Click here to switch to the map view.

The map label for this gene is hisC

Identifier: 152975041

GI number: 152975041

Start: 1351256

End: 1352368

Strand: Direct

Name: hisC

Synonym: Bcer98_1241

Alternate gene names: 152975041

Gene position: 1351256-1352368 (Clockwise)

Preceding gene: 152975040

Following gene: 152975042

Centisome position: 33.06

GC content: 37.2

Gene sequence:

>1113_bases
ATGAAAGTGAAAGAGCAGTTGTTCAGTTTAAATGCGTATGTACCTGGCAAAAACATTGAAGAAGTAAAGAGGGAGTATGG
ACTATCGAAAATTGTTAAGCTAGCATCGAATGAAAATCCATTTGGTTGTTCGAAACGTGTAAAAGAAGCACTTGCTTTAT
TAAATGAGCAATATGCACTATATCCAGATGGCGCTGCATTTGAACTTCGTCAAAAGGTAGCGAATCATCTGAAAGTGCAA
CCAGAGCAACTTCTATTTGGTAGCGGATTGGATGAGGTTATTCAGATGATTAGTCGTGCTTTATTACATAAAGGCACAAA
TGTTGTGATGGCGAGGCCAACTTTTTCTCAATATCGTCATCATGCTATCATCGAAGGGGCTGAAGTTCGTGAAGTACCGT
TAAAAGATGGGATTCATGACTTAGATGCTATGCTTGAACAAGTAGATTACAATACGCGCATTGTCTGGGTCTGTAATCCG
AATAATCCGACTGGTACATATGTAGAAAAGCAGAAATTACTTTCATTTTTAGAGAATGTTCCAAAGTCATCGCTCGTTAT
TATGGATGAAGCATACTATGAATATGCAGGTGCTGAAGATTACCCGCAAACATTACCACTTCTTGAAAAATATGAAAACC
TTATGGTGTTACGTACATTTTCGAAAGCTTACGGATTAGCTGCTTTTCGGATTGGATATGCTGTAGGATACGCGGAGTTA
ATAAAGAAGTTGGAAGTAGCAAGATTGCCATTTAATACATCGACTGTTGCGCAAGTCGTGGCATCAGTGGCAATAGACGA
TCAATCATTTCTACAAGAATGTGTGAAAAAGAATGCGGAAGGTTTAGAACAATATTATCAATTTTGTAAAGAATATGATG
TGTTTTATTATCCATCTCAAACGAATTTCATTTTCCTAAAGATTGGTCTTCCGGGTAACGAAGTGTTTGAGAGATTAATG
AAAAAAGGATATATTGTTCGATCAGGTGCACCGTTTGGTTTATTGGATGGTATTCGTATTACAGTTGGTTTAAAAGAAGA
GAACGCTGAGATTATTGCGTTGCTTGCGAATCTCGTAAAAGAACATGTGAAGAAAGAAGAAACATACTCTTAA

Upstream 100 bases:

>100_bases
ATGAATTTTGAATGATGGTGACGGTTGGAAAAGAGTATGTAGTATAAGAAACGGCTTCTTATATTGCCGCTGATTAAACA
AAATGACTGGGGGAAGAAAA

Downstream 100 bases:

>100_bases
TTGATTATAGCGGCCTCCTATAAGGGGAGCCGTTTATTTTATTCCGCTATTTTAGGGGAATAAGACTCTCGCTACGTGAT
TTAGGAAGAAACAATTGAAT

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 370; Mature: 370

Protein sequence:

>370_residues
MKVKEQLFSLNAYVPGKNIEEVKREYGLSKIVKLASNENPFGCSKRVKEALALLNEQYALYPDGAAFELRQKVANHLKVQ
PEQLLFGSGLDEVIQMISRALLHKGTNVVMARPTFSQYRHHAIIEGAEVREVPLKDGIHDLDAMLEQVDYNTRIVWVCNP
NNPTGTYVEKQKLLSFLENVPKSSLVIMDEAYYEYAGAEDYPQTLPLLEKYENLMVLRTFSKAYGLAAFRIGYAVGYAEL
IKKLEVARLPFNTSTVAQVVASVAIDDQSFLQECVKKNAEGLEQYYQFCKEYDVFYYPSQTNFIFLKIGLPGNEVFERLM
KKGYIVRSGAPFGLLDGIRITVGLKEENAEIIALLANLVKEHVKKEETYS

Sequences:

>Translated_370_residues
MKVKEQLFSLNAYVPGKNIEEVKREYGLSKIVKLASNENPFGCSKRVKEALALLNEQYALYPDGAAFELRQKVANHLKVQ
PEQLLFGSGLDEVIQMISRALLHKGTNVVMARPTFSQYRHHAIIEGAEVREVPLKDGIHDLDAMLEQVDYNTRIVWVCNP
NNPTGTYVEKQKLLSFLENVPKSSLVIMDEAYYEYAGAEDYPQTLPLLEKYENLMVLRTFSKAYGLAAFRIGYAVGYAEL
IKKLEVARLPFNTSTVAQVVASVAIDDQSFLQECVKKNAEGLEQYYQFCKEYDVFYYPSQTNFIFLKIGLPGNEVFERLM
KKGYIVRSGAPFGLLDGIRITVGLKEENAEIIALLANLVKEHVKKEETYS
>Mature_370_residues
MKVKEQLFSLNAYVPGKNIEEVKREYGLSKIVKLASNENPFGCSKRVKEALALLNEQYALYPDGAAFELRQKVANHLKVQ
PEQLLFGSGLDEVIQMISRALLHKGTNVVMARPTFSQYRHHAIIEGAEVREVPLKDGIHDLDAMLEQVDYNTRIVWVCNP
NNPTGTYVEKQKLLSFLENVPKSSLVIMDEAYYEYAGAEDYPQTLPLLEKYENLMVLRTFSKAYGLAAFRIGYAVGYAEL
IKKLEVARLPFNTSTVAQVVASVAIDDQSFLQECVKKNAEGLEQYYQFCKEYDVFYYPSQTNFIFLKIGLPGNEVFERLM
KKGYIVRSGAPFGLLDGIRITVGLKEENAEIIALLANLVKEHVKKEETYS

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=341, Percent_Identity=30.4985337243402, Blast_Score=132, Evalue=5e-32,
Organism=Escherichia coli, GI1788722, Length=234, Percent_Identity=28.2051282051282, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322075, Length=355, Percent_Identity=29.5774647887324, Blast_Score=122, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_BACCN (A7GN55)

Other databases:

- EMBL:   CP000764
- RefSeq:   YP_001374558.1
- ProteinModelPortal:   A7GN55
- SMR:   A7GN55
- STRING:   A7GN55
- EnsemblBacteria:   EBBACT00000038063
- GeneID:   5345180
- GenomeReviews:   CP000764_GR
- KEGG:   bcy:Bcer98_1241
- eggNOG:   COG0079
- GeneTree:   EBGT00050000000787
- HOGENOM:   HBG646350
- OMA:   YAFELRT
- ProtClustDB:   PRK03158
- BioCyc:   BCER315749:BCER98_1241-MONOMER
- HAMAP:   MF_01023
- InterPro:   IPR001176
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PRINTS:   PR00753
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 41938; Mature: 41938

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVKEQLFSLNAYVPGKNIEEVKREYGLSKIVKLASNENPFGCSKRVKEALALLNEQYAL
CCHHHHHHHCCCCCCCCCHHHHHHHHCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEE
YPDGAAFELRQKVANHLKVQPEQLLFGSGLDEVIQMISRALLHKGTNVVMARPTFSQYRH
CCCCHHHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEECCCHHHHHH
HAIIEGAEVREVPLKDGIHDLDAMLEQVDYNTRIVWVCNPNNPTGTYVEKQKLLSFLENV
HHHCCCCCCCCCCHHCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHC
PKSSLVIMDEAYYEYAGAEDYPQTLPLLEKYENLMVLRTFSKAYGLAAFRIGYAVGYAEL
CCCCEEEEEHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IKKLEVARLPFNTSTVAQVVASVAIDDQSFLQECVKKNAEGLEQYYQFCKEYDVFYYPSQ
HHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCHHHHHHHHHHHHHCCEEEECCC
TNFIFLKIGLPGNEVFERLMKKGYIVRSGAPFGLLDGIRITVGLKEENAEIIALLANLVK
CCEEEEEECCCHHHHHHHHHHCCEEEECCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHH
EHVKKEETYS
HHHHHHCCCC
>Mature Secondary Structure
MKVKEQLFSLNAYVPGKNIEEVKREYGLSKIVKLASNENPFGCSKRVKEALALLNEQYAL
CCHHHHHHHCCCCCCCCCHHHHHHHHCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEE
YPDGAAFELRQKVANHLKVQPEQLLFGSGLDEVIQMISRALLHKGTNVVMARPTFSQYRH
CCCCHHHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEECCCHHHHHH
HAIIEGAEVREVPLKDGIHDLDAMLEQVDYNTRIVWVCNPNNPTGTYVEKQKLLSFLENV
HHHCCCCCCCCCCHHCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHC
PKSSLVIMDEAYYEYAGAEDYPQTLPLLEKYENLMVLRTFSKAYGLAAFRIGYAVGYAEL
CCCCEEEEEHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IKKLEVARLPFNTSTVAQVVASVAIDDQSFLQECVKKNAEGLEQYYQFCKEYDVFYYPSQ
HHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCHHHHHHHHHHHHHCCEEEECCC
TNFIFLKIGLPGNEVFERLMKKGYIVRSGAPFGLLDGIRITVGLKEENAEIIALLANLVK
CCEEEEEECCCHHHHHHHHHHCCEEEECCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHH
EHVKKEETYS
HHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA