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The map label for this gene is ytkP [H]

Identifier: 152975235

GI number: 152975235

Start: 1539489

End: 1540406

Strand: Direct

Name: ytkP [H]

Synonym: Bcer98_1438

Alternate gene names: 152975235

Gene position: 1539489-1540406 (Clockwise)

Preceding gene: 152975234

Following gene: 152975237

Centisome position: 37.67

GC content: 39.54

Gene sequence:

>918_bases
ATGAAACTATGCAAAAATGTTACAGAATTAATAGGGGATACACCTGTCGTGCGATTATCTAAATTTGTTCCGAAAGATGC
GGCGGATGTATATGTAAAGTTAGAAATGTTTAACCCATCTCGTAGTGTGAAAGATCGTGCAGCTTATCATTTAATTCATG
TTGCAGAGGAGCAAGGCTTTATTCAGCCGGGAGATACGATTATTGAACCGACAAGTGGAAATACGGGAATTGGTTTAGCG
ATGAATGCAGCGGCGAAAGGATATAAAGCGATTTTAATTATGCCGGATAATATGTCAAAAGAACGAATGAATCTGTTAAA
AGCATATGGTGCAGAAGTTATTTTGACACCGGCAGAACAAAGAATGCCAGGTGCAATTGCAAAAGCGATAGAACTGCAAA
AACAAATACCGAATAGTTTTATCCCGCAGCAATTTGAAAATCCAGCAAACCCAAATATTCATCGCTATACAACAGCACTT
GAAATTTATGAACAAATGGAAGGGAAGTTAGATGCCTTTGTAGCGACTGCTGGAACAGGTGGAACAATTACAGGGACAGG
GGAAACGTTGAAAGAGAAATTACCCAATTTACATATTGTAGTAGTGGAGCCGAAAGGATCGCCTGTTTTATCTGGCGGTG
TGCCAGGTCCTCATAAACTAGTTGGAACCAGTCCGGGGTTTATTCCAAAAAACTTAAATACAGAAATATATAACGAAATT
ATTCAAATTGCAGATGAAGAAGCGCTAAGTACGATGAGAAATTTAGCAAAACAAGAAGGGTTATTAGTAGGACCATCTTC
AGGGGCTTCCGTCTATGCCGCAATTATGATTGCGAAGCGATTAGGTGCGGGTAAGAAGGTATTGTGTATTGCACCTGATA
CAGGTGAACGGTATTTAAGTATGGGGCTGTTTGAATAA

Upstream 100 bases:

>100_bases
GCAGTTCATTATGGTATTATGTAGTTGTTTACCATTAATTGGACTTACTTCCTGGTTACTGCCGAGTGATAAAAAATCCG
TATAGAATAGGGGATGCGCT

Downstream 100 bases:

>100_bases
TAGATTGCGAGAGCATGCAAAGTAGAAAAATAAGAGATGTAACAATTTATACCGTTACATCTCTTATTTTTATTTTATAA
ATTTTCCTAATATCGGTAAT

Product: cysteine synthase A

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MKLCKNVTELIGDTPVVRLSKFVPKDAADVYVKLEMFNPSRSVKDRAAYHLIHVAEEQGFIQPGDTIIEPTSGNTGIGLA
MNAAAKGYKAILIMPDNMSKERMNLLKAYGAEVILTPAEQRMPGAIAKAIELQKQIPNSFIPQQFENPANPNIHRYTTAL
EIYEQMEGKLDAFVATAGTGGTITGTGETLKEKLPNLHIVVVEPKGSPVLSGGVPGPHKLVGTSPGFIPKNLNTEIYNEI
IQIADEEALSTMRNLAKQEGLLVGPSSGASVYAAIMIAKRLGAGKKVLCIAPDTGERYLSMGLFE

Sequences:

>Translated_305_residues
MKLCKNVTELIGDTPVVRLSKFVPKDAADVYVKLEMFNPSRSVKDRAAYHLIHVAEEQGFIQPGDTIIEPTSGNTGIGLA
MNAAAKGYKAILIMPDNMSKERMNLLKAYGAEVILTPAEQRMPGAIAKAIELQKQIPNSFIPQQFENPANPNIHRYTTAL
EIYEQMEGKLDAFVATAGTGGTITGTGETLKEKLPNLHIVVVEPKGSPVLSGGVPGPHKLVGTSPGFIPKNLNTEIYNEI
IQIADEEALSTMRNLAKQEGLLVGPSSGASVYAAIMIAKRLGAGKKVLCIAPDTGERYLSMGLFE
>Mature_305_residues
MKLCKNVTELIGDTPVVRLSKFVPKDAADVYVKLEMFNPSRSVKDRAAYHLIHVAEEQGFIQPGDTIIEPTSGNTGIGLA
MNAAAKGYKAILIMPDNMSKERMNLLKAYGAEVILTPAEQRMPGAIAKAIELQKQIPNSFIPQQFENPANPNIHRYTTAL
EIYEQMEGKLDAFVATAGTGGTITGTGETLKEKLPNLHIVVVEPKGSPVLSGGVPGPHKLVGTSPGFIPKNLNTEIYNEI
IQIADEEALSTMRNLAKQEGLLVGPSSGASVYAAIMIAKRLGAGKKVLCIAPDTGERYLSMGLFE

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=309, Percent_Identity=42.0711974110032, Blast_Score=239, Evalue=2e-63,
Organism=Homo sapiens, GI295821200, Length=309, Percent_Identity=42.0711974110032, Blast_Score=239, Evalue=2e-63,
Organism=Homo sapiens, GI4557415, Length=309, Percent_Identity=42.0711974110032, Blast_Score=239, Evalue=2e-63,
Organism=Escherichia coli, GI1788754, Length=313, Percent_Identity=45.0479233226837, Blast_Score=229, Evalue=2e-61,
Organism=Escherichia coli, GI2367138, Length=296, Percent_Identity=42.5675675675676, Blast_Score=224, Evalue=4e-60,
Organism=Escherichia coli, GI1790207, Length=265, Percent_Identity=26.4150943396226, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17535051, Length=298, Percent_Identity=46.6442953020134, Blast_Score=254, Evalue=4e-68,
Organism=Caenorhabditis elegans, GI115535073, Length=302, Percent_Identity=48.0132450331126, Blast_Score=242, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI17562970, Length=304, Percent_Identity=43.0921052631579, Blast_Score=234, Evalue=6e-62,
Organism=Caenorhabditis elegans, GI32566674, Length=299, Percent_Identity=43.8127090301003, Blast_Score=233, Evalue=1e-61,
Organism=Caenorhabditis elegans, GI17561720, Length=298, Percent_Identity=41.6107382550336, Blast_Score=203, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI32566672, Length=212, Percent_Identity=42.9245283018868, Blast_Score=168, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI17534315, Length=315, Percent_Identity=38.0952380952381, Blast_Score=165, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI25147552, Length=312, Percent_Identity=36.8589743589744, Blast_Score=154, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI17561716, Length=116, Percent_Identity=37.0689655172414, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17539800, Length=344, Percent_Identity=25.5813953488372, Blast_Score=73, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6321594, Length=315, Percent_Identity=38.0952380952381, Blast_Score=187, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6321449, Length=326, Percent_Identity=36.1963190184049, Blast_Score=154, Evalue=1e-38,
Organism=Drosophila melanogaster, GI24643623, Length=309, Percent_Identity=40.1294498381877, Blast_Score=209, Evalue=1e-54,
Organism=Drosophila melanogaster, GI20129101, Length=309, Percent_Identity=40.1294498381877, Blast_Score=209, Evalue=1e-54,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 32799; Mature: 32799

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLCKNVTELIGDTPVVRLSKFVPKDAADVYVKLEMFNPSRSVKDRAAYHLIHVAEEQGF
CCHHHHHHHHHCCCCHHHHHHHCCCCCCEEEEEEEEECCCCCHHHHHHHHEEEECCCCCC
IQPGDTIIEPTSGNTGIGLAMNAAAKGYKAILIMPDNMSKERMNLLKAYGAEVILTPAEQ
CCCCCCEEECCCCCCCEEEEECCCCCCCEEEEEECCCCCHHHHHHHHHCCCEEEEECCHH
RMPGAIAKAIELQKQIPNSFIPQQFENPANPNIHRYTTALEIYEQMEGKLDAFVATAGTG
HCCHHHHHHHHHHHHCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCC
GTITGTGETLKEKLPNLHIVVVEPKGSPVLSGGVPGPHKLVGTSPGFIPKNLNTEIYNEI
CEEECCCHHHHHHCCCEEEEEECCCCCEEEECCCCCCCCEECCCCCCCCCCCCHHHHHHH
IQIADEEALSTMRNLAKQEGLLVGPSSGASVYAAIMIAKRLGAGKKVLCIAPDTGERYLS
HHHCCHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHH
MGLFE
CCCCC
>Mature Secondary Structure
MKLCKNVTELIGDTPVVRLSKFVPKDAADVYVKLEMFNPSRSVKDRAAYHLIHVAEEQGF
CCHHHHHHHHHCCCCHHHHHHHCCCCCCEEEEEEEEECCCCCHHHHHHHHEEEECCCCCC
IQPGDTIIEPTSGNTGIGLAMNAAAKGYKAILIMPDNMSKERMNLLKAYGAEVILTPAEQ
CCCCCCEEECCCCCCCEEEEECCCCCCCEEEEEECCCCCHHHHHHHHHCCCEEEEECCHH
RMPGAIAKAIELQKQIPNSFIPQQFENPANPNIHRYTTALEIYEQMEGKLDAFVATAGTG
HCCHHHHHHHHHHHHCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCC
GTITGTGETLKEKLPNLHIVVVEPKGSPVLSGGVPGPHKLVGTSPGFIPKNLNTEIYNEI
CEEECCCHHHHHHCCCEEEEEECCCCCEEEECCCCCCCCEECCCCCCCCCCCCHHHHHHH
IQIADEEALSTMRNLAKQEGLLVGPSSGASVYAAIMIAKRLGAGKKVLCIAPDTGERYLS
HHHCCHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHH
MGLFE
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]