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The map label for this gene is leuS [H]

Identifier: 153951097

GI number: 153951097

Start: 573386

End: 575815

Strand: Direct

Name: leuS [H]

Synonym: JJD26997_0632

Alternate gene names: 153951097

Gene position: 573386-575815 (Clockwise)

Preceding gene: 153951817

Following gene: 153951565

Centisome position: 31.08

GC content: 31.11

Gene sequence:

>2430_bases
ATGGCTTATGAAGCAAGTTTAATAGAAAAAAAATGGCAAAAAATTTGGGATGAAAATGAATATTTTGAGCCAAAAGATGA
TTTAAATTTGCCTAAAAAATATATTTTATCGATGTTTCCTTATCCTAGCGGACGCATTCACATGGGGCATGTAAGAAATT
ATACTATAGGCGATGCTTTAGCAAGATATTATCGCAAGATAGGATTTAATGTTTTACATCCTATAGGTTTTGATAGTTTT
GGTATGCCTGCTGAAAATGCAGCTATTAAGCATAAAATTCATCCTAAGTCATGGACTTATGAAAATATAGCTTATATGAA
AAAAGAACTTTTTTCTTTAGGTTTTTCTTTTTCTAAAAAAAGAATGCTTGCTACTTCAGATCCACTTTATACAAAATTTG
AGCAAGAAATTTTTATTAAGATGTTTGAAAAAGGTTTGATTTACACTAAAGAAGCAAATGTAAATTGGTGTGAACAAGAT
CAAACGGTTTTGGCTAATGAGCAAGTTGAAGACGGAAAATGTTGGCGTTGTGGTCATGAAGTGGTGCAGAAAAAAATGCC
AGGTTATTATGTAAAAATCACTGCTTATGCTGAGAAACTTTTAAAAGATTTAGAAGGGTTGAGGGATAAATGGCCTAATC
AAGTTTTAACTATGCAAGAAAATTGGATAGGTAAAAGCGAAGGTTTGGCATTTTCTTTAAATTTAGACGAGAAAAGCAAG
CAAAAAGCCAAAGAAAGTTCTTTAGAAGTTTTTACTACAAGAGCAGATACAATTTATGGAGTTTCGTATGTCGCTTTAGC
CCCAGAACATAAAATCGTTCAAAATTTGCTTTTACAAAATTTATTAAATCAAGATGTATTAAATAAAATCAAAGCTATTC
AAAATCAAAGTCCAAGAGAAAGACAAAGTTCTGAAAAAGAAGGTTATTTTTTAGGAATTTATGCCATTCATCCTTTAAGT
GGAGAAAAAATTCCTTTGTGGGTGGCTAATTTTGTTTTATCTGATTATGGTAGCGGAGCGGTTATGGCTGTTCCAGCTCA
TGATGAAAGAGATTTTGAATTTGCAAAAAAATACAATCTTGCCATCAAACAAGTCATTCAAACACAAGAAAATTTGCCTT
ATACGCAAAAATTAGGAAAATTAATTCATAGTCAAGAATTTGATAATCTTGATTGTAATGAAGCAAGATTAAAAATCATT
TCTCAGTTTGAAGCTAAGAATATTGGAAAAAGGGTTGTAAATTTTAAAATTCGTGATTGGGGTGTTTCACGCCAAAGATA
TTGGGGTGCGCCTATTCCTATGATTAAATGTCAAAGTTGTGGTATAGCACCTCAAAAACTAGAAAATTTACCTATTACCT
TACCTGAAGATGTACAAATTACAGGTGAGGGTAATCCACTCGATAAACATCCAACTTGGAAAAATTGTATCTGTCCAAAA
TGTGGCAAAGAGGCTCAAAAAGAAAGTGATACTTTAGATACTTTTTTTGAAAGTTCTTGGTATTTTGCACGTTTTGCAAG
TGATGAGAAAACTTGGCAGGAAAAAGCTTTAGATGAAAAAAGTGTGAAGTATTGGATGAGTGTGGATCAATATATAGGTG
GTATTGAACATGCAATCTTACATTTACTTTATGCGAGATTTTTCCAAAAAGCTTTAAGAGACTTGGGTTATTTAACACAA
AATGAACCTTTTGATAGACTTTTAACTCAGGGTATGGTGTTAAAAGATGGTGCTAAAATGTCAAAATCAAAAGGCAATGT
TGTGGATCCTGATGAGATTATAGAAAAATATGGTGCTGATACTGCAAGACTTTTTATGCTTTTTGCTGCACCTCCAGCTA
AAGAACTTGAATGGAATGATGATGCGGTTGAAGGGGCTTATAGATTTATTTGTAAACTCTATGATAGGGCGCAAAATATT
AAAAAAGGTGAGCTTGTAGAATTAAAACAAGAAAATTTAAATAAAGAAGAAAAATATGCAAGATTAAAGGTATATGAAGC
TTTGAAAAAATCCGAAGAAGTTTATCATCAGAGTTTTGCTTTTAACACTTTAATTGCAGCTTGTATGGAAGCTTTAAATG
CTTTAGCTCTTTGTAAAAATGAGGCTTTAGAACAAGAGGCTTTTTATATTATTTTAAATATCTTAGAGCCTATTATTCCT
CATGTTTGTTTTGAGCTTAGCGAGGAGCTTTTTAAATGTAAAAATTTCAAAAAATTAGAACTTAAAGAAGAGGTTTTTGT
AAAAGATACTTTAAATTTAGCTGTAAGTATTAATGGTAAAAAAAGGGCTGAATTTAAAATTTCAAGTAGTGCGAGTAAAG
AAGAAATTTTAGCTTTTGCAAAAGAAAATACTGCTAAATGGCTTGAAGGTAAAAGCATAGTTAAAGAAATTTATGTGGAA
GGAAAGCTAGTTAATCTAGTGATTAAATGA

Upstream 100 bases:

>100_bases
GCTTGAGTTTAGAAATAAAGAAATTGAAAAAGCAAAAAGAAAACAAGATCAAGAACGCAATCGTGCAATGTATGAAAAAG
GAACAGTGTAAGGAGAATTT

Downstream 100 bases:

>100_bases
AAAAGATTTTAATTTTTTGTATAGGTTTATTTTTAGGTGCTTGTGGGTATGTTCCTACATCAAAAATCGCTAATAATATT
TTCGATGAGAAAGTTTATGT

Product: leucyl-tRNA synthetase

Products: NA

Alternate protein names: Leucine--tRNA ligase; LeuRS [H]

Number of amino acids: Translated: 809; Mature: 808

Protein sequence:

>809_residues
MAYEASLIEKKWQKIWDENEYFEPKDDLNLPKKYILSMFPYPSGRIHMGHVRNYTIGDALARYYRKIGFNVLHPIGFDSF
GMPAENAAIKHKIHPKSWTYENIAYMKKELFSLGFSFSKKRMLATSDPLYTKFEQEIFIKMFEKGLIYTKEANVNWCEQD
QTVLANEQVEDGKCWRCGHEVVQKKMPGYYVKITAYAEKLLKDLEGLRDKWPNQVLTMQENWIGKSEGLAFSLNLDEKSK
QKAKESSLEVFTTRADTIYGVSYVALAPEHKIVQNLLLQNLLNQDVLNKIKAIQNQSPRERQSSEKEGYFLGIYAIHPLS
GEKIPLWVANFVLSDYGSGAVMAVPAHDERDFEFAKKYNLAIKQVIQTQENLPYTQKLGKLIHSQEFDNLDCNEARLKII
SQFEAKNIGKRVVNFKIRDWGVSRQRYWGAPIPMIKCQSCGIAPQKLENLPITLPEDVQITGEGNPLDKHPTWKNCICPK
CGKEAQKESDTLDTFFESSWYFARFASDEKTWQEKALDEKSVKYWMSVDQYIGGIEHAILHLLYARFFQKALRDLGYLTQ
NEPFDRLLTQGMVLKDGAKMSKSKGNVVDPDEIIEKYGADTARLFMLFAAPPAKELEWNDDAVEGAYRFICKLYDRAQNI
KKGELVELKQENLNKEEKYARLKVYEALKKSEEVYHQSFAFNTLIAACMEALNALALCKNEALEQEAFYIILNILEPIIP
HVCFELSEELFKCKNFKKLELKEEVFVKDTLNLAVSINGKKRAEFKISSSASKEEILAFAKENTAKWLEGKSIVKEIYVE
GKLVNLVIK

Sequences:

>Translated_809_residues
MAYEASLIEKKWQKIWDENEYFEPKDDLNLPKKYILSMFPYPSGRIHMGHVRNYTIGDALARYYRKIGFNVLHPIGFDSF
GMPAENAAIKHKIHPKSWTYENIAYMKKELFSLGFSFSKKRMLATSDPLYTKFEQEIFIKMFEKGLIYTKEANVNWCEQD
QTVLANEQVEDGKCWRCGHEVVQKKMPGYYVKITAYAEKLLKDLEGLRDKWPNQVLTMQENWIGKSEGLAFSLNLDEKSK
QKAKESSLEVFTTRADTIYGVSYVALAPEHKIVQNLLLQNLLNQDVLNKIKAIQNQSPRERQSSEKEGYFLGIYAIHPLS
GEKIPLWVANFVLSDYGSGAVMAVPAHDERDFEFAKKYNLAIKQVIQTQENLPYTQKLGKLIHSQEFDNLDCNEARLKII
SQFEAKNIGKRVVNFKIRDWGVSRQRYWGAPIPMIKCQSCGIAPQKLENLPITLPEDVQITGEGNPLDKHPTWKNCICPK
CGKEAQKESDTLDTFFESSWYFARFASDEKTWQEKALDEKSVKYWMSVDQYIGGIEHAILHLLYARFFQKALRDLGYLTQ
NEPFDRLLTQGMVLKDGAKMSKSKGNVVDPDEIIEKYGADTARLFMLFAAPPAKELEWNDDAVEGAYRFICKLYDRAQNI
KKGELVELKQENLNKEEKYARLKVYEALKKSEEVYHQSFAFNTLIAACMEALNALALCKNEALEQEAFYIILNILEPIIP
HVCFELSEELFKCKNFKKLELKEEVFVKDTLNLAVSINGKKRAEFKISSSASKEEILAFAKENTAKWLEGKSIVKEIYVE
GKLVNLVIK
>Mature_808_residues
AYEASLIEKKWQKIWDENEYFEPKDDLNLPKKYILSMFPYPSGRIHMGHVRNYTIGDALARYYRKIGFNVLHPIGFDSFG
MPAENAAIKHKIHPKSWTYENIAYMKKELFSLGFSFSKKRMLATSDPLYTKFEQEIFIKMFEKGLIYTKEANVNWCEQDQ
TVLANEQVEDGKCWRCGHEVVQKKMPGYYVKITAYAEKLLKDLEGLRDKWPNQVLTMQENWIGKSEGLAFSLNLDEKSKQ
KAKESSLEVFTTRADTIYGVSYVALAPEHKIVQNLLLQNLLNQDVLNKIKAIQNQSPRERQSSEKEGYFLGIYAIHPLSG
EKIPLWVANFVLSDYGSGAVMAVPAHDERDFEFAKKYNLAIKQVIQTQENLPYTQKLGKLIHSQEFDNLDCNEARLKIIS
QFEAKNIGKRVVNFKIRDWGVSRQRYWGAPIPMIKCQSCGIAPQKLENLPITLPEDVQITGEGNPLDKHPTWKNCICPKC
GKEAQKESDTLDTFFESSWYFARFASDEKTWQEKALDEKSVKYWMSVDQYIGGIEHAILHLLYARFFQKALRDLGYLTQN
EPFDRLLTQGMVLKDGAKMSKSKGNVVDPDEIIEKYGADTARLFMLFAAPPAKELEWNDDAVEGAYRFICKLYDRAQNIK
KGELVELKQENLNKEEKYARLKVYEALKKSEEVYHQSFAFNTLIAACMEALNALALCKNEALEQEAFYIILNILEPIIPH
VCFELSEELFKCKNFKKLELKEEVFVKDTLNLAVSINGKKRAEFKISSSASKEEILAFAKENTAKWLEGKSIVKEIYVEG
KLVNLVIK

Specific function: Unknown

COG id: COG0495

COG function: function code J; Leucyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI7661872, Length=879, Percent_Identity=32.7645051194539, Blast_Score=462, Evalue=1e-130,
Organism=Homo sapiens, GI94721239, Length=261, Percent_Identity=30.2681992337165, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI94721241, Length=261, Percent_Identity=30.2681992337165, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI1786861, Length=868, Percent_Identity=43.2027649769585, Blast_Score=708, Evalue=0.0,
Organism=Escherichia coli, GI1790708, Length=227, Percent_Identity=26.431718061674, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71997510, Length=694, Percent_Identity=31.5561959654179, Blast_Score=300, Evalue=3e-81,
Organism=Caenorhabditis elegans, GI71997517, Length=694, Percent_Identity=31.5561959654179, Blast_Score=299, Evalue=4e-81,
Organism=Caenorhabditis elegans, GI212645227, Length=216, Percent_Identity=33.7962962962963, Blast_Score=100, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6323414, Length=782, Percent_Identity=38.2352941176471, Blast_Score=482, Evalue=1e-136,
Organism=Saccharomyces cerevisiae, GI6321531, Length=692, Percent_Identity=22.5433526011561, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI21355409, Length=864, Percent_Identity=31.25, Blast_Score=380, Evalue=1e-105,
Organism=Drosophila melanogaster, GI17864482, Length=440, Percent_Identity=22.0454545454545, Blast_Score=101, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24653289, Length=440, Percent_Identity=22.0454545454545, Blast_Score=101, Evalue=2e-21,

Paralogues:

None

Copy number: 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001412
- InterPro:   IPR002300
- InterPro:   IPR002302
- InterPro:   IPR014729
- InterPro:   IPR009080
- InterPro:   IPR009008 [H]

Pfam domain/function: PF00133 tRNA-synt_1 [H]

EC number: =6.1.1.4 [H]

Molecular weight: Translated: 93269; Mature: 93138

Theoretical pI: Translated: 7.65; Mature: 7.65

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYEASLIEKKWQKIWDENEYFEPKDDLNLPKKYILSMFPYPSGRIHMGHVRNYTIGDAL
CCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCEEECCCCCCCHHHHH
ARYYRKIGFNVLHPIGFDSFGMPAENAAIKHKIHPKSWTYENIAYMKKELFSLGFSFSKK
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHCCCCCCC
RMLATSDPLYTKFEQEIFIKMFEKGLIYTKEANVNWCEQDQTVLANEQVEDGKCWRCGHE
CEEECCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCEECCCCCCCCCCHHHHHHH
VVQKKMPGYYVKITAYAEKLLKDLEGLRDKWPNQVLTMQENWIGKSEGLAFSLNLDEKSK
HHHHCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCEEEEHHHCCCCCCCEEEEECCCHHHH
QKAKESSLEVFTTRADTIYGVSYVALAPEHKIVQNLLLQNLLNQDVLNKIKAIQNQSPRE
HHHHHCCCEEEEECCCCEECCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
RQSSEKEGYFLGIYAIHPLSGEKIPLWVANFVLSDYGSGAVMAVPAHDERDFEFAKKYNL
HHCCCCCCEEEEEEEEECCCCCCCHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHH
AIKQVIQTQENLPYTQKLGKLIHSQEFDNLDCNEARLKIISQFEAKNIGKRVVNFKIRDW
HHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEECC
GVSRQRYWGAPIPMIKCQSCGIAPQKLENLPITLPEDVQITGEGNPLDKHPTWKNCICPK
CCCCHHCCCCCCCCEEECCCCCCHHHHCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCC
CGKEAQKESDTLDTFFESSWYFARFASDEKTWQEKALDEKSVKYWMSVDQYIGGIEHAIL
CCCHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
HLLYARFFQKALRDLGYLTQNEPFDRLLTQGMVLKDGAKMSKSKGNVVDPDEIIEKYGAD
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCEEECCCHHCCCCCCCCCHHHHHHHHCCC
TARLFMLFAAPPAKELEWNDDAVEGAYRFICKLYDRAQNIKKGELVELKQENLNKEEKYA
HHHEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCHHHHHH
RLKVYEALKKSEEVYHQSFAFNTLIAACMEALNALALCKNEALEQEAFYIILNILEPIIP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HVCFELSEELFKCKNFKKLELKEEVFVKDTLNLAVSINGKKRAEFKISSSASKEEILAFA
HHHHHHHHHHHHHCCCCCCCHHHHHHHEEEEEEEEEECCCCCEEEEECCCCCHHHHHHHH
KENTAKWLEGKSIVKEIYVEGKLVNLVIK
HHCHHHHHHHHHHHHHHHHCCEEEEEEEC
>Mature Secondary Structure 
AYEASLIEKKWQKIWDENEYFEPKDDLNLPKKYILSMFPYPSGRIHMGHVRNYTIGDAL
CCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCEEECCCCCCCHHHHH
ARYYRKIGFNVLHPIGFDSFGMPAENAAIKHKIHPKSWTYENIAYMKKELFSLGFSFSKK
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHCCCCCCC
RMLATSDPLYTKFEQEIFIKMFEKGLIYTKEANVNWCEQDQTVLANEQVEDGKCWRCGHE
CEEECCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCEECCCCCCCCCCHHHHHHH
VVQKKMPGYYVKITAYAEKLLKDLEGLRDKWPNQVLTMQENWIGKSEGLAFSLNLDEKSK
HHHHCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCEEEEHHHCCCCCCCEEEEECCCHHHH
QKAKESSLEVFTTRADTIYGVSYVALAPEHKIVQNLLLQNLLNQDVLNKIKAIQNQSPRE
HHHHHCCCEEEEECCCCEECCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
RQSSEKEGYFLGIYAIHPLSGEKIPLWVANFVLSDYGSGAVMAVPAHDERDFEFAKKYNL
HHCCCCCCEEEEEEEEECCCCCCCHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHH
AIKQVIQTQENLPYTQKLGKLIHSQEFDNLDCNEARLKIISQFEAKNIGKRVVNFKIRDW
HHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEECC
GVSRQRYWGAPIPMIKCQSCGIAPQKLENLPITLPEDVQITGEGNPLDKHPTWKNCICPK
CCCCHHCCCCCCCCEEECCCCCCHHHHCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCC
CGKEAQKESDTLDTFFESSWYFARFASDEKTWQEKALDEKSVKYWMSVDQYIGGIEHAIL
CCCHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
HLLYARFFQKALRDLGYLTQNEPFDRLLTQGMVLKDGAKMSKSKGNVVDPDEIIEKYGAD
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCEEECCCHHCCCCCCCCCHHHHHHHHCCC
TARLFMLFAAPPAKELEWNDDAVEGAYRFICKLYDRAQNIKKGELVELKQENLNKEEKYA
HHHEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCHHHHHH
RLKVYEALKKSEEVYHQSFAFNTLIAACMEALNALALCKNEALEQEAFYIILNILEPIIP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HVCFELSEELFKCKNFKKLELKEEVFVKDTLNLAVSINGKKRAEFKISSSASKEEILAFA
HHHHHHHHHHHHHCCCCCCCHHHHHHHEEEEEEEEEECCCCCEEEEECCCCCHHHHHHHH
KENTAKWLEGKSIVKEIYVEGKLVNLVIK
HHCHHHHHHHHHHHHHHHHCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA