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The map label for this gene is icd [H]

Identifier: 152976974

GI number: 152976974

Start: 3345761

End: 3347053

Strand: Reverse

Name: icd [H]

Synonym: Bcer98_3277

Alternate gene names: 152976974

Gene position: 3347053-3345761 (Counterclockwise)

Preceding gene: 152976975

Following gene: 152976973

Centisome position: 81.89

GC content: 37.97

Gene sequence:

>1293_bases
GTGACGACAGGAGAAAAAATTACTGTAACAAATGGTGTTATGAATGTACCGAACAATCCAATTATTCCTTTCATCGAAGG
GGACGGAATTGGACCGGATATTTGGGCAGCTGCATCTCGTGTATTAGAAGCGGCTGTAGAGAAAGCTTATAATGGTGAGA
AGAAAATTATTTGGAAAGAAGTGCTTGCAGGGGAAAAAGCATTCAACCAAACGGGTGAATGGTTACCAGAGGAAACTTTA
AATGCAATTCGTGAGTATTTAATTGCGATTAAAGGTCCGCTTACAACTCCTGTTGGTGGTGGAATTCGTTCTTTAAACGT
AGCGCTTCGCCAAGAGTTAGATTTATATGTATGTTTACGTCCGGTTCGTTATTTTGAAGGTGTTCCTTCACCTGTAAAAC
GTCCGGAAGATACCGATATGGTTATTTTCCGTGAAAATACAGAAGACATTTATGCTGGTATTGAATATGCAAAAGGATCT
CCAGAAGCAGAAAAAGTTCTTGCTTTCTTAAAAGATACAATGGGTGTAAATAAAATCCGCTTCCCAGAAACATCAGGAAT
TGGTATCAAACCAATTTCAGAAGAAGGGACAAAGCGTCTTGTTCGTGCTGCAATTCAATACGCAATTAACGAAAAACGTT
CCTCTGTTACATTAGTTCATAAAGGAAATATTATGAAATTCACAGAAGGTGCTTTCAAAAATTGGGGTTATGAAGTTGCT
GAACAAGAGTTTGGTGATAAAGTATTTACATGGGCAGAATATGATCGTATTGTTGAAAAAGATGGCAAAGATGCAGCAAA
TAAAGCGATGGCAGAAGCTGAAGCAGCTGGTAAAATCATCGTAAAAGATTCTATTGCAGATATTTTCTTACAACAAATTT
TAACACGTCCACGTGAATTTGATGTTGTGGCAACAATGAACTTAAATGGTGACTATATCTCTGATGCACTTGCAGCTCAA
GTAGGTGGCATTGGTATTGCTCCAGGTGCAAATATTAACTACGTGACTGGTCATGCAATTTTTGAAGCTACTCATGGTAC
GGCTCCGAAATATGCAGGCTTAGATAAAGTAAACCCATCTTCTGTTCTTCTTTCAGGAGTATTATTGTTAGAACATTTAG
GGTGGAATGAAGCAGCAAAATTAGTAACTGGGGCAGTGGAAAAAACAATTGCTTCAAAAGTGGTAACATATGACTTCGCA
CGTCTAATGGATGGTGCAACTGAAGTGAAATGTTCTGAATTTGCTGATGCTCTTATTAACAATATGGACGTAGCAGTAAT
TAAAAACGCATAA

Upstream 100 bases:

>100_bases
GAAGTAATGATTGGAATATTTTAATTTGACTAACGGTTTGAACTGAGGGTTATTCCCTCAGTCTCATACATATGAAATTT
CAAACATGGGGGTTATCACA

Downstream 100 bases:

>100_bases
TAAAAGCGGGGGTGAACGTATGACAATCAAACGCAAAAAAGTATCAGTCATCGGTGCGGGATTTACAGGAGCAACAACGG
CGTTCTTATTAGCTCAAAAA

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 430; Mature: 429

Protein sequence:

>430_residues
MTTGEKITVTNGVMNVPNNPIIPFIEGDGIGPDIWAAASRVLEAAVEKAYNGEKKIIWKEVLAGEKAFNQTGEWLPEETL
NAIREYLIAIKGPLTTPVGGGIRSLNVALRQELDLYVCLRPVRYFEGVPSPVKRPEDTDMVIFRENTEDIYAGIEYAKGS
PEAEKVLAFLKDTMGVNKIRFPETSGIGIKPISEEGTKRLVRAAIQYAINEKRSSVTLVHKGNIMKFTEGAFKNWGYEVA
EQEFGDKVFTWAEYDRIVEKDGKDAANKAMAEAEAAGKIIVKDSIADIFLQQILTRPREFDVVATMNLNGDYISDALAAQ
VGGIGIAPGANINYVTGHAIFEATHGTAPKYAGLDKVNPSSVLLSGVLLLEHLGWNEAAKLVTGAVEKTIASKVVTYDFA
RLMDGATEVKCSEFADALINNMDVAVIKNA

Sequences:

>Translated_430_residues
MTTGEKITVTNGVMNVPNNPIIPFIEGDGIGPDIWAAASRVLEAAVEKAYNGEKKIIWKEVLAGEKAFNQTGEWLPEETL
NAIREYLIAIKGPLTTPVGGGIRSLNVALRQELDLYVCLRPVRYFEGVPSPVKRPEDTDMVIFRENTEDIYAGIEYAKGS
PEAEKVLAFLKDTMGVNKIRFPETSGIGIKPISEEGTKRLVRAAIQYAINEKRSSVTLVHKGNIMKFTEGAFKNWGYEVA
EQEFGDKVFTWAEYDRIVEKDGKDAANKAMAEAEAAGKIIVKDSIADIFLQQILTRPREFDVVATMNLNGDYISDALAAQ
VGGIGIAPGANINYVTGHAIFEATHGTAPKYAGLDKVNPSSVLLSGVLLLEHLGWNEAAKLVTGAVEKTIASKVVTYDFA
RLMDGATEVKCSEFADALINNMDVAVIKNA
>Mature_429_residues
TTGEKITVTNGVMNVPNNPIIPFIEGDGIGPDIWAAASRVLEAAVEKAYNGEKKIIWKEVLAGEKAFNQTGEWLPEETLN
AIREYLIAIKGPLTTPVGGGIRSLNVALRQELDLYVCLRPVRYFEGVPSPVKRPEDTDMVIFRENTEDIYAGIEYAKGSP
EAEKVLAFLKDTMGVNKIRFPETSGIGIKPISEEGTKRLVRAAIQYAINEKRSSVTLVHKGNIMKFTEGAFKNWGYEVAE
QEFGDKVFTWAEYDRIVEKDGKDAANKAMAEAEAAGKIIVKDSIADIFLQQILTRPREFDVVATMNLNGDYISDALAAQV
GGIGIAPGANINYVTGHAIFEATHGTAPKYAGLDKVNPSSVLLSGVLLLEHLGWNEAAKLVTGAVEKTIASKVVTYDFAR
LMDGATEVKCSEFADALINNMDVAVIKNA

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=402, Percent_Identity=32.8358208955224, Blast_Score=182, Evalue=5e-46,
Organism=Homo sapiens, GI28178816, Length=404, Percent_Identity=26.980198019802, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI28178821, Length=370, Percent_Identity=27.027027027027, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI4758582, Length=368, Percent_Identity=28.2608695652174, Blast_Score=116, Evalue=5e-26,
Organism=Homo sapiens, GI28178838, Length=379, Percent_Identity=27.7044854881267, Blast_Score=115, Evalue=8e-26,
Organism=Escherichia coli, GI1787381, Length=421, Percent_Identity=65.3206650831354, Blast_Score=556, Evalue=1e-160,
Organism=Escherichia coli, GI1788101, Length=394, Percent_Identity=27.4111675126904, Blast_Score=121, Evalue=7e-29,
Organism=Escherichia coli, GI87081683, Length=409, Percent_Identity=24.6943765281174, Blast_Score=90, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI71986051, Length=390, Percent_Identity=31.2820512820513, Blast_Score=169, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI25144293, Length=376, Percent_Identity=27.3936170212766, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17505779, Length=373, Percent_Identity=27.0777479892761, Blast_Score=108, Evalue=7e-24,
Organism=Saccharomyces cerevisiae, GI6324709, Length=408, Percent_Identity=31.3725490196078, Blast_Score=166, Evalue=8e-42,
Organism=Saccharomyces cerevisiae, GI6322097, Length=379, Percent_Identity=30.8707124010554, Blast_Score=146, Evalue=8e-36,
Organism=Saccharomyces cerevisiae, GI6324291, Length=407, Percent_Identity=28.009828009828, Blast_Score=133, Evalue=7e-32,
Organism=Drosophila melanogaster, GI24661184, Length=402, Percent_Identity=33.3333333333333, Blast_Score=195, Evalue=4e-50,
Organism=Drosophila melanogaster, GI24643270, Length=399, Percent_Identity=32.8320802005013, Blast_Score=185, Evalue=4e-47,
Organism=Drosophila melanogaster, GI24643268, Length=399, Percent_Identity=32.8320802005013, Blast_Score=185, Evalue=5e-47,
Organism=Drosophila melanogaster, GI161078639, Length=318, Percent_Identity=28.9308176100629, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI161078637, Length=318, Percent_Identity=28.9308176100629, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI161078633, Length=318, Percent_Identity=28.9308176100629, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24650122, Length=318, Percent_Identity=28.9308176100629, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI161078635, Length=318, Percent_Identity=28.9308176100629, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI281362242, Length=410, Percent_Identity=26.3414634146341, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24648872, Length=410, Percent_Identity=26.3414634146341, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI20130355, Length=401, Percent_Identity=23.1920199501247, Blast_Score=99, Evalue=5e-21,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004439 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 46817; Mature: 46686

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS00066 HMG_COA_REDUCTASE_1 ; PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTGEKITVTNGVMNVPNNPIIPFIEGDGIGPDIWAAASRVLEAAVEKAYNGEKKIIWKE
CCCCCEEEEECCEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
VLAGEKAFNQTGEWLPEETLNAIREYLIAIKGPLTTPVGGGIRSLNVALRQELDLYVCLR
HHCCHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCHHHHHH
PVRYFEGVPSPVKRPEDTDMVIFRENTEDIYAGIEYAKGSPEAEKVLAFLKDTMGVNKIR
HHHHHCCCCCCCCCCCCCCEEEEECCCHHHHHCCHHCCCCCHHHHHHHHHHHHCCCCEEE
FPETSGIGIKPISEEGTKRLVRAAIQYAINEKRSSVTLVHKGNIMKFTEGAFKNWGYEVA
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEECCCHHHHCCHHHH
EQEFGDKVFTWAEYDRIVEKDGKDAANKAMAEAEAAGKIIVKDSIADIFLQQILTRPREF
HHHCCCCEEEHHHHHHHHHCCCCHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHCCCCCE
DVVATMNLNGDYISDALAAQVGGIGIAPGANINYVTGHAIFEATHGTAPKYAGLDKVNPS
EEEEEEECCCHHHHHHHHHHHCCEEECCCCCCEEEECCEEEEECCCCCCCCCCCCCCCHH
SVLLSGVLLLEHLGWNEAAKLVTGAVEKTIASKVVTYDFARLMDGATEVKCSEFADALIN
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHC
NMDVAVIKNA
CCCEEEEECC
>Mature Secondary Structure 
TTGEKITVTNGVMNVPNNPIIPFIEGDGIGPDIWAAASRVLEAAVEKAYNGEKKIIWKE
CCCCEEEEECCEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
VLAGEKAFNQTGEWLPEETLNAIREYLIAIKGPLTTPVGGGIRSLNVALRQELDLYVCLR
HHCCHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCHHHHHH
PVRYFEGVPSPVKRPEDTDMVIFRENTEDIYAGIEYAKGSPEAEKVLAFLKDTMGVNKIR
HHHHHCCCCCCCCCCCCCCEEEEECCCHHHHHCCHHCCCCCHHHHHHHHHHHHCCCCEEE
FPETSGIGIKPISEEGTKRLVRAAIQYAINEKRSSVTLVHKGNIMKFTEGAFKNWGYEVA
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEECCCHHHHCCHHHH
EQEFGDKVFTWAEYDRIVEKDGKDAANKAMAEAEAAGKIIVKDSIADIFLQQILTRPREF
HHHCCCCEEEHHHHHHHHHCCCCHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHCCCCCE
DVVATMNLNGDYISDALAAQVGGIGIAPGANINYVTGHAIFEATHGTAPKYAGLDKVNPS
EEEEEEECCCHHHHHHHHHHHCCEEECCCCCCEEEECCEEEEECCCCCCCCCCCCCCCHH
SVLLSGVLLLEHLGWNEAAKLVTGAVEKTIASKVVTYDFARLMDGATEVKCSEFADALIN
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHC
NMDVAVIKNA
CCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8045898; 9387221; 9384377; 11751849; 11290745 [H]