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The map label for this gene is lysN [H]

Identifier: 153936139

GI number: 153936139

Start: 1850489

End: 1851679

Strand: Direct

Name: lysN [H]

Synonym: CLC_1744

Alternate gene names: 153936139

Gene position: 1850489-1851679 (Clockwise)

Preceding gene: 153936246

Following gene: 153935187

Centisome position: 49.21

GC content: 30.9

Gene sequence:

>1191_bases
ATGAATATACGTTTTTCAGAAAGAGCAGCAGGATTAAAAGCATCAGAGATAAGAGAATTATTAAAATTAACCGAAATGCC
AGAAATAATTTCTTTTGCGGGAGGATTACCAGCACCAGAATTATTCCCTGTAGAAGAAATGAAAGGTATAATGCAAGAAG
TATTAGATACTCAAGGAAGAGCAGCATTACAATACAGCTCTACTGAAGGGTATAAACCATTAAGAGAAATCATAGCTAAT
GAAAGAATGAAACCAGCAGGTGTAAACGTTTCTTTTGAAAATATTGCTATAACTAATGGTTCCCAACAAGGTATAGAATT
TTCAGCTAAAATTTTCTTAAATGAAGGAGATATAGTTGTTTGTGAAAGTCCTAGTTATTTAGGTGCTATAAATGCATTTA
AATCTTATAGACCTAAATTTGTTGAAATACCTATGGACGATAATGGAATGATTATAGAAGAATTAGAAAAAGCTTTAGCA
GAGAATAAAGGCAAAGTTAAAATGATATATACAATCCCTGATTTCCAAAATCCAACTGGTAGAACTATGCCAGACGATAG
AAGAAAGAGAATAGCAGAATTAGCTGCAGAATATGAAATACCTGTAATAGAAGATAATCCATATGGAGATCTTATATATG
AAGGTGAAAGACATCCATCTATAAAGAGTTTTGATAAAGAAGGATGGGTTATTTATCTTGGAACTTTCTCTAAAAACTTC
TGTCCAGGATTAAGACTTGCATGGGTTTGTGCTGAACCTGAAATATTAGATAAATATATAATTGTAAAACAAGGTGTTGA
TTTACAGGCTGGTACATTAGATCAAAGAGCGACAGCTTTATTTATGCAGAAATATGATTTAAATGAACATATTGAAAAAA
TTAAAAAAGTTTATGAAAAACGCAGAGATTTAATGCTAGATAGTATGAAAAAATACTTCCCAGCAGATGTAAAATATACT
CATCCTGTTGGAGGATTATTTACATGGGTTGAATTAAGAGAAGATTTAGATGCTAAAGAATTAATGAAAGATGCTTTAGC
TGAAAATGTTGCTTATGTACCTGGTGGTTCTTTCTTCCCTAACGGAGGACATGAAAATTACTTTAGATTAAACTACTCTT
GTATGAGTGATGAAAAAATAGTTGAAGGTGTAAAAAGACTAGGTAAAGTTTTAGATAAATATTATAAATAA

Upstream 100 bases:

>100_bases
TTTTTTATATATTTAAAAGAAGGATATAATGAGTGTTTGTAGAATAGATATAATTACAAGGGTATTGATTAACCTATTAT
ATTTTTGGAGGGATTTGCTA

Downstream 100 bases:

>100_bases
TATTAAATTATTTTAATAAAACGTACTAGATAAAATAAATTATCTCCTTTTAGGTTAAAATAAAACTAGAAGGAGATGAT
TTATGTGTATGATGTAAAGG

Product: aminotransferase, classes I and II

Products: NA

Alternate protein names: 2-aminoadipate aminotransferase; Alpha-aminoadipate aminotransferase; AAA-AT; AadAT [H]

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MNIRFSERAAGLKASEIRELLKLTEMPEIISFAGGLPAPELFPVEEMKGIMQEVLDTQGRAALQYSSTEGYKPLREIIAN
ERMKPAGVNVSFENIAITNGSQQGIEFSAKIFLNEGDIVVCESPSYLGAINAFKSYRPKFVEIPMDDNGMIIEELEKALA
ENKGKVKMIYTIPDFQNPTGRTMPDDRRKRIAELAAEYEIPVIEDNPYGDLIYEGERHPSIKSFDKEGWVIYLGTFSKNF
CPGLRLAWVCAEPEILDKYIIVKQGVDLQAGTLDQRATALFMQKYDLNEHIEKIKKVYEKRRDLMLDSMKKYFPADVKYT
HPVGGLFTWVELREDLDAKELMKDALAENVAYVPGGSFFPNGGHENYFRLNYSCMSDEKIVEGVKRLGKVLDKYYK

Sequences:

>Translated_396_residues
MNIRFSERAAGLKASEIRELLKLTEMPEIISFAGGLPAPELFPVEEMKGIMQEVLDTQGRAALQYSSTEGYKPLREIIAN
ERMKPAGVNVSFENIAITNGSQQGIEFSAKIFLNEGDIVVCESPSYLGAINAFKSYRPKFVEIPMDDNGMIIEELEKALA
ENKGKVKMIYTIPDFQNPTGRTMPDDRRKRIAELAAEYEIPVIEDNPYGDLIYEGERHPSIKSFDKEGWVIYLGTFSKNF
CPGLRLAWVCAEPEILDKYIIVKQGVDLQAGTLDQRATALFMQKYDLNEHIEKIKKVYEKRRDLMLDSMKKYFPADVKYT
HPVGGLFTWVELREDLDAKELMKDALAENVAYVPGGSFFPNGGHENYFRLNYSCMSDEKIVEGVKRLGKVLDKYYK
>Mature_396_residues
MNIRFSERAAGLKASEIRELLKLTEMPEIISFAGGLPAPELFPVEEMKGIMQEVLDTQGRAALQYSSTEGYKPLREIIAN
ERMKPAGVNVSFENIAITNGSQQGIEFSAKIFLNEGDIVVCESPSYLGAINAFKSYRPKFVEIPMDDNGMIIEELEKALA
ENKGKVKMIYTIPDFQNPTGRTMPDDRRKRIAELAAEYEIPVIEDNPYGDLIYEGERHPSIKSFDKEGWVIYLGTFSKNF
CPGLRLAWVCAEPEILDKYIIVKQGVDLQAGTLDQRATALFMQKYDLNEHIEKIKKVYEKRRDLMLDSMKKYFPADVKYT
HPVGGLFTWVELREDLDAKELMKDALAENVAYVPGGSFFPNGGHENYFRLNYSCMSDEKIVEGVKRLGKVLDKYYK

Specific function: Catalyzes the transfer of an amino group between 2- oxoadipate (2-OA) and glutamate (Glu) to yield alpha-aminodipate (AAA). It can also transaminate glutamate, leucine, and aromatic amino acids. It also conbtributes in the biosynthesis of other amino acid

COG id: COG1167

COG function: function code KE; Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7705897, Length=419, Percent_Identity=26.7303102625298, Blast_Score=162, Evalue=7e-40,
Organism=Homo sapiens, GI33469970, Length=419, Percent_Identity=26.7303102625298, Blast_Score=162, Evalue=7e-40,
Organism=Escherichia coli, GI1790797, Length=381, Percent_Identity=29.9212598425197, Blast_Score=181, Evalue=7e-47,
Organism=Escherichia coli, GI1787710, Length=383, Percent_Identity=28.1984334203655, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI48994949, Length=399, Percent_Identity=24.3107769423559, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1788722, Length=374, Percent_Identity=25.668449197861, Blast_Score=81, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6321236, Length=484, Percent_Identity=23.5537190082645, Blast_Score=133, Evalue=5e-32,
Organism=Saccharomyces cerevisiae, GI6321929, Length=468, Percent_Identity=23.0769230769231, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6321000, Length=251, Percent_Identity=26.2948207171315, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21356535, Length=415, Percent_Identity=25.5421686746988, Blast_Score=139, Evalue=4e-33,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.39 [H]

Molecular weight: Translated: 45014; Mature: 45014

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIRFSERAAGLKASEIRELLKLTEMPEIISFAGGLPAPELFPVEEMKGIMQEVLDTQGR
CCCCCCHHHCCCCHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCC
AALQYSSTEGYKPLREIIANERMKPAGVNVSFENIAITNGSQQGIEFSAKIFLNEGDIVV
EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEECEEEEECCCCCCCEEEEEEEEECCCEEE
CESPSYLGAINAFKSYRPKFVEIPMDDNGMIIEELEKALAENKGKVKMIYTIPDFQNPTG
ECCCCHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCC
RTMPDDRRKRIAELAAEYEIPVIEDNPYGDLIYEGERHPSIKSFDKEGWVIYLGTFSKNF
CCCCHHHHHHHHHHHHHCCCEEECCCCCCCEEECCCCCCCCCCCCCCCCEEEEECCCCCC
CPGLRLAWVCAEPEILDKYIIVKQGVDLQAGTLDQRATALFMQKYDLNEHIEKIKKVYEK
CCCCEEEEEECCHHHHHHEEEEECCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHH
RRDLMLDSMKKYFPADVKYTHPVGGLFTWVELREDLDAKELMKDALAENVAYVPGGSFFP
HHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHCCCHHHHHHHHHHHCEEECCCCCCCC
NGGHENYFRLNYSCMSDEKIVEGVKRLGKVLDKYYK
CCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNIRFSERAAGLKASEIRELLKLTEMPEIISFAGGLPAPELFPVEEMKGIMQEVLDTQGR
CCCCCCHHHCCCCHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCC
AALQYSSTEGYKPLREIIANERMKPAGVNVSFENIAITNGSQQGIEFSAKIFLNEGDIVV
EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEECEEEEECCCCCCCEEEEEEEEECCCEEE
CESPSYLGAINAFKSYRPKFVEIPMDDNGMIIEELEKALAENKGKVKMIYTIPDFQNPTG
ECCCCHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCC
RTMPDDRRKRIAELAAEYEIPVIEDNPYGDLIYEGERHPSIKSFDKEGWVIYLGTFSKNF
CCCCHHHHHHHHHHHHHCCCEEECCCCCCCEEECCCCCCCCCCCCCCCCEEEEECCCCCC
CPGLRLAWVCAEPEILDKYIIVKQGVDLQAGTLDQRATALFMQKYDLNEHIEKIKKVYEK
CCCCEEEEEECCHHHHHHEEEEECCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHH
RRDLMLDSMKKYFPADVKYTHPVGGLFTWVELREDLDAKELMKDALAENVAYVPGGSFFP
HHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHCCCHHHHHHHHHHHCEEECCCCCCCC
NGGHENYFRLNYSCMSDEKIVEGVKRLGKVLDKYYK
CCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA