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The map label for this gene is cpx [H]

Identifier: 153934932

GI number: 153934932

Start: 363230

End: 364531

Strand: Direct

Name: cpx [H]

Synonym: CLC_0374

Alternate gene names: 153934932

Gene position: 363230-364531 (Clockwise)

Preceding gene: 153935555

Following gene: 153937838

Centisome position: 9.66

GC content: 33.72

Gene sequence:

>1302_bases
ATGAAAAAAAACGAGATGGATATTCAGTTAATGTATGGGGTTAATGATAAGCCACAAATATTAATGCAAATTTTATTAGG
GCTGCAGCATATTTTTGCGGCTTTTGGTGGAATAATTGTTGTTCCAATTGTTATTTCAGCAGCTTTAGGCTTTGATGCTC
AAACTTCAACAGCATTAATTAGTAGTGCAATTTTAGCGGCAGGAGTGGCTACTTTTATTCAGTCAAGAGGAATAGGACCT
ATTGGAGCACGCGTTGCCTGTATTATGGGAACTGACTTTACATTTGTTGCACCAGCAATTGCTGTTGGTGGAAAGTTTGG
ATTATCAGGAATTTTTGGAGCAACAATTTTAGGTGCAGGCATAGTAATCATTTTAAGTTTTTTTGTTAAACCACTAATGA
AGCTATTTCCACCTATTGTAACAGGAACAGTTGTGAGTTTAATTGGGTTAACATTATTACCAGTTTCAATAGATTGGGCA
GCAGGAGGTGCAGGATCTGCTAATTATGGAAGTTTAAAAAATATTTCTATTGCTTTATTTATAATGATAGTTACATTATT
ACTAAATCATTATGGAAAGGGATTAGTAAGTAGTGCTTCAATCTTAATAGGTATGATTGTTGGATATATAATTTGTATTC
CATTAGAAATGGTTGATTTTTCATCAGTAAGCCAAGCTAGTTGGGTATCATTACCTAAAATTTTTGGCTATGGTATAACT
TTTAACTTACAGGTTTTATTACCTTTTATTCCTGCATATTTTGTTACTATCATTGGAACTGTTGGATGTCTTAAAGCCAT
TACTGAAGTTTCTGGAATTAAAGCAGACGAAAAGCCTATTACAGCTGGAGTCCTATCCGATGGTGTAGGAAGTATGTTAG
CAGGGGTTTTTGGTGCCTTACCCAATACATCATTTAGTCAAAATATTGGATTAATTCCTCTAACAAAAGTAGCTAGCCGT
TATGTAACAATGATGGCTGGAATACTATTAGTTATTTTAGGATTGTTTCCTAAATTTGCTGCACTAATCAACATAATGCC
ACAGCCGGTACTTGGTGGTGTAGGAATTGTTATGTTTGGAACAGTTGCTGCAGCAGGAATTCAAACTTTAAGTAGTGTAA
AGTTAAACAATAGAAATATGTTAATAATTGCCACATCCATTGGCTTAGGATTAGGGGTTACCTTCCGTCCGGAATTTATT
GCTCAATTACCAGAATCCTTAAAAATGATTTTTTCATCAGGAATTTCAACTGGAACAATTGTAGCTTTATTATTAAATGT
AATATTAAAAGAAAAAGAATAA

Upstream 100 bases:

>100_bases
TTATCTCCTATATAGGTGGATTCTTATTTATGTACCTTAAGATGCTGTATGATAAATAAATTTTTAGAGCATTAATAAAG
TTAGGGAGGAGAGTAGTAAA

Downstream 100 bases:

>100_bases
GGAATTTTACGGGGTGATATAAGTGGAAAAATTACAAAATCGTATTTTACAAGAAGGTCATGCATTATCTGAAACTGTAT
TAAAGGTGGATTCTTTTTTA

Product: xanthine/uracil permease family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MKKNEMDIQLMYGVNDKPQILMQILLGLQHIFAAFGGIIVVPIVISAALGFDAQTSTALISSAILAAGVATFIQSRGIGP
IGARVACIMGTDFTFVAPAIAVGGKFGLSGIFGATILGAGIVIILSFFVKPLMKLFPPIVTGTVVSLIGLTLLPVSIDWA
AGGAGSANYGSLKNISIALFIMIVTLLLNHYGKGLVSSASILIGMIVGYIICIPLEMVDFSSVSQASWVSLPKIFGYGIT
FNLQVLLPFIPAYFVTIIGTVGCLKAITEVSGIKADEKPITAGVLSDGVGSMLAGVFGALPNTSFSQNIGLIPLTKVASR
YVTMMAGILLVILGLFPKFAALINIMPQPVLGGVGIVMFGTVAAAGIQTLSSVKLNNRNMLIIATSIGLGLGVTFRPEFI
AQLPESLKMIFSSGISTGTIVALLLNVILKEKE

Sequences:

>Translated_433_residues
MKKNEMDIQLMYGVNDKPQILMQILLGLQHIFAAFGGIIVVPIVISAALGFDAQTSTALISSAILAAGVATFIQSRGIGP
IGARVACIMGTDFTFVAPAIAVGGKFGLSGIFGATILGAGIVIILSFFVKPLMKLFPPIVTGTVVSLIGLTLLPVSIDWA
AGGAGSANYGSLKNISIALFIMIVTLLLNHYGKGLVSSASILIGMIVGYIICIPLEMVDFSSVSQASWVSLPKIFGYGIT
FNLQVLLPFIPAYFVTIIGTVGCLKAITEVSGIKADEKPITAGVLSDGVGSMLAGVFGALPNTSFSQNIGLIPLTKVASR
YVTMMAGILLVILGLFPKFAALINIMPQPVLGGVGIVMFGTVAAAGIQTLSSVKLNNRNMLIIATSIGLGLGVTFRPEFI
AQLPESLKMIFSSGISTGTIVALLLNVILKEKE
>Mature_433_residues
MKKNEMDIQLMYGVNDKPQILMQILLGLQHIFAAFGGIIVVPIVISAALGFDAQTSTALISSAILAAGVATFIQSRGIGP
IGARVACIMGTDFTFVAPAIAVGGKFGLSGIFGATILGAGIVIILSFFVKPLMKLFPPIVTGTVVSLIGLTLLPVSIDWA
AGGAGSANYGSLKNISIALFIMIVTLLLNHYGKGLVSSASILIGMIVGYIICIPLEMVDFSSVSQASWVSLPKIFGYGIT
FNLQVLLPFIPAYFVTIIGTVGCLKAITEVSGIKADEKPITAGVLSDGVGSMLAGVFGALPNTSFSQNIGLIPLTKVASR
YVTMMAGILLVILGLFPKFAALINIMPQPVLGGVGIVMFGTVAAAGIQTLSSVKLNNRNMLIIATSIGLGLGVTFRPEFI
AQLPESLKMIFSSGISTGTIVALLLNVILKEKE

Specific function: Unknown

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680145, Length=470, Percent_Identity=26.1702127659574, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI44680143, Length=474, Percent_Identity=26.3713080168776, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI44680148, Length=502, Percent_Identity=25.6972111553785, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI40316845, Length=502, Percent_Identity=25.6972111553785, Blast_Score=117, Evalue=3e-26,
Organism=Escherichia coli, GI87082181, Length=411, Percent_Identity=39.6593673965937, Blast_Score=277, Evalue=1e-75,
Organism=Escherichia coli, GI1790087, Length=452, Percent_Identity=35.3982300884956, Blast_Score=240, Evalue=1e-64,
Organism=Escherichia coli, GI87082178, Length=442, Percent_Identity=34.6153846153846, Blast_Score=224, Evalue=1e-59,
Organism=Escherichia coli, GI1788843, Length=398, Percent_Identity=30.4020100502513, Blast_Score=145, Evalue=3e-36,
Organism=Escherichia coli, GI87081818, Length=446, Percent_Identity=28.47533632287, Blast_Score=133, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17558856, Length=448, Percent_Identity=25.6696428571429, Blast_Score=108, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI17541904, Length=455, Percent_Identity=24.6153846153846, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17542262, Length=445, Percent_Identity=24.7191011235955, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71993493, Length=443, Percent_Identity=23.7020316027088, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI193206893, Length=458, Percent_Identity=24.8908296943231, Blast_Score=78, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17542260, Length=109, Percent_Identity=37.6146788990826, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21356175, Length=436, Percent_Identity=25.9174311926606, Blast_Score=112, Evalue=7e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017588
- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 44998; Mature: 44998

Theoretical pI: Translated: 9.69; Mature: 9.69

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKNEMDIQLMYGVNDKPQILMQILLGLQHIFAAFGGIIVVPIVISAALGFDAQTSTALI
CCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
SSAILAAGVATFIQSRGIGPIGARVACIMGTDFTFVAPAIAVGGKFGLSGIFGATILGAG
HHHHHHHHHHHHHHHCCCCCHHHHEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHH
IVIILSFFVKPLMKLFPPIVTGTVVSLIGLTLLPVSIDWAAGGAGSANYGSLKNISIALF
HHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCEEEEECCCCCCCCCCCCCHHHHHHHH
IMIVTLLLNHYGKGLVSSASILIGMIVGYIICIPLEMVDFSSVSQASWVSLPKIFGYGIT
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCE
FNLQVLLPFIPAYFVTIIGTVGCLKAITEVSGIKADEKPITAGVLSDGVGSMLAGVFGAL
EEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCHHHHHHHHHHCC
PNTSFSQNIGLIPLTKVASRYVTMMAGILLVILGLFPKFAALINIMPQPVLGGVGIVMFG
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCHHHHHHHH
TVAAAGIQTLSSVKLNNRNMLIIATSIGLGLGVTFRPEFIAQLPESLKMIFSSGISTGTI
HHHHHHHHHHHHHEECCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHH
VALLLNVILKEKE
HHHHHHHHHCCCC
>Mature Secondary Structure
MKKNEMDIQLMYGVNDKPQILMQILLGLQHIFAAFGGIIVVPIVISAALGFDAQTSTALI
CCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
SSAILAAGVATFIQSRGIGPIGARVACIMGTDFTFVAPAIAVGGKFGLSGIFGATILGAG
HHHHHHHHHHHHHHHCCCCCHHHHEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHH
IVIILSFFVKPLMKLFPPIVTGTVVSLIGLTLLPVSIDWAAGGAGSANYGSLKNISIALF
HHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCEEEEECCCCCCCCCCCCCHHHHHHHH
IMIVTLLLNHYGKGLVSSASILIGMIVGYIICIPLEMVDFSSVSQASWVSLPKIFGYGIT
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCE
FNLQVLLPFIPAYFVTIIGTVGCLKAITEVSGIKADEKPITAGVLSDGVGSMLAGVFGAL
EEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCHHHHHHHHHHCC
PNTSFSQNIGLIPLTKVASRYVTMMAGILLVILGLFPKFAALINIMPQPVLGGVGIVMFG
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCHHHHHHHH
TVAAAGIQTLSSVKLNNRNMLIIATSIGLGLGVTFRPEFIAQLPESLKMIFSSGISTGTI
HHHHHHHHHHHHHEECCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHH
VALLLNVILKEKE
HHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11792842; 8162194 [H]