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The map label for this gene is lysP [H]

Identifier: 153936614

GI number: 153936614

Start: 290577

End: 292040

Strand: Direct

Name: lysP [H]

Synonym: CLC_0308

Alternate gene names: 153936614

Gene position: 290577-292040 (Clockwise)

Preceding gene: 153934977

Following gene: 153935426

Centisome position: 7.73

GC content: 34.43

Gene sequence:

>1464_bases
ATGAGTACTACAAAAGAAAAAGATTCTAATTCACATAATCTTAAAAGAAGTTTACAAGCAAGACATCTTAATATGATTGC
CATGGGTGGAGCTATAGGAACAGGAATATTCCTAGCACTTGGTGCTACTATCAAGCAAGCAGGACCTGGTGGAGCACTTA
CTGCTTATGCTTGCATAGGAGTTATGGTTTACTTTCTAATGACAAGCTTAGGAGAAATGGCAACCTTTATGCCTGTATCA
GGTTCTTTCGAAACTTATGCTTCAAGATTCATCGATCCTGCATTTGGATTTGCACTTGGTTGGAATTACTGGTATAACTG
GGCTATTACAGTTGCTGCTGAAATGGTGGCAGGTGCACTAATTATGAAATTTTGGTTTCCTAATGTTCCAGCTATTATTT
GGAGTGTTTTATTCCTTGTATTAATAGTTAGCCTTAACTTATTATCTACAAAAGCTTATGGTGAATCAGAATATTGGTTT
GCAGGTATTAAAGTATTTACTGTTATTGTATTTTTATTAATAGGTATTGCTACTATTTTAGGTATATTAGGTGGGCATAC
AGTAGGACTTCAGAACTTTACTATTAAGGATGCTCCATTTGTTGGAGGAGTTAAATCTATTTTTATGGTATTTTTAATTG
CAGGTTTTTCTTTCCAAGGTACAGAGCTTGTTGGTATAGCTGCTGGTGAAAGTGAAAACCCTAAGAAAACTATTCCCAAA
GCAATCAATACAATATTTTGGAGAATTATAGTTTTTTATTTAGGAACAATATTTGTTGTAAGTGCAATAATTCCTTATAC
AGATGCTGGAGTTAATACAAGTCCATTTACATTAGTATTTGAAAGAGCTGGTATTGCAGCTGATGCATCGCTGATGAACG
CAGTTATTTTAACCTCAGTAATATCTTGTGGAAACTCAGGAATGTATGCTTCAAGTAGAATGCTGTATGCAATGGCTAAA
GAAGGGAAAGCGCCTAGTTGGTTAGGAAAACTTAATTCAAGAGGAGTTCCAGTAAATGCATTAGCATTAACTACTCTAGT
AGCATCAGCTTGTTTCTTAACAGGGCTTTATGCTGAAACCACTGTTTATGTGTGGCTAGTTGCAGCTTCAGGGCTTGCAG
GTTTTATTGCTTGGGTTGGTATAGCATTATGTCATTATCGTTTCCGTAAAGCTTATGTTGCTCAAGGACGTGATTTGAAT
AAGCTTGTTTATAAAGCAAAGTTATTCCCACTTGGTCCAATAATAGCGCTAGTATTATGCATAATAGTTATTCTAGGACA
AGGTATTAGCTATTTTGAAGCTACTAAAATTGACTGGAATGGAATAATAGCATCTTATATAGGATTACCAATATTCTTTG
GTTTATGGTTTAGTTATAAGAAGAAACATAAAACAAAAGTTGTTAACTTACAGGAGATAAGCTTTGATGTAGAAGATACT
CATTTAAAAACAGAAATTGTTTAA

Upstream 100 bases:

>100_bases
AATACATGATTTAATATCCTGAGATAGTCTCAGGATATTTTTTTATGCTCGTCTTAGTTAATTCGCTTATCGGAAAATAA
AACCGATAAGGAGGAAAAAA

Downstream 100 bases:

>100_bases
GATAAAATATAAAGACTGCTGATATTTAATCAGCAGTCTTTATATTTATTAGGTGATAGTATAAGACAATATATAAGGTA
ATTCATAAATGAAGCTATAT

Product: lysine-specific permease

Products: Proton [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 487; Mature: 486

Protein sequence:

>487_residues
MSTTKEKDSNSHNLKRSLQARHLNMIAMGGAIGTGIFLALGATIKQAGPGGALTAYACIGVMVYFLMTSLGEMATFMPVS
GSFETYASRFIDPAFGFALGWNYWYNWAITVAAEMVAGALIMKFWFPNVPAIIWSVLFLVLIVSLNLLSTKAYGESEYWF
AGIKVFTVIVFLLIGIATILGILGGHTVGLQNFTIKDAPFVGGVKSIFMVFLIAGFSFQGTELVGIAAGESENPKKTIPK
AINTIFWRIIVFYLGTIFVVSAIIPYTDAGVNTSPFTLVFERAGIAADASLMNAVILTSVISCGNSGMYASSRMLYAMAK
EGKAPSWLGKLNSRGVPVNALALTTLVASACFLTGLYAETTVYVWLVAASGLAGFIAWVGIALCHYRFRKAYVAQGRDLN
KLVYKAKLFPLGPIIALVLCIIVILGQGISYFEATKIDWNGIIASYIGLPIFFGLWFSYKKKHKTKVVNLQEISFDVEDT
HLKTEIV

Sequences:

>Translated_487_residues
MSTTKEKDSNSHNLKRSLQARHLNMIAMGGAIGTGIFLALGATIKQAGPGGALTAYACIGVMVYFLMTSLGEMATFMPVS
GSFETYASRFIDPAFGFALGWNYWYNWAITVAAEMVAGALIMKFWFPNVPAIIWSVLFLVLIVSLNLLSTKAYGESEYWF
AGIKVFTVIVFLLIGIATILGILGGHTVGLQNFTIKDAPFVGGVKSIFMVFLIAGFSFQGTELVGIAAGESENPKKTIPK
AINTIFWRIIVFYLGTIFVVSAIIPYTDAGVNTSPFTLVFERAGIAADASLMNAVILTSVISCGNSGMYASSRMLYAMAK
EGKAPSWLGKLNSRGVPVNALALTTLVASACFLTGLYAETTVYVWLVAASGLAGFIAWVGIALCHYRFRKAYVAQGRDLN
KLVYKAKLFPLGPIIALVLCIIVILGQGISYFEATKIDWNGIIASYIGLPIFFGLWFSYKKKHKTKVVNLQEISFDVEDT
HLKTEIV
>Mature_486_residues
STTKEKDSNSHNLKRSLQARHLNMIAMGGAIGTGIFLALGATIKQAGPGGALTAYACIGVMVYFLMTSLGEMATFMPVSG
SFETYASRFIDPAFGFALGWNYWYNWAITVAAEMVAGALIMKFWFPNVPAIIWSVLFLVLIVSLNLLSTKAYGESEYWFA
GIKVFTVIVFLLIGIATILGILGGHTVGLQNFTIKDAPFVGGVKSIFMVFLIAGFSFQGTELVGIAAGESENPKKTIPKA
INTIFWRIIVFYLGTIFVVSAIIPYTDAGVNTSPFTLVFERAGIAADASLMNAVILTSVISCGNSGMYASSRMLYAMAKE
GKAPSWLGKLNSRGVPVNALALTTLVASACFLTGLYAETTVYVWLVAASGLAGFIAWVGIALCHYRFRKAYVAQGRDLNK
LVYKAKLFPLGPIIALVLCIIVILGQGISYFEATKIDWNGIIASYIGLPIFFGLWFSYKKKHKTKVVNLQEISFDVEDTH
LKTEIV

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of lysine [H]

COG id: COG0833

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Escherichia coli, GI1788480, Length=485, Percent_Identity=55.0515463917526, Blast_Score=560, Evalue=1e-161,
Organism=Escherichia coli, GI87081708, Length=473, Percent_Identity=38.2663847780127, Blast_Score=348, Evalue=4e-97,
Organism=Escherichia coli, GI1786789, Length=426, Percent_Identity=36.6197183098592, Blast_Score=298, Evalue=4e-82,
Organism=Escherichia coli, GI48994972, Length=435, Percent_Identity=38.3908045977011, Blast_Score=297, Evalue=9e-82,
Organism=Escherichia coli, GI1786302, Length=420, Percent_Identity=37.6190476190476, Blast_Score=290, Evalue=1e-79,
Organism=Escherichia coli, GI1789017, Length=396, Percent_Identity=35.3535353535354, Blast_Score=246, Evalue=2e-66,
Organism=Escherichia coli, GI1790653, Length=431, Percent_Identity=34.8027842227378, Blast_Score=243, Evalue=3e-65,
Organism=Escherichia coli, GI87081915, Length=504, Percent_Identity=30.952380952381, Blast_Score=237, Evalue=1e-63,
Organism=Escherichia coli, GI1786602, Length=385, Percent_Identity=36.8831168831169, Blast_Score=235, Evalue=6e-63,
Organism=Escherichia coli, GI87081869, Length=327, Percent_Identity=23.8532110091743, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6324061, Length=508, Percent_Identity=35.4330708661417, Blast_Score=316, Evalue=5e-87,
Organism=Saccharomyces cerevisiae, GI6320772, Length=500, Percent_Identity=35.4, Blast_Score=315, Evalue=1e-86,
Organism=Saccharomyces cerevisiae, GI6324990, Length=492, Percent_Identity=35.3658536585366, Blast_Score=294, Evalue=3e-80,
Organism=Saccharomyces cerevisiae, GI6324059, Length=506, Percent_Identity=33.9920948616601, Blast_Score=282, Evalue=8e-77,
Organism=Saccharomyces cerevisiae, GI6324924, Length=523, Percent_Identity=32.3135755258126, Blast_Score=276, Evalue=7e-75,
Organism=Saccharomyces cerevisiae, GI6322892, Length=502, Percent_Identity=34.4621513944223, Blast_Score=272, Evalue=8e-74,
Organism=Saccharomyces cerevisiae, GI6321629, Length=492, Percent_Identity=31.5040650406504, Blast_Score=270, Evalue=3e-73,
Organism=Saccharomyces cerevisiae, GI6324553, Length=496, Percent_Identity=33.2661290322581, Blast_Score=265, Evalue=1e-71,
Organism=Saccharomyces cerevisiae, GI6319824, Length=495, Percent_Identity=30.5050505050505, Blast_Score=257, Evalue=4e-69,
Organism=Saccharomyces cerevisiae, GI6320717, Length=477, Percent_Identity=29.559748427673, Blast_Score=251, Evalue=2e-67,
Organism=Saccharomyces cerevisiae, GI6321053, Length=472, Percent_Identity=32.4152542372881, Blast_Score=244, Evalue=2e-65,
Organism=Saccharomyces cerevisiae, GI6320251, Length=510, Percent_Identity=30, Blast_Score=239, Evalue=5e-64,
Organism=Saccharomyces cerevisiae, GI6319542, Length=502, Percent_Identity=29.0836653386454, Blast_Score=236, Evalue=5e-63,
Organism=Saccharomyces cerevisiae, GI6319543, Length=472, Percent_Identity=29.6610169491525, Blast_Score=229, Evalue=6e-61,
Organism=Saccharomyces cerevisiae, GI6322967, Length=515, Percent_Identity=29.5145631067961, Blast_Score=226, Evalue=6e-60,
Organism=Saccharomyces cerevisiae, GI6324981, Length=497, Percent_Identity=31.7907444668008, Blast_Score=211, Evalue=3e-55,
Organism=Saccharomyces cerevisiae, GI6319608, Length=513, Percent_Identity=28.4600389863548, Blast_Score=210, Evalue=3e-55,
Organism=Saccharomyces cerevisiae, GI6320364, Length=563, Percent_Identity=26.6429840142096, Blast_Score=160, Evalue=3e-40,
Organism=Drosophila melanogaster, GI221512776, Length=427, Percent_Identity=22.9508196721311, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24666159, Length=427, Percent_Identity=22.9508196721311, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 52815; Mature: 52684

Theoretical pI: Translated: 9.54; Mature: 9.54

Prosite motif: PS00435 PEROXIDASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTTKEKDSNSHNLKRSLQARHLNMIAMGGAIGTGIFLALGATIKQAGPGGALTAYACIG
CCCCCCCCCCHHHHHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
VMVYFLMTSLGEMATFMPVSGSFETYASRFIDPAFGFALGWNYWYNWAITVAAEMVAGAL
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCHHHHHHHCHHHHHHHHHHHHHHHHHHHH
IMKFWFPNVPAIIWSVLFLVLIVSLNLLSTKAYGESEYWFAGIKVFTVIVFLLIGIATIL
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
GILGGHTVGLQNFTIKDAPFVGGVKSIFMVFLIAGFSFQGTELVGIAAGESENPKKTIPK
HHHCCCEECCCCCEECCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHH
AINTIFWRIIVFYLGTIFVVSAIIPYTDAGVNTSPFTLVFERAGIAADASLMNAVILTSV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHH
ISCGNSGMYASSRMLYAMAKEGKAPSWLGKLNSRGVPVNALALTTLVASACFLTGLYAET
HHCCCCCCCHHHHHHHHHHHCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
TVYVWLVAASGLAGFIAWVGIALCHYRFRKAYVAQGRDLNKLVYKAKLFPLGPIIALVLC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHH
IIVILGQGISYFEATKIDWNGIIASYIGLPIFFGLWFSYKKKHKTKVVNLQEISFDVEDT
HHHHHCCCCCHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHCCCCCCC
HLKTEIV
CEEEECC
>Mature Secondary Structure 
STTKEKDSNSHNLKRSLQARHLNMIAMGGAIGTGIFLALGATIKQAGPGGALTAYACIG
CCCCCCCCCHHHHHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
VMVYFLMTSLGEMATFMPVSGSFETYASRFIDPAFGFALGWNYWYNWAITVAAEMVAGAL
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCHHHHHHHCHHHHHHHHHHHHHHHHHHHH
IMKFWFPNVPAIIWSVLFLVLIVSLNLLSTKAYGESEYWFAGIKVFTVIVFLLIGIATIL
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
GILGGHTVGLQNFTIKDAPFVGGVKSIFMVFLIAGFSFQGTELVGIAAGESENPKKTIPK
HHHCCCEECCCCCEECCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHH
AINTIFWRIIVFYLGTIFVVSAIIPYTDAGVNTSPFTLVFERAGIAADASLMNAVILTSV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHH
ISCGNSGMYASSRMLYAMAKEGKAPSWLGKLNSRGVPVNALALTTLVASACFLTGLYAET
HHCCCCCCCHHHHHHHHHHHCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
TVYVWLVAASGLAGFIAWVGIALCHYRFRKAYVAQGRDLNKLVYKAKLFPLGPIIALVLC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHH
IIVILGQGISYFEATKIDWNGIIASYIGLPIFFGLWFSYKKKHKTKVVNLQEISFDVEDT
HHHHHCCCCCHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHCCCCCCC
HLKTEIV
CEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-lysine [Periplasm] = Proton [Cytoplasm] + L-lysine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1315732; 9278503; 7551055 [H]