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The map label for this gene is pip [H]

Identifier: 153936432

GI number: 153936432

Start: 2163956

End: 2164861

Strand: Reverse

Name: pip [H]

Synonym: CLC_2041

Alternate gene names: 153936432

Gene position: 2164861-2163956 (Counterclockwise)

Preceding gene: 153935655

Following gene: 153937237

Centisome position: 57.57

GC content: 30.91

Gene sequence:

>906_bases
ATGGGAGAGTATTATAAAATTAGAGGAAAAGATATATATACTGATACTTTAGGAGAGGGATCCTCTCCAGCACTGCTATT
TATTCATGGTGGTCCTGGTGGAATCGGTGTCGTAGATTTTATTAAATATCAGGGGGATAGATTATCAAAGAACTTCAAAG
TTATAGCTCCAGAGCAAAGGGGAGTATGGAGATCTGAAGCTATTTTAGAGGAAGAACATATTTCACTGGAGGATATTGTT
AAAGACTTTGAAGAATTAAGAATAAAATTACATATAAATAAATGGTCATTGCTTAGTCACTCGTTTGGAGGATATCTTGC
TGTTCTTTATGCTAACTTATATCCTAATTCTATTGAATATATGATATATGAATGTCCATCTTTTGATTTTTCACTTTCAG
AGCGTTCTATGCTAAATAAAGCAGCCAAAGAATTGATTAAATTAGGAAATTTATCATTGGCACAAAAGTATTTTAAGGCT
TTAGGAGAAATTACAGATTATAAGGAAATCAATAGACTACTTATGAAGGCGTTAAATGAGCTTGGTGCTAACTGCAATAA
CTTTATGTGGTTTGGAAATGATAAGCAAATTATTGACAGAATAGCTATGAATGCTAAGGATTTATGGAACAAGTCCACCA
ATACAAGAATTAAATTATTGAAGGATTGGCGTATATATAATGATGTTTTTAATGGATTATCAAATGTAAACAAGCCTTCT
TTATTAATTAAAGGTAAATATGATCCAGTAACCTGTGAAGTGCAAATGACAGAATTTATAAATCGAGTGCCAGATAAACA
AGTAGTTATATTTAATTTTTCTGGTCATTATGTTAGAATTGAGGAACCTGATAAGTATTGTGAAGTTATAACAAATTACA
TATATAATAAGATGAAATGCGTGTGA

Upstream 100 bases:

>100_bases
AAGCACAATAAGACAGAAATAAAACATTATCTTTTGATATAATTTATAGGAAGTAGAAAAGTAGGAAATGCTTAATGTTA
TTATATGGAGGCCTTATTGG

Downstream 100 bases:

>100_bases
TTTACGTTCTTATAATGAATGAACTTATTTTGAAAGGAGATGAGAAGCTTGGAAACAATCATGTTACTTAACAATACACT
TGAATATATTGAAAGAAATT

Product: alpha/beta fold family hydrolase

Products: NA

Alternate protein names: PIP; Prolyl aminopeptidase; PAP [H]

Number of amino acids: Translated: 301; Mature: 300

Protein sequence:

>301_residues
MGEYYKIRGKDIYTDTLGEGSSPALLFIHGGPGGIGVVDFIKYQGDRLSKNFKVIAPEQRGVWRSEAILEEEHISLEDIV
KDFEELRIKLHINKWSLLSHSFGGYLAVLYANLYPNSIEYMIYECPSFDFSLSERSMLNKAAKELIKLGNLSLAQKYFKA
LGEITDYKEINRLLMKALNELGANCNNFMWFGNDKQIIDRIAMNAKDLWNKSTNTRIKLLKDWRIYNDVFNGLSNVNKPS
LLIKGKYDPVTCEVQMTEFINRVPDKQVVIFNFSGHYVRIEEPDKYCEVITNYIYNKMKCV

Sequences:

>Translated_301_residues
MGEYYKIRGKDIYTDTLGEGSSPALLFIHGGPGGIGVVDFIKYQGDRLSKNFKVIAPEQRGVWRSEAILEEEHISLEDIV
KDFEELRIKLHINKWSLLSHSFGGYLAVLYANLYPNSIEYMIYECPSFDFSLSERSMLNKAAKELIKLGNLSLAQKYFKA
LGEITDYKEINRLLMKALNELGANCNNFMWFGNDKQIIDRIAMNAKDLWNKSTNTRIKLLKDWRIYNDVFNGLSNVNKPS
LLIKGKYDPVTCEVQMTEFINRVPDKQVVIFNFSGHYVRIEEPDKYCEVITNYIYNKMKCV
>Mature_300_residues
GEYYKIRGKDIYTDTLGEGSSPALLFIHGGPGGIGVVDFIKYQGDRLSKNFKVIAPEQRGVWRSEAILEEEHISLEDIVK
DFEELRIKLHINKWSLLSHSFGGYLAVLYANLYPNSIEYMIYECPSFDFSLSERSMLNKAAKELIKLGNLSLAQKYFKAL
GEITDYKEINRLLMKALNELGANCNNFMWFGNDKQIIDRIAMNAKDLWNKSTNTRIKLLKDWRIYNDVFNGLSNVNKPSL
LIKGKYDPVTCEVQMTEFINRVPDKQVVIFNFSGHYVRIEEPDKYCEVITNYIYNKMKCV

Specific function: Specifically catalyzes the removal of N-terminal proline residues from peptides [H]

COG id: COG0596

COG function: function code R; Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S33 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR005944
- InterPro:   IPR002410 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: =3.4.11.5 [H]

Molecular weight: Translated: 34797; Mature: 34665

Theoretical pI: Translated: 7.86; Mature: 7.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGEYYKIRGKDIYTDTLGEGSSPALLFIHGGPGGIGVVDFIKYQGDRLSKNFKVIAPEQR
CCCEEEECCCEEEEECCCCCCCCEEEEEECCCCCCHHHHHHHHCCCCCCCCCEEECCCCC
GVWRSEAILEEEHISLEDIVKDFEELRIKLHINKWSLLSHSFGGYLAVLYANLYPNSIEY
CCCHHHHHHHHHCCCHHHHHHHHHHEEEEEEECCHHHHHHCCCHHEEHHHHHCCCCCEEE
MIYECPSFDFSLSERSMLNKAAKELIKLGNLSLAQKYFKALGEITDYKEINRLLMKALNE
EEEECCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
LGANCNNFMWFGNDKQIIDRIAMNAKDLWNKSTNTRIKLLKDWRIYNDVFNGLSNVNKPS
HCCCCCCEEEECCCHHHHHHHHCCHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCC
LLIKGKYDPVTCEVQMTEFINRVPDKQVVIFNFSGHYVRIEEPDKYCEVITNYIYNKMKC
EEEEECCCCEEEEEEHHHHHHHCCCCEEEEEECCCCEEEECCCHHHHHHHHHHHHHHHCC
V
C
>Mature Secondary Structure 
GEYYKIRGKDIYTDTLGEGSSPALLFIHGGPGGIGVVDFIKYQGDRLSKNFKVIAPEQR
CCEEEECCCEEEEECCCCCCCCEEEEEECCCCCCHHHHHHHHCCCCCCCCCEEECCCCC
GVWRSEAILEEEHISLEDIVKDFEELRIKLHINKWSLLSHSFGGYLAVLYANLYPNSIEY
CCCHHHHHHHHHCCCHHHHHHHHHHEEEEEEECCHHHHHHCCCHHEEHHHHHCCCCCEEE
MIYECPSFDFSLSERSMLNKAAKELIKLGNLSLAQKYFKALGEITDYKEINRLLMKALNE
EEEECCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
LGANCNNFMWFGNDKQIIDRIAMNAKDLWNKSTNTRIKLLKDWRIYNDVFNGLSNVNKPS
HCCCCCCEEEECCCHHHHHHHHCCHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCC
LLIKGKYDPVTCEVQMTEFINRVPDKQVVIFNFSGHYVRIEEPDKYCEVITNYIYNKMKC
EEEEECCCCEEEEEEHHHHHHHCCCCEEEEEECCCCEEEECCCHHHHHHHHHHHHHHHCC
V
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8948633 [H]