| Definition | Clostridium botulinum A str. Hall, complete genome. |
|---|---|
| Accession | NC_009698 |
| Length | 3,760,560 |
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The map label for this gene is uvrA [H]
Identifier: 153936378
GI number: 153936378
Start: 790707
End: 792944
Strand: Direct
Name: uvrA [H]
Synonym: CLC_0765
Alternate gene names: 153936378
Gene position: 790707-792944 (Clockwise)
Preceding gene: 153937129
Following gene: 153935697
Centisome position: 21.03
GC content: 31.77
Gene sequence:
>2238_bases ATGGAGCAGGAATTTATAGTTTTAAAAGGATGTAAGGAAAATAATTTAAAAGATATTTCATTAAATATACCTAAGAGAAA AATAACAATATTTACAGGGGTATCTGGTTCAGGGAAGTCATCAATTGTTTTTGAGACAGTAGCAAAGGAAGCTCAACGTC AATTGAATGAGACCTTCACTGCCTTCATAAGAAATTTTTTACCTAAGTATGGTGAGGTTAAAGCTGATCACATAGAAAAT TTATCAACGCCAATTATTATTGACCAAAGTAGGCTCGGTGGTAATTCAAGATCAACTTTAGGTACTATTACAGATATAAA TTCATTCCTTAGAGCGCTATATTCAAGGTTTGGAAGTAATTATATCGGTAAGGCTAATATGTTTTCCTTTAATGATATTA ATGGTATGTGTCCGGAATGTCAGGGTCTTGGTAAAAAGTTGGTTCCAAATATGGAGGAGATATTTGATAAAAGTAAATCC CTAAATGAGGGAGCTATTTTACTTTCAGGTTTTGGAGTAGGTTCCTGGCATTGGAAAATATTTGCCCAGTCAGGATACTT TGATAATGATAAGAAAATATGTGATTATTCAGAAGAAGAATTAGATAAGTTTTTATATGGTGGGCCAGATAAAATTAAGA TAGATGAAACAGGTGGAATGAACATAACCTATGAAGGCTTATTGGTTAAGTTTAATAGGCTATATTTAAAGAAAGAAGGA GAAACCTCTGAAGCTGCAAAGAAAAAACTAAATAAACTACTTATAGAGGACCAGTGCCCTGCTTGCGGGGGAAAAAGGCT TCACCAAAGAGTATATGGATCTTTAATTAATGGTTATAATATAGCAGATTTAACTAGTATGCAAATTGATGAATTAGTTG AGGTAGTTAAAGAAATAAATGATCCAGAAGCAGAACCTTTAGTTAAAGGTATAATAGAAAAGCTAAATAATATTATAGAT ATAGGTCTTGGATATTTGACTTTAGATAGAGAAACTTCATCATTATCTGGTGGAGAATCTCAACGTATAAAGATGGTAAA GCATTTAAATAGTAACCTTGTAGATTTAATGTATATCTTTGATGAGCCTAGTATAGGTCTTCATCCAAGAGATGTCCATA AATTAAACAATCTATTAAAAAAGCTACGTGATAAAGGCAATACTGTAATAGTTGTTGAGCATGACCCTGATGTTATTAAA ATTGCAGACCATATTATAGATGTAGGCCCAAAGGCAGGTAAGTATGGTGGTGAAATTGTATATGAGGGAACCTATGAAAA TTTACTTAAATCAGGAACCTTAACTGGAAATGCCTTAAATAAAAGTCTTTCTATTAAAGAAAAGGTAAGAGATCATAAGG GATATTTAAAGGTTGTAAATTGTAATAAAAATAATTTAAAAAATATATCTGTGACAATACCTAAGGGTGTATTAACAGTA GTAACAGGAGTTGCAGGTTCAGGTAAAAGTACATTAATTAAACATGAGTTCTTAAAACAAAATAAAAATGCTGTATTAAT AGATCAAAGTCCTGTGTCAGCTAATTCTAGGTCCAGCTTAGCCACCTATAGCGGAATTATGGATAATATAAGAAAAGCTT TTGCTAAGGCAAATGGAGTTAATGCGTCATTATTTAGTTCAAATTCAAAAGGAGCCTGCGAAAATTGTAATGGAAGCGGA ATAATAGAAACAAATCTTGCATTTATGGAAAACATAAAAAGTACTTGCGATGTTTGTGAAGGTAAAAAGTATAAAAAAGA AGTTTTAGATTATAAATTACATGGGGAAAACATAATAGAAGTTCTTGAAATGTCAGTTTCAGATGCAATTGAATTTTTCA ACTTAAGGTCAGTTAAGGCAAAACTGCAGTCTATAGAAGATATGGGCATTGGATATTTAACCTTAGGGCAAACTCTCGAT ACCTTATCTGGCGGAGAATGTCAAAGATTAAAGCTTGCCAGTGAATTGCATAATGAAAGTTCTATATATATATTGGATGA GCCTACAACAGGTCTTCATATAGCTGATATTGAAAAATTTATCAACATAGTTGAAAATATTGTGGATAGTGGCAATACAG TTATAATAATTGAACATAATGTAGATATAATTAAAAGAGCAGATTGGATTATTGATATGGGGCCTGATGGTGGAACAAAA GGTGGAGAGATAATATTTGAAGGGACTCCCAAACAATTACATAATTGCCAAGTATCATTAACAGCTAAGTATATTTAG
Upstream 100 bases:
>100_bases TAAGAACTATAGAACATCAGAGATTAATAAATAGTAAATTTGTGTCAGTTCAAGGAGAAGATATAAATTAAAAACAAAGG AGTGCCAAGGAGGAATATAG
Downstream 100 bases:
>100_bases TTTATAACTAAGGAGAATTCTATTTGTAGAACTCTCCCTCACTTTAATTATAACATATGTAAAGCGTGAAATATAGACTA CTAAATTTTGAATCTAACTG
Product: putative drug resistance ABC transporter, ATP-binding protein
Products: NA
Alternate protein names: UvrA protein; Excinuclease ABC subunit A [H]
Number of amino acids: Translated: 745; Mature: 745
Protein sequence:
>745_residues MEQEFIVLKGCKENNLKDISLNIPKRKITIFTGVSGSGKSSIVFETVAKEAQRQLNETFTAFIRNFLPKYGEVKADHIEN LSTPIIIDQSRLGGNSRSTLGTITDINSFLRALYSRFGSNYIGKANMFSFNDINGMCPECQGLGKKLVPNMEEIFDKSKS LNEGAILLSGFGVGSWHWKIFAQSGYFDNDKKICDYSEEELDKFLYGGPDKIKIDETGGMNITYEGLLVKFNRLYLKKEG ETSEAAKKKLNKLLIEDQCPACGGKRLHQRVYGSLINGYNIADLTSMQIDELVEVVKEINDPEAEPLVKGIIEKLNNIID IGLGYLTLDRETSSLSGGESQRIKMVKHLNSNLVDLMYIFDEPSIGLHPRDVHKLNNLLKKLRDKGNTVIVVEHDPDVIK IADHIIDVGPKAGKYGGEIVYEGTYENLLKSGTLTGNALNKSLSIKEKVRDHKGYLKVVNCNKNNLKNISVTIPKGVLTV VTGVAGSGKSTLIKHEFLKQNKNAVLIDQSPVSANSRSSLATYSGIMDNIRKAFAKANGVNASLFSSNSKGACENCNGSG IIETNLAFMENIKSTCDVCEGKKYKKEVLDYKLHGENIIEVLEMSVSDAIEFFNLRSVKAKLQSIEDMGIGYLTLGQTLD TLSGGECQRLKLASELHNESSIYILDEPTTGLHIADIEKFINIVENIVDSGNTVIIIEHNVDIIKRADWIIDMGPDGGTK GGEIIFEGTPKQLHNCQVSLTAKYI
Sequences:
>Translated_745_residues MEQEFIVLKGCKENNLKDISLNIPKRKITIFTGVSGSGKSSIVFETVAKEAQRQLNETFTAFIRNFLPKYGEVKADHIEN LSTPIIIDQSRLGGNSRSTLGTITDINSFLRALYSRFGSNYIGKANMFSFNDINGMCPECQGLGKKLVPNMEEIFDKSKS LNEGAILLSGFGVGSWHWKIFAQSGYFDNDKKICDYSEEELDKFLYGGPDKIKIDETGGMNITYEGLLVKFNRLYLKKEG ETSEAAKKKLNKLLIEDQCPACGGKRLHQRVYGSLINGYNIADLTSMQIDELVEVVKEINDPEAEPLVKGIIEKLNNIID IGLGYLTLDRETSSLSGGESQRIKMVKHLNSNLVDLMYIFDEPSIGLHPRDVHKLNNLLKKLRDKGNTVIVVEHDPDVIK IADHIIDVGPKAGKYGGEIVYEGTYENLLKSGTLTGNALNKSLSIKEKVRDHKGYLKVVNCNKNNLKNISVTIPKGVLTV VTGVAGSGKSTLIKHEFLKQNKNAVLIDQSPVSANSRSSLATYSGIMDNIRKAFAKANGVNASLFSSNSKGACENCNGSG IIETNLAFMENIKSTCDVCEGKKYKKEVLDYKLHGENIIEVLEMSVSDAIEFFNLRSVKAKLQSIEDMGIGYLTLGQTLD TLSGGECQRLKLASELHNESSIYILDEPTTGLHIADIEKFINIVENIVDSGNTVIIIEHNVDIIKRADWIIDMGPDGGTK GGEIIFEGTPKQLHNCQVSLTAKYI >Mature_745_residues MEQEFIVLKGCKENNLKDISLNIPKRKITIFTGVSGSGKSSIVFETVAKEAQRQLNETFTAFIRNFLPKYGEVKADHIEN LSTPIIIDQSRLGGNSRSTLGTITDINSFLRALYSRFGSNYIGKANMFSFNDINGMCPECQGLGKKLVPNMEEIFDKSKS LNEGAILLSGFGVGSWHWKIFAQSGYFDNDKKICDYSEEELDKFLYGGPDKIKIDETGGMNITYEGLLVKFNRLYLKKEG ETSEAAKKKLNKLLIEDQCPACGGKRLHQRVYGSLINGYNIADLTSMQIDELVEVVKEINDPEAEPLVKGIIEKLNNIID IGLGYLTLDRETSSLSGGESQRIKMVKHLNSNLVDLMYIFDEPSIGLHPRDVHKLNNLLKKLRDKGNTVIVVEHDPDVIK IADHIIDVGPKAGKYGGEIVYEGTYENLLKSGTLTGNALNKSLSIKEKVRDHKGYLKVVNCNKNNLKNISVTIPKGVLTV VTGVAGSGKSTLIKHEFLKQNKNAVLIDQSPVSANSRSSLATYSGIMDNIRKAFAKANGVNASLFSSNSKGACENCNGSG IIETNLAFMENIKSTCDVCEGKKYKKEVLDYKLHGENIIEVLEMSVSDAIEFFNLRSVKAKLQSIEDMGIGYLTLGQTLD TLSGGECQRLKLASELHNESSIYILDEPTTGLHIADIEKFINIVENIVDSGNTVIIIEHNVDIIKRADWIIDMGPDGGTK GGEIIFEGTPKQLHNCQVSLTAKYI
Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion h
COG id: COG0178
COG function: function code L; Excinuclease ATPase subunit
Gene ontology:
Cell location: Cytoplasm [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 2 ABC transporter domains [H]
Homologues:
Organism=Escherichia coli, GI2367343, Length=685, Percent_Identity=37.5182481751825, Blast_Score=434, Evalue=1e-123,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR003439 - InterPro: IPR017871 - InterPro: IPR013815 - InterPro: IPR003593 - InterPro: IPR004602 [H]
Pfam domain/function: PF00005 ABC_tran [H]
EC number: NA
Molecular weight: Translated: 82251; Mature: 82251
Theoretical pI: Translated: 6.68; Mature: 6.68
Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.7 %Cys (Translated Protein) 1.7 %Met (Translated Protein) 3.5 %Cys+Met (Translated Protein) 1.7 %Cys (Mature Protein) 1.7 %Met (Mature Protein) 3.5 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MEQEFIVLKGCKENNLKDISLNIPKRKITIFTGVSGSGKSSIVFETVAKEAQRQLNETFT CCCCEEEEECCCCCCCEEEEEECCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHH AFIRNFLPKYGEVKADHIENLSTPIIIDQSRLGGNSRSTLGTITDINSFLRALYSRFGSN HHHHHHCCCCCCCCHHHHHCCCCCEEEEHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCC YIGKANMFSFNDINGMCPECQGLGKKLVPNMEEIFDKSKSLNEGAILLSGFGVGSWHWKI CCCCCCCEEECCCCCCCCHHHCCCHHCCCCHHHHHHHCCCCCCCEEEEEECCCCCEEEEE FAQSGYFDNDKKICDYSEEELDKFLYGGPDKIKIDETGGMNITYEGLLVKFNRLYLKKEG EEECCCCCCCCCCCCCCHHHHHHHHCCCCCEEEEECCCCCEEEECCEEEEEEEEEEECCC ETSEAAKKKLNKLLIEDQCPACGGKRLHQRVYGSLINGYNIADLTSMQIDELVEVVKEIN CHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCC DPEAEPLVKGIIEKLNNIIDIGLGYLTLDRETSSLSGGESQRIKMVKHLNSNLVDLMYIF CCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEE DEPSIGLHPRDVHKLNNLLKKLRDKGNTVIVVEHDPDVIKIADHIIDVGPKAGKYGGEIV CCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCCCCEEE YEGTYENLLKSGTLTGNALNKSLSIKEKVRDHKGYLKVVNCNKNNLKNISVTIPKGVLTV ECCCHHHHHHCCCCCCHHHCCCCHHHHHHHCCCCEEEEEECCCCCCCEEEEECCCCHHHH VTGVAGSGKSTLIKHEFLKQNKNAVLIDQSPVSANSRSSLATYSGIMDNIRKAFAKANGV HHCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC NASLFSSNSKGACENCNGSGIIETNLAFMENIKSTCDVCEGKKYKKEVLDYKLHGENIIE CEEEECCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCHHHHHHHHCEEECCHHHHH VLEMSVSDAIEFFNLRSVKAKLQSIEDMGIGYLTLGQTLDTLSGGECQRLKLASELHNES HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHCCCCCCHHHHHHHHHHCCCC SIYILDEPTTGLHIADIEKFINIVENIVDSGNTVIIIEHNVDIIKRADWIIDMGPDGGTK EEEEEECCCCCEEHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEECCCEEEEECCCCCCC GGEIIFEGTPKQLHNCQVSLTAKYI CCEEEEECCCHHHHCCEEEEEEECC >Mature Secondary Structure MEQEFIVLKGCKENNLKDISLNIPKRKITIFTGVSGSGKSSIVFETVAKEAQRQLNETFT CCCCEEEEECCCCCCCEEEEEECCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHH AFIRNFLPKYGEVKADHIENLSTPIIIDQSRLGGNSRSTLGTITDINSFLRALYSRFGSN HHHHHHCCCCCCCCHHHHHCCCCCEEEEHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCC YIGKANMFSFNDINGMCPECQGLGKKLVPNMEEIFDKSKSLNEGAILLSGFGVGSWHWKI CCCCCCCEEECCCCCCCCHHHCCCHHCCCCHHHHHHHCCCCCCCEEEEEECCCCCEEEEE FAQSGYFDNDKKICDYSEEELDKFLYGGPDKIKIDETGGMNITYEGLLVKFNRLYLKKEG EEECCCCCCCCCCCCCCHHHHHHHHCCCCCEEEEECCCCCEEEECCEEEEEEEEEEECCC ETSEAAKKKLNKLLIEDQCPACGGKRLHQRVYGSLINGYNIADLTSMQIDELVEVVKEIN CHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCC DPEAEPLVKGIIEKLNNIIDIGLGYLTLDRETSSLSGGESQRIKMVKHLNSNLVDLMYIF CCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEE DEPSIGLHPRDVHKLNNLLKKLRDKGNTVIVVEHDPDVIKIADHIIDVGPKAGKYGGEIV CCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCCCCEEE YEGTYENLLKSGTLTGNALNKSLSIKEKVRDHKGYLKVVNCNKNNLKNISVTIPKGVLTV ECCCHHHHHHCCCCCCHHHCCCCHHHHHHHCCCCEEEEEECCCCCCCEEEEECCCCHHHH VTGVAGSGKSTLIKHEFLKQNKNAVLIDQSPVSANSRSSLATYSGIMDNIRKAFAKANGV HHCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC NASLFSSNSKGACENCNGSGIIETNLAFMENIKSTCDVCEGKKYKKEVLDYKLHGENIIE CEEEECCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCHHHHHHHHCEEECCHHHHH VLEMSVSDAIEFFNLRSVKAKLQSIEDMGIGYLTLGQTLDTLSGGECQRLKLASELHNES HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHCCCCCCHHHHHHHHHHCCCC SIYILDEPTTGLHIADIEKFINIVENIVDSGNTVIIIEHNVDIIKRADWIIDMGPDGGTK EEEEEECCCCCEEHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEECCCEEEEECCCCCCC GGEIIFEGTPKQLHNCQVSLTAKYI CCEEEEECCCHHHHCCEEEEEEECC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: DNA [C]
Specific reaction: Protein + DNA = Protein-DNA [C]
General reaction: Hydrolase; Acting on ester bonds [C]
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 9371463 [H]