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The map label for this gene is pyrP [H]

Identifier: 152976251

GI number: 152976251

Start: 2640222

End: 2641505

Strand: Reverse

Name: pyrP [H]

Synonym: Bcer98_2539

Alternate gene names: 152976251

Gene position: 2641505-2640222 (Counterclockwise)

Preceding gene: 152976252

Following gene: 152976250

Centisome position: 64.63

GC content: 39.49

Gene sequence:

>1284_bases
ATGGAGCAAAAGCCAGTGTTAGACATTCATGAAATACCGAAACCGGGAAGATGGTTATTTTTAAGCATACAGCATTTGTT
TGCAATGTTCGGATCAACAGTGCTGGTTCCGTTTTTAACAGGATTAAATCCATCAGTAGCTTTAATTTCCAGTGGATTAG
GAACATTAGCGTTTCTTCTTATAACAAAAGGGCAAGTACCTGCCTATTTAGGATCATCGTTCGCATTTATTGCTCCAATT
ATAACGGCAAAAACAGCGGGGGGGCCGGGAGCAGCAATGCTCGGTGGTATGCTAGCAGGACTTGTTTATCTCCTAGTTTC
GCTAGGAATTAAAAAGTCAGGATCAGCTTGGATTATGAAGTTACTCCCTCCAATTGTAGTTGGTCCAGTTGTAATGGTTA
TTGGTTTAGCTTTAGCGCATACGGCTGTGAATATGGCAATGAATGATGTCGATGGAAAATATAGCTTTACACACTTTTCA
GTAGCATTAGTCACATTAGTAATTACGATTATTTGCTCCATATTTGGAAGAGGATTCTTCAGTATTATACCGGTATTGCT
TGGAATTATTGGCGGATATATTTTTGCATACTTTCAAGGGTTAGTCGATTTTAAGCCGGTAGCTGAGGCAAGCTGGTTCA
ATGTACCAGACTTTGTTGTACCGTTTGTAACATATACACCGGAATTTTCTTGGAAAATTATGCTTCTGATGGTTCCGGTA
GCACTAGTAACGATTTCAGAACATATTGGGCACCAAATTGTACTTGGAAATGTTATTAATCGAGATTTAATTGCAAAACC
AGGCTTACATCGTTCAATCTTTGGTGATGGTGTAGCGACATTAATAGCATCTGTAATTGGTGGGCCGCCGAATACAACAT
ATGGTGAAAATATCGGGGTGCTAGCAATTACAAGAGCGTATAGTGTATATTTATTCGCTGGATCAGCAATCTTCGCAATC
GTGTTTGGATTTATCGGTAAGATTTCAGCGCTGATTCATTCGATTCCAACACCAGTCATGGGCGGTGTCTCCATCCTGCT
CTTTGGTGTCATCGCATCAAGTGGTTTACGTATGATGGTGGACGAAAAAACAGACTTAAGTGACAAACGTAACTTAATGA
TTGCATCTGTTATTCTTGTTATTGGTATAGGCGGTGCAGTGCTTCATATCGGAGAATCATTCCAAGTAGAAGGAATGGCG
CTTGCAGCAATTGTAGGTGTATTGTTAAATTTACTACTACCAGAAATAAAAGAAAAACAACAATCTAAGCAGATTGCTTC
ATAA

Upstream 100 bases:

>100_bases
TTCATATGTCAAATTTGCCATATGAAAGTATAGGACTCTTTGTGCACGGACACAAAGAGTTTTTTTATTGCAAAATTTTA
AATTGAAGGAGGATATAACA

Downstream 100 bases:

>100_bases
AAACGAACCTTTTAAATCAGTCTTGCGAGACAGAAAAGGGTGGCTTCTTTCTTGCACCCTAGTCTCGCATGACTAGGGTG
TTTTTATGCGATTGTTAGTA

Product: uracil-xanthine permease

Products: Proton [Cytoplasm]; uracil [Cytoplasm] [C]

Alternate protein names: Uracil transporter [H]

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MEQKPVLDIHEIPKPGRWLFLSIQHLFAMFGSTVLVPFLTGLNPSVALISSGLGTLAFLLITKGQVPAYLGSSFAFIAPI
ITAKTAGGPGAAMLGGMLAGLVYLLVSLGIKKSGSAWIMKLLPPIVVGPVVMVIGLALAHTAVNMAMNDVDGKYSFTHFS
VALVTLVITIICSIFGRGFFSIIPVLLGIIGGYIFAYFQGLVDFKPVAEASWFNVPDFVVPFVTYTPEFSWKIMLLMVPV
ALVTISEHIGHQIVLGNVINRDLIAKPGLHRSIFGDGVATLIASVIGGPPNTTYGENIGVLAITRAYSVYLFAGSAIFAI
VFGFIGKISALIHSIPTPVMGGVSILLFGVIASSGLRMMVDEKTDLSDKRNLMIASVILVIGIGGAVLHIGESFQVEGMA
LAAIVGVLLNLLLPEIKEKQQSKQIAS

Sequences:

>Translated_427_residues
MEQKPVLDIHEIPKPGRWLFLSIQHLFAMFGSTVLVPFLTGLNPSVALISSGLGTLAFLLITKGQVPAYLGSSFAFIAPI
ITAKTAGGPGAAMLGGMLAGLVYLLVSLGIKKSGSAWIMKLLPPIVVGPVVMVIGLALAHTAVNMAMNDVDGKYSFTHFS
VALVTLVITIICSIFGRGFFSIIPVLLGIIGGYIFAYFQGLVDFKPVAEASWFNVPDFVVPFVTYTPEFSWKIMLLMVPV
ALVTISEHIGHQIVLGNVINRDLIAKPGLHRSIFGDGVATLIASVIGGPPNTTYGENIGVLAITRAYSVYLFAGSAIFAI
VFGFIGKISALIHSIPTPVMGGVSILLFGVIASSGLRMMVDEKTDLSDKRNLMIASVILVIGIGGAVLHIGESFQVEGMA
LAAIVGVLLNLLLPEIKEKQQSKQIAS
>Mature_427_residues
MEQKPVLDIHEIPKPGRWLFLSIQHLFAMFGSTVLVPFLTGLNPSVALISSGLGTLAFLLITKGQVPAYLGSSFAFIAPI
ITAKTAGGPGAAMLGGMLAGLVYLLVSLGIKKSGSAWIMKLLPPIVVGPVVMVIGLALAHTAVNMAMNDVDGKYSFTHFS
VALVTLVITIICSIFGRGFFSIIPVLLGIIGGYIFAYFQGLVDFKPVAEASWFNVPDFVVPFVTYTPEFSWKIMLLMVPV
ALVTISEHIGHQIVLGNVINRDLIAKPGLHRSIFGDGVATLIASVIGGPPNTTYGENIGVLAITRAYSVYLFAGSAIFAI
VFGFIGKISALIHSIPTPVMGGVSILLFGVIASSGLRMMVDEKTDLSDKRNLMIASVILVIGIGGAVLHIGESFQVEGMA
LAAIVGVLLNLLLPEIKEKQQSKQIAS

Specific function: Transport of uracil in the cell [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680148, Length=447, Percent_Identity=24.6085011185682, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI40316845, Length=447, Percent_Identity=24.6085011185682, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI44680145, Length=444, Percent_Identity=22.972972972973, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI44680143, Length=445, Percent_Identity=22.6966292134831, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI1788843, Length=417, Percent_Identity=45.083932853717, Blast_Score=356, Evalue=1e-99,
Organism=Escherichia coli, GI87081818, Length=426, Percent_Identity=38.7323943661972, Blast_Score=259, Evalue=3e-70,
Organism=Escherichia coli, GI87082181, Length=440, Percent_Identity=25.2272727272727, Blast_Score=141, Evalue=6e-35,
Organism=Escherichia coli, GI1790087, Length=453, Percent_Identity=25.1655629139073, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI87082178, Length=327, Percent_Identity=23.8532110091743, Blast_Score=76, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17558856, Length=225, Percent_Identity=27.1111111111111, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17541904, Length=253, Percent_Identity=23.3201581027668, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17542262, Length=437, Percent_Identity=22.1967963386728, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI21356175, Length=421, Percent_Identity=23.0403800475059, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 45175; Mature: 45175

Theoretical pI: Translated: 9.19; Mature: 9.19

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHCCCC
>Mature Secondary Structure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HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; uracil [Periplasm] [C]

Specific reaction: Proton [Periplasm] + uracil [Periplasm] = Proton [Cytoplasm] + uracil [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8206848 [H]