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The map label for this gene is cobA [H]

Identifier: 152974951

GI number: 152974951

Start: 1258780

End: 1259556

Strand: Direct

Name: cobA [H]

Synonym: Bcer98_1148

Alternate gene names: 152974951

Gene position: 1258780-1259556 (Clockwise)

Preceding gene: 152974950

Following gene: 152974952

Centisome position: 30.8

GC content: 39.64

Gene sequence:

>777_bases
ATGGGCAAAGTATATATTGTGGGTGCGGGACCAGGAGATCCAGAATTAATTTCAATTAAGGGAGTAAAGTGCATTGAACA
AGCGGATGTCATTTTATATGACCGGCTTGTGAATAAAGAATTACTTTCTTATGCAAAACCAGATGCAGACCTAATTTATT
GTGGGAAATTACCAAACTATCATACGATGAAGCAAGAAACAATCCATACGTTTTTAGTGAAATATGCGAAAAAAGGAAAG
GTTGTAACAAGGCTAAAAGGAGGGGATCCGTTTGTATTTGGCCGAGGTGGTGAGGAAGCAGAAGTGTTAGCAAAACATGG
TATTCCTTTTGAAATTGTTCCTGGCATTACAGCAGGAATAGCAGCTTCTGCGTATGCAGGTATTCCTGTTACGCATAGAG
AAGTAAGTGCCAGTTTTGCTGTTGTAACAGGTCATCGCAAAGAAGGGACAGAGGAAGAAATAAAATGGAGAAATTTAGCA
GAAGGTGTCGATACATTAGCGGTATATATGGGAGTTAGTAATCTTCCGTATATATGTGAGAAACTTTTGCAATATGGGAA
AGAAGCAGAGACACCGGCTGCTATTATTGAATGGGGGACTACTTCGTCACAGCGTACGGTTGTAGGAACGTTAGGGACAA
TCGTTTCTATCGCGGAAATTGAAAATATTCAAAATCCGAGTATGATTGTCATTGGAGAAGTCGTTCGTTTTAGGGAAAAG
ATTCACTGGTTTGAACAGCAAACAGAAGTAGCATATTCAGTAAGCGGAGTATTGTAA

Upstream 100 bases:

>100_bases
TTGATGAACAAGAGACTTTGTAGTACGAAATAAACAATAATGGAAACTTCCATTCATAGAATGGAAGTTTCACTTTAACT
AGGAGAAATGAGGAGAGAGG

Downstream 100 bases:

>100_bases
AATGAAAGCAGTGCTGTATATATGTCATGGAAGTAGATTAAAAGCTGCGAAAGAAGAGGCGATACAGTTCGTTACTTCTT
GTATGAGTCACATTCATGCG

Product: uroporphyrin-III C-methyltransferase

Products: NA

Alternate protein names: Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM [H]

Number of amino acids: Translated: 258; Mature: 257

Protein sequence:

>258_residues
MGKVYIVGAGPGDPELISIKGVKCIEQADVILYDRLVNKELLSYAKPDADLIYCGKLPNYHTMKQETIHTFLVKYAKKGK
VVTRLKGGDPFVFGRGGEEAEVLAKHGIPFEIVPGITAGIAASAYAGIPVTHREVSASFAVVTGHRKEGTEEEIKWRNLA
EGVDTLAVYMGVSNLPYICEKLLQYGKEAETPAAIIEWGTTSSQRTVVGTLGTIVSIAEIENIQNPSMIVIGEVVRFREK
IHWFEQQTEVAYSVSGVL

Sequences:

>Translated_258_residues
MGKVYIVGAGPGDPELISIKGVKCIEQADVILYDRLVNKELLSYAKPDADLIYCGKLPNYHTMKQETIHTFLVKYAKKGK
VVTRLKGGDPFVFGRGGEEAEVLAKHGIPFEIVPGITAGIAASAYAGIPVTHREVSASFAVVTGHRKEGTEEEIKWRNLA
EGVDTLAVYMGVSNLPYICEKLLQYGKEAETPAAIIEWGTTSSQRTVVGTLGTIVSIAEIENIQNPSMIVIGEVVRFREK
IHWFEQQTEVAYSVSGVL
>Mature_257_residues
GKVYIVGAGPGDPELISIKGVKCIEQADVILYDRLVNKELLSYAKPDADLIYCGKLPNYHTMKQETIHTFLVKYAKKGKV
VTRLKGGDPFVFGRGGEEAEVLAKHGIPFEIVPGITAGIAASAYAGIPVTHREVSASFAVVTGHRKEGTEEEIKWRNLAE
GVDTLAVYMGVSNLPYICEKLLQYGKEAETPAAIIEWGTTSSQRTVVGTLGTIVSIAEIENIQNPSMIVIGEVVRFREKI
HWFEQQTEVAYSVSGVL

Specific function: Catalyzes both methylations at C-2 and C-7 of uroporphyrinogen III leading to precorrin-1 and precorrin-2; their oxidative esterification gives respectively factor I octamethyl ester and sirohydrochlorin [H]

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=243, Percent_Identity=48.559670781893, Blast_Score=248, Evalue=2e-67,
Organism=Saccharomyces cerevisiae, GI6322922, Length=239, Percent_Identity=29.7071129707113, Blast_Score=120, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR003043 [H]

Pfam domain/function: PF00590 TP_methylase [H]

EC number: =2.1.1.107 [H]

Molecular weight: Translated: 28168; Mature: 28037

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS00840 SUMT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKVYIVGAGPGDPELISIKGVKCIEQADVILYDRLVNKELLSYAKPDADLIYCGKLPNY
CCEEEEEECCCCCCCEEEECCCCHHHHCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCC
HTMKQETIHTFLVKYAKKGKVVTRLKGGDPFVFGRGGEEAEVLAKHGIPFEIVPGITAGI
CHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEECCCCCHHHHHHHCCCCEEECCCCHHHH
AASAYAGIPVTHREVSASFAVVTGHRKEGTEEEIKWRNLAEGVDTLAVYMGVSNLPYICE
HHHHHCCCCEEHHHHCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
KLLQYGKEAETPAAIIEWGTTSSQRTVVGTLGTIVSIAEIENIQNPSMIVIGEVVRFREK
HHHHCCCCCCCCEEEEEECCCCCCEEEEEHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHH
IHWFEQQTEVAYSVSGVL
HHHHHHHHHHHHEECCCC
>Mature Secondary Structure 
GKVYIVGAGPGDPELISIKGVKCIEQADVILYDRLVNKELLSYAKPDADLIYCGKLPNY
CEEEEEECCCCCCCEEEECCCCHHHHCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCC
HTMKQETIHTFLVKYAKKGKVVTRLKGGDPFVFGRGGEEAEVLAKHGIPFEIVPGITAGI
CHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEECCCCCHHHHHHHCCCCEEECCCCHHHH
AASAYAGIPVTHREVSASFAVVTGHRKEGTEEEIKWRNLAEGVDTLAVYMGVSNLPYICE
HHHHHCCCCEEHHHHCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
KLLQYGKEAETPAAIIEWGTTSSQRTVVGTLGTIVSIAEIENIQNPSMIVIGEVVRFREK
HHHHCCCCCCCCEEEEEECCCCCCEEEEEHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHH
IHWFEQQTEVAYSVSGVL
HHHHHHHHHHHHEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1906874 [H]