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The map label for this gene is msrAB [H]

Identifier: 152977616

GI number: 152977616

Start: 4013469

End: 4014434

Strand: Reverse

Name: msrAB [H]

Synonym: Bcer98_3954

Alternate gene names: 152977616

Gene position: 4014434-4013469 (Counterclockwise)

Preceding gene: 152977617

Following gene: 152977614

Centisome position: 98.22

GC content: 37.47

Gene sequence:

>966_bases
ATGTCTATCAATGAAAAGGTAGAGCTTGCGACGTTTGCGGGAGGTTGCTTTTGGTGTATGGTTTCACCATTTGAAGAGAT
GGAAGGGGTTATAAGAATCATTTCTGGTTATACAGGTGGTCATAAAGAAAATCCAACTTATAAAGAAGTTTGTTCTGAAA
CGACAGGACATTATGAAGCAGTTCAAATTACATTTGACCCAGATAAAATGCCGTATGAAAAATTATTAAATATGTATTGG
AGACAAATTGATCCAACAGATGCGGGTGGACAGTTTCATGATCGTGGGCAATCATATGAAACAGCTATCTTTTATCATAA
TGAAGAGCAACGGAAACTAGCTGAAGTATCGAAAAAGGAGCTTGCTGAGAGCGGGCGTTTTTCTAAACCAATTGTTACGA
AAATTATTCCAGCATCTACATTCTATCCAGCTGAGGAGTATCACCAAGATTATCATAAGAAAAATGCATTCCGTTATGCA
TTGTATCGCCAAGGATCAGGACGTGATGCATTTATTAAAAAGCATTGGCCAAAAGATAATGCACATTTAAAAGAACAATT
AACGGAGATGCAATTTTATGTAACGCAGGAAAACGGAACAGAACCTCCATTTCAAAATGAGTATTGGGATCATAAAGAAG
AAGGACTATATGTAGACATCGTGTCTGGTGAACCGCTATTTACTTCCTTAGATAAATTTGATAGTGGCTGTGGTTGGCCA
AGCTTTACAAAGCCTGTTATGGCAGCCAGTGTAAAAGAAAAAATTGACCTTAGTCATAATATGACGCGTACAGAAGTAAG
AAGCAGGGAAGGCGATTCACATCTTGGCCATGTTTTTCCAGATGGACCAGGACCAAACGGTCTTCGCTATTGCATTAATT
CAGCAGCACTTCGATTTATTCCAAAGGAAGACTTAGAAAAAGAAGGATATGGAGATTTTCTAATCTTGTTTCATCAAAAA
AAATAA

Upstream 100 bases:

>100_bases
ATCAGTGGGGATGAAAAAACAATGATTAGAGTTTCACTTTATAACTTCATTTCATATATGCCATACTGTAAGAAGAATAC
AAATAATTGAGGTGAAAGAA

Downstream 100 bases:

>100_bases
CCTCGCGATTGCGAGGTTATTTTACTGTTTTCTTTCTAAATTTGCTGAGCACTTCATATACAATCGGAACAATGAGAAGT
GTTAGTAATGTTGAACTTGT

Product: bifunctional methionine sulfoxide reductase A/B protein

Products: NA

Alternate protein names: Peptide methionine sulfoxide reductase msrA; Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase; Peptide methionine sulfoxide reductase msrB; Peptide-methionine (R)-S-oxide reductase [H]

Number of amino acids: Translated: 321; Mature: 320

Protein sequence:

>321_residues
MSINEKVELATFAGGCFWCMVSPFEEMEGVIRIISGYTGGHKENPTYKEVCSETTGHYEAVQITFDPDKMPYEKLLNMYW
RQIDPTDAGGQFHDRGQSYETAIFYHNEEQRKLAEVSKKELAESGRFSKPIVTKIIPASTFYPAEEYHQDYHKKNAFRYA
LYRQGSGRDAFIKKHWPKDNAHLKEQLTEMQFYVTQENGTEPPFQNEYWDHKEEGLYVDIVSGEPLFTSLDKFDSGCGWP
SFTKPVMAASVKEKIDLSHNMTRTEVRSREGDSHLGHVFPDGPGPNGLRYCINSAALRFIPKEDLEKEGYGDFLILFHQK
K

Sequences:

>Translated_321_residues
MSINEKVELATFAGGCFWCMVSPFEEMEGVIRIISGYTGGHKENPTYKEVCSETTGHYEAVQITFDPDKMPYEKLLNMYW
RQIDPTDAGGQFHDRGQSYETAIFYHNEEQRKLAEVSKKELAESGRFSKPIVTKIIPASTFYPAEEYHQDYHKKNAFRYA
LYRQGSGRDAFIKKHWPKDNAHLKEQLTEMQFYVTQENGTEPPFQNEYWDHKEEGLYVDIVSGEPLFTSLDKFDSGCGWP
SFTKPVMAASVKEKIDLSHNMTRTEVRSREGDSHLGHVFPDGPGPNGLRYCINSAALRFIPKEDLEKEGYGDFLILFHQK
K
>Mature_320_residues
SINEKVELATFAGGCFWCMVSPFEEMEGVIRIISGYTGGHKENPTYKEVCSETTGHYEAVQITFDPDKMPYEKLLNMYWR
QIDPTDAGGQFHDRGQSYETAIFYHNEEQRKLAEVSKKELAESGRFSKPIVTKIIPASTFYPAEEYHQDYHKKNAFRYAL
YRQGSGRDAFIKKHWPKDNAHLKEQLTEMQFYVTQENGTEPPFQNEYWDHKEEGLYVDIVSGEPLFTSLDKFDSGCGWPS
FTKPVMAASVKEKIDLSHNMTRTEVRSREGDSHLGHVFPDGPGPNGLRYCINSAALRFIPKEDLEKEGYGDFLILFHQKK

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the msrB Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI301336164, Length=150, Percent_Identity=45.3333333333333, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI301336162, Length=150, Percent_Identity=45.3333333333333, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI73089054, Length=150, Percent_Identity=45.3333333333333, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI37620216, Length=121, Percent_Identity=49.5867768595041, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI117606353, Length=134, Percent_Identity=46.2686567164179, Blast_Score=128, Evalue=8e-30,
Organism=Homo sapiens, GI6912516, Length=160, Percent_Identity=41.875, Blast_Score=121, Evalue=8e-28,
Organism=Homo sapiens, GI208609995, Length=160, Percent_Identity=41.875, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI208609993, Length=112, Percent_Identity=40.1785714285714, Blast_Score=75, Evalue=6e-14,
Organism=Escherichia coli, GI1788077, Length=125, Percent_Identity=55.2, Blast_Score=148, Evalue=4e-37,
Organism=Escherichia coli, GI1790665, Length=157, Percent_Identity=40.1273885350318, Blast_Score=120, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17553450, Length=131, Percent_Identity=45.0381679389313, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI115532676, Length=131, Percent_Identity=45.0381679389313, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17533973, Length=145, Percent_Identity=37.2413793103448, Blast_Score=91, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6320881, Length=163, Percent_Identity=31.9018404907975, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6319816, Length=147, Percent_Identity=30.6122448979592, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI221378664, Length=119, Percent_Identity=47.8991596638655, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24645799, Length=119, Percent_Identity=47.8991596638655, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI221378662, Length=126, Percent_Identity=45.2380952380952, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI45553335, Length=119, Percent_Identity=47.8991596638655, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI21356369, Length=119, Percent_Identity=47.8991596638655, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24645804, Length=130, Percent_Identity=43.8461538461538, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24645801, Length=130, Percent_Identity=43.8461538461538, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24664627, Length=155, Percent_Identity=34.8387096774194, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24664631, Length=155, Percent_Identity=34.1935483870968, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI45553131, Length=143, Percent_Identity=34.965034965035, Blast_Score=88, Evalue=9e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002579
- InterPro:   IPR011057
- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR; PF01641 SelR [H]

EC number: =1.8.4.11; =1.8.4.12 [H]

Molecular weight: Translated: 36975; Mature: 36844

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSINEKVELATFAGGCFWCMVSPFEEMEGVIRIISGYTGGHKENPTYKEVCSETTGHYEA
CCCCCCEEEEEECCCEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCCEEE
VQITFDPDKMPYEKLLNMYWRQIDPTDAGGQFHDRGQSYETAIFYHNEEQRKLAEVSKKE
EEEEECCCCCCHHHHHHHHHHHCCCCCCCCCHHHCCCCEEEEEEEECHHHHHHHHHHHHH
LAESGRFSKPIVTKIIPASTFYPAEEYHQDYHKKNAFRYALYRQGSGRDAFIKKHWPKDN
HHHCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCCCHHHCCCCCCC
AHLKEQLTEMQFYVTQENGTEPPFQNEYWDHKEEGLYVDIVSGEPLFTSLDKFDSGCGWP
HHHHHHHHHHEEEEEECCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHCCCCCCC
SFTKPVMAASVKEKIDLSHNMTRTEVRSREGDSHLGHVFPDGPGPNGLRYCINSAALRFI
CHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCC
PKEDLEKEGYGDFLILFHQKK
CHHHHCCCCCCCEEEEEECCC
>Mature Secondary Structure 
SINEKVELATFAGGCFWCMVSPFEEMEGVIRIISGYTGGHKENPTYKEVCSETTGHYEA
CCCCCEEEEEECCCEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCCEEE
VQITFDPDKMPYEKLLNMYWRQIDPTDAGGQFHDRGQSYETAIFYHNEEQRKLAEVSKKE
EEEEECCCCCCHHHHHHHHHHHCCCCCCCCCHHHCCCCEEEEEEEECHHHHHHHHHHHHH
LAESGRFSKPIVTKIIPASTFYPAEEYHQDYHKKNAFRYALYRQGSGRDAFIKKHWPKDN
HHHCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCCCHHHCCCCCCC
AHLKEQLTEMQFYVTQENGTEPPFQNEYWDHKEEGLYVDIVSGEPLFTSLDKFDSGCGWP
HHHHHHHHHHEEEEEECCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHCCCCCCC
SFTKPVMAASVKEKIDLSHNMTRTEVRSREGDSHLGHVFPDGPGPNGLRYCINSAALRFI
CHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCC
PKEDLEKEGYGDFLILFHQKK
CHHHHCCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]