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The map label for this gene is lytC [H]

Identifier: 153935314

GI number: 153935314

Start: 525541

End: 526962

Strand: Direct

Name: lytC [H]

Synonym: CLC_0518

Alternate gene names: 153935314

Gene position: 525541-526962 (Clockwise)

Preceding gene: 153936608

Following gene: 153935218

Centisome position: 13.98

GC content: 31.79

Gene sequence:

>1422_bases
ATGAAAAAAAGATTGTTAAATATTACTTCTGCTGTAGTTGCATCTTGTGTGATGTTTTTTTCGTCAAATGTTGTAAGTGC
AGCAACGCTACAAGAGAGACTGTGTGGAAATAATAGGTATGAAACTAACTCTAAAATTGTAGACTCAGGCTGGACATCAT
CGGAGTATGCAGTAGTAGCAAGTGGAGATGATTTTGCAGATGCACTATGCGCAGCTCCTTTAGCTAAACAAAATAAGGCC
CCCATACTCTTAGCTAATAAAGATACTTTAAGTATAGAAAGCAAAAAACAATTATCAAGGCTTAAAGTAAAAAAAGTATT
TATTATTGGTGGAATTGGAGTTATAACTGATAATGTGAAATTGGAAATAGAAAGCATGGGCATCGAAACTTCTAGAATAT
ATGGAGAAAATAGATTTGAAACATCTATAGAAGTAGCTAAAAACCTAAAAAATATAAGTGGAGTAGTAGTAGCTAATGGT
TATGGATTTGCAGATGCGTTATCCATAGCTCCTGTTGCGGCACAAAAAGGTATGCCAATACTGCTTACTAATAGAGGAGA
CTTATCTAAAGTAGCTAAAGAATTTTTAGATACTAAAACGCTTACTGAAAGTTATGTAGTTGGTGGAACTGGAGTTGTAA
GTAGCAAGATTTCTTCACAATTAAATAATAACACAAGACTTGGAGGAGAAAATAGATATGAAACAAATTCAGCTGTATTA
AATCACTTTGCCGATAAGTTTAGTTATGATAAAGTTTATGTTGCATCAGGTGAGAATTATCCAGATGCACTATCTGGTAG
TGTATTAGCAGCAGCAAGCAAATCACCTTTAGTATTAGTGGGGGATTCTGTTAATTCCTCAGTAATGTCTTCAGTAAAAG
CTCAACATGATAAATATAATAATGTAATAGTCTTAGGTGGCACTGGAGTAGTTTCAGATGTATCAGCCAATAGTATTGTA
CATGGCATTAAATATTTAAATGATAGGGAAGCACTAACCCTTATAAATAATGCTAATAAGTTAGGATATCCAGTAATAGA
ATCTAATGCTATGCCTAGTATATATATTGGTGATAAGATATATCAAAAATTCCAAGATGAGTTTAATAGTCCTGAAAAGA
TATATGCTTATTTAAATAAATATTATACAAGATCTTCCATAAATGAGATTATGAATATGCTTCAAGTAAGGGAAATAGAT
GGAGCATACTGCAAAATAGTTGGTCAGCTAGGCGATTATAATCCTGATATATTAAATGCTAAAATCAAAAGTAAATCAAT
TTTTAATAATAAGATGGATTTAGTTATATCAACTAGACATTTACATTTACCTGATGATTATACGAATAATTATAAAGTTG
AATTGTTATATGAAGACGGAAAATGGCGTGTGAATTATTGGGAGGGTTTAATACAGAGATAG

Upstream 100 bases:

>100_bases
ATAATTACCCCTCTATTTAATAATCAAAAAAATACATATTGTAATTAATGTATTTAAATAGGCATAGTAATTATAGTGAT
TATAGATAGAGGAGGTAACT

Downstream 100 bases:

>100_bases
TGGAATGTTAATTAAAGAGTTATCCTAACGTTAGTGTATTAAAAAGAAGGATGTGTGTCATAAAAGGTATTAAAATAAAA
AATACTTTTAGAGAAAATAG

Product: N-acetylmuramoyl-L-alanine amidase-like protein

Products: NA

Alternate protein names: Cell wall hydrolase; Cell wall-associated polypeptide CWBP49; CWBP49; Major autolysin [H]

Number of amino acids: Translated: 473; Mature: 473

Protein sequence:

>473_residues
MKKRLLNITSAVVASCVMFFSSNVVSAATLQERLCGNNRYETNSKIVDSGWTSSEYAVVASGDDFADALCAAPLAKQNKA
PILLANKDTLSIESKKQLSRLKVKKVFIIGGIGVITDNVKLEIESMGIETSRIYGENRFETSIEVAKNLKNISGVVVANG
YGFADALSIAPVAAQKGMPILLTNRGDLSKVAKEFLDTKTLTESYVVGGTGVVSSKISSQLNNNTRLGGENRYETNSAVL
NHFADKFSYDKVYVASGENYPDALSGSVLAAASKSPLVLVGDSVNSSVMSSVKAQHDKYNNVIVLGGTGVVSDVSANSIV
HGIKYLNDREALTLINNANKLGYPVIESNAMPSIYIGDKIYQKFQDEFNSPEKIYAYLNKYYTRSSINEIMNMLQVREID
GAYCKIVGQLGDYNPDILNAKIKSKSIFNNKMDLVISTRHLHLPDDYTNNYKVELLYEDGKWRVNYWEGLIQR

Sequences:

>Translated_473_residues
MKKRLLNITSAVVASCVMFFSSNVVSAATLQERLCGNNRYETNSKIVDSGWTSSEYAVVASGDDFADALCAAPLAKQNKA
PILLANKDTLSIESKKQLSRLKVKKVFIIGGIGVITDNVKLEIESMGIETSRIYGENRFETSIEVAKNLKNISGVVVANG
YGFADALSIAPVAAQKGMPILLTNRGDLSKVAKEFLDTKTLTESYVVGGTGVVSSKISSQLNNNTRLGGENRYETNSAVL
NHFADKFSYDKVYVASGENYPDALSGSVLAAASKSPLVLVGDSVNSSVMSSVKAQHDKYNNVIVLGGTGVVSDVSANSIV
HGIKYLNDREALTLINNANKLGYPVIESNAMPSIYIGDKIYQKFQDEFNSPEKIYAYLNKYYTRSSINEIMNMLQVREID
GAYCKIVGQLGDYNPDILNAKIKSKSIFNNKMDLVISTRHLHLPDDYTNNYKVELLYEDGKWRVNYWEGLIQR
>Mature_473_residues
MKKRLLNITSAVVASCVMFFSSNVVSAATLQERLCGNNRYETNSKIVDSGWTSSEYAVVASGDDFADALCAAPLAKQNKA
PILLANKDTLSIESKKQLSRLKVKKVFIIGGIGVITDNVKLEIESMGIETSRIYGENRFETSIEVAKNLKNISGVVVANG
YGFADALSIAPVAAQKGMPILLTNRGDLSKVAKEFLDTKTLTESYVVGGTGVVSSKISSQLNNNTRLGGENRYETNSAVL
NHFADKFSYDKVYVASGENYPDALSGSVLAAASKSPLVLVGDSVNSSVMSSVKAQHDKYNNVIVLGGTGVVSDVSANSIV
HGIKYLNDREALTLINNANKLGYPVIESNAMPSIYIGDKIYQKFQDEFNSPEKIYAYLNKYYTRSSINEIMNMLQVREID
GAYCKIVGQLGDYNPDILNAKIKSKSIFNNKMDLVISTRHLHLPDDYTNNYKVELLYEDGKWRVNYWEGLIQR

Specific function: Autolysins are involved in some important biological processes such as cell separation, cell-wall turnover, competence for genetic transformation, formation of the flagella - in particular of its basal body - and sporulation. Has a high affinity for teich

COG id: COG2247

COG function: function code M; Putative cell wall-binding domain

Gene ontology:

Cell location: Secreted, cell wall [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007253
- InterPro:   IPR002508 [H]

Pfam domain/function: PF01520 Amidase_3; PF04122 CW_binding_2 [H]

EC number: =3.5.1.28 [H]

Molecular weight: Translated: 51891; Mature: 51891

Theoretical pI: Translated: 8.46; Mature: 8.46

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKRLLNITSAVVASCVMFFSSNVVSAATLQERLCGNNRYETNSKIVDSGWTSSEYAVVA
CCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCEEEEE
SGDDFADALCAAPLAKQNKAPILLANKDTLSIESKKQLSRLKVKKVFIIGGIGVITDNVK
CCCHHHHHHHHCCHHCCCCCCEEEECCCCCCCCHHHHHHHHEEEEEEEEECCEEEECCEE
LEIESMGIETSRIYGENRFETSIEVAKNLKNISGVVVANGYGFADALSIAPVAAQKGMPI
EEEEECCCEEHHCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHCHHHHHCCCEE
LLTNRGDLSKVAKEFLDTKTLTESYVVGGTGVVSSKISSQLNNNTRLGGENRYETNSAVL
EEECCCCHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHH
NHFADKFSYDKVYVASGENYPDALSGSVLAAASKSPLVLVGDSVNSSVMSSVKAQHDKYN
HHHHHHCCCCEEEEECCCCCCCCCCCCEEEECCCCCEEEECCCCCHHHHHHHHHHHCCCC
NVIVLGGTGVVSDVSANSIVHGIKYLNDREALTLINNANKLGYPVIESNAMPSIYIGDKI
CEEEECCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCEEECCCCCEEEECHHH
YQKFQDEFNSPEKIYAYLNKYYTRSSINEIMNMLQVREIDGAYCKIVGQLGDYNPDILNA
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCEEE
KIKSKSIFNNKMDLVISTRHLHLPDDYTNNYKVELLYEDGKWRVNYWEGLIQR
EECCCHHCCCCEEEEEEEEEEECCCCCCCCEEEEEEEECCCEEEEHHHHHHCC
>Mature Secondary Structure
MKKRLLNITSAVVASCVMFFSSNVVSAATLQERLCGNNRYETNSKIVDSGWTSSEYAVVA
CCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCEEEEE
SGDDFADALCAAPLAKQNKAPILLANKDTLSIESKKQLSRLKVKKVFIIGGIGVITDNVK
CCCHHHHHHHHCCHHCCCCCCEEEECCCCCCCCHHHHHHHHEEEEEEEEECCEEEECCEE
LEIESMGIETSRIYGENRFETSIEVAKNLKNISGVVVANGYGFADALSIAPVAAQKGMPI
EEEEECCCEEHHCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHCHHHHHCCCEE
LLTNRGDLSKVAKEFLDTKTLTESYVVGGTGVVSSKISSQLNNNTRLGGENRYETNSAVL
EEECCCCHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHH
NHFADKFSYDKVYVASGENYPDALSGSVLAAASKSPLVLVGDSVNSSVMSSVKAQHDKYN
HHHHHHCCCCEEEEECCCCCCCCCCCCEEEECCCCCEEEECCCCCHHHHHHHHHHHCCCC
NVIVLGGTGVVSDVSANSIVHGIKYLNDREALTLINNANKLGYPVIESNAMPSIYIGDKI
CEEEECCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCEEECCCCCEEEECHHH
YQKFQDEFNSPEKIYAYLNKYYTRSSINEIMNMLQVREIDGAYCKIVGQLGDYNPDILNA
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCEEE
KIKSKSIFNNKMDLVISTRHLHLPDDYTNNYKVELLYEDGKWRVNYWEGLIQR
EECCCHHCCCCEEEEEEEEEEECCCCCCCCEEEEEEEECCCEEEEHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1357079; 1682302; 9384377 [H]