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The map label for this gene is copA [H]

Identifier: 153951001

GI number: 153951001

Start: 508843

End: 510942

Strand: Direct

Name: copA [H]

Synonym: JJD26997_0569

Alternate gene names: 153951001

Gene position: 508843-510942 (Clockwise)

Preceding gene: 153952649

Following gene: 153951967

Centisome position: 27.58

GC content: 30.43

Gene sequence:

>2100_bases
ATGGAAGAATTGCGTATAAAAATAGGCAAAATGACTTGCGTTAATTGTTCTAACGCTATAGAAAGAGCTTGTAAGAAAAT
TGATGGTGTTAAAGATGCTAGTGTTTCTTATGTGAATTCTAGTGGGGTTTTTTTACTCGAAGATCAAGAAAAACGCAAAG
ATATCATCGCAAAAATTAAAAATTTAGGCTTTGAAATTTTAGAAGATGAACAAAGCTTGAACGCATACAAGGCAAAAAAA
CATTTAGAATTAAGAAAAAATTTGCTTTTAAGTATAGTTTTGAGTGTGATTATTATGTATTTTGAAATGTTTGTTAAAAG
TTCTTTTTCGCAAAATATTCAAATGGCTTTGAGTTTTTTTGGGATATTTTATTGTGGGAGAGACTTTTTTTCTCATGCTT
TTTTGGGGCTTAAAAGTAAAAATTTAGATATGAATACCCTTGTAGCTTTGGGGACTTTGAGTGCTTTTGTGTATTCTTTT
TTGGTGTATTTGCAAATTTTTAAAGAAGAAGATTTGTATTTTAGCGGTGCAATGATGATTATTTCTTTTGTGCTTTTAGG
AAAATATCTTGAAAGTAAGGCCAAATTTAAAGCACAAGATTATCAAAGAATTTTAGAAAATATAGATACAAAAAAGACAA
AAATTTTACTTGAAGATGAAAGTATTAAAGAAATTTCAAGTTCTTTTGTCAAAAGTGGTGATGTGCTTTTGGTAAAAGAA
GGAGAAAGTATTGTCGCAGATGGAGTGGTGCTTTTAGGGAGTGCAGAGCTTGATATGAGTTTTTTAAATGGGGAGTTTTT
GCCTGTTTTAAAAAAAGAAGGCGATGAAGTTCAAGCAGGAGGAGTAGTTTTAAATGGTGCTTTAAGGATCAAAGCAAATA
AAAAGGCTATAGATAGTACTTTAGAGCAAATTAAAAATCTAGTTTTTGAAGCAGGAAATATCAAAAGTCCTTTGGCAAAT
TTAGCAGATCAAATTTCTAAATACTTTGTAGGTGGTATTATATTTTTTGCTTTTTTAGTTTTTATTTTTTGGGTGGTAAA
AGCGGATTTAAATACAGCTTTTTTACACGCTTGTGCTGCGCTTTTGATCTCTTGTCCTTGTGCTTTAGGGCTTGCAACAC
CTGTAGCTTTGGTTGTGGCAAGTGCAAATGCGGCAAAAAATTTCATTCTTATTAAAAATCCTGCTGCTTTAGAAAAATTA
GCCTTAGTTAAGTATGCTTTTTTTGATAAAACGGGCACATTGACAAAGGAAAATTTGAGTATTTTTAAACACAATCTTTC
TAAAGATGATTTTGATAAATTATGTCAAATTGAAAGTTTAAGCTCTCATCCTATAGCTAAGGCTTTGCATAAAGATCAAA
TTTTTGATTTAAAGGGCGAGGGAAGAGTGATTGTGGGTTCTGGCATAAAATACAAAGAAGATAGTGATATTTATCTCGCA
GGTAGTGCGCAGTTTTTGCACGAAAATGAAATTGACACAAAAGAAAGTGATATCTTTTTTGATACTTTTAAAGAATATAT
TAGGGTGTATTTTGCTAAGAATAAAAAGTGTTTAGGCGGTGTTTTGCTAAGTAATGCTTTAAAAGATGGGGCTAAAGAGC
TTGTGTTAAATTTAAAAAAGCAAAATCTTAAAACTTTTATTTTAAGTGGCGATCATGTAAAAAATGTAGAAAAAATAGTC
AAAGAATTACAAATCGATGAATTTTACGCTCAACTTAAGAGTGAAGAAAAACTACACATCATTCAAAAATTTGAAAAAAC
TCTTTTTGTAGGGGATGGGATCAATGACGCAGCGGCTTTGTCTGCTGCAAGTGTGAGTATGAGTTTTTCAAAGGCAAATG
AACTTGCAAAAAAAACAGGGGATTTTATCTTGATAAAAGATGATTTATCAGCTATTTTTAAATGCTTTAAACTCGCTAAG
AAAACAAGAAGTATTATTAAGTTAAATCTTTTTTGGGCTTTTATTTATAATGTACTTTGCATTCCTGTTGCGGCAGGATT
TATACCTTTTATCACTTTAAGTCCTCATATAGCAGCATTTGCAATGTGTTTTAGTTCTATTACTGTAGTGCTTAATTCTT
TATTAATATTTAAATTTTAA

Upstream 100 bases:

>100_bases
TGGAGAAAAAAATTCTAAGTTTAAATTTAGAAGAGAATCAAGTGTCAAATTTTACAAAAGAATTTCAAGATTTAGGTTTT
GAAATTGTAGAGCGTTTGTG

Downstream 100 bases:

>100_bases
ATATTAATAAAGTTCTAATAATTTCTATGCTATAATACCAACGAAACTACAATAAAGGAGACCCCCCCCCATATGAATTC
AGCTATAGAAAGAATAAAAA

Product: copper-translocating P-type ATPase

Products: ADP; Orthophosphate. [C]

Alternate protein names: NA

Number of amino acids: Translated: 699; Mature: 699

Protein sequence:

>699_residues
MEELRIKIGKMTCVNCSNAIERACKKIDGVKDASVSYVNSSGVFLLEDQEKRKDIIAKIKNLGFEILEDEQSLNAYKAKK
HLELRKNLLLSIVLSVIIMYFEMFVKSSFSQNIQMALSFFGIFYCGRDFFSHAFLGLKSKNLDMNTLVALGTLSAFVYSF
LVYLQIFKEEDLYFSGAMMIISFVLLGKYLESKAKFKAQDYQRILENIDTKKTKILLEDESIKEISSSFVKSGDVLLVKE
GESIVADGVVLLGSAELDMSFLNGEFLPVLKKEGDEVQAGGVVLNGALRIKANKKAIDSTLEQIKNLVFEAGNIKSPLAN
LADQISKYFVGGIIFFAFLVFIFWVVKADLNTAFLHACAALLISCPCALGLATPVALVVASANAAKNFILIKNPAALEKL
ALVKYAFFDKTGTLTKENLSIFKHNLSKDDFDKLCQIESLSSHPIAKALHKDQIFDLKGEGRVIVGSGIKYKEDSDIYLA
GSAQFLHENEIDTKESDIFFDTFKEYIRVYFAKNKKCLGGVLLSNALKDGAKELVLNLKKQNLKTFILSGDHVKNVEKIV
KELQIDEFYAQLKSEEKLHIIQKFEKTLFVGDGINDAAALSAASVSMSFSKANELAKKTGDFILIKDDLSAIFKCFKLAK
KTRSIIKLNLFWAFIYNVLCIPVAAGFIPFITLSPHIAAFAMCFSSITVVLNSLLIFKF

Sequences:

>Translated_699_residues
MEELRIKIGKMTCVNCSNAIERACKKIDGVKDASVSYVNSSGVFLLEDQEKRKDIIAKIKNLGFEILEDEQSLNAYKAKK
HLELRKNLLLSIVLSVIIMYFEMFVKSSFSQNIQMALSFFGIFYCGRDFFSHAFLGLKSKNLDMNTLVALGTLSAFVYSF
LVYLQIFKEEDLYFSGAMMIISFVLLGKYLESKAKFKAQDYQRILENIDTKKTKILLEDESIKEISSSFVKSGDVLLVKE
GESIVADGVVLLGSAELDMSFLNGEFLPVLKKEGDEVQAGGVVLNGALRIKANKKAIDSTLEQIKNLVFEAGNIKSPLAN
LADQISKYFVGGIIFFAFLVFIFWVVKADLNTAFLHACAALLISCPCALGLATPVALVVASANAAKNFILIKNPAALEKL
ALVKYAFFDKTGTLTKENLSIFKHNLSKDDFDKLCQIESLSSHPIAKALHKDQIFDLKGEGRVIVGSGIKYKEDSDIYLA
GSAQFLHENEIDTKESDIFFDTFKEYIRVYFAKNKKCLGGVLLSNALKDGAKELVLNLKKQNLKTFILSGDHVKNVEKIV
KELQIDEFYAQLKSEEKLHIIQKFEKTLFVGDGINDAAALSAASVSMSFSKANELAKKTGDFILIKDDLSAIFKCFKLAK
KTRSIIKLNLFWAFIYNVLCIPVAAGFIPFITLSPHIAAFAMCFSSITVVLNSLLIFKF
>Mature_699_residues
MEELRIKIGKMTCVNCSNAIERACKKIDGVKDASVSYVNSSGVFLLEDQEKRKDIIAKIKNLGFEILEDEQSLNAYKAKK
HLELRKNLLLSIVLSVIIMYFEMFVKSSFSQNIQMALSFFGIFYCGRDFFSHAFLGLKSKNLDMNTLVALGTLSAFVYSF
LVYLQIFKEEDLYFSGAMMIISFVLLGKYLESKAKFKAQDYQRILENIDTKKTKILLEDESIKEISSSFVKSGDVLLVKE
GESIVADGVVLLGSAELDMSFLNGEFLPVLKKEGDEVQAGGVVLNGALRIKANKKAIDSTLEQIKNLVFEAGNIKSPLAN
LADQISKYFVGGIIFFAFLVFIFWVVKADLNTAFLHACAALLISCPCALGLATPVALVVASANAAKNFILIKNPAALEKL
ALVKYAFFDKTGTLTKENLSIFKHNLSKDDFDKLCQIESLSSHPIAKALHKDQIFDLKGEGRVIVGSGIKYKEDSDIYLA
GSAQFLHENEIDTKESDIFFDTFKEYIRVYFAKNKKCLGGVLLSNALKDGAKELVLNLKKQNLKTFILSGDHVKNVEKIV
KELQIDEFYAQLKSEEKLHIIQKFEKTLFVGDGINDAAALSAASVSMSFSKANELAKKTGDFILIKDDLSAIFKCFKLAK
KTRSIIKLNLFWAFIYNVLCIPVAAGFIPFITLSPHIAAFAMCFSSITVVLNSLLIFKF

Specific function: Probably involved in copper and silver export [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 HMA domains [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=787, Percent_Identity=27.5730622617535, Blast_Score=271, Evalue=1e-72,
Organism=Homo sapiens, GI115529486, Length=826, Percent_Identity=27.1186440677966, Blast_Score=256, Evalue=5e-68,
Organism=Homo sapiens, GI55743073, Length=529, Percent_Identity=29.4896030245747, Blast_Score=189, Evalue=7e-48,
Organism=Escherichia coli, GI1786691, Length=730, Percent_Identity=28.7671232876712, Blast_Score=283, Evalue=3e-77,
Organism=Escherichia coli, GI1789879, Length=671, Percent_Identity=26.9746646795827, Blast_Score=188, Evalue=9e-49,
Organism=Escherichia coli, GI1786914, Length=493, Percent_Identity=22.3123732251521, Blast_Score=95, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17556548, Length=791, Percent_Identity=27.5600505689001, Blast_Score=239, Evalue=5e-63,
Organism=Saccharomyces cerevisiae, GI6320475, Length=688, Percent_Identity=28.6337209302326, Blast_Score=221, Evalue=2e-58,
Organism=Saccharomyces cerevisiae, GI6319772, Length=679, Percent_Identity=25.920471281296, Blast_Score=204, Evalue=5e-53,
Organism=Saccharomyces cerevisiae, GI6321430, Length=511, Percent_Identity=20.9393346379648, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6325221, Length=517, Percent_Identity=20.1160541586073, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI221329854, Length=518, Percent_Identity=31.0810810810811, Blast_Score=191, Evalue=2e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR006403
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR006122
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: 3.6.3.4 [C]

Molecular weight: Translated: 77792; Mature: 77792

Theoretical pI: Translated: 8.59; Mature: 8.59

Prosite motif: PS00154 ATPASE_E1_E2 ; PS50846 HMA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEELRIKIGKMTCVNCSNAIERACKKIDGVKDASVSYVNSSGVFLLEDQEKRKDIIAKIK
CCCCEEEECCEEEECHHHHHHHHHHHHCCCCCCCEEEECCCCEEEECCCHHHHHHHHHHH
NLGFEILEDEQSLNAYKAKKHLELRKNLLLSIVLSVIIMYFEMFVKSSFSQNIQMALSFF
HCCHHEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GIFYCGRDFFSHAFLGLKSKNLDMNTLVALGTLSAFVYSFLVYLQIFKEEDLYFSGAMMI
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHH
ISFVLLGKYLESKAKFKAQDYQRILENIDTKKTKILLEDESIKEISSSFVKSGDVLLVKE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHCCCCEEEEEC
GESIVADGVVLLGSAELDMSFLNGEFLPVLKKEGDEVQAGGVVLNGALRIKANKKAIDST
CCCEEECCEEEEECCCCCHHHHCCCEEEHHHCCCCCEEECCEEEECEEEEECCHHHHHHH
LEQIKNLVFEAGNIKSPLANLADQISKYFVGGIIFFAFLVFIFWVVKADLNTAFLHACAA
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
LLISCPCALGLATPVALVVASANAAKNFILIKNPAALEKLALVKYAFFDKTGTLTKENLS
HHHHCHHHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCHHHHH
IFKHNLSKDDFDKLCQIESLSSHPIAKALHKDQIFDLKGEGRVIVGSGIKYKEDSDIYLA
HHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHCCEEEECCCCEEEEECCCCCCCCCCEEEE
GSAQFLHENEIDTKESDIFFDTFKEYIRVYFAKNKKCLGGVLLSNALKDGAKELVLNLKK
CCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
QNLKTFILSGDHVKNVEKIVKELQIDEFYAQLKSEEKLHIIQKFEKTLFVGDGINDAAAL
CCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHEEECCCCCHHHHH
SAASVSMSFSKANELAKKTGDFILIKDDLSAIFKCFKLAKKTRSIIKLNLFWAFIYNVLC
HHHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IPVAAGFIPFITLSPHIAAFAMCFSSITVVLNSLLIFKF
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEELRIKIGKMTCVNCSNAIERACKKIDGVKDASVSYVNSSGVFLLEDQEKRKDIIAKIK
CCCCEEEECCEEEECHHHHHHHHHHHHCCCCCCCEEEECCCCEEEECCCHHHHHHHHHHH
NLGFEILEDEQSLNAYKAKKHLELRKNLLLSIVLSVIIMYFEMFVKSSFSQNIQMALSFF
HCCHHEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GIFYCGRDFFSHAFLGLKSKNLDMNTLVALGTLSAFVYSFLVYLQIFKEEDLYFSGAMMI
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHH
ISFVLLGKYLESKAKFKAQDYQRILENIDTKKTKILLEDESIKEISSSFVKSGDVLLVKE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHCCCCEEEEEC
GESIVADGVVLLGSAELDMSFLNGEFLPVLKKEGDEVQAGGVVLNGALRIKANKKAIDST
CCCEEECCEEEEECCCCCHHHHCCCEEEHHHCCCCCEEECCEEEECEEEEECCHHHHHHH
LEQIKNLVFEAGNIKSPLANLADQISKYFVGGIIFFAFLVFIFWVVKADLNTAFLHACAA
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
LLISCPCALGLATPVALVVASANAAKNFILIKNPAALEKLALVKYAFFDKTGTLTKENLS
HHHHCHHHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCHHHHH
IFKHNLSKDDFDKLCQIESLSSHPIAKALHKDQIFDLKGEGRVIVGSGIKYKEDSDIYLA
HHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHCCEEEECCCCEEEEECCCCCCCCCCEEEE
GSAQFLHENEIDTKESDIFFDTFKEYIRVYFAKNKKCLGGVLLSNALKDGAKELVLNLKK
CCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
QNLKTFILSGDHVKNVEKIVKELQIDEFYAQLKSEEKLHIIQKFEKTLFVGDGINDAAAL
CCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHEEECCCCCHHHHH
SAASVSMSFSKANELAKKTGDFILIKDDLSAIFKCFKLAKKTRSIIKLNLFWAFIYNVLC
HHHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IPVAAGFIPFITLSPHIAAFAMCFSSITVVLNSLLIFKF
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Cu [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O [C]

Specific reaction: ATP + H2O = ADP + Orthophosphate. [C]

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]