAGCGAGTGCTTATGATGCGAGCAAGGCTTCAAAAAAAGCAGATTTACTAAAAAGGGAATTT
TATTCTAAGCTTGTTGTGGCTATAGCTTGTGTGATGAATATCATGTGGATAGCAGTGGCAAAATACGCAGGATTTTTTAG
CGGTATGGATAAGGATACTAAGGATATTTTAAATTTTGCTGAATTTATCCTTTGTTCTCCTGTGCTTTTTTATACGGGAT
CTCATTTTTATAAAAGCGCTTTTAAAACTTTAAAAATGCATAGTTTAAATATGGATGTATTGGTGATTAGCGGAGCGAGT
TTGGCTTATGTTTATTCTTTATGGGCTATGTTTTTTAGGGTAGGGGAGGTGTATTTTGATTCCGTGGCGATGATAGTTTG
CTTTGTTTTTATAGGAAAATATCTTGAGATGTTTAGTAAAAAGTGTGCTTTAGACACTATAGATGGGCTTAATGATTTTT
TGCGAAATGAAGTTTTAGTTTTCAATGGCAAAGAATTTACTCCCAAAGAAGTGCAAAAGGTTTGTTTGGGAGATAGAATT
TTACTTAAAACTGGAGATAAAATTTTAATCGATGGGGTTTGCAAAAGTGGTGAAATGAGCGTGGATACTTCTTCTTTAAA
TGGAGAAAGTATTCCCAAACTCATACAAAAAGAAGATGAAATTTTTTCAGCTTGTATAGTGCTTGATGGAAGTGTGGAGT
ATGAAGCAACAAAGCTTTATAAGGATTCAAAACTCAGTCAAATTATAGGGCTTTTAGAACTTGCAAGTTCTAAAAAAGCA
AAACTTGAAAGTTTGGTTAATAGTCTTTCGGCTTATTTTTCTAGAACGGTTTTGTTGATCGCTTTTATTTGTTTTGCTTT
TTGGTTTTTTTACAAGGAAGCGAGTTTTGAAATTTCTTTAGTCAATGCGATTGCAGTTTTGATTATCGCTTGTCCTTGTG
CTTTGGCTTTAGCAACGCCCGTGAGTAATCTTGTGGCCTTAGGTAGAGCTTTGAAAAAACATATTTTATTTAAAAGTTCT
AGTGTGATAGAAGATTTAAGTAAATGTGATTATGTGGTATTTGATAAAACGGGTATTTTGACTAAAATAGAGCTTGAACT
TAAAGAGGTTTTTTTGGATAAAATGCTTGATTTAAATGAGTTTTATAATTTTGTAAAACTTTCTAAACATCCTATCTCTC
AAAATATTGCGTCGTATTTAAAGCAAAAAGGAGCTAAGGATTTAAATTTGGATTTTAAAAAGCATTCAAGCATTCAAGCT
AAAGGTTTAAGTGCTGAGTTAAATAAAGGGTTGCTTTTAGGTGGAAGTTCTAAATTTTTGCAAGAAAAGGGTATTGCAAC
TAAGGAATTTGATAATACGCATTTTATTTTTGCCAAGGAAGGTAAAATTTTAGCTTTTTTTGAGTTTGATAGTGTTTTAA
GAGAAGGTGTAAAAGAGCTTATCGCTTATCTTAAAAAAGAAAAGAAAGAATTAATGATACTAAGTGGCGATCATCAAAAA
GCAGTGGAAAAAATCGCTAAAAAGCTAGAAATTCAAAATTATCAAGCTTTTTGTTTGCCAGAAGATAAGATGAAAACTAT
AGAAAATTTAAGCAAAAATTACAAAGTTTTATTTGTGGGCGATGGGGTAAATGATGCGCTAGCTTTAAAATACGCAAGTG
TTTCGATGACTTTAAGAGAAGGAAGTGATCTAGCCATCGAAAGTAGTGATGTTTTACTTTTGAAAAATGACTTACTTTCT
TTAAAAAAAGCCATAAAATTATCTAAAAATACCTTTAAAATTATCAAGCAAAATCTTGCTTTTTCTTTGTTTTATAATGC
TTGTACCATACCTTTGGCTTTTTTGGGTATGATTAATCCTTTATTCGCTGCTATTTCTATGTCTTTTAGTAGTACAATAG
TCGTTTTAAATGCTCTAAGGATCAAAGAATGA

Upstream 100 bases:

>100_bases
TTTAGCAGGATAATTTTTGTAAAATGTGATTTTAGTAAAAAAATGCACTTTTTGTCAAATTTGTCTATAATTATAAAAAA
TATTTTTTTAAAGAATGGTT

Downstream 100 bases:

>100_bases
ATAGTATAATCATGATGATGATAGGGGTGTCTATCTTAGCGTTTTTTATCATTTTGGCAACTTTGCTTTGGGGGATTAAA
AATAAACAATTTGATGATGA

Product: heavy metal translocating P-type ATPase

Products: ADP; Orthophosphate. [C]

Alternate protein names: NA

Number of amino acids: Translated: 783; Mature: 783

Protein sequence:

>783_residues
MKCEHCRLDYKQVQMIEYKGKFFCCKGCESVWEILHESGLDEFYEKLGNQTLSPVNFQNEMKNYDEFITKTKEGFSEIYL
MIHGIECAACVWLNEKILTKQEGILELDINHLNHKARIVFDEQSISLVQILRLIESIGYKASAYDASKASKKADLLKREF
YSKLVVAIACVMNIMWIAVAKYAGFFSGMDKDTKDILNFAEFILCSPVLFYTGSHFYKSAFKTLKMHSLNMDVLVISGAS
LAYVYSLWAMFFRVGEVYFDSVAMIVCFVFIGKYLEMFSKKCALDTIDGLNDFLRNEVLVFNGKEFTPKEVQKVCLGDRI
LLKTGDKILIDGVCKSGEMSVDTSSLNGESIPKLIQKEDEIFSACIVLDGSVEYEATKLYKDSKLSQIIGLLELASSKKA
KLESLVNSLSAYFSRTVLLIAFICFAFWFFYKEASFEISLVNAIAVLIIACPCALALATPVSNLVALGRALKKHILFKSS
SVIEDLSKCDYVVFDKTGILTKIELELKEVFLDKMLDLNEFYNFVKLSKHPISQNIASYLKQKGAKDLNLDFKKHSSIQA
KGLSAELNKGLLLGGSSKFLQEKGIATKEFDNTHFIFAKEGKILAFFEFDSVLREGVKELIAYLKKEKKELMILSGDHQK
AVEKIAKKLEIQNYQAFCLPEDKMKTIENLSKNYKVLFVGDGVNDALALKYASVSMTLREGSDLAIESSDVLLLKNDLLS
LKKAIKLSKNTFKIIKQNLAFSLFYNACTIPLAFLGMINPLFAAISMSFSSTIVVLNALRIKE

Sequences:

>Translated_783_residues
MKCEHCRLDYKQVQMIEYKGKFFCCKGCESVWEILHESGLDEFYEKLGNQTLSPVNFQNEMKNYDEFITKTKEGFSEIYL
MIHGIECAACVWLNEKILTKQEGILELDINHLNHKARIVFDEQSISLVQILRLIESIGYKASAYDASKASKKADLLKREF
YSKLVVAIACVMNIMWIAVAKYAGFFSGMDKDTKDILNFAEFILCSPVLFYTGSHFYKSAFKTLKMHSLNMDVLVISGAS
LAYVYSLWAMFFRVGEVYFDSVAMIVCFVFIGKYLEMFSKKCALDTIDGLNDFLRNEVLVFNGKEFTPKEVQKVCLGDRI
LLKTGDKILIDGVCKSGEMSVDTSSLNGESIPKLIQKEDEIFSACIVLDGSVEYEATKLYKDSKLSQIIGLLELASSKKA
KLESLVNSLSAYFSRTVLLIAFICFAFWFFYKEASFEISLVNAIAVLIIACPCALALATPVSNLVALGRALKKHILFKSS
SVIEDLSKCDYVVFDKTGILTKIELELKEVFLDKMLDLNEFYNFVKLSKHPISQNIASYLKQKGAKDLNLDFKKHSSIQA
KGLSAELNKGLLLGGSSKFLQEKGIATKEFDNTHFIFAKEGKILAFFEFDSVLREGVKELIAYLKKEKKELMILSGDHQK
AVEKIAKKLEIQNYQAFCLPEDKMKTIENLSKNYKVLFVGDGVNDALALKYASVSMTLREGSDLAIESSDVLLLKNDLLS
LKKAIKLSKNTFKIIKQNLAFSLFYNACTIPLAFLGMINPLFAAISMSFSSTIVVLNALRIKE
>Mature_783_residues
MKCEHCRLDYKQVQMIEYKGKFFCCKGCESVWEILHESGLDEFYEKLGNQTLSPVNFQNEMKNYDEFITKTKEGFSEIYL
MIHGIECAACVWLNEKILTKQEGILELDINHLNHKARIVFDEQSISLVQILRLIESIGYKASAYDASKASKKADLLKREF
YSKLVVAIACVMNIMWIAVAKYAGFFSGMDKDTKDILNFAEFILCSPVLFYTGSHFYKSAFKTLKMHSLNMDVLVISGAS
LAYVYSLWAMFFRVGEVYFDSVAMIVCFVFIGKYLEMFSKKCALDTIDGLNDFLRNEVLVFNGKEFTPKEVQKVCLGDRI
LLKTGDKILIDGVCKSGEMSVDTSSLNGESIPKLIQKEDEIFSACIVLDGSVEYEATKLYKDSKLSQIIGLLELASSKKA
KLESLVNSLSAYFSRTVLLIAFICFAFWFFYKEASFEISLVNAIAVLIIACPCALALATPVSNLVALGRALKKHILFKSS
SVIEDLSKCDYVVFDKTGILTKIELELKEVFLDKMLDLNEFYNFVKLSKHPISQNIASYLKQKGAKDLNLDFKKHSSIQA
KGLSAELNKGLLLGGSSKFLQEKGIATKEFDNTHFIFAKEGKILAFFEFDSVLREGVKELIAYLKKEKKELMILSGDHQK
AVEKIAKKLEIQNYQAFCLPEDKMKTIENLSKNYKVLFVGDGVNDALALKYASVSMTLREGSDLAIESSDVLLLKNDLLS
LKKAIKLSKNTFKIIKQNLAFSLFYNACTIPLAFLGMINPLFAAISMSFSSTIVVLNALRIKE

Specific function: Involved in copper export [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 HMA domains [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=778, Percent_Identity=28.4061696658098, Blast_Score=269, Evalue=7e-72,
Organism=Homo sapiens, GI115529486, Length=557, Percent_Identity=27.4685816876122, Blast_Score=192, Evalue=1e-48,
Organism=Homo sapiens, GI55743073, Length=811, Percent_Identity=24.0443896424168, Blast_Score=179, Evalue=7e-45,
Organism=Escherichia coli, GI1786691, Length=832, Percent_Identity=28.9663461538462, Blast_Score=321, Evalue=9e-89,
Organism=Escherichia coli, GI1789879, Length=710, Percent_Identity=23.3802816901408, Blast_Score=180, Evalue=3e-46,
Organism=Escherichia coli, GI1786914, Length=459, Percent_Identity=22.0043572984749, Blast_Score=95, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17556548, Length=521, Percent_Identity=26.8714011516315, Blast_Score=165, Evalue=9e-41,
Organism=Saccharomyces cerevisiae, GI6320475, Length=765, Percent_Identity=27.7124183006536, Blast_Score=233, Evalue=7e-62,
Organism=Saccharomyces cerevisiae, GI6319772, Length=589, Percent_Identity=27.8438030560272, Blast_Score=219, Evalue=1e-57,
Organism=Saccharomyces cerevisiae, GI6321271, Length=143, Percent_Identity=32.8671328671329, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI221329854, Length=556, Percent_Identity=25.5395683453237, Blast_Score=166, Evalue=4e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR006403
- InterPro:   IPR000695
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: 3.6.3.4 [C]

Molecular weight: Translated: 88225; Mature: 88225

Theoretical pI: Translated: 8.00; Mature: 8.00

Prosite motif: PS50846 HMA_2 ; PS01229 COF_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKCEHCRLDYKQVQMIEYKGKFFCCKGCESVWEILHESGLDEFYEKLGNQTLSPVNFQNE
CCCCCCCCCHHHHHHHEECCCEEEEHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCHHHH
MKNYDEFITKTKEGFSEIYLMIHGIECAACVWLNEKILTKQEGILELDINHLNHKARIVF
HHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEEECHHHHHCCCCEEEEEHHHCCCEEEEEE
DEQSISLVQILRLIESIGYKASAYDASKASKKADLLKREFYSKLVVAIACVMNIMWIAVA
CCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KYAGFFSGMDKDTKDILNFAEFILCSPVLFYTGSHFYKSAFKTLKMHSLNMDVLVISGAS
HHHHHHCCCCCCHHHHHHHHHHHHHCHHHHHCCCHHHHHHHHHHHHHCCCCEEEEECCCH
LAYVYSLWAMFFRVGEVYFDSVAMIVCFVFIGKYLEMFSKKCALDTIDGLNDFLRNEVLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCEEE
FNGKEFTPKEVQKVCLGDRILLKTGDKILIDGVCKSGEMSVDTSSLNGESIPKLIQKEDE
ECCCCCCHHHHHHHHCCCEEEEECCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHH
IFSACIVLDGSVEYEATKLYKDSKLSQIIGLLELASSKKAKLESLVNSLSAYFSRTVLLI
HHEEHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
AFICFAFWFFYKEASFEISLVNAIAVLIIACPCALALATPVSNLVALGRALKKHILFKSS
HHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
SVIEDLSKCDYVVFDKTGILTKIELELKEVFLDKMLDLNEFYNFVKLSKHPISQNIASYL
HHHHHHHHCCEEEEECCCCEEEEHHHHHHHHHHHHHCHHHHHHHHHHCCCCHHHHHHHHH
KQKGAKDLNLDFKKHSSIQAKGLSAELNKGLLLGGSSKFLQEKGIATKEFDNTHFIFAKE
HHCCCCCCCCCHHHCCCCCCCCCCHHCCCCEEECCCHHHHHHCCCCCEECCCCEEEEEEC
GKILAFFEFDSVLREGVKELIAYLKKEKKELMILSGDHQKAVEKIAKKLEIQNYQAFCLP
CCEEEEECHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHCCCEEEECC
EDKMKTIENLSKNYKVLFVGDGVNDALALKYASVSMTLREGSDLAIESSDVLLLKNDLLS
HHHHHHHHHHCCCCEEEEEECCCCCHHHEEEHHEEEEEECCCCCEEECCCEEEEHHHHHH
LKKAIKLSKNTFKIIKQNLAFSLFYNACTIPLAFLGMINPLFAAISMSFSSTIVVLNALR
HHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHH
IKE
CCC
>Mature Secondary Structure
MKCEHCRLDYKQVQMIEYKGKFFCCKGCESVWEILHESGLDEFYEKLGNQTLSPVNFQNE
CCCCCCCCCHHHHHHHEECCCEEEEHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCHHHH
MKNYDEFITKTKEGFSEIYLMIHGIECAACVWLNEKILTKQEGILELDINHLNHKARIVF
HHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEEECHHHHHCCCCEEEEEHHHCCCEEEEEE
DEQSISLVQILRLIESIGYKASAYDASKASKKADLLKREFYSKLVVAIACVMNIMWIAVA
CCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KYAGFFSGMDKDTKDILNFAEFILCSPVLFYTGSHFYKSAFKTLKMHSLNMDVLVISGAS
HHHHHHCCCCCCHHHHHHHHHHHHHCHHHHHCCCHHHHHHHHHHHHHCCCCEEEEECCCH
LAYVYSLWAMFFRVGEVYFDSVAMIVCFVFIGKYLEMFSKKCALDTIDGLNDFLRNEVLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCEEE
FNGKEFTPKEVQKVCLGDRILLKTGDKILIDGVCKSGEMSVDTSSLNGESIPKLIQKEDE
ECCCCCCHHHHHHHHCCCEEEEECCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHH
IFSACIVLDGSVEYEATKLYKDSKLSQIIGLLELASSKKAKLESLVNSLSAYFSRTVLLI
HHEEHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
AFICFAFWFFYKEASFEISLVNAIAVLIIACPCALALATPVSNLVALGRALKKHILFKSS
HHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
SVIEDLSKCDYVVFDKTGILTKIELELKEVFLDKMLDLNEFYNFVKLSKHPISQNIASYL
HHHHHHHHCCEEEEECCCCEEEEHHHHHHHHHHHHHCHHHHHHHHHHCCCCHHHHHHHHH
KQKGAKDLNLDFKKHSSIQAKGLSAELNKGLLLGGSSKFLQEKGIATKEFDNTHFIFAKE
HHCCCCCCCCCHHHCCCCCCCCCCHHCCCCEEECCCHHHHHHCCCCCEECCCCEEEEEEC
GKILAFFEFDSVLREGVKELIAYLKKEKKELMILSGDHQKAVEKIAKKLEIQNYQAFCLP
CCEEEEECHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHCCCEEEECC
EDKMKTIENLSKNYKVLFVGDGVNDALALKYASVSMTLREGSDLAIESSDVLLLKNDLLS
HHHHHHHHHHCCCCEEEEEECCCCCHHHEEEHHEEEEEECCCCCEEECCCEEEEHHHHHH
LKKAIKLSKNTFKIIKQNLAFSLFYNACTIPLAFLGMINPLFAAISMSFSSTIVVLNALR
HHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHH
IKE
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Cu [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O [C]

Specific reaction: ATP + H2O = ADP + Orthophosphate. [C]

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA