Click here to switch to the map view.

The map label for this gene is kynU

Identifier: 152975669

GI number: 152975669

Start: 2016902

End: 2018188

Strand: Reverse

Name: kynU

Synonym: Bcer98_1903

Alternate gene names: 152975669

Gene position: 2018188-2016902 (Counterclockwise)

Preceding gene: 152975671

Following gene: 152975668

Centisome position: 49.38

GC content: 36.29

Gene sequence:

>1287_bases
ATGGATCAAAACCCATTTGAGGCATCTTATGAGTATGCAATCCAAAGTGATAAACAGGATGAACTTGCTGCTTTTCAAAA
TGAATTTTATAAAAAAGCAGATACAATATATTTAGATGGAAATTCATTAGGATTATTATCTAAACGAGCTGAAAAGTCAT
TACTTACTATGTTAAATTCATGGAAAGAGCATGGAATTGATGGATGGACAGAAGGAGAGTATCCGTGGTTTTTTCTATCG
GAACAATTAAGTGAACATATCGCACCGCTTATTGGTGCATTGTCTGAGGAAATAATTGTAACCGGTTCCACGACGACGAA
TATTCATCAGGTGATTGCGACATTTTATGAACCGAAAGGGATTCGTACAAAGATTTTAGCAGATGAATTAACATTTCCAT
CAGATATATATGCTTTGCAAAGCCAAATTCGTTTAAAAGGATTAGACCCAAATGAACATCTTGTTCGAGTGAAAAGTCGA
GACGGCAGAACGTTAGATGAGGAAGATATTATTGCTGCTATGACAGATGATATCGCTTTAATTTTATTGCCAGCAGTTTT
ATATCGAAGCGGACAAATTTTAGATATGAAGCGATTGACGGCTGAAGCACATAAGAGAGGGATTCATATCGGATTTGATT
TATGTCATTCAATCGGGGCGATTCCGCATCAATTTCAAGAGTGGGGTGTTGATTTTGCGGTATGGTGTAATTATAAATAT
TTAAATGCAGGTCCTGGTAGTGTTGGCGGATTATATGTAAATAAAAAACATTTTGCTCGTTTGCCCGGTCTTTCCGGCTG
GTTCAGTTCAAGAAAAGATAAACAATTTGATATGGAACATACATTAACAGCAGCTGAGCATGCTGGAGCGTATCAAATTG
GAACACCACATATATTCAGTATCGCACCATTAATTGGCTCACTTGAGATCTTTAAAGAGGCGGGCATAGATCGATTACGT
CAAAAATCATTACATATAACACGGTATATGCTACATTTGATTGATTATGAATTAACAGATAAAGGATTTACAATTGGAAA
TCCTTTAGAAGACGAAAAACGAGGAGGACATATTTATTTAGAGCACCCAGAAGCTGCTCGTATATGTAAAGCGTTAAAAG
CAAATGGAGTAATTCCTGATTTTCGCGCGCCAAATGGCATTCGCCTTGCACCAGTTGCTTTATATAATACATATGAAGAA
GTGTGGAAGTCCGTTCGAATTTTAAAGAAAATTATGACAAATGAAGAGTATAAACAATTTGAAAATAAACGAGGGGTTGT
GGCGTAA

Upstream 100 bases:

>100_bases
GGAAGAGAGCAACGAATACAATATCATTGACGTTACAATAGTTATAATGTTATATTTCAATTAGTTAGAATAAACAGAAA
ATTAAAAAGAAGGTGGAACT

Downstream 100 bases:

>100_bases
GATGAAGGCATCTGAATGGATCGATATTTCACAGCCATTAAATAATGAGATTGCAACTTGGCCAGGAGATACACCTTTCT
CATATGAAGTGTCTTGCACG

Product: kynureninase

Products: NA

Alternate protein names: L-kynurenine hydrolase

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MDQNPFEASYEYAIQSDKQDELAAFQNEFYKKADTIYLDGNSLGLLSKRAEKSLLTMLNSWKEHGIDGWTEGEYPWFFLS
EQLSEHIAPLIGALSEEIIVTGSTTTNIHQVIATFYEPKGIRTKILADELTFPSDIYALQSQIRLKGLDPNEHLVRVKSR
DGRTLDEEDIIAAMTDDIALILLPAVLYRSGQILDMKRLTAEAHKRGIHIGFDLCHSIGAIPHQFQEWGVDFAVWCNYKY
LNAGPGSVGGLYVNKKHFARLPGLSGWFSSRKDKQFDMEHTLTAAEHAGAYQIGTPHIFSIAPLIGSLEIFKEAGIDRLR
QKSLHITRYMLHLIDYELTDKGFTIGNPLEDEKRGGHIYLEHPEAARICKALKANGVIPDFRAPNGIRLAPVALYNTYEE
VWKSVRILKKIMTNEEYKQFENKRGVVA

Sequences:

>Translated_428_residues
MDQNPFEASYEYAIQSDKQDELAAFQNEFYKKADTIYLDGNSLGLLSKRAEKSLLTMLNSWKEHGIDGWTEGEYPWFFLS
EQLSEHIAPLIGALSEEIIVTGSTTTNIHQVIATFYEPKGIRTKILADELTFPSDIYALQSQIRLKGLDPNEHLVRVKSR
DGRTLDEEDIIAAMTDDIALILLPAVLYRSGQILDMKRLTAEAHKRGIHIGFDLCHSIGAIPHQFQEWGVDFAVWCNYKY
LNAGPGSVGGLYVNKKHFARLPGLSGWFSSRKDKQFDMEHTLTAAEHAGAYQIGTPHIFSIAPLIGSLEIFKEAGIDRLR
QKSLHITRYMLHLIDYELTDKGFTIGNPLEDEKRGGHIYLEHPEAARICKALKANGVIPDFRAPNGIRLAPVALYNTYEE
VWKSVRILKKIMTNEEYKQFENKRGVVA
>Mature_428_residues
MDQNPFEASYEYAIQSDKQDELAAFQNEFYKKADTIYLDGNSLGLLSKRAEKSLLTMLNSWKEHGIDGWTEGEYPWFFLS
EQLSEHIAPLIGALSEEIIVTGSTTTNIHQVIATFYEPKGIRTKILADELTFPSDIYALQSQIRLKGLDPNEHLVRVKSR
DGRTLDEEDIIAAMTDDIALILLPAVLYRSGQILDMKRLTAEAHKRGIHIGFDLCHSIGAIPHQFQEWGVDFAVWCNYKY
LNAGPGSVGGLYVNKKHFARLPGLSGWFSSRKDKQFDMEHTLTAAEHAGAYQIGTPHIFSIAPLIGSLEIFKEAGIDRLR
QKSLHITRYMLHLIDYELTDKGFTIGNPLEDEKRGGHIYLEHPEAARICKALKANGVIPDFRAPNGIRLAPVALYNTYEE
VWKSVRILKKIMTNEEYKQFENKRGVVA

Specific function: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively

COG id: COG3844

COG function: function code E; Kynureninase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kynureninase family

Homologues:

Organism=Homo sapiens, GI4504937, Length=436, Percent_Identity=34.4036697247706, Blast_Score=242, Evalue=4e-64,
Organism=Homo sapiens, GI74101437, Length=278, Percent_Identity=34.5323741007194, Blast_Score=159, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI17550466, Length=394, Percent_Identity=35.7868020304569, Blast_Score=266, Evalue=1e-71,
Organism=Saccharomyces cerevisiae, GI6323261, Length=413, Percent_Identity=35.5932203389831, Blast_Score=249, Evalue=7e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KYNU_BACCN (A7GPY3)

Other databases:

- EMBL:   CP000764
- RefSeq:   YP_001375186.1
- ProteinModelPortal:   A7GPY3
- SMR:   A7GPY3
- STRING:   A7GPY3
- EnsemblBacteria:   EBBACT00000039491
- GeneID:   5345277
- GenomeReviews:   CP000764_GR
- KEGG:   bcy:Bcer98_1903
- eggNOG:   COG3844
- GeneTree:   EBGT00050000000895
- HOGENOM:   HBG523016
- OMA:   MTDDIAL
- ProtClustDB:   CLSK904618
- BioCyc:   BCER315749:BCER98_1903-MONOMER
- GO:   GO:0005737
- InterPro:   IPR000192
- InterPro:   IPR010111
- InterPro:   IPR015424
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR14084
- TIGRFAMs:   TIGR01814

Pfam domain/function: PF00266 Aminotran_5; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =3.7.1.3

Molecular weight: Translated: 48443; Mature: 48443

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: NA

Important sites: BINDING 104-104 BINDING 105-105 BINDING 213-213 BINDING 216-216 BINDING 238-238 BINDING 267-267 BINDING 295-295

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDQNPFEASYEYAIQSDKQDELAAFQNEFYKKADTIYLDGNSLGLLSKRAEKSLLTMLNS
CCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHH
WKEHGIDGWTEGEYPWFFLSEQLSEHIAPLIGALSEEIIVTGSTTTNIHQVIATFYEPKG
HHHHCCCCCCCCCCCEEEHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHCCCC
IRTKILADELTFPSDIYALQSQIRLKGLDPNEHLVRVKSRDGRTLDEEDIIAAMTDDIAL
CEEEEEHHHCCCCHHHHHHHHHHEEECCCCCCCEEEEECCCCCCCCHHHHHHHHHCCHHH
ILLPAVLYRSGQILDMKRLTAEAHKRGIHIGFDLCHSIGAIPHQFQEWGVDFAVWCNYKY
HHHHHHHHCCCCEEHHHHHHHHHHHCCCEEHHHHHHHHCCCHHHHHHHCCCEEEEECEEE
LNAGPGSVGGLYVNKKHFARLPGLSGWFSSRKDKQFDMEHTLTAAEHAGAYQIGTPHIFS
ECCCCCCCCCEEECHHHHHHCCCCCCHHCCCCCCCCCHHHHHHHHHHCCCEECCCCCHHH
IAPLIGSLEIFKEAGIDRLRQKSLHITRYMLHLIDYELTDKGFTIGNPLEDEKRGGHIYL
HHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHCCCCEEEE
EHPEAARICKALKANGVIPDFRAPNGIRLAPVALYNTYEEVWKSVRILKKIMTNEEYKQF
ECCHHHHHHHHHHHCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
ENKRGVVA
HCCCCCCC
>Mature Secondary Structure
MDQNPFEASYEYAIQSDKQDELAAFQNEFYKKADTIYLDGNSLGLLSKRAEKSLLTMLNS
CCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHH
WKEHGIDGWTEGEYPWFFLSEQLSEHIAPLIGALSEEIIVTGSTTTNIHQVIATFYEPKG
HHHHCCCCCCCCCCCEEEHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHCCCC
IRTKILADELTFPSDIYALQSQIRLKGLDPNEHLVRVKSRDGRTLDEEDIIAAMTDDIAL
CEEEEEHHHCCCCHHHHHHHHHHEEECCCCCCCEEEEECCCCCCCCHHHHHHHHHCCHHH
ILLPAVLYRSGQILDMKRLTAEAHKRGIHIGFDLCHSIGAIPHQFQEWGVDFAVWCNYKY
HHHHHHHHCCCCEEHHHHHHHHHHHCCCEEHHHHHHHHCCCHHHHHHHCCCEEEEECEEE
LNAGPGSVGGLYVNKKHFARLPGLSGWFSSRKDKQFDMEHTLTAAEHAGAYQIGTPHIFS
ECCCCCCCCCEEECHHHHHHCCCCCCHHCCCCCCCCCHHHHHHHHHHCCCEECCCCCHHH
IAPLIGSLEIFKEAGIDRLRQKSLHITRYMLHLIDYELTDKGFTIGNPLEDEKRGGHIYL
HHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHCCCCEEEE
EHPEAARICKALKANGVIPDFRAPNGIRLAPVALYNTYEEVWKSVRILKKIMTNEEYKQF
ECCHHHHHHHHHHHCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
ENKRGVVA
HCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA