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The map label for this gene is thrB

Identifier: 152975291

GI number: 152975291

Start: 1606805

End: 1607698

Strand: Direct

Name: thrB

Synonym: Bcer98_1498

Alternate gene names: 152975291

Gene position: 1606805-1607698 (Clockwise)

Preceding gene: 152975290

Following gene: 152975292

Centisome position: 39.31

GC content: 39.37

Gene sequence:

>894_bases
GTGATACCATTTAAAATTCGTGTTCCAGCGAGTACAGCAAATATAGGCCCTGGTTTTGATTCTGTAGGGATGGCACTATC
TTTATATTTAGAAGTTATTGTGAAGGAAGAAGTGCCGCATTGGTATGTTATACATCCATTTGACCAATCCGTTCCAAACG
ATGATAGCAATTTAATTATAAGTACGGCCCTTCAAGTATGCCCATCGTTACCTTCTCATATAATAGAAGTCATAAGTAAT
ATTCCACTTACAAGAGGATTAGGAAGCAGTGCTTCTGCCATTGTTGCTGGAATTGAACTAGCGAATCAGTTAGGAGCGTT
ACACTTAACAACAGACGAAAAAATTCATCTTGCTACAAAGTTTGAGGGGCACCCGGATAATGTAGCAGCTTCTATTTTAG
GAGGAACAGTCATTGGTGCAATAGATGAGGGGCATGTATCCGTTGTTCGGATTGAAAGTAAAGAATTAGGAGTTATTTCT
GTAATACCAGATGAAGAACTAAATACAAATGAAAGTCGTTTCGTGCTACCTGAAACATTTTCATTTCATCATGCTGTTCG
TGCAAGCTCGATTAGTAACGTATTAGTGGCAGCACTATGTGAAAAGAAATGGGAAATAGTTGGTGAAATGATGGAACGAG
ATTTATTTCATGAGCCGTATCGTTCGCAATTGGTTCCTCTTCTACCTTCTGTTCGTGAATATGCGAAGCGATTTGGAGCA
TATGGAACAGCACTAAGTGGGGCAGGGCCATCTCTCTTCATTTTAACCCCATATGAAAATCGTCAGGAGATTGCTGAACA
GTTAATGAAAGTCTTTCCAAAGATAGAGGTGTGTGAACTGGAGATTGATTACGAGGGAGTAGTCGTAAATATGGACATAT
CAGTGAACAGATAA

Upstream 100 bases:

>100_bases
AAGATCCGGATATCGCAATCTCCTCGAATTCATTACAAATTACAAATATCTCAAATGATTTAGAACAAATGAAAGGTCAT
ATTAAGGGAGTGATTATTTC

Downstream 100 bases:

>100_bases
TTAGCATTAAATATGTGAAAACAGAAAAAGGAAAATCGTGAGGAGAGAAAGCTGGCCGTGTACTAGCTTTCTTTTTTTAT
TATTACATTTTTGTAATAAA

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MIPFKIRVPASTANIGPGFDSVGMALSLYLEVIVKEEVPHWYVIHPFDQSVPNDDSNLIISTALQVCPSLPSHIIEVISN
IPLTRGLGSSASAIVAGIELANQLGALHLTTDEKIHLATKFEGHPDNVAASILGGTVIGAIDEGHVSVVRIESKELGVIS
VIPDEELNTNESRFVLPETFSFHHAVRASSISNVLVAALCEKKWEIVGEMMERDLFHEPYRSQLVPLLPSVREYAKRFGA
YGTALSGAGPSLFILTPYENRQEIAEQLMKVFPKIEVCELEIDYEGVVVNMDISVNR

Sequences:

>Translated_297_residues
MIPFKIRVPASTANIGPGFDSVGMALSLYLEVIVKEEVPHWYVIHPFDQSVPNDDSNLIISTALQVCPSLPSHIIEVISN
IPLTRGLGSSASAIVAGIELANQLGALHLTTDEKIHLATKFEGHPDNVAASILGGTVIGAIDEGHVSVVRIESKELGVIS
VIPDEELNTNESRFVLPETFSFHHAVRASSISNVLVAALCEKKWEIVGEMMERDLFHEPYRSQLVPLLPSVREYAKRFGA
YGTALSGAGPSLFILTPYENRQEIAEQLMKVFPKIEVCELEIDYEGVVVNMDISVNR
>Mature_297_residues
MIPFKIRVPASTANIGPGFDSVGMALSLYLEVIVKEEVPHWYVIHPFDQSVPNDDSNLIISTALQVCPSLPSHIIEVISN
IPLTRGLGSSASAIVAGIELANQLGALHLTTDEKIHLATKFEGHPDNVAASILGGTVIGAIDEGHVSVVRIESKELGVIS
VIPDEELNTNESRFVLPETFSFHHAVRASSISNVLVAALCEKKWEIVGEMMERDLFHEPYRSQLVPLLPSVREYAKRFGA
YGTALSGAGPSLFILTPYENRQEIAEQLMKVFPKIEVCELEIDYEGVVVNMDISVNR

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily

Homologues:

Organism=Escherichia coli, GI1786184, Length=301, Percent_Identity=26.2458471760797, Blast_Score=95, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6321814, Length=352, Percent_Identity=32.1022727272727, Blast_Score=122, Evalue=7e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KHSE_BACCN (A7GNV5)

Other databases:

- EMBL:   CP000764
- RefSeq:   YP_001374808.1
- ProteinModelPortal:   A7GNV5
- SMR:   A7GNV5
- STRING:   A7GNV5
- EnsemblBacteria:   EBBACT00000038778
- GeneID:   5346192
- GenomeReviews:   CP000764_GR
- KEGG:   bcy:Bcer98_1498
- eggNOG:   COG0083
- GeneTree:   EBGT00050000000874
- HOGENOM:   HBG646290
- OMA:   FDCLGAA
- ProtClustDB:   PRK01212
- BioCyc:   BCER315749:BCER98_1498-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00384
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.230.10
- PIRSF:   PIRSF000676
- PRINTS:   PR00958
- TIGRFAMs:   TIGR00191

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =2.7.1.39

Molecular weight: Translated: 32480; Mature: 32480

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPFKIRVPASTANIGPGFDSVGMALSLYLEVIVKEEVPHWYVIHPFDQSVPNDDSNLII
CCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCHH
STALQVCPSLPSHIIEVISNIPLTRGLGSSASAIVAGIELANQLGALHLTTDEKIHLATK
HHHHHHCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEECCCEEEEEEE
FEGHPDNVAASILGGTVIGAIDEGHVSVVRIESKELGVISVIPDEELNTNESRFVLPETF
CCCCCCHHHHHHHCCEEEEEECCCCEEEEEEECCCCCEEEECCCCCCCCCCCEEECCCCC
SFHHAVRASSISNVLVAALCEKKWEIVGEMMERDLFHEPYRSQLVPLLPSVREYAKRFGA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCC
YGTALSGAGPSLFILTPYENRQEIAEQLMKVFPKIEVCELEIDYEGVVVNMDISVNR
CCCEECCCCCEEEEECCCCCHHHHHHHHHHHCCCCEEEEEEECCCEEEEEEEEEECC
>Mature Secondary Structure
MIPFKIRVPASTANIGPGFDSVGMALSLYLEVIVKEEVPHWYVIHPFDQSVPNDDSNLII
CCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCHH
STALQVCPSLPSHIIEVISNIPLTRGLGSSASAIVAGIELANQLGALHLTTDEKIHLATK
HHHHHHCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEECCCEEEEEEE
FEGHPDNVAASILGGTVIGAIDEGHVSVVRIESKELGVISVIPDEELNTNESRFVLPETF
CCCCCCHHHHHHHCCEEEEEECCCCEEEEEEECCCCCEEEECCCCCCCCCCCEEECCCCC
SFHHAVRASSISNVLVAALCEKKWEIVGEMMERDLFHEPYRSQLVPLLPSVREYAKRFGA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCC
YGTALSGAGPSLFILTPYENRQEIAEQLMKVFPKIEVCELEIDYEGVVVNMDISVNR
CCCEECCCCCEEEEECCCCCHHHHHHHHHHHCCCCEEEEEEECCCEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA