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The map label for this gene is ilvA [H]

Identifier: 152975244

GI number: 152975244

Start: 1550422

End: 1551684

Strand: Direct

Name: ilvA [H]

Synonym: Bcer98_1447

Alternate gene names: 152975244

Gene position: 1550422-1551684 (Clockwise)

Preceding gene: 152975243

Following gene: 152975245

Centisome position: 37.94

GC content: 36.9

Gene sequence:

>1263_bases
ATGGTGCATAAGGTAAAGGAGAGAGTAAAAATTGAAGATATCCTTATGGCTCATAATTGTTTAAAGGATATTGTCAATAA
AACACCACTTCAACGAGATGCAGTTTTATCTGAGAAATATAAATGTGAAGTATATGTGAAAAGAGAAGATTTACAAGTAA
TCCGTTCCTTTAAAATTCGCGGTGCTTACAATTTAATTCAAAGTTTATCAAAAGAGAAGTTGCAAAACGGAGTTGTGTGC
GCAAGTGCTGGAAATCATGCACAAGGCGTTGCATATACGTGTAATTTATTAGAAATTCCAGCGAACATCTTTATGCCAAC
GACAACGCCAAAGCAGAAAGTATCGCAAGTCAAATTTTTCGGTGGTGATGTGGCAGACATTATGTTAGTTGGTGATACAT
TTGATAGCTCCTTTCAAGAAGCGCAGCGCTATTGTGAAGAAAATGGCATGACATTTGTACATCCTTTTGATGATCCACAC
GTAATTGCCGGTCAAGGAACAGTGGCAGTCGAGATTTTACATGATACGGAAAAAACGATTGATTATGTATTTACAGCAAT
TGGCGGTGGGGGTCTCGCTTCTGGCATCGGTACATATGTAAAGGGAGTGAGTCCAAATACAAAAGTCATCGGTGTGGAAC
CTAAAGGGGCAGCGTCGATGAAAGAAGCTTTTTTACAAAACGAAAATGTAACGCTAGAAATGATTGATAGTTTTGTAGAT
GGTGCAGCGGTAAAGAAAGTAGGAAAGCTAACTTTTGAGACTTGTAAAGATGTGTTAGATGATATTGTCTTAGTTCCTGA
AGGGAAAATTTGTACAACGATTTTAGAATTGTATAAGAAGAATGCAATTGTTGCAGAACCTGCCGGAGCTCTCTCGATTG
CAGCGCTCGATTTTTATAAAGATGAAATAAAAGGAAAGACAGTCGTTTGTGTGTTAAGCGGTGGGAATAATGATATTGAC
CGAATGCAAGAAATGAAAGAACGCTCTCTCATTTACGAAGGGATAAAACATTATTTTATTATTCAATTTCCACAGCGATC
AGGAGCATTGCGAGAGTTCCTTGATAAAGGATTAGGCCCTGAGGATGATATTACTCGTTTTGAGTATATTAAGAAGCATA
ATAAAGAAAATGGTCCTGCACTTGTCGGTGTAGAGTTAAAACATAAAGAAGATTATGAGCCACTGATTGCTCGTTTTAAG
GAAAATCATATTCAATTTCTGGAACTGAACAAAAATCCTGTTTTGTTTGATTTATTAACTTAA

Upstream 100 bases:

>100_bases
CCGCTATGCCCAGATGGTTACATCAGCAAATACTGGAGCAGTACTGAAAATGCAAAACTTTGATTGAATGATAGAAAAAA
AGGATAAGGAATGATATGAG

Downstream 100 bases:

>100_bases
TAAATAAAGAGAAAGAGGGCGAAAGTGATAAGCTCTCTTTCTTAGTTTTTATCTTTGTTATTTATGCTAGTTGAATTGTT
TAATGAAAATTCGTAATATT

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 420; Mature: 420

Protein sequence:

>420_residues
MVHKVKERVKIEDILMAHNCLKDIVNKTPLQRDAVLSEKYKCEVYVKREDLQVIRSFKIRGAYNLIQSLSKEKLQNGVVC
ASAGNHAQGVAYTCNLLEIPANIFMPTTTPKQKVSQVKFFGGDVADIMLVGDTFDSSFQEAQRYCEENGMTFVHPFDDPH
VIAGQGTVAVEILHDTEKTIDYVFTAIGGGGLASGIGTYVKGVSPNTKVIGVEPKGAASMKEAFLQNENVTLEMIDSFVD
GAAVKKVGKLTFETCKDVLDDIVLVPEGKICTTILELYKKNAIVAEPAGALSIAALDFYKDEIKGKTVVCVLSGGNNDID
RMQEMKERSLIYEGIKHYFIIQFPQRSGALREFLDKGLGPEDDITRFEYIKKHNKENGPALVGVELKHKEDYEPLIARFK
ENHIQFLELNKNPVLFDLLT

Sequences:

>Translated_420_residues
MVHKVKERVKIEDILMAHNCLKDIVNKTPLQRDAVLSEKYKCEVYVKREDLQVIRSFKIRGAYNLIQSLSKEKLQNGVVC
ASAGNHAQGVAYTCNLLEIPANIFMPTTTPKQKVSQVKFFGGDVADIMLVGDTFDSSFQEAQRYCEENGMTFVHPFDDPH
VIAGQGTVAVEILHDTEKTIDYVFTAIGGGGLASGIGTYVKGVSPNTKVIGVEPKGAASMKEAFLQNENVTLEMIDSFVD
GAAVKKVGKLTFETCKDVLDDIVLVPEGKICTTILELYKKNAIVAEPAGALSIAALDFYKDEIKGKTVVCVLSGGNNDID
RMQEMKERSLIYEGIKHYFIIQFPQRSGALREFLDKGLGPEDDITRFEYIKKHNKENGPALVGVELKHKEDYEPLIARFK
ENHIQFLELNKNPVLFDLLT
>Mature_420_residues
MVHKVKERVKIEDILMAHNCLKDIVNKTPLQRDAVLSEKYKCEVYVKREDLQVIRSFKIRGAYNLIQSLSKEKLQNGVVC
ASAGNHAQGVAYTCNLLEIPANIFMPTTTPKQKVSQVKFFGGDVADIMLVGDTFDSSFQEAQRYCEENGMTFVHPFDDPH
VIAGQGTVAVEILHDTEKTIDYVFTAIGGGGLASGIGTYVKGVSPNTKVIGVEPKGAASMKEAFLQNENVTLEMIDSFVD
GAAVKKVGKLTFETCKDVLDDIVLVPEGKICTTILELYKKNAIVAEPAGALSIAALDFYKDEIKGKTVVCVLSGGNNDID
RMQEMKERSLIYEGIKHYFIIQFPQRSGALREFLDKGLGPEDDITRFEYIKKHNKENGPALVGVELKHKEDYEPLIARFK
ENHIQFLELNKNPVLFDLLT

Specific function: Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=339, Percent_Identity=31.5634218289086, Blast_Score=151, Evalue=9e-37,
Organism=Homo sapiens, GI33469958, Length=314, Percent_Identity=27.7070063694268, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI19923959, Length=317, Percent_Identity=27.4447949526814, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1790207, Length=362, Percent_Identity=38.6740331491713, Blast_Score=216, Evalue=2e-57,
Organism=Escherichia coli, GI1789505, Length=322, Percent_Identity=38.8198757763975, Blast_Score=192, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI71991565, Length=348, Percent_Identity=34.1954022988506, Blast_Score=171, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI17537387, Length=342, Percent_Identity=31.5789473684211, Blast_Score=144, Evalue=9e-35,
Organism=Caenorhabditis elegans, GI17508781, Length=321, Percent_Identity=28.0373831775701, Blast_Score=111, Evalue=8e-25,
Organism=Saccharomyces cerevisiae, GI6320930, Length=363, Percent_Identity=38.0165289256198, Blast_Score=243, Evalue=6e-65,
Organism=Saccharomyces cerevisiae, GI6322631, Length=309, Percent_Identity=35.2750809061489, Blast_Score=180, Evalue=4e-46,
Organism=Saccharomyces cerevisiae, GI6319788, Length=288, Percent_Identity=26.0416666666667, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI21355833, Length=348, Percent_Identity=34.7701149425287, Blast_Score=164, Evalue=9e-41,
Organism=Drosophila melanogaster, GI24645328, Length=250, Percent_Identity=34.4, Blast_Score=106, Evalue=2e-23,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR001721
- InterPro:   IPR011820 [H]

Pfam domain/function: PF00291 PALP; PF00585 Thr_dehydrat_C [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 46701; Mature: 46701

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVHKVKERVKIEDILMAHNCLKDIVNKTPLQRDAVLSEKYKCEVYVKREDLQVIRSFKIR
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCEEEEEEEEHHHHHHHHHHHHC
GAYNLIQSLSKEKLQNGVVCASAGNHAQGVAYTCNLLEIPANIFMPTTTPKQKVSQVKFF
HHHHHHHHHHHHHHHCCEEEECCCCCCCCEEEEEEEEECCCCEEECCCCCHHHHHHHHHC
GGDVADIMLVGDTFDSSFQEAQRYCEENGMTFVHPFDDPHVIAGQGTVAVEILHDTEKTI
CCCEEEEEEEECCCCHHHHHHHHHHHHCCCEEEECCCCCEEEECCCEEEEEEECCCHHHH
DYVFTAIGGGGLASGIGTYVKGVSPNTKVIGVEPKGAASMKEAFLQNENVTLEMIDSFVD
HHHHHHCCCCHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHCCCCCHHHHHHHHHC
GAAVKKVGKLTFETCKDVLDDIVLVPEGKICTTILELYKKNAIVAEPAGALSIAALDFYK
CHHHHHHHHHHHHHHHHHHHCEEECCCCHHHHHHHHHHHCCCEEECCCCCEEEHHHHHHH
DEIKGKTVVCVLSGGNNDIDRMQEMKERSLIYEGIKHYFIIQFPQRSGALREFLDKGLGP
HHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHCCCCC
EDDITRFEYIKKHNKENGPALVGVELKHKEDYEPLIARFKENHIQFLELNKNPVLFDLLT
CCHHHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCEEEEEECCCCEEEEECC
>Mature Secondary Structure
MVHKVKERVKIEDILMAHNCLKDIVNKTPLQRDAVLSEKYKCEVYVKREDLQVIRSFKIR
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCEEEEEEEEHHHHHHHHHHHHC
GAYNLIQSLSKEKLQNGVVCASAGNHAQGVAYTCNLLEIPANIFMPTTTPKQKVSQVKFF
HHHHHHHHHHHHHHHCCEEEECCCCCCCCEEEEEEEEECCCCEEECCCCCHHHHHHHHHC
GGDVADIMLVGDTFDSSFQEAQRYCEENGMTFVHPFDDPHVIAGQGTVAVEILHDTEKTI
CCCEEEEEEEECCCCHHHHHHHHHHHHCCCEEEECCCCCEEEECCCEEEEEEECCCHHHH
DYVFTAIGGGGLASGIGTYVKGVSPNTKVIGVEPKGAASMKEAFLQNENVTLEMIDSFVD
HHHHHHCCCCHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHCCCCCHHHHHHHHHC
GAAVKKVGKLTFETCKDVLDDIVLVPEGKICTTILELYKKNAIVAEPAGALSIAALDFYK
CHHHHHHHHHHHHHHHHHHHCEEECCCCHHHHHHHHHHHCCCEEECCCCCEEEHHHHHHH
DEIKGKTVVCVLSGGNNDIDRMQEMKERSLIYEGIKHYFIIQFPQRSGALREFLDKGLGP
HHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHCCCCC
EDDITRFEYIKKHNKENGPALVGVELKHKEDYEPLIARFKENHIQFLELNKNPVLFDLLT
CCHHHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCEEEEEECCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]