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The map label for this gene is hisI

Identifier: 152974937

GI number: 152974937

Start: 1246156

End: 1246461

Strand: Direct

Name: hisI

Synonym: Bcer98_1134

Alternate gene names: 152974937

Gene position: 1246156-1246461 (Clockwise)

Preceding gene: 152974936

Following gene: 152974938

Centisome position: 30.49

GC content: 33.66

Gene sequence:

>306_bases
ATGAGACCTAATTTTTCTAAAGGATTATTACCTGCTATTGTTATAAATGAGGAGACAAAAGAAGTTTTAATGCTAGCTTA
TATGAATGAAGAGGCATATGAAAAGACGTTAAAAACAAAAAAAACATGGTTTTATTCCCGTTCGCGGCAAACACTTTGGA
ATAAAGGAGCAACATCGGGCCATGTACAACATGTGAAATCACTTTATTTAGATTGTGATCAAGATGCTATTGTGATAACA
GTGAATCAAGTAGGAGTGGCCTGCCATACAGGTGAAAAAACATGTTTTCATCATAAAATAATCTAG

Upstream 100 bases:

>100_bases
CTGTAAATGCAGCGCTAGCAGCATCCATTTTTCATTATGGAGAATGCACAGTACAGGAAGTAAAACAAAAATTACAATAT
GCAGGTATTGAGGTGAGAAT

Downstream 100 bases:

>100_bases
GGAGATTTGAACATGGAGAAAGTACTAAAATCATTATTTGAAACGATTGAAAATCGAAAACAAAGCCCGCTGCAGGGTTC
ATATACAAATTATTTATTAA

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH

Number of amino acids: Translated: 101; Mature: 101

Protein sequence:

>101_residues
MRPNFSKGLLPAIVINEETKEVLMLAYMNEEAYEKTLKTKKTWFYSRSRQTLWNKGATSGHVQHVKSLYLDCDQDAIVIT
VNQVGVACHTGEKTCFHHKII

Sequences:

>Translated_101_residues
MRPNFSKGLLPAIVINEETKEVLMLAYMNEEAYEKTLKTKKTWFYSRSRQTLWNKGATSGHVQHVKSLYLDCDQDAIVIT
VNQVGVACHTGEKTCFHHKII
>Mature_101_residues
MRPNFSKGLLPAIVINEETKEVLMLAYMNEEAYEKTLKTKKTWFYSRSRQTLWNKGATSGHVQHVKSLYLDCDQDAIVIT
VNQVGVACHTGEKTCFHHKII

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=91, Percent_Identity=47.2527472527472, Blast_Score=98, Evalue=8e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS3_BACCN (A7GMV1)

Other databases:

- EMBL:   CP000764
- RefSeq:   YP_001374454.1
- ProteinModelPortal:   A7GMV1
- SMR:   A7GMV1
- STRING:   A7GMV1
- EnsemblBacteria:   EBBACT00000036061
- GeneID:   5344533
- GenomeReviews:   CP000764_GR
- KEGG:   bcy:Bcer98_1134
- eggNOG:   COG0139
- GeneTree:   EBGT00050000000892
- HOGENOM:   HBG294308
- OMA:   LWLKGES
- ProtClustDB:   PRK00051
- BioCyc:   BCER315749:BCER98_1134-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01021
- InterPro:   IPR002496
- ProDom:   PD002610

Pfam domain/function: PF01502 PRA-CH

EC number: =3.5.4.19

Molecular weight: Translated: 11585; Mature: 11585

Theoretical pI: Translated: 8.84; Mature: 8.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPNFSKGLLPAIVINEETKEVLMLAYMNEEAYEKTLKTKKTWFYSRSRQTLWNKGATSG
CCCCCCCCCCEEEEECCCCHHEEEEEECCCHHHHHHHHHHHHHEECCCCHHHHCCCCCCH
HVQHVKSLYLDCDQDAIVITVNQVGVACHTGEKTCFHHKII
HHHHHHHHHCCCCCCEEEEEEECCEEEEECCCCCCEEECCC
>Mature Secondary Structure
MRPNFSKGLLPAIVINEETKEVLMLAYMNEEAYEKTLKTKKTWFYSRSRQTLWNKGATSG
CCCCCCCCCCEEEEECCCCHHEEEEEECCCHHHHHHHHHHHHHEECCCCHHHHCCCCCCH
HVQHVKSLYLDCDQDAIVITVNQVGVACHTGEKTCFHHKII
HHHHHHHHHCCCCCCEEEEEEECCEEEEECCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA