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The map label for this gene is hisE

Identifier: 152974938

GI number: 152974938

Start: 1246474

End: 1246797

Strand: Direct

Name: hisE

Synonym: Bcer98_1135

Alternate gene names: 152974938

Gene position: 1246474-1246797 (Clockwise)

Preceding gene: 152974937

Following gene: 152974939

Centisome position: 30.5

GC content: 31.79

Gene sequence:

>324_bases
ATGGAGAAAGTACTAAAATCATTATTTGAAACGATTGAAAATCGAAAACAAAGCCCGCTGCAGGGTTCATATACAAATTA
TTTATTAACAAAAGGAGCAGACAAAATTTTAAAGAAAATAGGAGAGGAATGTACGGAAGTTGTCATTGCTGCGAAAAACG
ATAATAAAGAAGAGATTGTTAAAGAGATGGTGGATGTATTGTATCACTGTTTCGTTTTATTAGTAGCAAAAAATATTTCA
TTAGAAGAAATTGAAAAAGAAGTGAGAGAAAGAACAGGGAAGATATCAAAGACAGAAGAGCGGAAAGAGATTGATACATT
GTAG

Upstream 100 bases:

>100_bases
TCAAGATGCTATTGTGATAACAGTGAATCAAGTAGGAGTGGCCTGCCATACAGGTGAAAAAACATGTTTTCATCATAAAA
TAATCTAGGGAGATTTGAAC

Downstream 100 bases:

>100_bases
GGAGGAAGGGAAATACATGACAGTTGATTATCACCTCTCCCCTTTATTTATCTCGCTATTTTAGGGCTCATAATCAGTGG
GGGGATGAAGAAAGCCCCCA

Product: phosphoribosyl-ATP pyrophosphatase

Products: NA

Alternate protein names: PRA-PH

Number of amino acids: Translated: 107; Mature: 107

Protein sequence:

>107_residues
MEKVLKSLFETIENRKQSPLQGSYTNYLLTKGADKILKKIGEECTEVVIAAKNDNKEEIVKEMVDVLYHCFVLLVAKNIS
LEEIEKEVRERTGKISKTEERKEIDTL

Sequences:

>Translated_107_residues
MEKVLKSLFETIENRKQSPLQGSYTNYLLTKGADKILKKIGEECTEVVIAAKNDNKEEIVKEMVDVLYHCFVLLVAKNIS
LEEIEKEVRERTGKISKTEERKEIDTL
>Mature_107_residues
MEKVLKSLFETIENRKQSPLQGSYTNYLLTKGADKILKKIGEECTEVVIAAKNDNKEEIVKEMVDVLYHCFVLLVAKNIS
LEEIEKEVRERTGKISKTEERKEIDTL

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0140

COG function: function code E; Phosphoribosyl-ATP pyrophosphohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-PH family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS2_BACCN (A7GMV2)

Other databases:

- EMBL:   CP000764
- RefSeq:   YP_001374455.1
- ProteinModelPortal:   A7GMV2
- SMR:   A7GMV2
- STRING:   A7GMV2
- EnsemblBacteria:   EBBACT00000037821
- GeneID:   5344540
- GenomeReviews:   CP000764_GR
- KEGG:   bcy:Bcer98_1135
- eggNOG:   COG0140
- GeneTree:   EBGT00050000000893
- HOGENOM:   HBG646527
- OMA:   KLGEETT
- ProtClustDB:   PRK00400
- BioCyc:   BCER315749:BCER98_1135-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01020
- InterPro:   IPR008179
- InterPro:   IPR021130
- TIGRFAMs:   TIGR03188

Pfam domain/function: PF01503 PRA-PH

EC number: =3.6.1.31

Molecular weight: Translated: 12345; Mature: 12345

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKVLKSLFETIENRKQSPLQGSYTNYLLTKGADKILKKIGEECTEVVIAAKNDNKEEIV
CHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHH
KEMVDVLYHCFVLLVAKNISLEEIEKEVRERTGKISKTEERKEIDTL
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHCCCC
>Mature Secondary Structure
MEKVLKSLFETIENRKQSPLQGSYTNYLLTKGADKILKKIGEECTEVVIAAKNDNKEEIV
CHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHH
KEMVDVLYHCFVLLVAKNISLEEIEKEVRERTGKISKTEERKEIDTL
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA