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The map label for this gene is argH [H]

Identifier: 152977000

GI number: 152977000

Start: 3374244

End: 3375632

Strand: Reverse

Name: argH [H]

Synonym: Bcer98_3305

Alternate gene names: 152977000

Gene position: 3375632-3374244 (Counterclockwise)

Preceding gene: 152977001

Following gene: 152976998

Centisome position: 82.59

GC content: 38.37

Gene sequence:

>1389_bases
GTGAGTAAGCTGTGGGGGGGACGCTTTACAGAAGAAGCAGAAGCATGGGTCGAGGAGTTTGGGGCATCCATCTCCTTTGA
CAAACAATTAGTGAAACAAGATATAGAAGGCAGTATTGCACATGTTATGATGCTTGCGAAACAAGGGATTGTAACAAACG
ATGAAGCAGAGAAAATAAAAGAGGGCCTTCAATATTTATTAGAAGAAGCGAAAGAGAACAAACTACACTTTTCGGTAGAA
GCTGAAGATGTTCATTTGAATATTGAAAAGATGTTAATTGAACAAATTGGCGAAGTAGGAGGAAAGCTTCATACAGGTCG
CAGCCGTAATGATCAAGTCGCAACAGATATGCACTTGTATTTAAAAGAGAAAGTACAAGATATAATAAATGCTATAAAAC
AATTGCAGAAGGTTCTTGTCGATCAAGCAGAAGAGAATATTGAAACCATTATGCCAGGGTATACACATTTGCAGCGTGCA
CAACCGATTTCTTTTGCACACCATATACTCGCATACTTTTGGATGTTAGAACGTGATGTGAATCGCTATGAAGATTCTTT
GAAACGTATAAATGTTTCCCCGCTTGGCGCAGGTGCTCTTGCAGGAACAACATTTCCAATTGATCGTGCATATAGCGCAA
AGCTTCTCGATTTTGAAGGGATATATGAAAATAGTTTAGATGCGGTAAGTGATCGTGATTTTATACTAGAATTTTTGAGC
AATTCATCTATGTTAATGATGCATATATCACGCTTTTGTGAAGAACTTATTTTATGGAGCAGTCAGGAGTTTCAATTTAT
TGAAATGAGCGATCGATATGCAACGGGAAGTAGCATTATGCCACAAAAGAAAAATCCGGATATGGCGGAACTGATCCGTG
GTAAAACAGGAAGAGTGTATGGGAACTTATTCAGTTTATTAACAGTAATGAAAGGATTACCGCTAGCCTATAACAAAGAT
TTGCAAGAAGATAAAGAAGGAATGTTTGATACAGTTAAAACGGTAGAAGGCTGTCTTCATATTATGGCTGGTATGTTAGA
AACGATGACTGTAAATAAAGAAAACATGGGGCAGGCTGTAACGCAGGATTTTTCTAATGCAACAGAAGTCGCTGATTACT
TAGCAAACAAAGGACTCCCATTCCGCCAGGCGCATGAAATTGTTGGCAAGCTCGTTCTTCATTGCACGAAAAAAGGAATC
TATTTATTAGATGTGCCGCTTGAAACATATAAAGAAATGAGCCCTTTATTTGAAGAAGATTTATATGAGGTTCTATCACC
TTATGCAGCAGTAAAACGCCGTAATAGTGCAGGTGGGACAGGATTTGTTCAAATTGAACAGGCGTTGGAAAAAGCGAAGA
TATTAGTGGGAGAAGTTACTAGGAATTGA

Upstream 100 bases:

>100_bases
TGAATGATGAATTTAACCACGATGCAGCAGTTGGTTTTATTTCACTATTTGGTCTTCCAACAAAGGTATATAGTCAAGTA
AATCAGAAGAAGGTGGAAGC

Downstream 100 bases:

>100_bases
GTTGAAAGGTACACCAGTCTGTTAAAATCTGATGTGCTTTCTGTTTTGTTAGTATTTAAGTAAAATAACAATTTGGGGGA
AGTTTATCCCGCTATTTTAG

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 462; Mature: 461

Protein sequence:

>462_residues
MSKLWGGRFTEEAEAWVEEFGASISFDKQLVKQDIEGSIAHVMMLAKQGIVTNDEAEKIKEGLQYLLEEAKENKLHFSVE
AEDVHLNIEKMLIEQIGEVGGKLHTGRSRNDQVATDMHLYLKEKVQDIINAIKQLQKVLVDQAEENIETIMPGYTHLQRA
QPISFAHHILAYFWMLERDVNRYEDSLKRINVSPLGAGALAGTTFPIDRAYSAKLLDFEGIYENSLDAVSDRDFILEFLS
NSSMLMMHISRFCEELILWSSQEFQFIEMSDRYATGSSIMPQKKNPDMAELIRGKTGRVYGNLFSLLTVMKGLPLAYNKD
LQEDKEGMFDTVKTVEGCLHIMAGMLETMTVNKENMGQAVTQDFSNATEVADYLANKGLPFRQAHEIVGKLVLHCTKKGI
YLLDVPLETYKEMSPLFEEDLYEVLSPYAAVKRRNSAGGTGFVQIEQALEKAKILVGEVTRN

Sequences:

>Translated_462_residues
MSKLWGGRFTEEAEAWVEEFGASISFDKQLVKQDIEGSIAHVMMLAKQGIVTNDEAEKIKEGLQYLLEEAKENKLHFSVE
AEDVHLNIEKMLIEQIGEVGGKLHTGRSRNDQVATDMHLYLKEKVQDIINAIKQLQKVLVDQAEENIETIMPGYTHLQRA
QPISFAHHILAYFWMLERDVNRYEDSLKRINVSPLGAGALAGTTFPIDRAYSAKLLDFEGIYENSLDAVSDRDFILEFLS
NSSMLMMHISRFCEELILWSSQEFQFIEMSDRYATGSSIMPQKKNPDMAELIRGKTGRVYGNLFSLLTVMKGLPLAYNKD
LQEDKEGMFDTVKTVEGCLHIMAGMLETMTVNKENMGQAVTQDFSNATEVADYLANKGLPFRQAHEIVGKLVLHCTKKGI
YLLDVPLETYKEMSPLFEEDLYEVLSPYAAVKRRNSAGGTGFVQIEQALEKAKILVGEVTRN
>Mature_461_residues
SKLWGGRFTEEAEAWVEEFGASISFDKQLVKQDIEGSIAHVMMLAKQGIVTNDEAEKIKEGLQYLLEEAKENKLHFSVEA
EDVHLNIEKMLIEQIGEVGGKLHTGRSRNDQVATDMHLYLKEKVQDIINAIKQLQKVLVDQAEENIETIMPGYTHLQRAQ
PISFAHHILAYFWMLERDVNRYEDSLKRINVSPLGAGALAGTTFPIDRAYSAKLLDFEGIYENSLDAVSDRDFILEFLSN
SSMLMMHISRFCEELILWSSQEFQFIEMSDRYATGSSIMPQKKNPDMAELIRGKTGRVYGNLFSLLTVMKGLPLAYNKDL
QEDKEGMFDTVKTVEGCLHIMAGMLETMTVNKENMGQAVTQDFSNATEVADYLANKGLPFRQAHEIVGKLVLHCTKKGIY
LLDVPLETYKEMSPLFEEDLYEVLSPYAAVKRRNSAGGTGFVQIEQALEKAKILVGEVTRN

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=454, Percent_Identity=44.0528634361233, Blast_Score=401, Evalue=1e-112,
Organism=Homo sapiens, GI68303542, Length=454, Percent_Identity=44.0528634361233, Blast_Score=401, Evalue=1e-112,
Organism=Homo sapiens, GI68303549, Length=454, Percent_Identity=41.4096916299559, Blast_Score=368, Evalue=1e-102,
Organism=Homo sapiens, GI68303547, Length=454, Percent_Identity=41.4096916299559, Blast_Score=366, Evalue=1e-101,
Organism=Escherichia coli, GI1790398, Length=455, Percent_Identity=48.5714285714286, Blast_Score=457, Evalue=1e-130,
Organism=Caenorhabditis elegans, GI17553882, Length=336, Percent_Identity=24.702380952381, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI32565146, Length=318, Percent_Identity=24.8427672955975, Blast_Score=70, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6321806, Length=454, Percent_Identity=45.5947136563877, Blast_Score=397, Evalue=1e-111,
Organism=Drosophila melanogaster, GI221473854, Length=451, Percent_Identity=40.5764966740577, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI78706858, Length=451, Percent_Identity=40.5764966740577, Blast_Score=365, Evalue=1e-101,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 52246; Mature: 52114

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKLWGGRFTEEAEAWVEEFGASISFDKQLVKQDIEGSIAHVMMLAKQGIVTNDEAEKIK
CCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
EGLQYLLEEAKENKLHFSVEAEDVHLNIEKMLIEQIGEVGGKLHTGRSRNDQVATDMHLY
HHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
LKEKVQDIINAIKQLQKVLVDQAEENIETIMPGYTHLQRAQPISFAHHILAYFWMLERDV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHHHH
NRYEDSLKRINVSPLGAGALAGTTFPIDRAYSAKLLDFEGIYENSLDAVSDRDFILEFLS
HHHHHHHHHCCCCCCCCCHHCCCCCCCCCCCCCHHCCCCCHHHCCCHHHCHHHHHHHHHC
NSSMLMMHISRFCEELILWSSQEFQFIEMSDRYATGSSIMPQKKNPDMAELIRGKTGRVY
CCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCHHHHHCCCCCHHH
GNLFSLLTVMKGLPLAYNKDLQEDKEGMFDTVKTVEGCLHIMAGMLETMTVNKENMGQAV
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
TQDFSNATEVADYLANKGLPFRQAHEIVGKLVLHCTKKGIYLLDVPLETYKEMSPLFEED
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHH
LYEVLSPYAAVKRRNSAGGTGFVQIEQALEKAKILVGEVTRN
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SKLWGGRFTEEAEAWVEEFGASISFDKQLVKQDIEGSIAHVMMLAKQGIVTNDEAEKIK
CCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
EGLQYLLEEAKENKLHFSVEAEDVHLNIEKMLIEQIGEVGGKLHTGRSRNDQVATDMHLY
HHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
LKEKVQDIINAIKQLQKVLVDQAEENIETIMPGYTHLQRAQPISFAHHILAYFWMLERDV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHHHH
NRYEDSLKRINVSPLGAGALAGTTFPIDRAYSAKLLDFEGIYENSLDAVSDRDFILEFLS
HHHHHHHHHCCCCCCCCCHHCCCCCCCCCCCCCHHCCCCCHHHCCCHHHCHHHHHHHHHC
NSSMLMMHISRFCEELILWSSQEFQFIEMSDRYATGSSIMPQKKNPDMAELIRGKTGRVY
CCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCHHHHHCCCCCHHH
GNLFSLLTVMKGLPLAYNKDLQEDKEGMFDTVKTVEGCLHIMAGMLETMTVNKENMGQAV
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
TQDFSNATEVADYLANKGLPFRQAHEIVGKLVLHCTKKGIYLLDVPLETYKEMSPLFEED
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHH
LYEVLSPYAAVKRRNSAGGTGFVQIEQALEKAKILVGEVTRN
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA