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The map label for this gene is atoC [H]

Identifier: 153002987

GI number: 153002987

Start: 135314

End: 136687

Strand: Reverse

Name: atoC [H]

Synonym: Anae109_0110

Alternate gene names: 153002987

Gene position: 136687-135314 (Counterclockwise)

Preceding gene: 153002988

Following gene: 153002986

Centisome position: 2.59

GC content: 72.78

Gene sequence:

>1374_bases
GTGACGAAGCCCAACCTGATGGTCATCGACGACCTCGACTCCGCGCGGCAGATGATGAAGCGCACGCTGGGGCGGTCGTA
CGCGGTGTTCGACTTCGCCTCGGTGGCGGAGGCGCTGCCCGCCGTCGAGCGGGCGGAGTTCGACGCCATCGTCACCGACC
TGCGCATGCCCGGCATCGACGGCATCGAGGGGATGCGCCGCTTCAAGGAGCGGGTGCCGGAGATCCCGGTCATCCTCGTC
ACGGCCTTCGCCACCGTGGAGACCGCGGTCGAGGCGATGAAGGCCGGCGCCTTCGACTACCTCAAGAAGCCCTTCGAGCC
GGAGGAGCTCGAGCTCGTGGTCGCGCGCGCGGTGGAGCACGCGCGCATCAAGCGCGACAACGCGCGCCTGCGGAGCGCGC
TCGCCGGCGAGTTCGGCGTGCACGGCATCATCGGCAAGTCGCAGCCGATGAAGGCCCTCGTGGAGATGCTCGGGCGGATC
GCCCCCTCCGACGTGCCCATCCTGGTGGAGGGCGAGTCCGGCACCGGCAAGGACCTTCTCGCGCGCGCGGCGCACGCCAT
GAGCCGGCGCGCGAGCGGACCCTACGTGGCGCTCAACATGAGCGCCATCCCCGAGAACCTCGCCGAGGCCGAGCTCTTCG
GCCACGAGAAGGGGGCCTTCACCGGCGCCGAGCAGGCGCGGGCCGGCTTCTTCGCCGAGGCGGAGGGGGGCACGCTGTTC
CTCGACGAGATCGGGCTCCTCCCGCCCGCGCTCCAGCCCAAGCTCCTGCGCGTCCTGCAGGACGGCGAGTACATCCCGGT
CGGCAGCCGCAAGGCGCGCAAGGGGAACGTGCGCGTGGTGGCGGCCACGAACGAGGACCTCGCCCGCGCGGTGAAGGAGG
GGAAGTTCCGCGAGGACCTGTGGTTCCGGCTGCGCGTCGTCCCGCTGCGGCTCCCGCCCCTGCGCGAGCGGAAGGAGGAC
ATCCCGCTCCTCGTCCACCACTTCGTGGAGAAGCACGCGCTGCGGCTGGGGCGGCCGCCGCTCGAGCCGGACGCCGAGGC
GATGCGGGCGCTCCTCGACCACCCCTGGCCGGGCAACATCCGCGAGCTGGAGCACGCCATCGAGCGCGGGCTCCTCCTCG
CGCGCGGGGAGACCATCACCCTCGCGGATCTCCCGCCCGAGCTCGCCCAGCCCGCCGCCGAAGCCGCCGCGGGCGGGGCG
GAGGGGCGCTACCGGCGCGCCCGCGACGCCTGGGAGCGGAAGTTCCTCGAGGACCTGCTGCGCGAGGCGGGCGGCAACGT
CGCGAAGGCCGCCGAGGCGGCCGGGCTCCATCGCTCCACCCTGTACGAGAAGCTCCAGCGCTACGGCCTCGTGGAGAAGG
ACGCCAAGGCGTGA

Upstream 100 bases:

>100_bases
GCATCCGCCTGCCCGTCGCGCCGGCCGAGCCGGCCGCGGCGGGCGCAGGCGCCGCGCCGTGAGCCCATCACCCGGCGCGC
GATCTCGTTAGAGGACTCCC

Downstream 100 bases:

>100_bases
GCGGACGCACCGCCGCGTCGGGCGGCGCGCCACCGCCGCGCCGCGCCCCTCGCGCGCCCAGGCTCCGCGCGGGGGACGTC
GCCGACGCCCCCGCCCTCGC

Product: two component sigma54 specific Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 457; Mature: 456

Protein sequence:

>457_residues
MTKPNLMVIDDLDSARQMMKRTLGRSYAVFDFASVAEALPAVERAEFDAIVTDLRMPGIDGIEGMRRFKERVPEIPVILV
TAFATVETAVEAMKAGAFDYLKKPFEPEELELVVARAVEHARIKRDNARLRSALAGEFGVHGIIGKSQPMKALVEMLGRI
APSDVPILVEGESGTGKDLLARAAHAMSRRASGPYVALNMSAIPENLAEAELFGHEKGAFTGAEQARAGFFAEAEGGTLF
LDEIGLLPPALQPKLLRVLQDGEYIPVGSRKARKGNVRVVAATNEDLARAVKEGKFREDLWFRLRVVPLRLPPLRERKED
IPLLVHHFVEKHALRLGRPPLEPDAEAMRALLDHPWPGNIRELEHAIERGLLLARGETITLADLPPELAQPAAEAAAGGA
EGRYRRARDAWERKFLEDLLREAGGNVAKAAEAAGLHRSTLYEKLQRYGLVEKDAKA

Sequences:

>Translated_457_residues
MTKPNLMVIDDLDSARQMMKRTLGRSYAVFDFASVAEALPAVERAEFDAIVTDLRMPGIDGIEGMRRFKERVPEIPVILV
TAFATVETAVEAMKAGAFDYLKKPFEPEELELVVARAVEHARIKRDNARLRSALAGEFGVHGIIGKSQPMKALVEMLGRI
APSDVPILVEGESGTGKDLLARAAHAMSRRASGPYVALNMSAIPENLAEAELFGHEKGAFTGAEQARAGFFAEAEGGTLF
LDEIGLLPPALQPKLLRVLQDGEYIPVGSRKARKGNVRVVAATNEDLARAVKEGKFREDLWFRLRVVPLRLPPLRERKED
IPLLVHHFVEKHALRLGRPPLEPDAEAMRALLDHPWPGNIRELEHAIERGLLLARGETITLADLPPELAQPAAEAAAGGA
EGRYRRARDAWERKFLEDLLREAGGNVAKAAEAAGLHRSTLYEKLQRYGLVEKDAKA
>Mature_456_residues
TKPNLMVIDDLDSARQMMKRTLGRSYAVFDFASVAEALPAVERAEFDAIVTDLRMPGIDGIEGMRRFKERVPEIPVILVT
AFATVETAVEAMKAGAFDYLKKPFEPEELELVVARAVEHARIKRDNARLRSALAGEFGVHGIIGKSQPMKALVEMLGRIA
PSDVPILVEGESGTGKDLLARAAHAMSRRASGPYVALNMSAIPENLAEAELFGHEKGAFTGAEQARAGFFAEAEGGTLFL
DEIGLLPPALQPKLLRVLQDGEYIPVGSRKARKGNVRVVAATNEDLARAVKEGKFREDLWFRLRVVPLRLPPLRERKEDI
PLLVHHFVEKHALRLGRPPLEPDAEAMRALLDHPWPGNIRELEHAIERGLLLARGETITLADLPPELAQPAAEAAAGGAE
GRYRRARDAWERKFLEDLLREAGGNVAKAAEAAGLHRSTLYEKLQRYGLVEKDAKA

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=460, Percent_Identity=42.3913043478261, Blast_Score=360, Evalue=1e-101,
Organism=Escherichia coli, GI1790299, Length=476, Percent_Identity=41.1764705882353, Blast_Score=335, Evalue=3e-93,
Organism=Escherichia coli, GI1790437, Length=462, Percent_Identity=41.5584415584416, Blast_Score=329, Evalue=2e-91,
Organism=Escherichia coli, GI1788905, Length=452, Percent_Identity=39.8230088495575, Blast_Score=296, Evalue=1e-81,
Organism=Escherichia coli, GI87082117, Length=338, Percent_Identity=44.9704142011834, Blast_Score=269, Evalue=3e-73,
Organism=Escherichia coli, GI1789087, Length=322, Percent_Identity=45.3416149068323, Blast_Score=256, Evalue=1e-69,
Organism=Escherichia coli, GI1789233, Length=325, Percent_Identity=41.5384615384615, Blast_Score=243, Evalue=2e-65,
Organism=Escherichia coli, GI87082152, Length=316, Percent_Identity=44.620253164557, Blast_Score=228, Evalue=7e-61,
Organism=Escherichia coli, GI1787583, Length=312, Percent_Identity=38.7820512820513, Blast_Score=203, Evalue=2e-53,
Organism=Escherichia coli, GI87081872, Length=305, Percent_Identity=39.672131147541, Blast_Score=201, Evalue=8e-53,
Organism=Escherichia coli, GI1786524, Length=335, Percent_Identity=39.1044776119403, Blast_Score=187, Evalue=8e-49,
Organism=Escherichia coli, GI1789828, Length=318, Percent_Identity=34.9056603773585, Blast_Score=152, Evalue=4e-38,
Organism=Escherichia coli, GI87081858, Length=290, Percent_Identity=31.3793103448276, Blast_Score=137, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 50258; Mature: 50126

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKPNLMVIDDLDSARQMMKRTLGRSYAVFDFASVAEALPAVERAEFDAIVTDLRMPGID
CCCCCEEEEECCHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
GIEGMRRFKERVPEIPVILVTAFATVETAVEAMKAGAFDYLKKPFEPEELELVVARAVEH
CHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHHHHH
ARIKRDNARLRSALAGEFGVHGIIGKSQPMKALVEMLGRIAPSDVPILVEGESGTGKDLL
HHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEECCCCCCHHHH
ARAAHAMSRRASGPYVALNMSAIPENLAEAELFGHEKGAFTGAEQARAGFFAEAEGGTLF
HHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCEEECCCCEEE
LDEIGLLPPALQPKLLRVLQDGEYIPVGSRKARKGNVRVVAATNEDLARAVKEGKFREDL
EHHHCCCCCCCCHHHHHHHHCCCEECCCCCCCCCCCEEEEEECCHHHHHHHHHCCCHHHH
WFRLRVVPLRLPPLRERKEDIPLLVHHFVEKHALRLGRPPLEPDAEAMRALLDHPWPGNI
EEEEEEEEECCCCCHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCH
RELEHAIERGLLLARGETITLADLPPELAQPAAEAAAGGAEGRYRRARDAWERKFLEDLL
HHHHHHHHHCEEEECCCEEEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
REAGGNVAKAAEAAGLHRSTLYEKLQRYGLVEKDAKA
HHCCCCHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TKPNLMVIDDLDSARQMMKRTLGRSYAVFDFASVAEALPAVERAEFDAIVTDLRMPGID
CCCCEEEEECCHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
GIEGMRRFKERVPEIPVILVTAFATVETAVEAMKAGAFDYLKKPFEPEELELVVARAVEH
CHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHHHHH
ARIKRDNARLRSALAGEFGVHGIIGKSQPMKALVEMLGRIAPSDVPILVEGESGTGKDLL
HHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEECCCCCCHHHH
ARAAHAMSRRASGPYVALNMSAIPENLAEAELFGHEKGAFTGAEQARAGFFAEAEGGTLF
HHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCEEECCCCEEE
LDEIGLLPPALQPKLLRVLQDGEYIPVGSRKARKGNVRVVAATNEDLARAVKEGKFREDL
EHHHCCCCCCCCHHHHHHHHCCCEECCCCCCCCCCCEEEEEECCHHHHHHHHHCCCHHHH
WFRLRVVPLRLPPLRERKEDIPLLVHHFVEKHALRLGRPPLEPDAEAMRALLDHPWPGNI
EEEEEEEEECCCCCHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCH
RELEHAIERGLLLARGETITLADLPPELAQPAAEAAAGGAEGRYRRARDAWERKFLEDLL
HHHHHHHHHCEEEECCCEEEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
REAGGNVAKAAEAAGLHRSTLYEKLQRYGLVEKDAKA
HHCCCCHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]