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The map label for this gene is moeA [H]

Identifier: 152977084

GI number: 152977084

Start: 3458017

End: 3459306

Strand: Reverse

Name: moeA [H]

Synonym: Bcer98_3394

Alternate gene names: 152977084

Gene position: 3459306-3458017 (Counterclockwise)

Preceding gene: 152977086

Following gene: 152977083

Centisome position: 84.64

GC content: 40.39

Gene sequence:

>1290_bases
ATGCTAGAAAAACGAGTACCAATTCCAGTTGCTGAAGCAGTAAAGAGAGTGATGAAATATGCTCAGCGCGGTGAAATAGA
AGAGACGATTCTTATGGAGAGTTATGGAAGAGTGCTTGGAGAGGATGTTGTAGCTGATCACGATGTACCTTATTTCAATC
GTTCTCCTTATGATGGATTCGCAATTCGGGCAGAAGATACGAAAGAGGCAAGTCAAAGTAATCCAATTGAATTTCAAGTA
GTGGGAGAGATCGGAGCAGGGTCTGTTTTTCAAGGAGAAGTGAAAGCATTTGAAGCTGTTCGAATTATGACAGGAGCAGC
GATTCCAGAAGGATGTAATGCTGTTGTTATGTTAGAGTTGACAGAAGTTTGTACAAGAGATGGAAAAACATATATGAAGT
TGAAACGTTCTTTTCGAGCAGGAGATAATGTTTCATTTAAAGGTGAAGATATAAAGAAAAATCATGTGCTCGTGAAAAAA
GGAACGAGAATAAATCCAGGTGTGGCAGCGTTATTAGCAACGTTTGGATACAGTTCCGTTCATGTTGTAAAACAACCAGT
TGTTGGAATTATCACAACTGGAAGTGAACTGTTAGAAGTGTATGAACCACTTGAACTGGGAAAAATTCGAAATAGTAATT
CCTATATGATTGCAGCTCAAATTATGAAAGCAGGCGGAAAAGTGCGATATTATGGGCAACTTGCAGATCAATTGGATGCC
TGCTATGAAGCTGTGAAAGCGGCACTGGATGAAGTTGATATTTTAATTACAACCGGCGGTGTTTCAGTAGGGGATTATGA
TTATTTACCTGCTATTTATGAACGATTACAGGCGAATGTACTATTTAATAAGGTTGCCATGAGACCAGGTAGTGTGACAA
CAGTAGCGGAAGTGGGGAGAAAGCTATTATTCGGATTATCGGGTAATCCATCAGCTTGTTATGTTGGGTTCGAATTATTT
GTTCACCCAGTTATACAAACGCATCTTTATGCAAAGGAACCACATGTATATCGCGCAGATGCCGTTTTGCAAAAAGATTT
CCCAAAAGCAAATCCATTCACACGTTTTGTAAGGGGAAAAGTAAGCATTGTAAATGGTATGTTACATGTAACTCCGGTAG
GATTGGATAAGTCGAGCGCTGTATCATGTCTTGCAGAGGCAAATGCATTCATTGTATTACCAGGAGGAACGCGAGGGTTC
GAAACAGGTATGACCGTCTCGGTTCTATTGCTTGATTCGAGTCAAGGAAGTGAATGGCCATGGGCAGAGCCACTCCAATC
TTACAAATAG

Upstream 100 bases:

>100_bases
AAGACATGGAATTCCTCCTTGAAGTAATTGCTAGTATGGTTAGCATTGTACAATATAAAGTGTAATCAAGATGTGATATT
TTGCAAACAGGGGTGAAAAA

Downstream 100 bases:

>100_bases
TAGGATATCAAAATAGTGGGAAAACAACATTAATGGAGAAGTTAGTTCATGCTTTTTCAAGTGAAGGAAGGAAAGTTGCC
ACAATTAAGCATCATGGACA

Product: molybdenum cofactor synthesis domain-containing protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MLEKRVPIPVAEAVKRVMKYAQRGEIEETILMESYGRVLGEDVVADHDVPYFNRSPYDGFAIRAEDTKEASQSNPIEFQV
VGEIGAGSVFQGEVKAFEAVRIMTGAAIPEGCNAVVMLELTEVCTRDGKTYMKLKRSFRAGDNVSFKGEDIKKNHVLVKK
GTRINPGVAALLATFGYSSVHVVKQPVVGIITTGSELLEVYEPLELGKIRNSNSYMIAAQIMKAGGKVRYYGQLADQLDA
CYEAVKAALDEVDILITTGGVSVGDYDYLPAIYERLQANVLFNKVAMRPGSVTTVAEVGRKLLFGLSGNPSACYVGFELF
VHPVIQTHLYAKEPHVYRADAVLQKDFPKANPFTRFVRGKVSIVNGMLHVTPVGLDKSSAVSCLAEANAFIVLPGGTRGF
ETGMTVSVLLLDSSQGSEWPWAEPLQSYK

Sequences:

>Translated_429_residues
MLEKRVPIPVAEAVKRVMKYAQRGEIEETILMESYGRVLGEDVVADHDVPYFNRSPYDGFAIRAEDTKEASQSNPIEFQV
VGEIGAGSVFQGEVKAFEAVRIMTGAAIPEGCNAVVMLELTEVCTRDGKTYMKLKRSFRAGDNVSFKGEDIKKNHVLVKK
GTRINPGVAALLATFGYSSVHVVKQPVVGIITTGSELLEVYEPLELGKIRNSNSYMIAAQIMKAGGKVRYYGQLADQLDA
CYEAVKAALDEVDILITTGGVSVGDYDYLPAIYERLQANVLFNKVAMRPGSVTTVAEVGRKLLFGLSGNPSACYVGFELF
VHPVIQTHLYAKEPHVYRADAVLQKDFPKANPFTRFVRGKVSIVNGMLHVTPVGLDKSSAVSCLAEANAFIVLPGGTRGF
ETGMTVSVLLLDSSQGSEWPWAEPLQSYK
>Mature_429_residues
MLEKRVPIPVAEAVKRVMKYAQRGEIEETILMESYGRVLGEDVVADHDVPYFNRSPYDGFAIRAEDTKEASQSNPIEFQV
VGEIGAGSVFQGEVKAFEAVRIMTGAAIPEGCNAVVMLELTEVCTRDGKTYMKLKRSFRAGDNVSFKGEDIKKNHVLVKK
GTRINPGVAALLATFGYSSVHVVKQPVVGIITTGSELLEVYEPLELGKIRNSNSYMIAAQIMKAGGKVRYYGQLADQLDA
CYEAVKAALDEVDILITTGGVSVGDYDYLPAIYERLQANVLFNKVAMRPGSVTTVAEVGRKLLFGLSGNPSACYVGFELF
VHPVIQTHLYAKEPHVYRADAVLQKDFPKANPFTRFVRGKVSIVNGMLHVTPVGLDKSSAVSCLAEANAFIVLPGGTRGF
ETGMTVSVLLLDSSQGSEWPWAEPLQSYK

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=383, Percent_Identity=33.1592689295039, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI10880983, Length=397, Percent_Identity=32.7455919395466, Blast_Score=176, Evalue=4e-44,
Organism=Escherichia coli, GI1787049, Length=372, Percent_Identity=32.7956989247312, Blast_Score=170, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI25147659, Length=326, Percent_Identity=33.1288343558282, Blast_Score=164, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17562606, Length=367, Percent_Identity=24.5231607629428, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI17136978, Length=405, Percent_Identity=28.1481481481481, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24638841, Length=405, Percent_Identity=28.1481481481481, Blast_Score=117, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 46804; Mature: 46804

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEKRVPIPVAEAVKRVMKYAQRGEIEETILMESYGRVLGEDVVADHDVPYFNRSPYDGF
CCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCE
AIRAEDTKEASQSNPIEFQVVGEIGAGSVFQGEVKAFEAVRIMTGAAIPEGCNAVVMLEL
EEEECCCHHHCCCCCEEEEEEEECCCCCEEEHHHHHHHHHHHHHCCCCCCCCCEEEEEEE
TEVCTRDGKTYMKLKRSFRAGDNVSFKGEDIKKNHVLVKKGTRINPGVAALLATFGYSSV
HHHHHCCCHHHHHHHHHHCCCCCCEECCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCE
HVVKQPVVGIITTGSELLEVYEPLELGKIRNSNSYMIAAQIMKAGGKVRYYGQLADQLDA
EEECCCCEEEEECCHHHHHHHCCHHHCCEECCCCEEEEEHHHHCCCCEEEHHHHHHHHHH
CYEAVKAALDEVDILITTGGVSVGDYDYLPAIYERLQANVLFNKVAMRPGSVTTVAEVGR
HHHHHHHHHCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
KLLFGLSGNPSACYVGFELFVHPVIQTHLYAKEPHVYRADAVLQKDFPKANPFTRFVRGK
HHEECCCCCCCEEEEHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHCCCCCCCHHHHHHHH
VSIVNGMLHVTPVGLDKSSAVSCLAEANAFIVLPGGTRGFETGMTVSVLLLDSSQGSEWP
HHHHCCEEEEEECCCCCHHHHHHHHCCCEEEEECCCCCCCCCCCEEEEEEEECCCCCCCC
WAEPLQSYK
CCCHHHCCC
>Mature Secondary Structure
MLEKRVPIPVAEAVKRVMKYAQRGEIEETILMESYGRVLGEDVVADHDVPYFNRSPYDGF
CCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCE
AIRAEDTKEASQSNPIEFQVVGEIGAGSVFQGEVKAFEAVRIMTGAAIPEGCNAVVMLEL
EEEECCCHHHCCCCCEEEEEEEECCCCCEEEHHHHHHHHHHHHHCCCCCCCCCEEEEEEE
TEVCTRDGKTYMKLKRSFRAGDNVSFKGEDIKKNHVLVKKGTRINPGVAALLATFGYSSV
HHHHHCCCHHHHHHHHHHCCCCCCEECCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCE
HVVKQPVVGIITTGSELLEVYEPLELGKIRNSNSYMIAAQIMKAGGKVRYYGQLADQLDA
EEECCCCEEEEECCHHHHHHHCCHHHCCEECCCCEEEEEHHHHCCCCEEEHHHHHHHHHH
CYEAVKAALDEVDILITTGGVSVGDYDYLPAIYERLQANVLFNKVAMRPGSVTTVAEVGR
HHHHHHHHHCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
KLLFGLSGNPSACYVGFELFVHPVIQTHLYAKEPHVYRADAVLQKDFPKANPFTRFVRGK
HHEECCCCCCCEEEEHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHCCCCCCCHHHHHHHH
VSIVNGMLHVTPVGLDKSSAVSCLAEANAFIVLPGGTRGFETGMTVSVLLLDSSQGSEWP
HHHHCCEEEEEECCCCCHHHHHHHHCCCEEEEECCCCCCCCCCCEEEEEEEECCCCCCCC
WAEPLQSYK
CCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]