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The map label for this gene is pepP [H]

Identifier: 153935762

GI number: 153935762

Start: 466259

End: 467494

Strand: Direct

Name: pepP [H]

Synonym: CLC_0465

Alternate gene names: 153935762

Gene position: 466259-467494 (Clockwise)

Preceding gene: 153936962

Following gene: 153936592

Centisome position: 12.4

GC content: 28.16

Gene sequence:

>1236_bases
GTGAATAAAGAATTTTTTATGAGAAACAGGAAAAACTTAGGGGAGAGTATAGAAGAGGGAATAATTGTTATATTTGCAGG
CAAGGCACCTTATAAATCAGCAGACGAAACCTATCCATTTACACCTAACAGAAACTTTTATTATTTAACTGGAATAGAAG
AGGAACAGATAATATTAGTCATAACTAAGAAAAATAAAAAAATAAAAGAACATTTATATATACAAAGACCAGATCCAGTA
ATGGCAAGATGGGTAGGGGCAACCATTAGCGAAGAAGAAGCTGAAGAGGTAAGTGGGATAGAAAACATAGGGTATGTAGA
TAAATTTTTTGATGATTTTCCCATCTTTATAAATAGAAGTGGATCTAATAAAGTATACTTAGATTTAGAGAGGAGAGAAT
GGGAAGAAAATTTTACACCAGCTCAAATTTTTGCTAAAGAATTAAGAGAAAAATATCCTTATGTAAAAATAGAAAACATC
TATAAAGGTATAAGTGATTTAAGAACAATAAAAAGTAAAGAGGAAGTAGAATTAATCAAGAAAGCTATAGATATAACTAA
AGAAGGTATATATAACATGATGAAAAATATAAAGCCAAATATGATGGAATATGAAGTGGAAGCATATTTTGACTTTTCCT
TAAAGAAAAATGGTGTTACAGATTATGCCTTTGAAACTATAGCAGCAGCGGGAAAAAATGCTACAGTACTACATTATAGT
GAAAATAATTGTAAAATAGAAAATAACTCTTTAATCCTTTGTGATTTAGGAGCTCAACATAAATATTATAATGGTGATAT
AACAAGAACCTTTCCTGCTAATGGAAAGTTTACAGAGAGACAAAAAGAAGTATATAAAGTAGTTTTAGAAGCTAATAAAG
CTATAATTCAAAATGCAAAACCTGGAGTTACATTTAAAGAAATAGAAGATATAACTAAAAAAATATTAACAGAAGGATGC
AAAAAATTAGGAATATTACAAGATAAAAAAGAATTAAGGAAATATTATTTTCATAGTTTTGGACATTATTTAGGCTTAGA
TACTCATGACGTAGGAAGCTATGAAGTAAAATTAAAACCAGGTATGGTTATAACCAATGAACCAGGTCTTTATATAGAAG
AAGAAAGTATTGGAATAAGAATAGAGGATGATTTATTAATAACAGAAGATGGGTGTGAAGTTTTAAGTAAGGATATAATT
AAGAGTATAGAAGAAATAGAAAACTTCATGAAATAA

Upstream 100 bases:

>100_bases
GAAAAAAATTACATTTTATGGTATTAGTATTAATATAATTATACTCAATTTTTATTCAACTTTAATGAGATATTTAAATA
AATTAGTTAGGGGGACTTTT

Downstream 100 bases:

>100_bases
GGAAATTACAACTCAAAAGGAAGTCATACTACCCGTGGTTTAAAAAAGGGATATGTGGCGAGATCAGCAACTCACGACCA
TAAGAGATTCTAACTTGTTT

Product: xaa-pro aminopeptidase

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase; Aminopeptidase P II; APP-II; X-Pro aminopeptidase [H]

Number of amino acids: Translated: 411; Mature: 411

Protein sequence:

>411_residues
MNKEFFMRNRKNLGESIEEGIIVIFAGKAPYKSADETYPFTPNRNFYYLTGIEEEQIILVITKKNKKIKEHLYIQRPDPV
MARWVGATISEEEAEEVSGIENIGYVDKFFDDFPIFINRSGSNKVYLDLERREWEENFTPAQIFAKELREKYPYVKIENI
YKGISDLRTIKSKEEVELIKKAIDITKEGIYNMMKNIKPNMMEYEVEAYFDFSLKKNGVTDYAFETIAAAGKNATVLHYS
ENNCKIENNSLILCDLGAQHKYYNGDITRTFPANGKFTERQKEVYKVVLEANKAIIQNAKPGVTFKEIEDITKKILTEGC
KKLGILQDKKELRKYYFHSFGHYLGLDTHDVGSYEVKLKPGMVITNEPGLYIEEESIGIRIEDDLLITEDGCEVLSKDII
KSIEEIENFMK

Sequences:

>Translated_411_residues
MNKEFFMRNRKNLGESIEEGIIVIFAGKAPYKSADETYPFTPNRNFYYLTGIEEEQIILVITKKNKKIKEHLYIQRPDPV
MARWVGATISEEEAEEVSGIENIGYVDKFFDDFPIFINRSGSNKVYLDLERREWEENFTPAQIFAKELREKYPYVKIENI
YKGISDLRTIKSKEEVELIKKAIDITKEGIYNMMKNIKPNMMEYEVEAYFDFSLKKNGVTDYAFETIAAAGKNATVLHYS
ENNCKIENNSLILCDLGAQHKYYNGDITRTFPANGKFTERQKEVYKVVLEANKAIIQNAKPGVTFKEIEDITKKILTEGC
KKLGILQDKKELRKYYFHSFGHYLGLDTHDVGSYEVKLKPGMVITNEPGLYIEEESIGIRIEDDLLITEDGCEVLSKDII
KSIEEIENFMK
>Mature_411_residues
MNKEFFMRNRKNLGESIEEGIIVIFAGKAPYKSADETYPFTPNRNFYYLTGIEEEQIILVITKKNKKIKEHLYIQRPDPV
MARWVGATISEEEAEEVSGIENIGYVDKFFDDFPIFINRSGSNKVYLDLERREWEENFTPAQIFAKELREKYPYVKIENI
YKGISDLRTIKSKEEVELIKKAIDITKEGIYNMMKNIKPNMMEYEVEAYFDFSLKKNGVTDYAFETIAAAGKNATVLHYS
ENNCKIENNSLILCDLGAQHKYYNGDITRTFPANGKFTERQKEVYKVVLEANKAIIQNAKPGVTFKEIEDITKKILTEGC
KKLGILQDKKELRKYYFHSFGHYLGLDTHDVGSYEVKLKPGMVITNEPGLYIEEESIGIRIEDDLLITEDGCEVLSKDII
KSIEEIENFMK

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=424, Percent_Identity=30.8962264150943, Blast_Score=205, Evalue=5e-53,
Organism=Homo sapiens, GI149589008, Length=470, Percent_Identity=27.2340425531915, Blast_Score=170, Evalue=3e-42,
Organism=Homo sapiens, GI260593665, Length=305, Percent_Identity=30.8196721311475, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI260593663, Length=468, Percent_Identity=25.6410256410256, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI264681563, Length=280, Percent_Identity=27.1428571428571, Blast_Score=69, Evalue=5e-12,
Organism=Escherichia coli, GI1789275, Length=440, Percent_Identity=32.9545454545455, Blast_Score=243, Evalue=1e-65,
Organism=Escherichia coli, GI1788728, Length=237, Percent_Identity=30.8016877637131, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI1790282, Length=296, Percent_Identity=25, Blast_Score=79, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17508215, Length=474, Percent_Identity=29.3248945147679, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI71989583, Length=265, Percent_Identity=26.4150943396226, Blast_Score=102, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6321118, Length=436, Percent_Identity=28.2110091743119, Blast_Score=160, Evalue=5e-40,
Organism=Saccharomyces cerevisiae, GI6320922, Length=437, Percent_Identity=28.1464530892449, Blast_Score=152, Evalue=7e-38,
Organism=Drosophila melanogaster, GI19920384, Length=421, Percent_Identity=29.2161520190024, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI21357079, Length=438, Percent_Identity=28.9954337899543, Blast_Score=168, Evalue=7e-42,
Organism=Drosophila melanogaster, GI17137632, Length=178, Percent_Identity=32.5842696629214, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 47622; Mature: 47622

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKEFFMRNRKNLGESIEEGIIVIFAGKAPYKSADETYPFTPNRNFYYLTGIEEEQIILV
CCCHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCCCCEEEE
ITKKNKKIKEHLYIQRPDPVMARWVGATISEEEAEEVSGIENIGYVDKFFDDFPIFINRS
EECCCCCHHHCEEEECCCHHHHHHHCCCCCHHHHHHHCCCHHCCCHHHHHCCCCEEEECC
GSNKVYLDLERREWEENFTPAQIFAKELREKYPYVKIENIYKGISDLRTIKSKEEVELIK
CCCEEEEEEHHHHHHCCCCHHHHHHHHHHHHCCEEEEHHHHCCHHHHHHHCCHHHHHHHH
KAIDITKEGIYNMMKNIKPNMMEYEVEAYFDFSLKKNGVTDYAFETIAAAGKNATVLHYS
HHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEEEECCCCCCHHHHHHHHHCCCCCEEEEEE
ENNCKIENNSLILCDLGAQHKYYNGDITRTFPANGKFTERQKEVYKVVLEANKAIIQNAK
CCCCEEECCCEEEEECCCCCEEECCCEEEECCCCCCCHHHHHHHHHHHHHHCHHHHCCCC
PGVTFKEIEDITKKILTEGCKKLGILQDKKELRKYYFHSFGHYLGLDTHDVGSYEVKLKP
CCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECC
GMVITNEPGLYIEEESIGIRIEDDLLITEDGCEVLSKDIIKSIEEIENFMK
CEEEECCCCCEEEECCCEEEEECCEEEECCHHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MNKEFFMRNRKNLGESIEEGIIVIFAGKAPYKSADETYPFTPNRNFYYLTGIEEEQIILV
CCCHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCCCCEEEE
ITKKNKKIKEHLYIQRPDPVMARWVGATISEEEAEEVSGIENIGYVDKFFDDFPIFINRS
EECCCCCHHHCEEEECCCHHHHHHHCCCCCHHHHHHHCCCHHCCCHHHHHCCCCEEEECC
GSNKVYLDLERREWEENFTPAQIFAKELREKYPYVKIENIYKGISDLRTIKSKEEVELIK
CCCEEEEEEHHHHHHCCCCHHHHHHHHHHHHCCEEEEHHHHCCHHHHHHHCCHHHHHHHH
KAIDITKEGIYNMMKNIKPNMMEYEVEAYFDFSLKKNGVTDYAFETIAAAGKNATVLHYS
HHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEEEECCCCCCHHHHHHHHHCCCCCEEEEEE
ENNCKIENNSLILCDLGAQHKYYNGDITRTFPANGKFTERQKEVYKVVLEANKAIIQNAK
CCCCEEECCCEEEEECCCCCEEECCCEEEECCCCCCCHHHHHHHHHHHHHHCHHHHCCCC
PGVTFKEIEDITKKILTEGCKKLGILQDKKELRKYYFHSFGHYLGLDTHDVGSYEVKLKP
CCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECC
GMVITNEPGLYIEEESIGIRIEDDLLITEDGCEVLSKDIIKSIEEIENFMK
CEEEECCCCCEEEECCCEEEEECCEEEECCHHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2659585; 1339425; 9278503; 9520390 [H]