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The map label for this gene is waaD [H]

Identifier: 153951617

GI number: 153951617

Start: 519435

End: 520388

Strand: Direct

Name: waaD [H]

Synonym: JJD26997_0577

Alternate gene names: 153951617

Gene position: 519435-520388 (Clockwise)

Preceding gene: 153951278

Following gene: 153952428

Centisome position: 28.15

GC content: 30.92

Gene sequence:

>954_bases
ATGAAAATAGCAATCACAGGTGGTGCAGGATTTATAGGTTCGCAACTGGCTTTAAATTTGCAAGAAAAACATGAAATTTT
AATCATCGATAAAATGCGTAGTAGTGCGACTTTTGAAAATGGAAATTTACAAAGTTTTGGGCATTTTAAAAATTTACTTG
AATTTGACGGAGAGCTTTTTGCAGGCGATATTAATGATGAAAAAGTTTTAAAAAAGATTGAAGATTTTAAGCCAGAGATT
ATTTTTCATCAAGCAGCAATTTCAGACACTACGGTTTTTGATCAAACTAAGGTTTTACAAACCAATTTAAATACTTTTAA
AGATTTTATAGAACTTAGCATAGATCTTAATGCAAAGCTTATTTATGCAAGTTCAGCTTCGGTTTATGGTGATGCAAAAA
GTCCACAAACCGTAGATAAAGATGAAGAACCAAAAAATCCTTATGCTTTTTCAAAATTGATGATGGACAAGTTAGTGAAA
AAATACTATGATAAAGCCCATTTGGTAGGACTTAGATATTTTAATGTTTATGGAAAAGGTGAATTTTATAAAAACAAAAC
CGCTTCTATGGTTTTACAATTTGGCCATCAAATTTTAGCGGGAAAAAATCCATGCTTGTTTGAAGGAAGTGATCAAATTT
ATAGAGATTTTACTTATATTAAAGATGTTATTAGTGCCAATTTAGTCGCCCTTGATTCAAAATGTGGGGTTTATAATGTA
GGCAGCGGTAAAGCAAGGACTTTTCAAGATATAGTTGATATTTTACAAAAAGAGTTAAAGACTGATTTGCCTTGTGAATA
TATCCCAAATCCTTATGTAAAATCTTATCAATTCCACACTGAAGCAAAACTAGATCAAACTTGGGATTATCAGCCAAAAT
TTAGTCTTGAAGAGGGGATAAAAGATTATTTAGGCGAGATAAAAAGACTTTTCGAAAAGGAAGTAAATGCTTGA

Upstream 100 bases:

>100_bases
CACTTTGATTTTAGTAAATGAAGAAAAAAAAGGCAATTTTTTTAAGCAATTTAAAAATTTAAAAGAAATTTTGCGCTTTC
TTAAAGAAAAGGACATTTAA

Downstream 100 bases:

>100_bases
GTTTTTAAGCCAGCAAAAACCTAAAATTTTAATTATAGGGGATTTTATGGTGGATAATTACACTTGGTGTGATTGTTCGC
GTATCAGTCCTGAAGCCCCT

Product: ADP-L-glycero-D-mannoheptose-6-epimerase

Products: NA

Alternate protein names: ADP-L-glycero-beta-D-manno-heptose-6-epimerase; ADP-glyceromanno-heptose 6-epimerase; ADP-hep 6-epimerase; AGME [H]

Number of amino acids: Translated: 317; Mature: 317

Protein sequence:

>317_residues
MKIAITGGAGFIGSQLALNLQEKHEILIIDKMRSSATFENGNLQSFGHFKNLLEFDGELFAGDINDEKVLKKIEDFKPEI
IFHQAAISDTTVFDQTKVLQTNLNTFKDFIELSIDLNAKLIYASSASVYGDAKSPQTVDKDEEPKNPYAFSKLMMDKLVK
KYYDKAHLVGLRYFNVYGKGEFYKNKTASMVLQFGHQILAGKNPCLFEGSDQIYRDFTYIKDVISANLVALDSKCGVYNV
GSGKARTFQDIVDILQKELKTDLPCEYIPNPYVKSYQFHTEAKLDQTWDYQPKFSLEEGIKDYLGEIKRLFEKEVNA

Sequences:

>Translated_317_residues
MKIAITGGAGFIGSQLALNLQEKHEILIIDKMRSSATFENGNLQSFGHFKNLLEFDGELFAGDINDEKVLKKIEDFKPEI
IFHQAAISDTTVFDQTKVLQTNLNTFKDFIELSIDLNAKLIYASSASVYGDAKSPQTVDKDEEPKNPYAFSKLMMDKLVK
KYYDKAHLVGLRYFNVYGKGEFYKNKTASMVLQFGHQILAGKNPCLFEGSDQIYRDFTYIKDVISANLVALDSKCGVYNV
GSGKARTFQDIVDILQKELKTDLPCEYIPNPYVKSYQFHTEAKLDQTWDYQPKFSLEEGIKDYLGEIKRLFEKEVNA
>Mature_317_residues
MKIAITGGAGFIGSQLALNLQEKHEILIIDKMRSSATFENGNLQSFGHFKNLLEFDGELFAGDINDEKVLKKIEDFKPEI
IFHQAAISDTTVFDQTKVLQTNLNTFKDFIELSIDLNAKLIYASSASVYGDAKSPQTVDKDEEPKNPYAFSKLMMDKLVK
KYYDKAHLVGLRYFNVYGKGEFYKNKTASMVLQFGHQILAGKNPCLFEGSDQIYRDFTYIKDVISANLVALDSKCGVYNV
GSGKARTFQDIVDILQKELKTDLPCEYIPNPYVKSYQFHTEAKLDQTWDYQPKFSLEEGIKDYLGEIKRLFEKEVNA

Specific function: Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose [H]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family. HldD subfamily [H]

Homologues:

Organism=Homo sapiens, GI7657641, Length=325, Percent_Identity=25.8461538461538, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI1790049, Length=319, Percent_Identity=33.2288401253918, Blast_Score=151, Evalue=5e-38,
Organism=Escherichia coli, GI1786974, Length=331, Percent_Identity=24.4712990936556, Blast_Score=75, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI71982035, Length=334, Percent_Identity=26.9461077844311, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71982038, Length=336, Percent_Identity=27.3809523809524, Blast_Score=92, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6319493, Length=297, Percent_Identity=24.9158249158249, Blast_Score=72, Evalue=9e-14,
Organism=Drosophila melanogaster, GI19923002, Length=290, Percent_Identity=25.8620689655172, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: 220 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR011912
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.20 [H]

Molecular weight: Translated: 36057; Mature: 36057

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIAITGGAGFIGSQLALNLQEKHEILIIDKMRSSATFENGNLQSFGHFKNLLEFDGELF
CEEEEECCCCCCCHHHEEEECCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCEE
AGDINDEKVLKKIEDFKPEIIFHQAAISDTTVFDQTKVLQTNLNTFKDFIELSIDLNAKL
ECCCCHHHHHHHHHHCCCCEEEEHHHCCCCHHHHHHHHHHHHHHHHHHHHHEEECCCEEE
IYASSASVYGDAKSPQTVDKDEEPKNPYAFSKLMMDKLVKKYYDKAHLVGLRYFNVYGKG
EEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCHHHEEEEEEEEEECCC
EFYKNKTASMVLQFGHQILAGKNPCLFEGSDQIYRDFTYIKDVISANLVALDSKCGVYNV
CHHCCHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHCCEEEEECCCCEEEC
GSGKARTFQDIVDILQKELKTDLPCEYIPNPYVKSYQFHTEAKLDQTWDYQPKFSLEEGI
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHCEEECCCCCCCCCCCCCCCCCHHHHH
KDYLGEIKRLFEKEVNA
HHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKIAITGGAGFIGSQLALNLQEKHEILIIDKMRSSATFENGNLQSFGHFKNLLEFDGELF
CEEEEECCCCCCCHHHEEEECCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCEE
AGDINDEKVLKKIEDFKPEIIFHQAAISDTTVFDQTKVLQTNLNTFKDFIELSIDLNAKL
ECCCCHHHHHHHHHHCCCCEEEEHHHCCCCHHHHHHHHHHHHHHHHHHHHHEEECCCEEE
IYASSASVYGDAKSPQTVDKDEEPKNPYAFSKLMMDKLVKKYYDKAHLVGLRYFNVYGKG
EEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCHHHEEEEEEEEEECCC
EFYKNKTASMVLQFGHQILAGKNPCLFEGSDQIYRDFTYIKDVISANLVALDSKCGVYNV
CHHCCHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHCCEEEEECCCCEEEC
GSGKARTFQDIVDILQKELKTDLPCEYIPNPYVKSYQFHTEAKLDQTWDYQPKFSLEEGI
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHCEEECCCCCCCCCCCCCCCCCHHHHH
KDYLGEIKRLFEKEVNA
HHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA