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The map label for this gene is ilvD [H]

Identifier: 152975243

GI number: 152975243

Start: 1548715

End: 1550388

Strand: Direct

Name: ilvD [H]

Synonym: Bcer98_1446

Alternate gene names: 152975243

Gene position: 1548715-1550388 (Clockwise)

Preceding gene: 152975242

Following gene: 152975244

Centisome position: 37.89

GC content: 42.29

Gene sequence:

>1674_bases
ATGAGAAGTGACATGATTAAAAAAGGTTTCGATAAAGCGCCGCATCGCAGTTTATTAAAAGCAACCGGGCTCAAAGATGA
AGACTTCCACAAGCCGTTTGTAGCGATTTGTAATTCTTTTATTGAAATTATTCCTGGGCATAAACATTTAAATGAATTTG
GTCGCCTTGTAAAGGAAGCTGTACGTGCGGCGGGAATGGTTCCATTTGAATTTAACACAATTGGAGTCGATGACGGAATT
GCAATGGGGCATATCGGTATGCGCTATTCCCTTCCAAGTCGTGAGATTATTGCTGATTCAGTGGAAACAGTAGTCAATGC
GCATTGGTTCGATGGCATGATTTGTATTCCGAACTGTGACAAAATTACACCGGGCATGATGATGGCTGCGATGCGTATTA
ACATTCCAACGGTTTTTGTTTCAGGAGGACCAATGGCAGCGGGAAAAACGTCAAAAGGAGAGGTTGTTGACTTAAGCTCT
GTTTTTGAAGGAGTAGGCGCTTATCAATCTGGAAAAATTTCAGAGGAAGAATTAAAAGATATTGAAGATCACGGTTGTCC
ATCTTGTGGCTCTTGTTCGGGTATGTTTACAGCGAATTCGATGAACTGTCTATGTGAAGTATTAGGATTAGCCCTCCCGG
GAAATGGAAGCATCTTAGCGACAGACTCGCGCCGAGAGCAGTTAATTCAACGAGCAGCGGAGAGTTTAAAAATTTTAATG
GAACGTGATATTAAACCGAGAGACATTGTCACTGAAGAAGCCATTGATGACGCGTTTGCACTTGACATGGCAATGGGAGG
ATCTACAAATACAGTATTACATACGTTAGCAATTGCTCAAGAGGCAGGATTAGACTATGACATGAACCGGATTGATGCAG
TTTCAAGGAAAGTTCCTCATTTATGTAAAGTAAGCCCAGCCTCAAATTGGCATATGGAAGATATCGATCGTGCAGGTGGT
ATGAGTGCTATTTTAAAAGAATTAAGTAGAAAAGAAGGGGTACTGCACTTCGATCGGATAACAGTTACAGGGAAAACGTT
ACGAGAAAATATTGCCGATGCTGAAATTCAAGACAAAGAAGTCATTCATTCGCTTGAAAATCCTCATAGCCAAGAGGGGG
GCTTACGTATATTAAAAGGAAATCTCGCAAAAGATGGTGCTGTGATTAAAAGTGGTGCAACAGAAGTAAAGCGTTTTGAA
GGACCGTGTGTTATTTTTAATTCACAAGATGAAGCACTTGCGGGGATTATGCTTGGGAAAGTAAAAAAAGGAGATGTGGT
AGTTATTCGTTATGAAGGGCCAAGAGGTGGGCCTGGTATGCCAGAAATGTTAGCTCCAACATCAGCAATTGCTGGTATGG
GACTAGGAGCTGATGTAGCACTATTAACAGATGGCCGTTTTTCGGGAGCATCACGAGGTATTTCTGTCGGGCATATTTCC
CCAGAAGCTGCTGCGGGTGGGGAAATTGCACTTCTTCAGCAAGGAGATATCGTTTGTATTGATGTAGAGGAGCGTTTGCT
TGAAGTGAAAGTGAGTGATGAGGAATTAGCGAAACGCCGAAAAGAATGGAAAAGACCAGAGCCGAAAGTAAAAACAGGAT
GGCTTGGCCGCTATGCCCAGATGGTTACATCAGCAAATACTGGAGCAGTACTGAAAATGCAAAACTTTGATTGA

Upstream 100 bases:

>100_bases
GGTAGGAGCAGTACTTCGTGAAAGGATGTCTTGAATTCAGCCGCTAGAAACAAAAAAATAAACAGCAGCGTAAAAATGTA
TGAGGAAAGGAATTGAAAAT

Downstream 100 bases:

>100_bases
ATGATAGAAAAAAAGGATAAGGAATGATATGAGATGGTGCATAAGGTAAAGGAGAGAGTAAAAATTGAAGATATCCTTAT
GGCTCATAATTGTTTAAAGG

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 557; Mature: 557

Protein sequence:

>557_residues
MRSDMIKKGFDKAPHRSLLKATGLKDEDFHKPFVAICNSFIEIIPGHKHLNEFGRLVKEAVRAAGMVPFEFNTIGVDDGI
AMGHIGMRYSLPSREIIADSVETVVNAHWFDGMICIPNCDKITPGMMMAAMRINIPTVFVSGGPMAAGKTSKGEVVDLSS
VFEGVGAYQSGKISEEELKDIEDHGCPSCGSCSGMFTANSMNCLCEVLGLALPGNGSILATDSRREQLIQRAAESLKILM
ERDIKPRDIVTEEAIDDAFALDMAMGGSTNTVLHTLAIAQEAGLDYDMNRIDAVSRKVPHLCKVSPASNWHMEDIDRAGG
MSAILKELSRKEGVLHFDRITVTGKTLRENIADAEIQDKEVIHSLENPHSQEGGLRILKGNLAKDGAVIKSGATEVKRFE
GPCVIFNSQDEALAGIMLGKVKKGDVVVIRYEGPRGGPGMPEMLAPTSAIAGMGLGADVALLTDGRFSGASRGISVGHIS
PEAAAGGEIALLQQGDIVCIDVEERLLEVKVSDEELAKRRKEWKRPEPKVKTGWLGRYAQMVTSANTGAVLKMQNFD

Sequences:

>Translated_557_residues
MRSDMIKKGFDKAPHRSLLKATGLKDEDFHKPFVAICNSFIEIIPGHKHLNEFGRLVKEAVRAAGMVPFEFNTIGVDDGI
AMGHIGMRYSLPSREIIADSVETVVNAHWFDGMICIPNCDKITPGMMMAAMRINIPTVFVSGGPMAAGKTSKGEVVDLSS
VFEGVGAYQSGKISEEELKDIEDHGCPSCGSCSGMFTANSMNCLCEVLGLALPGNGSILATDSRREQLIQRAAESLKILM
ERDIKPRDIVTEEAIDDAFALDMAMGGSTNTVLHTLAIAQEAGLDYDMNRIDAVSRKVPHLCKVSPASNWHMEDIDRAGG
MSAILKELSRKEGVLHFDRITVTGKTLRENIADAEIQDKEVIHSLENPHSQEGGLRILKGNLAKDGAVIKSGATEVKRFE
GPCVIFNSQDEALAGIMLGKVKKGDVVVIRYEGPRGGPGMPEMLAPTSAIAGMGLGADVALLTDGRFSGASRGISVGHIS
PEAAAGGEIALLQQGDIVCIDVEERLLEVKVSDEELAKRRKEWKRPEPKVKTGWLGRYAQMVTSANTGAVLKMQNFD
>Mature_557_residues
MRSDMIKKGFDKAPHRSLLKATGLKDEDFHKPFVAICNSFIEIIPGHKHLNEFGRLVKEAVRAAGMVPFEFNTIGVDDGI
AMGHIGMRYSLPSREIIADSVETVVNAHWFDGMICIPNCDKITPGMMMAAMRINIPTVFVSGGPMAAGKTSKGEVVDLSS
VFEGVGAYQSGKISEEELKDIEDHGCPSCGSCSGMFTANSMNCLCEVLGLALPGNGSILATDSRREQLIQRAAESLKILM
ERDIKPRDIVTEEAIDDAFALDMAMGGSTNTVLHTLAIAQEAGLDYDMNRIDAVSRKVPHLCKVSPASNWHMEDIDRAGG
MSAILKELSRKEGVLHFDRITVTGKTLRENIADAEIQDKEVIHSLENPHSQEGGLRILKGNLAKDGAVIKSGATEVKRFE
GPCVIFNSQDEALAGIMLGKVKKGDVVVIRYEGPRGGPGMPEMLAPTSAIAGMGLGADVALLTDGRFSGASRGISVGHIS
PEAAAGGEIALLQQGDIVCIDVEERLLEVKVSDEELAKRRKEWKRPEPKVKTGWLGRYAQMVTSANTGAVLKMQNFD

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=606, Percent_Identity=48.5148514851485, Blast_Score=550, Evalue=1e-158,
Organism=Escherichia coli, GI1788157, Length=539, Percent_Identity=30.9833024118738, Blast_Score=218, Evalue=1e-57,
Organism=Escherichia coli, GI2367371, Length=526, Percent_Identity=31.9391634980989, Blast_Score=192, Evalue=4e-50,
Organism=Escherichia coli, GI1786464, Length=494, Percent_Identity=31.1740890688259, Blast_Score=177, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6322476, Length=545, Percent_Identity=42.9357798165138, Blast_Score=433, Evalue=1e-122,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 60086; Mature: 60086

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSDMIKKGFDKAPHRSLLKATGLKDEDFHKPFVAICNSFIEIIPGHKHLNEFGRLVKEA
CCCHHHHHCCCCCCHHHHHHHCCCCCCHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
VRAAGMVPFEFNTIGVDDGIAMGHIGMRYSLPSREIIADSVETVVNAHWFDGMICIPNCD
HHHCCCCCEEEEEECCCCCCEECCCCEEECCCCHHHHHHHHHHHHHHHHCCCEEECCCCC
KITPGMMMAAMRINIPTVFVSGGPMAAGKTSKGEVVDLSSVFEGVGAYQSGKISEEELKD
CCCHHHHHHHEEECCCEEEECCCCCCCCCCCCCCEEEHHHHHHHHCCCCCCCCCHHHHHH
IEDHGCPSCGSCSGMFTANSMNCLCEVLGLALPGNGSILATDSRREQLIQRAAESLKILM
HHHCCCCCCCCCCCCEECCHHHHHHHHHHCCCCCCCCEEEECHHHHHHHHHHHHHHHHHH
ERDIKPRDIVTEEAIDDAFALDMAMGGSTNTVLHTLAIAQEAGLDYDMNRIDAVSRKVPH
HCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCC
LCKVSPASNWHMEDIDRAGGMSAILKELSRKEGVLHFDRITVTGKTLRENIADAEIQDKE
CEECCCCCCCCHHHHHHCCCHHHHHHHHHHHCCCEEEEEEEEEHHHHHHHHCCCCCHHHH
VIHSLENPHSQEGGLRILKGNLAKDGAVIKSGATEVKRFEGPCVIFNSQDEALAGIMLGK
HHHHHCCCCCCCCCEEEEECCCCCCCCEEECCCHHHHHCCCCEEEECCCCHHHHHHHHCC
VKKGDVVVIRYEGPRGGPGMPEMLAPTSAIAGMGLGADVALLTDGRFSGASRGISVGHIS
CCCCCEEEEEECCCCCCCCCCHHHCCHHHHHCCCCCCCEEEEECCCCCCCCCCEEEECCC
PEAAAGGEIALLQQGDIVCIDVEERLLEVKVSDEELAKRRKEWKRPEPKVKTGWLGRYAQ
CCCCCCCCEEEEECCCEEEEEHHHCEEEEEECHHHHHHHHHHHCCCCCCCCCCHHHHHHH
MVTSANTGAVLKMQNFD
HHHCCCCCEEEEECCCC
>Mature Secondary Structure
MRSDMIKKGFDKAPHRSLLKATGLKDEDFHKPFVAICNSFIEIIPGHKHLNEFGRLVKEA
CCCHHHHHCCCCCCHHHHHHHCCCCCCHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
VRAAGMVPFEFNTIGVDDGIAMGHIGMRYSLPSREIIADSVETVVNAHWFDGMICIPNCD
HHHCCCCCEEEEEECCCCCCEECCCCEEECCCCHHHHHHHHHHHHHHHHCCCEEECCCCC
KITPGMMMAAMRINIPTVFVSGGPMAAGKTSKGEVVDLSSVFEGVGAYQSGKISEEELKD
CCCHHHHHHHEEECCCEEEECCCCCCCCCCCCCCEEEHHHHHHHHCCCCCCCCCHHHHHH
IEDHGCPSCGSCSGMFTANSMNCLCEVLGLALPGNGSILATDSRREQLIQRAAESLKILM
HHHCCCCCCCCCCCCEECCHHHHHHHHHHCCCCCCCCEEEECHHHHHHHHHHHHHHHHHH
ERDIKPRDIVTEEAIDDAFALDMAMGGSTNTVLHTLAIAQEAGLDYDMNRIDAVSRKVPH
HCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCC
LCKVSPASNWHMEDIDRAGGMSAILKELSRKEGVLHFDRITVTGKTLRENIADAEIQDKE
CEECCCCCCCCHHHHHHCCCHHHHHHHHHHHCCCEEEEEEEEEHHHHHHHHCCCCCHHHH
VIHSLENPHSQEGGLRILKGNLAKDGAVIKSGATEVKRFEGPCVIFNSQDEALAGIMLGK
HHHHHCCCCCCCCCEEEEECCCCCCCCEEECCCHHHHHCCCCEEEECCCCHHHHHHHHCC
VKKGDVVVIRYEGPRGGPGMPEMLAPTSAIAGMGLGADVALLTDGRFSGASRGISVGHIS
CCCCCEEEEEECCCCCCCCCCHHHCCHHHHHCCCCCCCEEEEECCCCCCCCCCEEEECCC
PEAAAGGEIALLQQGDIVCIDVEERLLEVKVSDEELAKRRKEWKRPEPKVKTGWLGRYAQ
CCCCCCCCEEEEECCCEEEEEHHHCEEEEEECHHHHHHHHHHHCCCCCCCCCCHHHHHHH
MVTSANTGAVLKMQNFD
HHHCCCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA